2. Others Cell Cycle/DNA Damage PI3K/Akt/mTOR Epigenetics Anti-infection
  3. PERK Akt Fungal Environmental Pollutants AMPK
  4. Triadimefon

Triadimefon is an orally active fungicide. Triadimefon significantly reduces the phosphorylation of AKT1 and ERK1/2. Triadimefon significantly increases pAMPK levels, but does not affect total AMPK levels. Triadimefon inhibits the growth of Saccharomyces cerevisiae, disrupts hormone homeostasis (affecting the synthesis of testosterone, etc.), inhibits fetal adrenal development in rats, induces metabolic shifts in hepatocytes, and impairs spatial learning and memory.

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Triadimefon

Triadimefon 構造式

CAS 番号 : 43121-43-3

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 在庫あり
Solution
10 mM * 1 mL in DMSO USD 55 在庫あり
Solid
250 mg $50 在庫あり
500 mg   お問い合わせ  
1 g   お問い合わせ  

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Triadimefon 関連抗体

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

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製品説明

Triadimefon is an orally active fungicide. Triadimefon significantly reduces the phosphorylation of AKT1 and ERK1/2. Triadimefon significantly increases pAMPK levels, but does not affect total AMPK levels. Triadimefon inhibits the growth of Saccharomyces cerevisiae, disrupts hormone homeostasis (affecting the synthesis of testosterone, etc.), inhibits fetal adrenal development in rats, induces metabolic shifts in hepatocytes, and impairs spatial learning and memory[1][2][3][4][5][6][7].

IC50 & Target[2]

Akt1

 

体外実験

Triadimefon (5-50 mg/L) significantly inhibits the growth of Saccharomyces cerevisiae (45%-100% inhibition)[1].
Triadimefon (0.15-0.3 mM; 3 days) significantly reduces albumin production in primary rat hepatocytes and induces a metabolic shift in hepatocytes (from glycolysis to gluconeogenesis and from fatty acid synthesis to fatty acid oxidation)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Triadimefon 関連抗体

Cell Viability Assay[1]

Cell Line: Saccharomyces cerevisiae CICC 1202
Concentration: 0.1 mg/L, 1.0 mg/L, 5.0 mg/L, 10 mg/L, 50 mg/L
Incubation Time:
Result: Did not significantly affect yeast growth at 0.1 mg/L and 1.0 mg/L.
Significantly reduced cell viability, with 45%, 80%, and 100% growth inhibition at 5 mg/L, 10 mg/L, and 50 mg/L, respectively.
体内実験

Triadimefon (25-100 mg/kg; p.o.; daily; 10 days (from gestational day 12 to 21)) inhibits fetal adrenal development in rats[2].
Triadimefon (25-100 mg/kg; p.o.; 9 days (GD 12-GD 20)) significantly reduces serum testosterone level, increases the number of fetal Leydig cells with abnormal aggregation in male fetuses, downregulates testis-related gene and protein expression, induces oxidative stress in pregnant Sprague-Dawley rats[5].
Triadimefon (20-200 mg/kg; i.p.; once daily; 7 consecutive days) significantly inhibits spatial learning ability, impairs spatial reference memory, and reduces hippocampal retinoic acid (HY-14649) concentration in rats[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pregnant Sprague-Dawley rats and their male fetuses[2]
Dosage: 0 mg/kg, 25 mg/kg, 50 mg/kg, 100 mg/kg
Administration: Gavage (2 mL/kg); daily; from gestational day (GD) 12 to GD 21 (10 days)
Result: Significantly reduced the thickness of zona fasciculata and serum aldosterone level in male fetuses.
Reduced serum corticosterone and ACTH levels.
Showed downregulation of Agtr1, Mc2r, Star, Cyp11b1, Cyp11b2, Igf1, Nr5a1, Sod2, Gpx1, and Cat mRNA.
Reduced AT1R, CYP11B2, IGF1, NR5A1, and MC2R protein levels.
Significantly reduced phosphorylation of AKT1 and ERK1/2.
Significantly increased pAMPK level without affecting total AMPK.
分子量

293.75

分子式

C14H16ClN3O2
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

CC(C)(C(C(N1N=CN=C1)OC2=CC=C(C=C2)Cl)=O)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 250 mg/mL (851.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4043 mL 17.0213 mL 34.0426 mL
5 mM 0.6809 mL 3.4043 mL 6.8085 mL
10 mM 0.3404 mL 1.7021 mL 3.4043 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 2.08 mg/mL (7.08 mM); Suspended solution; Need ultrasonic

    This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (7.08 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4043 mL 17.0213 mL 34.0426 mL 85.1064 mL
5 mM 0.6809 mL 3.4043 mL 6.8085 mL 17.0213 mL
10 mM 0.3404 mL 1.7021 mL 3.4043 mL 8.5106 mL
15 mM 0.2270 mL 1.1348 mL 2.2695 mL 5.6738 mL
20 mM 0.1702 mL 0.8511 mL 1.7021 mL 4.2553 mL
25 mM 0.1362 mL 0.6809 mL 1.3617 mL 3.4043 mL
30 mM 0.1135 mL 0.5674 mL 1.1348 mL 2.8369 mL
40 mM 0.0851 mL 0.4255 mL 0.8511 mL 2.1277 mL
50 mM 0.0681 mL 0.3404 mL 0.6809 mL 1.7021 mL
60 mM 0.0567 mL 0.2837 mL 0.5674 mL 1.4184 mL
80 mM 0.0426 mL 0.2128 mL 0.4255 mL 1.0638 mL
100 mM 0.0340 mL 0.1702 mL 0.3404 mL 0.8511 mL
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Triadimefon Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Triadimefon43121-43-3PERKAktFungalEnvironmental PollutantsAMPKProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinasePKBProtein kinase BEnvironmental ContaminantsAMP-activated protein kinaseInhibitorinhibitorinhibit

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製品名:
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製品番号:
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