43121-43-3
Chemical Structure
Triadimefon
- CAS No.: 43121-43-3
- Formula:C14H16ClN3O2
- Molecular Weight:293.75
IUPAC Name: 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one
InChIKey: WURBVZBTWMNKQT-UHFFFAOYSA-N
SMILES: CC(C)(C(C(N1N=CN=C1)OC2=CC=C(C=C2)Cl)=O)C
Biological Activity: Triadimefon is an orally active fungicide. Triadimefon significantly reduces the phosphorylation of AKT1 and ERK1/2. Triadimefon significantly increases pAMPK levels, but does not affect total AMPK levels. Triadimefon inhibits the growth of Saccharomyces cerevisiae, disrupts hormone homeostasis (affecting the synthesis of testosterone, etc.), inhibits fetal adrenal development in rats, induces metabolic shifts in hepatocytes, and impairs spatial learning and memory[1][2][3][4][5][6][7].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Triadimefon | 98.12% | Triadimefon is an orally active fungicide. Triadimefon significantly reduces the phosphorylation of AKT1 and ERK1/2. Triadimefon significantly increases pAMPK levels, but does not affect total AMPK levels. Triadimefon inhibits the growth of Saccharomyces cerevisiae, disrupts hormone homeostasis (affecting the synthesis of testosterone, etc.), inhibits fetal adrenal development in rats, induces metabolic shifts in hepatocytes, and impairs spatial learning and memory. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Triadimefon (Standard) | 98.05% | Triadimefon (Standard) is the analytical standard of Triadimefon (HY-123037). This product is intended for research and analytical applications. Triadimefon is an orally active fungicide. Triadimefon significantly reduces the phosphorylation of AKT1 and ERK1/2. Triadimefon significantly increases pAMPK levels, but does not affect total AMPK levels. Triadimefon inhibits the growth of Saccharomyces cerevisiae, disrupts hormone homeostasis (affecting the synthesis of testosterone, etc.), inhibits fetal adrenal development in rats, induces metabolic shifts in hepatocytes, and impairs spatial learning and memory. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
(±)-Triadimefon-d4 | (±)-Triadimefon-d4 is deuterium labeled Triadimefon. Triadimefon is a triazole fungicide used to control powdery mildew, rusts, and other fungal pests on grains, fruit and vegetable crops, turf, shrubs, and trees. Triadimefon inhibits lanosterol 14α-demethylase, interfering with oxidative demethylation reactions in the ergosterol biosynthesis pathway of fungi, and also blocks gibberellin biosynthesis. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Kong Z, et al. The fungicide triadimefon affects beer flavor and composition by influencing Saccharomyces cerevisiae metabolism. Sci Rep. 2016 Sep 15;6:33552. [Content Brief]
- [2]. Xu Q, et al. Triadimefon suppresses fetal adrenal gland development after in utero exposure. Toxicology. 2021 Oct;462:152932. [Content Brief]
- [3]. Iyer V V, et al. Effects of Triadimefon on the Metabolism of Cultured Hepatocytes[C]//2010 IEEE International Conference on BioInformatics and BioEngineering. IEEE, 2010: 118-123.
- [4]. Walker QD, et al. Triadimefon and triadimenol: effects on monoamine uptake and release. Toxicol Appl Pharmacol. 1996 Aug;139(2):227-33. [Content Brief]
- [5]. Lin L, et al. Triadimefon increases fetal Leydig cell proliferation but inhibits its differentiation of male fetuses after gestational exposure. Ecotoxicol Environ Saf. 2021 Oct 30;228:112942. [Content Brief]
- [6]. Di Renzo F, et al. Stage-dependent abnormalities induced by the fungicide triadimefon in the mouse. Reprod Toxicol. 2011 Feb;31(2):194-9. [Content Brief]
- [7]. Xi J, et al. Suppressive effect of triadimefon, a triazole fungicide, on spatial learning and reference memory in rats. Behav Pharmacol. 2012 Dec;23(8):727-34. [Content Brief]
