Paclobutrazol

Cat. No.: HY-B0853 Purity: 97.29%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Paclobutrazol is a triazole-containing plant growth retardant that is known to inhibit the biosynthesis of gibberellins. Paclobutrazol also has antifungal activities. Paclobutrazol, transported acropetally in plants, can also suppress the synthesis of abscisic acid and induce chilling tolerance in plants. Paclobutrazol is typically used to support research on the role of gibberellins in plant biology.

For research use only. We do not sell to patients.

Paclobutrazol Chemical Structure

CAS No. : 76738-62-0

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 33	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 33	In-stock	Estimated Time of Arrival: December 31
Solid
250 mg	USD 30	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 45	In-stock	Estimated Time of Arrival: December 31
1 g	USD 72	In-stock	Estimated Time of Arrival: December 31
5 g		Get quote
10 g		Get quote

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Other Forms of Paclobutrazol:

(Rac)-Paclobutrazol-¹⁵N₃ Get quote
Paclobutrazol-d₄ Get quote

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Biological Activity
Purity & Documentation
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Description

In Vitro

Paclobutrazol (Foliar spraying, 5-20 μg/mL) increases total soluble sugars, starch, protein and free amino acids in mature seeds of Brassica juncea^[1].
Paclobutrazol (0-19.8 μg·AI/mL) inhibits the growth of a panel of fungis (such as Sirococcus clavigignenti-juglandacearum and Ceratocystis fagacearum)^[2].
Paclobutrazol (5-100 μg/mL, 7-21 days) improves the quality of tomato seedlings and induces resistance to early blight disease^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

293.79

Formula

C₁₅H₂₀ClN₃O

CAS No.

76738-62-0

Appearance

Solid

Color

White to off-white

SMILES

O[C@@H](C(C)(C)C)[C@@H](N1N=CN=C1)CC2=CC=C(Cl)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (850.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4038 mL	17.0190 mL	34.0379 mL
5 mM	0.6808 mL	3.4038 mL	6.8076 mL
10 mM	0.3404 mL	1.7019 mL	3.4038 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (7.08 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (7.08 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (7.08 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 97.29%

Select Batch:

Data Sheet (250 KB) SDS (774 KB)

COA (253 KB) HNMR (250 KB) RP-HPLC (243 KB) LCMS (91 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.4038 mL	17.0190 mL	34.0379 mL	85.0948 mL
	5 mM	0.6808 mL	3.4038 mL	6.8076 mL	17.0190 mL
	10 mM	0.3404 mL	1.7019 mL	3.4038 mL	8.5095 mL
	15 mM	0.2269 mL	1.1346 mL	2.2692 mL	5.6730 mL
	20 mM	0.1702 mL	0.8509 mL	1.7019 mL	4.2547 mL
	25 mM	0.1362 mL	0.6808 mL	1.3615 mL	3.4038 mL
	30 mM	0.1135 mL	0.5673 mL	1.1346 mL	2.8365 mL
	40 mM	0.0851 mL	0.4255 mL	0.8509 mL	2.1274 mL
	50 mM	0.0681 mL	0.3404 mL	0.6808 mL	1.7019 mL
	60 mM	0.0567 mL	0.2836 mL	0.5673 mL	1.4182 mL
	80 mM	0.0425 mL	0.2127 mL	0.4255 mL	1.0637 mL
	100 mM	0.0340 mL	0.1702 mL	0.3404 mL	0.8509 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Paclobutrazol76738-62-0Inhibitorinhibitorinhibit

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