1,3-Dihydroxyacetone (Synonyms: Dihydroxyacetone)

Art. -Nr.: HY-Y0335 Reinheit: 98.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

1,3-Dihydroxyacetone (DHA), the main active ingredient in sunless tanning skin-care preparations and an important precursor for the synthesis of various fine chemicals, is produced on an industrial scale by microbial fermentation of glycerol (HY-B1659) in Gluconobacter oxydans. 1,3-Dihydroxyacetone is also used for synthesis of new biodegradable polymers by combining with lactic acid (HY-B2227).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

1,3-Dihydroxyacetone Chemische Struktur

CAS. Nr. : 96-26-4

Größe	Verfügbarkeit	Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
Solid
500 mg	Auf Lager	Estimated Time of Arrival: December 31
1 g	Auf Lager	Estimated Time of Arrival: December 31
5 g	Auf Lager	Estimated Time of Arrival: December 31
10 g	Auf Lager	Estimated Time of Arrival: December 31
25 g	Auf Lager	Estimated Time of Arrival: December 31
50 g	Auf Lager	Estimated Time of Arrival: December 31
100 g	Auf Lager	Estimated Time of Arrival: December 31
> 100 g	Angebot einholen

or Massenanfrage

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

This product is a controlled substance and not for sale in your territory.

Other Forms of 1,3-Dihydroxyacetone:

1,3-Dihydroxyacetone (Standard) Angebot einholen

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Antibiotic Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

IC₅₀ & Target

Microbial Metabolite

In Vitro

DHA (20-30 g/L) can inhibit the mitotic activity of the gram-negative bacterium G. oxydans^[3].
At higher concentrations of 1,3-Dihydroxyacetone (70 g/L), it completely inhibits G. oxydans cells, blocking the fermentation process and thereby affecting the production of 1,3-Dihydroxyacetone^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Klinische Studie

Molekulargewicht

90.08

Formel

C₃H₆O₃

CAS. Nr.

96-26-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(CO)CO

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Microorganisms

Gluconobacter oxydans

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 116.67 mg/mL (1295.18 mM; Need ultrasonic)

DMSO : 100 mg/mL (1110.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	11.1012 mL	55.5062 mL	111.0124 mL
5 mM	2.2202 mL	11.1012 mL	22.2025 mL
10 mM	1.1101 mL	5.5506 mL	11.1012 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (27.75 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (27.75 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (27.75 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Reinheit & Dokumentation

Purity: 99.49%

Select Batch:

Data Sheet (270 KB) SDS (393 KB)

COA (243 KB) HNMR (115 KB) GC (214 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Zheng Z, et al. Novel Process for 1,3-Dihydroxyacetone Production from Glycerol. 1. Technological Feasibility Study and Process Design. Ind. Eng. Chem. Res. 2012, 51, 9, 3715–3721.

[2]. Dikshit PK, et al. Optimization of 1,3-dihydroxyacetone production from crude glycerol by immobilized Gluconobacter oxydans MTCC 904. Bioresour Technol. 2016 Sep;216:1058-65. [Content Brief]

[3]. Dikshit PK, et al. Process optimization and analysis of product inhibition kinetics of crude glycerol fermentation for 1,3-Dihydroxyacetone production. Bioresour Technol. 2017 Nov;244(Pt 1):362-370. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	11.1012 mL	55.5062 mL	111.0124 mL	277.5311 mL
	5 mM	2.2202 mL	11.1012 mL	22.2025 mL	55.5062 mL
	10 mM	1.1101 mL	5.5506 mL	11.1012 mL	27.7531 mL
	15 mM	0.7401 mL	3.7004 mL	7.4008 mL	18.5021 mL
	20 mM	0.5551 mL	2.7753 mL	5.5506 mL	13.8766 mL
	25 mM	0.4440 mL	2.2202 mL	4.4405 mL	11.1012 mL
	30 mM	0.3700 mL	1.8502 mL	3.7004 mL	9.2510 mL
	40 mM	0.2775 mL	1.3877 mL	2.7753 mL	6.9383 mL
	50 mM	0.2220 mL	1.1101 mL	2.2202 mL	5.5506 mL
	60 mM	0.1850 mL	0.9251 mL	1.8502 mL	4.6255 mL
	80 mM	0.1388 mL	0.6938 mL	1.3877 mL	3.4691 mL
	100 mM	0.1110 mL	0.5551 mL	1.1101 mL	2.7753 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

1,3-Dihydroxyacetone Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,3-Dihydroxyacetone96-26-4DihydroxyacetoneBacterialAntibioticDrug IntermediateDrug IintermediatetanningGluconobacter oxydansglycerolbiodegradable polymersprecursorInhibitorinhibitorinhibit

Ihre kürzlich angesehenen Produkte:

Produktname

Requested Quantity *

Name des Antragstellers *

Anrede

E-Mail-Addresse *

Telefonnummer *

Department

Name der Organisation *

City

Bundesland

Country or Region *

Bemerkungen

Produktname

Lot #

Name des Antragstellers *

E-Mail-Addresse *

Telefonnummer

Department *