2. GPCR/G Protein Neuronal Signaling Anti-infection
  3. 5-HT Receptor Flavivirus
  4. Palonosetron hydrochloride

パロノセトロン 塩酸塩  (Synonyms: Palonosetron (hydrochloride))

製品番号: HY-A0021 純度: 99.94%
COA 取扱説明書 Technical Support

Palonosetron hydrochloride is a 5-HT3 antagonist primarily used to prevent acute, delayed, and overall chemotherapy-induced nausea and vomiting. In addition, Palonosetron hydrochloride exhibits moderate anti-flavivirus activity and potent anti-Zika virus activity in mammalian cells. Palonosetron hydrochloride also possesses antidepressant activity.

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Palonosetron hydrochloride

パロノセトロン 塩酸塩 構造式

CAS 番号 : 135729-62-3

容量 価格（税別） 在庫状況 数量
50 mg $60 在庫あり
100 mg $95 在庫あり
200 mg $150 在庫あり
500 mg   お問い合わせ  
1 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

Other Forms of Palonosetron hydrochloride:

パロノセトロン 塩酸塩 関連抗体

Top Publications Citing Use of Products

5-HT Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

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  • 純度とドキュメンテーション

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製品説明

Palonosetron hydrochloride is a 5-HT3 antagonist primarily used to prevent acute, delayed, and overall chemotherapy-induced nausea and vomiting. In addition, Palonosetron hydrochloride exhibits moderate anti-flavivirus activity and potent anti-Zika virus activity in mammalian cells. Palonosetron hydrochloride also possesses antidepressant activity[1][2][3][4].

IC50 & Target

5-HT3 Receptor

 

体外実験

Palonosetron (10 nM, 2 hours) hydrochloride inhibits the enhancement effect of 5-HT on substance P (SP)-induced calcium release in NG108-15 cells, increasing the EC50 of SP from 0.62 µM to 3.7 µM[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

パロノセトロン 塩酸塩 関連抗体
体内実験

Palonosetron (0.05 mg/kg, i.p., single dose) hydrochloride significantly reduces immobility in Swiss albino mice, demonstrating potential antidepressant activity[5].
alonosetron (30-300 µg/kg, i.v., single dose) hydrochloride dose-dependently inhibits SP-mediated neuronal responses in the Cisplatin (HY-17394)-induced rat emesis model, indicating its impact on neurotransmission[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss albino mice (25-40 g)[5]
Dosage: 0.025 and 0.05 mg/kg
Administration: Intraperitoneal injection (i.p.), single dose, efficacy tested after 1 hour and 24 hours
Result: Reduced immobility time in a dose-dependent manner. The 0.05 mg/kg dose significantly reduced immobility time after 1 hour and 24 hours.
Animal Model: Cisplatin-induced emesis model in adult male Sprague-Dawley rats (270-350 g)[6]
Dosage: 30 µg/kg, 100 µg/kg, 300 µg/kg
Administration: Intravenous injection (i.v.), single dose
Result: Dose-dependently inhibited the Cisplatin (HY-17394)-induced enhancement of neuronal response to substance P (SP) in the nodose ganglia.
分子量

332.87

分子式

C19H25ClN2O
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C[C@@]([H])(CCC2)C3=C2C=CC=C13)[C@@H]4CN5CCC4CC5.[H]Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
体外: 

H2O : 100 mg/mL (300.42 mM; Need ultrasonic)

DMSO : 3.33 mg/mL (10.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0042 mL 15.0209 mL 30.0418 mL
5 mM 0.6008 mL 3.0042 mL 6.0084 mL
10 mM 0.3004 mL 1.5021 mL 3.0042 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

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体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 0.33 mg/mL (0.99 mM); Clear solution

    This protocol yields a clear solution of ≥ 0.33 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (3.3 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 0.33 mg/mL (0.99 mM); Clear solution

    This protocol yields a clear solution of ≥ 0.33 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (3.3 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (300.42 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.94%

COA (260 KB) LCMS (93 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 3.0042 mL 15.0209 mL 30.0418 mL 75.1044 mL
5 mM 0.6008 mL 3.0042 mL 6.0084 mL 15.0209 mL
H2O 15 mM 0.2003 mL 1.0014 mL 2.0028 mL 5.0070 mL
20 mM 0.1502 mL 0.7510 mL 1.5021 mL 3.7552 mL
25 mM 0.1202 mL 0.6008 mL 1.2017 mL 3.0042 mL
30 mM 0.1001 mL 0.5007 mL 1.0014 mL 2.5035 mL
40 mM 0.0751 mL 0.3755 mL 0.7510 mL 1.8776 mL
50 mM 0.0601 mL 0.3004 mL 0.6008 mL 1.5021 mL
60 mM 0.0501 mL 0.2503 mL 0.5007 mL 1.2517 mL
80 mM 0.0376 mL 0.1878 mL 0.3755 mL 0.9388 mL
100 mM 0.0300 mL 0.1502 mL 0.3004 mL 0.7510 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Palonosetron hydrochloride Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Palonosetron135729-62-35-HT ReceptorFlavivirusSerotonin Receptor5-hydroxytryptamine ReceptorNG108-15 cellsSwiss albino miceCisplatin-induced emesis modelInhibitorinhibitorinhibit

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