1. Apoptosis
    Anti-infection
  2. Caspase
    HIV
  3. Q-VD-OPh

Q-VD-OPh (Synonyms: QVD-OPH; Quinoline-Val-Asp-Difluorophenoxymethylketone)

製品番号: HY-12305 純度: 99.26%
取扱説明書

Q-VD-OPh is an irreversible pan-caspase inhibitor with potent antiapoptotic properties; inhibits caspase 7 with an IC50 of 48 nM and 25-400 nM for other caspases including caspase 1, 3, 8, 9, 10, and 12. Q-VD-OPh can inhibits HIV infection. Q-VD-OPh is able to cross the blood-brain barrier.

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Q-VD-OPh 構造式

Q-VD-OPh 構造式

CAS 番号 : 1135695-98-5

容量 価格(税別) 在庫状況 数量
10 mM * 1 mL in DMSO USD 122 在庫あり
Estimated Time of Arrival: December 31
1 mg USD 60 在庫あり
Estimated Time of Arrival: December 31
5 mg USD 108 在庫あり
Estimated Time of Arrival: December 31
10 mg USD 180 在庫あり
Estimated Time of Arrival: December 31
25 mg USD 288 在庫あり
Estimated Time of Arrival: December 31
50 mg USD 528 在庫あり
Estimated Time of Arrival: December 31
100 mg   お問い合わせ  
200 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

カスタマーレビュー

Based on 9 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Q-VD-OPh purchased from MCE. Usage Cited in: Cancer Sci. 2019 May;110(5):1746-1759.

    Cells are treated with RA in the presence or absence of the caspase inhibitor Q-VD-OPh, and cleaved caspase-3 and caspase-8 and total and cleaved PARP were analyzed.
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    製品説明

    Q-VD-OPh is an irreversible pan-caspase inhibitor with potent antiapoptotic properties; inhibits caspase 7 with an IC50 of 48 nM and 25-400 nM for other caspases including caspase 1, 3, 8, 9, 10, and 12. Q-VD-OPh can inhibits HIV infection. Q-VD-OPh is able to cross the blood-brain barrier.

    IC50 & Target[1]

    Caspase-7

    48 nM (IC50)

    Caspase-3

    25-400 nM (IC50)

    Caspase-1

    25-400 nM (IC50)

    Caspase-8

    25-400 nM (IC50)

    Caspase-9

    25-400 nM (IC50)

    Caspase-10

    25-400 nM (IC50)

    Caspase-12

    25-400 nM (IC50)

    体外実験

    Q-VD-OPh is a potent inhibitor of caspase-7 with an IC50 of 48 nM utilizing a cell-free assay consisting of human recombinant caspase-7, Q-VD-OPh, and the substrate AMC-DEVD-pNa[1]. Q-VD-OPh fully inhibits caspase-3 and -7 activity at 0.05 μM. Caspase-8 is also inhibited at low Q-VD-OPh concentrations. The cleavage of PARP-1 is fully prevented at 10 μM Q-VD-OPh. DNA fragmentation and disruption of the cell membrane functionality are both prevented at 2 μM Q-VD-OPh[2]. Q-VD-OPh is significantly more effective in preventing apoptosis than the widely used inhibitors, ZVAD-fmk and Boc-D-fmk, and is also equally effective in preventing apoptosis mediated by the three major apoptotic pathways, caspase 9/3, caspase 8/10, and caspase12. Q-VD-OPh is not toxic to cells even at extremely high concentrations[3]. QVD is also able to increase the expression of differentiation markers in acute myeloid leukemia (AmL) blasts. QVD alone or combined with VDDs increases differentiation and HPK1-cJun signaling in AmL cell context-dependent manner[4].

    体内実験

    Chronic treatment with Q-VD-OPh prevents caspase-7 activation and limits the pathological changes associated with tau, including caspase cleavage. Q-VD-OPh could be a potential therapeutic compound for the treatment of Alzheimer's disease[1].

    分子量

    513.49

    分子式

    C₂₆H₂₅F₂N₃O₆

    CAS 番号

    1135695-98-5

    SMILES

    O=C(O)C[[email protected]](NC([[email protected]@H](NC(C1=NC2=CC=CC=C2C=C1)=O)C(C)C)=O)C(COC3=C(F)C=CC=C3F)=O

    輸送条件

    Room temperature in continental US; may vary elsewhere.

    保管条件
    Powder -20°C 3 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 93.33 mg/mL (181.76 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9475 mL 9.7373 mL 19.4746 mL
    5 mM 0.3895 mL 1.9475 mL 3.8949 mL
    10 mM 0.1947 mL 0.9737 mL 1.9475 mL
    *Please refer to the solubility information to select the appropriate solvent.
    体内:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.33 mg/mL (4.54 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.08 mg/mL (4.05 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.33 mg/mL (4.54 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    参考文献
    動物実験
    [1]

    Mouse: Stock solutions of Q-VD-OPh are prepared in DMSO and diluted in sterile PBS solution prior to injection. A final concentration of 10 mg/kg is chosen indicating neuroprotection at this concentration of Q-VD-OPh. Three-month old mice are divided into two groups: control, vehicle (n=3) or treated (n=2). Mice are injected i.p. three times a week with either Q-VD-OPh or vehicle for a total time period of 3 months[1].

    MCE はこれらの方法の精度を確認していません。 こちらは参照専用です。

    参考文献

    純度: 99.26%

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    Keywords:

    Q-VD-OPhQVD-OPHQuinoline-Val-Asp-DifluorophenoxymethylketoneCaspaseHIVHuman immunodeficiency virusInhibitorinhibitorinhibit

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    製品名:
    Q-VD-OPh
    製品番号:
    HY-12305
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