2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Cathepsin

Cathepsin

Cathepsin

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Cathepsins are protease enzymes, categorized into multiple families. Cathepsins can be serine protease, cysteine protease, or aspartyl protease. There are about 15 classes of cathepsins in humans (Cathepsin A, B, C, D, E, F, G, H, K, L, O, S, V, W, and Z). Cathepsins are active in the low pH milieu of lysosomes and are versatile in their functions. Like other enzymes, they are vital for the normal physiological functions such as digestion, blood coagulation, bone resorption, ion channel activity, innate immunity, complement activation, apoptosis, vesicular trafficking, autophagy, angiogenesis, proliferation, and metastasis, among scores of others.

Numerous pathologies have been attributed to the dysregulated cathepsins, some of which include arthritis, periodontitis, pancreatitis, macular degeneration, muscular dystrophy, atherosclerosis, obesity, stroke, Alzheimer's disease, schizophrenia, tuberculosis, and Ebola.

Cathepsin Isoform Specific Products:

Cathepsin Isoform Comparison
Cat. No. 상품명 효과 Purity Chemical Structure
  • HY-108044
    ONO-5334
    		Inhibitor 99.83%
    ONO-5334 is a potent, selective and orally active cathepsin K inhibitor with Ki values of 0.10 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively. ONO 5334 is an effective antiviral compound against SAR-COV-2 virus activity with an EC50 value of 500 nM. ONO-5334 has the potential for the study of osteoporosis and COVID-19 disease.
    ONO-5334
  • HY-W596474C
    Poly-L-glutamic acid sodium salt (MW 15000)
    		Substrate
    Poly-L-glutamic acid sodium salt (MW 15000) is a synthetic polypeptide with biocompatibility, biodegradability and non-immunogenicity. Poly-L-glutamic acid sodium salt is an ideal tumor-targeting polymer carrier. Poly-L-glutamic acid sodium salt can be hydrolyzed by cathepsin B during metabolic decomposition.
    Poly-L-glutamic acid sodium salt (MW 15000)
  • HY-P3012
    Cathepsin G
    Cathepsin G is a pH-dependent serine protease. Cathepsin G hydrolyzes diverse synthetic and protein substrates and remodels extracellular matrix. Cathepsin G exerts immunomodulatory effects via recruiting phagocytes, enhancing T cell motility, activating ERK1/2 and p38 MAPK signaling, and mediating PKCζ membrane translocation. Cathepsin G regulates inflammatory responses by cleaving inflammatory mediators. Cathepsin G participates in vascular regulation by converting angiotensin I to angiotensin II. Cathepsin G induces PAR4-dependent platelet activation, facilitates platelet-neutrophil aggregation, and mediates VITT-related NETosis, thrombus formation. Cathepsin G can be used for the research of immune thrombotic thrombocytopenia, cardiovascular disease, and select autoimmune and inflammatory diseases.
    Cathepsin G
  • HY-U00377
    Cathepsin Inhibitor 2
    		Inhibitor 99.77%
    Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor extracted from patent WO2009123623A1, has a Ki of <20 nM.
    Cathepsin Inhibitor 2
  • HY-P1645A
    Papain (1.5-10 units/mg)
    Papain (1.5-10 units/mg) is a cysteine protease of the peptidase C1 family. Papain (1.5-10 units/mg) enhances red cell agglutination by anti-D and anti-A, and increases red cell sensitivity to K cell-mediated lysis in ADCC assays. Papain (1.5-10 units/mg) can induce pulmonary emphysema. Papain (1.5-10 units/mg) can be used for the researches of Rh haemolytic disease of the newborn and pulmonary emphysema.
    Papain (1.5-10 units/mg)
  • HY-P4500
    Z-Arg-Arg-pNA
    		99.17%
    Z-Arg-Arg-pNA is a substrate for cathepsin B and can be used to detect this enzyme activity.
    Z-Arg-Arg-pNA
  • HY-162076
    AEP-IN-3
    		99.71%
    AEP-IN-3 (compound 18) is an orally active, potent and brain penetrant asparagine endopeptidase (AEP) inhibitor, with an IC50 of 7.8 ± 0.9 nM. AEP-IN-3 can be used for Alzheimer’s Disease (AD) research.
    AEP-IN-3
  • HY-152204
    Cathepsin L/S-IN-1
    		Inhibitor 99.89%
    Cathepsin L/S-IN-1 is a dual inhibitor of Cathepsin L and Cathepsin S with IC50s of 4.10 μM and 1.79 μM, respectively. Cathepsin L/S-IN-1 shows a significant antimetastatic and invasive effects on pancreatic cancer BxPC-3 and PANC-1 cells.
    Cathepsin L/S-IN-1
  • HY-144636
    Atg4B-IN-2
    		Inhibitor 98.03%
    Atg4B-IN-2 is a potent competitive Atg4B inhibitor with Ki value of 3.1 μM, also possesses declining PLA2 inhibitory potency, IC50s of 11 μM and 3.5 μM for Atg4B and PLA2, respectively. Atg4B-IN-2 enhances the anticancer activity of anti-castration-resistant prostate cancer agents via autophagy inhibition.
    Atg4B-IN-2
  • HY-171045
    Abz-FRF(4NO2)
    Abz-FRF(4NO2) is an Abz-tripeptide substrate commonly used for studying the activity of enzymes, especially cysteine proteases such as Cathepsin X.
    Abz-FRF(4NO2)
  • HY-W596474B
    Poly-L-glutamic acid sodium salt (MW 7500)
    		Substrate
    Poly-L-glutamic acid sodium salt (MW 7500) is a synthetic polypeptide with biocompatibility, biodegradability and non-immunogenicity. Poly-L-glutamic acid sodium salt is an ideal tumor-targeting polymer carrier. Poly-L-glutamic acid sodium salt can be hydrolyzed by cathepsin B during metabolic decomposition.
    Poly-L-glutamic acid sodium salt (MW 7500)
  • HY-128523A
    Kgp-IN-1 hydrochloride
    		Inhibitor
    Kgp-IN-1 hydrochloride is an arginine-specific gingipain (Rgp) inhibitor extracted from patent WO2017201322A1, compound 13-R.
    Kgp-IN-1 hydrochloride
  • HY-RS03331
    CTSE Human Pre-designed siRNA Set A
    		Inhibitor

    CTSE Human Pre-designed siRNA Set A contains three designed siRNAs for CTSE gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    CTSE Human Pre-designed siRNA Set A
  • HY-17541A
    Cysteine Protease inhibitor hydrochloride
    		Inhibitor
    Cysteine Protease inhibitor hydrochloride, an inhibitor of Cysteine Protease, binds to acetylcholinesterase (AChE). Cysteine Protease inhibitor hydrochloride is applicable to the research of Alzheimer's disease.
    Cysteine Protease inhibitor hydrochloride
  • HY-P4390
    Z-Leu-Leu-Arg-AMC
    		99.27%
    Z-Leu-Leu-Arg-AMC is a peptide substrate of cathepsin S.
    Z-Leu-Leu-Arg-AMC
  • HY-138208
    Z-Phe-Tyr(tBu)-diazomethylketone
    		Inhibitor ≥99.0%
    Z-Phe-Tyr(tBu)-diazomethylketone is a potent cathepsin L inhibitor. Z-Phe-Tyr(tBu)-diazomethylketone mediates reovirus disassembly. Z-Phe-Tyr(tBu)-diazomethylketone decreases viral detection.
    Z-Phe-Tyr(tBu)-diazomethylketone
  • HY-RS03329
    Ctsd Mouse Pre-designed siRNA Set A
    		Inhibitor

    Ctsd Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ctsd gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ctsd Mouse Pre-designed siRNA Set A
  • HY-W596474H
    Poly-L-glutamic acid sodium salt (MW 60000)
    		Substrate
    Poly-L-glutamic acid sodium salt (MW 60000) is a synthetic polypeptide with biocompatibility, biodegradability and non-immunogenicity. Poly-L-glutamic acid sodium salt is an ideal tumor-targeting polymer carrier. Poly-L-glutamic acid sodium salt can be hydrolyzed by cathepsin B during metabolic decomposition.
    Poly-L-glutamic acid sodium salt (MW 60000)
  • HY-129461
    Dibenzyl trisulfide
    		Inducer 98.24%
    Dibenzyl trisulfide (DTS) is an active ingredient that can be isolated from Petiveria alliacea L.. Dibenzyl trisulfide inhibits cell proliferation and migration. Dibenzyl trisulfide decreased the mRNA and protein expression of BAK-1 and LTA. Dibenzyl trisulfide induces lysosomal membrane permeabilization and cathepsin B release.
    Dibenzyl trisulfide
  • HY-128523
    Kgp-IN-1
    		Inhibitor
    Kgp-IN-1 is an arginine-specific gingipain (Rgp) inhibitor extracted from patent WO2017201322A1, compound 13-R.
    Kgp-IN-1
Cat. No. 상품명 / Synonyms Species Source
Cat. No. 상품명 / Synonyms Application Reactivity
Cathepsin Isoform Comparison

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