Kgp-IN-1 hydrochloride

Name: Kgp-IN-1 hydrochloride
Brand: MedChemExpress
SKU: HY-128523A
Rating: 4.5 (1 reviews)

Cat. No.: HY-128523A Purity: 95.52%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Kgp-IN-1 hydrochloride is an arginine-specific gingipain (Rgp) inhibitor extracted from patent WO2017201322A1, compound 13-R.

For research use only. We do not sell to patients.

Kgp-IN-1 hydrochloride Chemical Structure

CAS No. : 2097865-47-7

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 464	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 464	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 780	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2300	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 3600	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Kgp-IN-1 hydrochloride:

Kgp-IN-1 Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Kgp-IN-1 hydrochloride is an arginine-specific gingipain (Rgp) inhibitor extracted from patent WO2017201322A1, compound 13-R^[1].

IC₅₀ & Target

Rgp^[1]

Molecular Weight

468.87

Formula

C₁₉H₂₅ClF₄N₄O₃

CAS No.

2097865-47-7

Appearance

Solid

Color

White to off-white

SMILES

O=C(N[C@@H](CCCNC(N)=N)C(COC1=C(F)C(F)=CC(F)=C1F)=O)C2CCCC2.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (266.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1328 mL	10.6639 mL	21.3279 mL
5 mM	0.4266 mL	2.1328 mL	4.2656 mL
10 mM	0.2133 mL	1.0664 mL	2.1328 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (4.44 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (4.44 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (4.44 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 95.52%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (251 KB) HNMR (221 KB) LCMS (113 KB)

Handling Instructions (2659 KB)

References

[1]. Stephen S. Dominy, et al. Treatment of osteoarthritis with gingipain blocking agents. WO2017201322A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1328 mL	10.6639 mL	21.3279 mL	53.3197 mL
	5 mM	0.4266 mL	2.1328 mL	4.2656 mL	10.6639 mL
	10 mM	0.2133 mL	1.0664 mL	2.1328 mL	5.3320 mL
	15 mM	0.1422 mL	0.7109 mL	1.4219 mL	3.5546 mL
	20 mM	0.1066 mL	0.5332 mL	1.0664 mL	2.6660 mL
	25 mM	0.0853 mL	0.4266 mL	0.8531 mL	2.1328 mL
	30 mM	0.0711 mL	0.3555 mL	0.7109 mL	1.7773 mL
	40 mM	0.0533 mL	0.2666 mL	0.5332 mL	1.3330 mL
	50 mM	0.0427 mL	0.2133 mL	0.4266 mL	1.0664 mL
	60 mM	0.0355 mL	0.1777 mL	0.3555 mL	0.8887 mL
	80 mM	0.0267 mL	0.1333 mL	0.2666 mL	0.6665 mL
	100 mM	0.0213 mL	0.1066 mL	0.2133 mL	0.5332 mL