2. Stem Cell/Wnt Cell Cycle/DNA Damage Epigenetics
  3. Organoid HDAC
  4. Trichostatin A

Trichostatine A (TSA) est un inhibiteur puissant et spécifique de la HDAC classe I / II, avec une valeur IC50 de 1,8 nM pour la HDAC.

Trichostatin A (TSA) ist ein wirksamer und spezifischer Inhibitor der HDAC-Klasse I/II mit einem IC50 -Wert von 1,8 nM für HDAC.

Trichostatin A (TSA) is a potent and specific inhibitor of HDAC class I/II, with an IC50 value of 1.8 nM for HDAC.

For research use only. We do not sell to patients.

CAS No. : 58880-19-6

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Customer Review

Based on 185 publication(s) in Google Scholar

Other Forms of Trichostatin A:

Trichostatin A Related Antibodies

Top Publications Citing Use of Products

185 Publications Citing Use of MCE Trichostatin A

WB
IP
RT-PCR

    Trichostatin A purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 18;16(1):1736.  [Abstract]

    Trichostatin A (TSA) (0.5 µM, 12 h) rescues the let-7d-5p overexpression-induced decrease in E2F1 acetylation and restores the expression of target proteins GLUT1, PFKP, and HK2 in pulmonary fibroblasts.

    Trichostatin A purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jan 31:e2408845.  [Abstract]

    Trichostatin A (TSA) (0.1 µM, 24 h) significantly reduces the expression of FSP1 in CRC cells.

    Trichostatin A purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Apr;12(14):e2413121.  [Abstract]

    Trichostatin A (TSA) (1 µM, 6 h) increases the lactylation modification of METTL3 in HEK293T cells transfected with the indicated constructs.

    Trichostatin A purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Jun 26:e2405332.  [Abstract]

    Trichostatin A (TSA) (500 nM, 12 h) significantly enhances SNORA28-mediated upregulation of LIFR mRNA and protein levels in CRC cells with stable SNORA28 overexpression.

    Trichostatin A purchased from MedChemExpress. Usage Cited in: Cell Discov. 2024 Sep 17;10(1):96.  [Abstract]

    Trichostatin A (TSA) (10 μM, 16 h) increases SNRNP200 protein levels in BT-549 cells.

    Trichostatin A purchased from MedChemExpress. Usage Cited in: Nat Immunol. 2023 Jan;24(1):162-173.  [Abstract]

    A485 (10 μM; 24 h) leads to the downregulation of H3K9bhb and CPS1 in BHB-treated CD8+ TM cells; however, the use of 3-TYP (10 μM; 24 h) or Trichostatin A (TSA; 5 nM; 24 h) result in the increase of H3K9bhb and CPS1.

    Trichostatin A purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2023 Nov;30(11):2382-2392.  [Abstract]

    Trichostatin A (TSA) (0.2 μM, 4 h)​​ increases RACK1 acetylation levels in OVCAR3 and SKOV3 cells when combined with Nicotinamide (NAM) (HY-B0150) (10 mM, 4 h).

    Trichostatin A purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 Dec;10(35):e2300698.  [Abstract]

    Trichostatin A (TSA) (2.5-10 µM, 24 h) reduces the level of AML1‐ETO protein in Kasumi-1 cells.

    Trichostatin A purchased from MedChemExpress. Usage Cited in: Cancer Res. 2021 Apr 1;81(7):1813-1826.  [Abstract]

    Trichostatin A (TSA) (1 μM, 48 h) increases MICA/B mRNA levels in SCLC cell lines H510 and H69.

    Trichostatin A purchased from MedChemExpress. Usage Cited in: Nat Commun. 2021 Sep 20;12(1):5548.  [Abstract]

    Trichostatin A (TSA) (3 μM, 12 h) increases histone isonicotinylation levels in HepG2 cells.

    Trichostatin A purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2022 Feb;12(2):838-852.

    Trichostatin A (TSA) (1 μM, 12 h) significantly increases Parkin acetylation levels in HEK293 cells.HEK293 cells were transiently transfected with Flag-Parkin and then treated with 1 μmol/L TSA for 12 h. Cells were lysed and subjected to FLAG immunoprecipitation followed by immunoblotting for acetyl-lysine.

    Trichostatin A purchased from MedChemExpress. Usage Cited in: Theranostics. 2019 Apr 13;9(9):2424-2438.  [Abstract]

    Trichostatin A (TSA) (5 μM, 16 h) increases endogenous FH acetylation in cell.

    Trichostatin A purchased from MedChemExpress. Usage Cited in: Kidney Int. 2017 Sep;92(3):669-679.  [Abstract]

    PPARγ lysine 240 and 265 are essential for PPARγ acetylation-associated Klotho derepression. Cellular PPARγ acetylation assay. Human embryonic kidney 293 (HEK293) or human proximal tubular epithelial cells (HK2) cells are treated with trichostatin A (TSA) (100 ng/mL) for 4 hours then subjected to immunoprecipitation with anti-PPARγ antibody. Acetylated PPARγ is detected with a pan anti-acetyl-lysine (ac-K) antibody by Western blotting (WB). The cell lysates are also assayed for total PPARg, Klot

    Trichostatin A purchased from MedChemExpress. Usage Cited in: Kidney Int. 2017 Sep;92(3):669-679.  [Abstract]

    Trichostatin A (TSA) (100 ng/mL, 4 h) enhances the binding of PPARγ and acetylated histone 3 (H3) to PPRE1 in HK2 cells, but does not increase binding to PPRE2 or to promoter regions lacking PPRE (PPREn).

    Trichostatin A purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):9967-76.  [Abstract]

    SDL screens for TDP1 and validation pipeline. Acetylation levels after treatment with TSA in RMS (RH30) cells.

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    HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

    • Biological Activity

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    • Customer Review

    Description

    Trichostatin A (TSA) is a potent and specific inhibitor of HDAC class I/II, with an IC50 value of 1.8 nM for HDAC[1].

    IC50 & Target[1]

    HDAC

    1.8 nM (IC50)

    Cellular Effect
    Cell Line Type Value Description References
    A-431 IC50
    0.18 3
    Compound: TSA
    Antiproliferative activity against human A431 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human A431 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    A2780 IC50
    0.22 3
    Compound: TSA
    Cytotoxicity against cisplatin resistant human A2780 cells after 72 hrs by MTT assay
    Cytotoxicity against cisplatin resistant human A2780 cells after 72 hrs by MTT assay
    		[PMID: 23252603]
    A20 IC50
    0.002 3
    Compound: TSA
    In vitro for anti-HDAC1 (Histone deacetylase 1) activity in mouse A20 cells
    In vitro for anti-HDAC1 (Histone deacetylase 1) activity in mouse A20 cells
    		[PMID: 11960489]
    A2058 IC50
    0.43 3
    Compound: 4; TSA
    Cytotoxicity against human A2058 cells assessed as reduction in cell viability
    Cytotoxicity against human A2058 cells assessed as reduction in cell viability
    		[PMID: 32005414]
    A20 IC50
    0.002 3
    Compound: TSA
    In vitro for anti-HDAC1 (Histone deacetylase 1) activity in mouse A20 cells
    In vitro for anti-HDAC1 (Histone deacetylase 1) activity in mouse A20 cells
    		[PMID: 11960489]
    A2780 IC50
    0.25 3
    Compound: TSA
    Inhibition of HDAC in cisplatin resistant human A2780 cells after 18 hrs by fluorescence assay
    Inhibition of HDAC in cisplatin resistant human A2780 cells after 18 hrs by fluorescence assay
    		[PMID: 23252603]
    A2058 IC50
    0.43 3
    Compound: 4; TSA
    Cytotoxicity against human A2058 cells assessed as reduction in cell viability
    Cytotoxicity against human A2058 cells assessed as reduction in cell viability
    		[PMID: 32005414]
    A2780 IC50
    0.22 3
    Compound: TSA
    Cytotoxicity against cisplatin resistant human A2780 cells after 72 hrs by MTT assay
    Cytotoxicity against cisplatin resistant human A2780 cells after 72 hrs by MTT assay
    		[PMID: 23252603]
    A2780 IC50
    0.29 3
    Compound: TSA
    Cytotoxicity against human A2780 cells after 72 hrs by MTT assay
    Cytotoxicity against human A2780 cells after 72 hrs by MTT assay
    		[PMID: 23252603]
    A2780 IC50
    0.22 3
    Compound: TSA
    Cytotoxicity against cisplatin resistant human A2780 cells after 72 hrs by MTT assay
    Cytotoxicity against cisplatin resistant human A2780 cells after 72 hrs by MTT assay
    		[PMID: 23252603]
    A2780 IC50
    0.29 3
    Compound: TSA
    Cytotoxicity against human A2780 cells after 72 hrs by MTT assay
    Cytotoxicity against human A2780 cells after 72 hrs by MTT assay
    		[PMID: 23252603]
    A2780 IC50
    0.43 3
    Compound: TSA
    Inhibition of HDAC in human A2780 cells after 18 hrs by fluorescence assay
    Inhibition of HDAC in human A2780 cells after 18 hrs by fluorescence assay
    		[PMID: 23252603]
    A-431 IC50
    0.18 3
    Compound: TSA
    Antiproliferative activity against human A431 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human A431 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    A2780 IC50
    0.25 3
    Compound: TSA
    Inhibition of HDAC in cisplatin resistant human A2780 cells after 18 hrs by fluorescence assay
    Inhibition of HDAC in cisplatin resistant human A2780 cells after 18 hrs by fluorescence assay
    		[PMID: 23252603]
    A2780 IC50
    0.25 3
    Compound: TSA
    Inhibition of HDAC in cisplatin resistant human A2780 cells after 18 hrs by fluorescence assay
    Inhibition of HDAC in cisplatin resistant human A2780 cells after 18 hrs by fluorescence assay
    		[PMID: 23252603]
    A2780 IC50
    0.43 3
    Compound: TSA
    Inhibition of HDAC in human A2780 cells after 18 hrs by fluorescence assay
    Inhibition of HDAC in human A2780 cells after 18 hrs by fluorescence assay
    		[PMID: 23252603]
    A2780 IC50
    0.29 3
    Compound: TSA
    Cytotoxicity against human A2780 cells after 72 hrs by MTT assay
    Cytotoxicity against human A2780 cells after 72 hrs by MTT assay
    		[PMID: 23252603]
    A549 IC50
    0.05 3
    Compound: Trichostatin A
    Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by CCK8 assay
    		10.1039/C3MD00371J
    A549 IC50
    0.05 3
    Compound: TSA
    Antiproliferative activity against human A549 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human A549 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    A2780 IC50
    0.43 3
    Compound: TSA
    Inhibition of HDAC in human A2780 cells after 18 hrs by fluorescence assay
    Inhibition of HDAC in human A2780 cells after 18 hrs by fluorescence assay
    		[PMID: 23252603]
    A-431 IC50
    0.18 3
    Compound: TSA
    Antiproliferative activity against human A431 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human A431 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    A549 IC50
    0.05 3
    Compound: TSA
    Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    		[PMID: 24960627]
    A549 IC50
    0.08 3
    Compound: TSA
    Antiproliferative activity against human A549 cells
    Antiproliferative activity against human A549 cells
    		[PMID: 18247554]
    A549 IC50
    0.05 3
    Compound: TSA
    Antiproliferative activity against human A549 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human A549 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    A549 IC50
    0.08 3
    Compound: TSA (1)
    Compound was tested for antiproliferative activity against human A549 cancer cell lines using MTT assay
    Compound was tested for antiproliferative activity against human A549 cancer cell lines using MTT assay
    		[PMID: 14667227]
    A549 IC50
    0.08 3
    Compound: TSA (1)
    Compound was tested for antiproliferative activity against human A549 cancer cell lines using MTT assay
    Compound was tested for antiproliferative activity against human A549 cancer cell lines using MTT assay
    		[PMID: 14667227]
    A549 IC50
    0.16 3
    Compound: TSA
    Inhibitory concentration required to reduce A549 tumor cell growth by 50% in MTT assay
    Inhibitory concentration required to reduce A549 tumor cell growth by 50% in MTT assay
    		[PMID: 12061890]
    A549 IC50
    80 1
    Compound: TSA
    Antiproliferative activity against human A549 cells after 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human A549 cells after 72 hrs by CellTiter Glo assay
    		[PMID: 35797900]
    A549 GI50
    80 1
    Compound: TSA
    Antiproliferative activity against human A549 cells after 72 hrs by MTS assay
    Antiproliferative activity against human A549 cells after 72 hrs by MTS assay
    		[PMID: 30004697]
    A549 IC50
    0.05 3
    Compound: Trichostatin A
    Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by CCK8 assay
    		10.1039/C3MD00371J
    A549 IC50
    0.05 3
    Compound: TSA
    Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    		[PMID: 24960627]
    A549 GI50
    80 1
    Compound: TSA
    Antiproliferative activity against human A549 cells after 72 hrs by MTS assay
    Antiproliferative activity against human A549 cells after 72 hrs by MTS assay
    		[PMID: 30004697]
    A549 IC50
    1.31 3
    Compound: 4; TSA
    Cytotoxicity against human A549 cells assessed as reduction in cell viability
    Cytotoxicity against human A549 cells assessed as reduction in cell viability
    		[PMID: 32005414]
    BE(2)-C IC50
    0.05 3
    Compound: 1, TSA, trichostatin A
    Antiproliferative activity against human BE(2)-C cells after 72 hrs by Alamar blue assay
    Antiproliferative activity against human BE(2)-C cells after 72 hrs by Alamar blue assay
    		[PMID: 22932316]
    A549 IC50
    0.05 3
    Compound: TSA
    Antiproliferative activity against human A549 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human A549 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    A549 IC50
    0.05 3
    Compound: TSA
    Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    		[PMID: 24960627]
    A549 IC50
    4.5 3
    Compound: TSA
    Inhibitory concentration against lung A549 cell line
    Inhibitory concentration against lung A549 cell line
    		[PMID: 12593661]
    A549 IC50
    0.05 3
    Compound: Trichostatin A
    Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by CCK8 assay
    		10.1039/C3MD00371J
    Bel-7402 IC50
    0.1 3
    Compound: TSA
    Antiproliferative activity against human Bel7402 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human Bel7402 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    BGC-823 IC50
    0.07 3
    Compound: TSA
    Antiproliferative activity against human BGC823 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human BGC823 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    A549 IC50
    0.08 3
    Compound: TSA
    Antiproliferative activity against human A549 cells
    Antiproliferative activity against human A549 cells
    		[PMID: 18247554]
    A549 IC50
    0.16 3
    Compound: TSA
    Inhibitory concentration required to reduce A549 tumor cell growth by 50% in MTT assay
    Inhibitory concentration required to reduce A549 tumor cell growth by 50% in MTT assay
    		[PMID: 12061890]
    A549 IC50
    0.08 3
    Compound: TSA (1)
    Compound was tested for antiproliferative activity against human A549 cancer cell lines using MTT assay
    Compound was tested for antiproliferative activity against human A549 cancer cell lines using MTT assay
    		[PMID: 14667227]
    BGC-823 IC50
    0.08 3
    Compound: Trichostatin A
    Cytotoxicity against human BGC823 cells assessed as cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human BGC823 cells assessed as cell viability after 72 hrs by CCK8 assay
    		10.1039/C3MD00371J
    S2 IC50
    0.6 1
    Compound: 3, TSA
    Inhibition of Plasmodium falciparum HDAC1 expressed in Drosophila melanogaster S2 cells
    Inhibition of Plasmodium falciparum HDAC1 expressed in Drosophila melanogaster S2 cells
    		[PMID: 19317450]
    BGC-823 IC50
    0.08 3
    Compound: TSA
    Cytotoxicity against human BGC823 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human BGC823 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    		[PMID: 24960627]
    A549 IC50
    0.16 3
    Compound: TSA
    Inhibitory concentration required to reduce A549 tumor cell growth by 50% in MTT assay
    Inhibitory concentration required to reduce A549 tumor cell growth by 50% in MTT assay
    		[PMID: 12061890]
    Sf9 IC50
    0.68 1
    Compound: TSA
    Inhibition of recombinant full length human HDAC1 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by electrophoretic mobility shift assay
    Inhibition of recombinant full length human HDAC1 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by electrophoretic mobility shift assay
    		[PMID: 31938464]
    BT-474 IC50
    33.3 1
    Compound: 8; TSA
    Antiproliferative activity against human BT-474 cells assessed as cell growth inhibition by SRB assay
    Antiproliferative activity against human BT-474 cells assessed as cell growth inhibition by SRB assay
    		[PMID: 34826681]
    A549 IC50
    1.31 3
    Compound: 4; TSA
    Cytotoxicity against human A549 cells assessed as reduction in cell viability
    Cytotoxicity against human A549 cells assessed as reduction in cell viability
    		[PMID: 32005414]
    BE(2)-C IC50
    0.05 3
    Compound: 1, TSA, trichostatin A
    Antiproliferative activity against human BE(2)-C cells after 72 hrs by Alamar blue assay
    Antiproliferative activity against human BE(2)-C cells after 72 hrs by Alamar blue assay
    		[PMID: 22932316]
    BXPC-3 GI50
    100 1
    Compound: TSA
    Antiproliferative activity against human BxPC3 cells after 72 hrs by MTS assay
    Antiproliferative activity against human BxPC3 cells after 72 hrs by MTS assay
    		[PMID: 30004697]
    Bel-7402 IC50
    0.1 3
    Compound: TSA
    Antiproliferative activity against human Bel7402 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human Bel7402 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    A549 IC50
    20 1
    Compound: TSA
    Antiproliferative activity against human A549 cells
    Antiproliferative activity against human A549 cells
    		[PMID: 30245394]
    DMS-53 IC50
    25 1
    Compound: Trichostatin A
    Cytostatic activity against human DMS53 cells assessed as inhibition of cell proliferation after 2 days by MTT assay
    Cytostatic activity against human DMS53 cells assessed as inhibition of cell proliferation after 2 days by MTT assay
    		[PMID: 21504214]
    A549 IC50
    4.5 3
    Compound: TSA
    Inhibitory concentration against lung A549 cell line
    Inhibitory concentration against lung A549 cell line
    		[PMID: 12593661]
    BGC-823 IC50
    0.07 3
    Compound: TSA
    Antiproliferative activity against human BGC823 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human BGC823 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    DU-145 IC50
    0.06 3
    Compound: TSA
    Antiproliferative activity against human DU145 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human DU145 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    A549 IC50
    80 1
    Compound: TSA
    Antiproliferative activity against human A549 cells after 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human A549 cells after 72 hrs by CellTiter Glo assay
    		[PMID: 35797900]
    BGC-823 IC50
    0.08 3
    Compound: Trichostatin A
    Cytotoxicity against human BGC823 cells assessed as cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human BGC823 cells assessed as cell viability after 72 hrs by CCK8 assay
    		10.1039/C3MD00371J
    BE(2)-C IC50
    0.05 3
    Compound: 1, TSA, trichostatin A
    Antiproliferative activity against human BE(2)-C cells after 72 hrs by Alamar blue assay
    Antiproliferative activity against human BE(2)-C cells after 72 hrs by Alamar blue assay
    		[PMID: 22932316]
    DU-145 IC50
    0.2 3
    Compound: TSA
    Inhibitory concentration required to reduce DU145 tumor cell growth by 50% in MTT assay
    Inhibitory concentration required to reduce DU145 tumor cell growth by 50% in MTT assay
    		[PMID: 12061890]
    BGC-823 IC50
    0.08 3
    Compound: TSA
    Cytotoxicity against human BGC823 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human BGC823 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    		[PMID: 24960627]
    BGC-823 IC50
    0.07 3
    Compound: TSA
    Antiproliferative activity against human BGC823 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human BGC823 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    HCT-116 IC50
    < 0.05 3
    Compound: TSA
    Inhibitory concentration required to reduce HCT 116 tumor cell growth by 50% in MTT assay
    Inhibitory concentration required to reduce HCT 116 tumor cell growth by 50% in MTT assay
    		[PMID: 12061890]
    Sf9 IC50
    0.9 1
    Compound: TSA
    Inhibition of human recombinant HDAC6 expressed in baculovirus/sf9 cells using RHKKAc as substrate
    Inhibition of human recombinant HDAC6 expressed in baculovirus/sf9 cells using RHKKAc as substrate
    		[PMID: 23905680]
    HCT-116 IC50
    0.013 3
    Compound: 1
    Concentration required to inhibit the HCT116 cell growth by 50%.
    Concentration required to inhibit the HCT116 cell growth by 50%.
    		[PMID: 11831887]
    C180-13S IC50
    0.06 3
    Compound: 1a
    Cytotoxicity of compound against normal human ovarian C18013S cell line
    Cytotoxicity of compound against normal human ovarian C18013S cell line
    		[PMID: 15163181]
    BGC-823 IC50
    0.08 3
    Compound: TSA
    Cytotoxicity against human BGC823 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human BGC823 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    		[PMID: 24960627]
    Cancer cell lines EC50
    1 3
    Compound: 1 (trichostatin A)
    Concentration of compound required for acetylation of histone-4 in human T24 cancer cells
    Concentration of compound required for acetylation of histone-4 in human T24 cancer cells
    		[PMID: 11597413]
    HCT-116 IC50
    0.043 3
    Compound: 1, TSA
    Growth inhibition of human HCT116 cells after 48 hrs by SRB assay
    Growth inhibition of human HCT116 cells after 48 hrs by SRB assay
    		[PMID: 21073160]
    BGC-823 IC50
    0.08 3
    Compound: Trichostatin A
    Cytotoxicity against human BGC823 cells assessed as cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human BGC823 cells assessed as cell viability after 72 hrs by CCK8 assay
    		10.1039/C3MD00371J
    HCT-116 IC50
    0.8 3
    Compound: TSA
    Cytotoxicity against human HCT116 cells after 3 days by WST-1 assay
    Cytotoxicity against human HCT116 cells after 3 days by WST-1 assay
    		[PMID: 20452226]
    BT-474 IC50
    33.3 1
    Compound: 8; TSA
    Antiproliferative activity against human BT-474 cells assessed as cell growth inhibition by SRB assay
    Antiproliferative activity against human BT-474 cells assessed as cell growth inhibition by SRB assay
    		[PMID: 34826681]
    Sf9 IC50
    1.2 1
    Compound: TSA
    Inhibition of human recombinant HDAC6 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrate
    Inhibition of human recombinant HDAC6 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrate
    		[PMID: 23009203]
    HCT-116 EC50
    1 3
    Compound: 1 (trichostatin A)
    In vitro antiproliferative activity against human colon cancer HCT 116 cells determined by MMT assay
    In vitro antiproliferative activity against human colon cancer HCT 116 cells determined by MMT assay
    		[PMID: 11597413]
    BXPC-3 GI50
    100 1
    Compound: TSA
    Antiproliferative activity against human BxPC3 cells after 72 hrs by MTS assay
    Antiproliferative activity against human BxPC3 cells after 72 hrs by MTS assay
    		[PMID: 30004697]
    HeLa IC50
    1.42 1
    Compound: TSA
    Inhibition of HDAC in human HeLa cell nuclear extract using BML-KI104 Fluor de Lys as substrate by fluorescence-based assay
    Inhibition of HDAC in human HeLa cell nuclear extract using BML-KI104 Fluor de Lys as substrate by fluorescence-based assay
    		[PMID: 26588603]
    HCT-116 GI50
    35 1
    Compound: TSA
    Antiproliferative activity against human HCT-116 cells after 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human HCT-116 cells after 72 hrs by CellTiter Glo assay
    		[PMID: 35797900]
    HeLa IC50
    3 1
    Compound: TSA
    Inhibition of HDAC in human HeLa cell cytosolic extract after 30 mins by fluorimetric assay
    Inhibition of HDAC in human HeLa cell cytosolic extract after 30 mins by fluorimetric assay
    		[PMID: 19705846]
    Bel-7402 IC50
    0.1 3
    Compound: TSA
    Antiproliferative activity against human Bel7402 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human Bel7402 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    HCT-116 GI50
    35 1
    Compound: TSA
    Antiproliferative activity against human HCT116 cells after 72 hrs by MTS assay
    Antiproliferative activity against human HCT116 cells after 72 hrs by MTS assay
    		[PMID: 30004697]
    C180-13S IC50
    0.06 3
    Compound: 1a
    Cytotoxicity of compound against normal human ovarian C18013S cell line
    Cytotoxicity of compound against normal human ovarian C18013S cell line
    		[PMID: 15163181]
    HeLa IC50
    3 1
    Compound: TSA
    Inhibition of HDAC in human HeLa cells using Ac-Arg-Gly-Lys(Ac)-AMC as fluorescent substrate after 20 mins by fluorescence assay
    Inhibition of HDAC in human HeLa cells using Ac-Arg-Gly-Lys(Ac)-AMC as fluorescent substrate after 20 mins by fluorescence assay
    		[PMID: 21621883]
    HEK293 IC50
    0.16 3
    Compound: 5
    Cytotoxicity against human HEK293 cells after 96 hrs by MTT assay
    Cytotoxicity against human HEK293 cells after 96 hrs by MTT assay
    		[PMID: 25556102]
    Jurkat IC50
    3.3 1
    Compound: TSA
    Tested for inhibitory concentration required to inhibit 50% of histone deacetylase (HDAC) from human T cell leukemia Jurkat cell
    Tested for inhibitory concentration required to inhibit 50% of histone deacetylase (HDAC) from human T cell leukemia Jurkat cell
    		[PMID: 11992774]
    HeLa IC50
    0.0011 3
    Compound: TSA
    Inhibition of HDAC2 in human HeLa cell nuclear extracts in presence of dithiothreitol by HDAC fluorescent assay
    Inhibition of HDAC2 in human HeLa cell nuclear extracts in presence of dithiothreitol by HDAC fluorescent assay
    		[PMID: 22465091]
    HT-29 IC50
    3.8 1
    Compound: TSA
    Antiproliferative activity against human HT-29 cells in presence of isoCA-4 after 72 hrs by MTS assay relative to control
    Antiproliferative activity against human HT-29 cells in presence of isoCA-4 after 72 hrs by MTS assay relative to control
    		[PMID: 30004697]
    HeLa EC50
    0.0052 3
    Compound: TSA
    Inhibition of HDAC6 in human HeLa cells assessed as inhibition of tubulin deacetylation incubated for overnight by cELISA
    Inhibition of HDAC6 in human HeLa cells assessed as inhibition of tubulin deacetylation incubated for overnight by cELISA
    		[PMID: 26611919]
    DO4 IC50
    0.09 3
    Compound: 1a
    Cytotoxicity of compound against normal human melanoma DO4 cell line
    Cytotoxicity of compound against normal human melanoma DO4 cell line
    		[PMID: 15163181]
    Cancer cell lines EC50
    1 3
    Compound: 1 (trichostatin A)
    Concentration of compound required for acetylation of histone-4 in human T24 cancer cells
    Concentration of compound required for acetylation of histone-4 in human T24 cancer cells
    		[PMID: 11597413]
    HeLa IC50
    0.0075 3
    Compound: Trichostatin A
    Inhibition of HDAC in human HeLa cell extract after 15 mins by fluorescence assay
    Inhibition of HDAC in human HeLa cell extract after 15 mins by fluorescence assay
    		[PMID: 25455492]
    DU-145 IC50
    0.06 3
    Compound: TSA
    Antiproliferative activity against human DU145 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human DU145 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    DMS-53 IC50
    25 1
    Compound: Trichostatin A
    Cytostatic activity against human DMS53 cells assessed as inhibition of cell proliferation after 2 days by MTT assay
    Cytostatic activity against human DMS53 cells assessed as inhibition of cell proliferation after 2 days by MTT assay
    		[PMID: 21504214]
    DO4 IC50
    0.09 3
    Compound: 1a
    Cytotoxicity of compound against normal human melanoma DO4 cell line
    Cytotoxicity of compound against normal human melanoma DO4 cell line
    		[PMID: 15163181]
    HeLa IC50
    0.02 3
    Compound: TSA
    Inhibition of HDAC in human HeLa cell nuclear extract assessed as inhibition of histone H4 deacetylation after 15 mins by fluorescence assay
    Inhibition of HDAC in human HeLa cell nuclear extract assessed as inhibition of histone H4 deacetylation after 15 mins by fluorescence assay
    		[PMID: 20381359]
    DU-145 IC50
    0.06 3
    Compound: 1a
    Cytotoxicity of compound against normal human prostate DU145 cell line
    Cytotoxicity of compound against normal human prostate DU145 cell line
    		[PMID: 15163181]
    HeLa IC50
    0.09 3
    Compound: TSA
    Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    DU-145 IC50
    0.06 3
    Compound: 1a
    Cytotoxicity of compound against normal human prostate DU145 cell line
    Cytotoxicity of compound against normal human prostate DU145 cell line
    		[PMID: 15163181]
    DU-145 IC50
    3.5 3
    Compound: TSA
    Inhibitory concentration against prostate DU145 cell line
    Inhibitory concentration against prostate DU145 cell line
    		[PMID: 12593661]
    HeLa IC50
    0.1 3
    Compound: Trichostatin A
    Cytotoxicity against human HeLa cells assessed as cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human HeLa cells assessed as cell viability after 72 hrs by CCK8 assay
    		10.1039/C3MD00371J
    DU-145 IC50
    0.2 3
    Compound: TSA
    Inhibitory concentration required to reduce DU145 tumor cell growth by 50% in MTT assay
    Inhibitory concentration required to reduce DU145 tumor cell growth by 50% in MTT assay
    		[PMID: 12061890]
    DU-145 IC50
    0.06 3
    Compound: TSA
    Antiproliferative activity against human DU145 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human DU145 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    HeLa IC50
    0.11 3
    Compound: TSA
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    		[PMID: 24960627]
    DU-145 IC50
    0.2 3
    Compound: TSA
    Inhibitory concentration required to reduce DU145 tumor cell growth by 50% in MTT assay
    Inhibitory concentration required to reduce DU145 tumor cell growth by 50% in MTT assay
    		[PMID: 12061890]
    HeLa IC50
    5 1
    Compound: TSA
    Inhibition of HDAC in human HeLa cell nuclear extracts after 15 mins by fluorescence assay
    Inhibition of HDAC in human HeLa cell nuclear extracts after 15 mins by fluorescence assay
    		[PMID: 19914074]
    HeLa IC50
    0.3 3
    Compound: Trichostatin A
    Inhibition of HDAC from human HeLa cells by fluorogenic enzyme assay
    Inhibition of HDAC from human HeLa cells by fluorogenic enzyme assay
    		[PMID: 19457659]
    DU-145 IC50
    3.5 3
    Compound: TSA
    Inhibitory concentration against prostate DU145 cell line
    Inhibitory concentration against prostate DU145 cell line
    		[PMID: 12593661]
    HeLa IC50
    5 1
    Compound: Trichostatin A
    Inhibition of histone deacetylase (HDAC) activity in HeLa cell nuclear extract
    Inhibition of histone deacetylase (HDAC) activity in HeLa cell nuclear extract
    		[PMID: 15109636]
    HeLa IC50
    0.85 3
    Compound: 5
    Cytotoxicity against human HeLa cells after 96 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 96 hrs by MTT assay
    		[PMID: 25556102]
    HeLa IC50
    5 1
    Compound: TSA
    Inhibition of human HDAC in HeLa cells by flour de lys assay
    Inhibition of human HDAC in HeLa cells by flour de lys assay
    		[PMID: 18397827]
    Erythrocyte IC50
    0.2 3
    Compound: TSA
    Cytotoxicity against erythrocytes (unknown origin)
    Cytotoxicity against erythrocytes (unknown origin)
    		[PMID: 24904967]
    HeLa IC50
    1.42 1
    Compound: TSA
    Inhibition of HDAC in human HeLa cell nuclear extract using BML-KI104 Fluor de Lys as substrate by fluorescence-based assay
    Inhibition of HDAC in human HeLa cell nuclear extract using BML-KI104 Fluor de Lys as substrate by fluorescence-based assay
    		[PMID: 26588603]
    Fibroblast IC50
    0.2 3
    Compound: TSA
    Toxicity in neonatal foreskin fibroblasts
    Toxicity in neonatal foreskin fibroblasts
    		[PMID: 18212103]
    Erythrocyte IC50
    0.2 3
    Compound: TSA
    Cytotoxicity against erythrocytes (unknown origin)
    Cytotoxicity against erythrocytes (unknown origin)
    		[PMID: 24904967]
    HeLa IC50
    12 1
    Compound: TSA
    Inhibition of HDAC isolated from human HeLa cells by fluorimetric assay
    Inhibition of HDAC isolated from human HeLa cells by fluorimetric assay
    		10.1039/C4MD00211C
    Fibroblast IC50
    0.2 3
    Compound: TSA
    Growth inhibition of human neonatal foreskin fibroblasts cells
    Growth inhibition of human neonatal foreskin fibroblasts cells
    		[PMID: 18247554]
    Sf9 IC50
    5 1
    Compound: TSA
    Inhibition of human recombinant HDAC1 expressed in baculovirus/sf9 cells using RHKKAc as substrate
    Inhibition of human recombinant HDAC1 expressed in baculovirus/sf9 cells using RHKKAc as substrate
    		[PMID: 23905680]
    HeLa IC50
    28.9 1
    Compound: TSA
    Inhibition of human HDAC in human HeLa cell nuclear extract after 15 mins by colorimetric assay
    Inhibition of human HDAC in human HeLa cell nuclear extract after 15 mins by colorimetric assay
    		[PMID: 20167479]
    Friend leukemia cell line IC50
    0.04 3
    Compound: 2
    Tested in vivo for the inhibition of proliferation of friend leukemic cells
    Tested in vivo for the inhibition of proliferation of friend leukemic cells
    		[PMID: 12109913]
    Sf9 IC50
    5 1
    Compound: TSA
    Inhibition of human recombinant HDAC1 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrate
    Inhibition of human recombinant HDAC1 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrate
    		[PMID: 23009203]
    HeLa IC50
    3 1
    Compound: TSA
    Inhibition of HDAC in human HeLa cells using Ac-Arg-Gly-Lys(Ac)-AMC as fluorescent substrate after 20 mins by fluorescence assay
    Inhibition of HDAC in human HeLa cells using Ac-Arg-Gly-Lys(Ac)-AMC as fluorescent substrate after 20 mins by fluorescence assay
    		[PMID: 21621883]
    Friend leukemia cell line IC50
    0.04 3
    Compound: 2 - TSA
    Inhibitory concentration against friend cells proliferation
    Inhibitory concentration against friend cells proliferation
    		[PMID: 14613312]
    Fibroblast IC50
    0.2 3
    Compound: TSA
    Growth inhibition of human neonatal foreskin fibroblasts cells
    Growth inhibition of human neonatal foreskin fibroblasts cells
    		[PMID: 18247554]
    HeLa IC50
    3 1
    Compound: TSA
    Inhibition of HDAC in human HeLa cell nuclear extract after 30 mins by fluorimetric assay
    Inhibition of HDAC in human HeLa cell nuclear extract after 30 mins by fluorimetric assay
    		[PMID: 19705846]
    Fibroblast IC50
    0.2 3
    Compound: TSA
    Toxicity in neonatal foreskin fibroblasts
    Toxicity in neonatal foreskin fibroblasts
    		[PMID: 18212103]
    HeLa IC50
    3 1
    Compound: TSA
    Inhibition of HDAC in human HeLa cell cytosolic extract after 30 mins by fluorimetric assay
    Inhibition of HDAC in human HeLa cell cytosolic extract after 30 mins by fluorimetric assay
    		[PMID: 19705846]
    Fibroblast MRHF cell line IC50
    36 3
    Compound: TSA
    Inhibitory concentration against normal fibroblast MRHF cell line
    Inhibitory concentration against normal fibroblast MRHF cell line
    		[PMID: 12593661]
    Friend leukemia cell line IC50
    0.04 3
    Compound: 2 - TSA
    Inhibitory concentration against friend cells proliferation
    Inhibitory concentration against friend cells proliferation
    		[PMID: 14613312]
    HeLa IC50
    39 1
    Compound: TSA
    Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
    Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
    		[PMID: 30245394]
    HeLa IC50
    41 1
    Compound: TSA
    Inhibition of Histone deacetylase in HeLa cell nuclear extracts by fluorescence-based assay
    Inhibition of Histone deacetylase in HeLa cell nuclear extracts by fluorescence-based assay
    		[PMID: 17419603]
    Friend leukemia cell line IC50
    0.04 3
    Compound: 2
    Tested in vivo for the inhibition of proliferation of friend leukemic cells
    Tested in vivo for the inhibition of proliferation of friend leukemic cells
    		[PMID: 12109913]
    HeLa IC50
    5 1
    Compound: TSA
    Inhibition of HDAC in human HeLa cell nuclear extracts after 15 mins by fluorescence assay
    Inhibition of HDAC in human HeLa cell nuclear extracts after 15 mins by fluorescence assay
    		[PMID: 19914074]
    HCT-116 EC50
    1 3
    Compound: 1 (trichostatin A)
    In vitro antiproliferative activity against human colon cancer HCT 116 cells determined by MMT assay
    In vitro antiproliferative activity against human colon cancer HCT 116 cells determined by MMT assay
    		[PMID: 11597413]
    HCT-116 EC50
    1 3
    Compound: 1 (trichostatin A)
    In vitro antiproliferative activity against human colon cancer HCT 116 cells determined by MMT assay
    In vitro antiproliferative activity against human colon cancer HCT 116 cells determined by MMT assay
    		[PMID: 11597413]
    HeLa IC50
    5 1
    Compound: TSA
    Inhibition of human HDAC in HeLa cells by flour de lys assay
    Inhibition of human HDAC in HeLa cells by flour de lys assay
    		[PMID: 18397827]
    HCT-116 EC50
    1 3
    Compound: 2 - TSA
    Inhibitory concentration against human colon cancer HCT116 cell proliferation
    Inhibitory concentration against human colon cancer HCT116 cell proliferation
    		[PMID: 14613312]
    HCT-116 EC50
    1 3
    Compound: 2 - TSA
    Inhibitory concentration against human colon cancer HCT116 cell proliferation
    Inhibitory concentration against human colon cancer HCT116 cell proliferation
    		[PMID: 14613312]
    HCT-116 IC50
    0.0013 3
    Compound: 1
    Antiproliferative activity against HCT116 cells
    Antiproliferative activity against HCT116 cells
    		[PMID: 16904890]
    HCT-116 GI50
    35 1
    Compound: TSA
    Antiproliferative activity against human HCT116 cells after 72 hrs by MTS assay
    Antiproliferative activity against human HCT116 cells after 72 hrs by MTS assay
    		[PMID: 30004697]
    HepG2 EC50
    0.38 3
    Compound: 5
    Up-regulation of transcriptional activity of human CLA-1 promoter region -1055 to -62bp transfected in HepG2 cells by luciferase reporter gene assay
    Up-regulation of transcriptional activity of human CLA-1 promoter region -1055 to -62bp transfected in HepG2 cells by luciferase reporter gene assay
    		[PMID: 25556102]
    HCT-116 IC50
    0.013 3
    Compound: 1
    Concentration required to inhibit the HCT116 cell growth by 50%.
    Concentration required to inhibit the HCT116 cell growth by 50%.
    		[PMID: 11831887]
    HepG2 IC50
    0.96 3
    Compound: 5
    Cytotoxicity against human HepG2 cells after 96 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 96 hrs by MTT assay
    		[PMID: 25556102]
    HCT-116 GI50
    35 1
    Compound: TSA
    Antiproliferative activity against human HCT-116 cells after 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human HCT-116 cells after 72 hrs by CellTiter Glo assay
    		[PMID: 35797900]
    HCT-116 IC50
    0.8 3
    Compound: TSA
    Cytotoxicity against human HCT116 cells after 3 days by WST-1 assay
    Cytotoxicity against human HCT116 cells after 3 days by WST-1 assay
    		[PMID: 20452226]
    HL-60 IC50
    0.03 3
    Compound: Trichostatin A
    Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by CCK8 assay
    		10.1039/C3MD00371J
    HCT-116 IC50
    0.0013 3
    Compound: 1
    Antiproliferative activity against HCT116 cells
    Antiproliferative activity against HCT116 cells
    		[PMID: 16904890]
    HCT-116 IC50
    0.043 3
    Compound: 1, TSA
    Growth inhibition of human HCT116 cells after 48 hrs by SRB assay
    Growth inhibition of human HCT116 cells after 48 hrs by SRB assay
    		[PMID: 21073160]
    HL-60 IC50
    0.08 3
    Compound: TSA
    Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    		[PMID: 24960627]
    HCT-116 IC50
    0.013 3
    Compound: 1
    Concentration required to inhibit the HCT116 cell growth by 50%.
    Concentration required to inhibit the HCT116 cell growth by 50%.
    		[PMID: 11831887]
    HCT-116 IC50
    0.043 3
    Compound: 1, TSA
    Growth inhibition of human HCT116 cells after 48 hrs by SRB assay
    Growth inhibition of human HCT116 cells after 48 hrs by SRB assay
    		[PMID: 21073160]
    HL-60 GI50
    0.59 3
    Compound: TRICHOSTATIN A
    Antiproliferative activity against human HL60 cells after 24 hrs by MTT assay
    Antiproliferative activity against human HL60 cells after 24 hrs by MTT assay
    		[PMID: 29454918]
    HCT-116 IC50
    0.9 3
    Compound: TSA
    Inhibitory concentration against colon HCT116 cell line
    Inhibitory concentration against colon HCT116 cell line
    		[PMID: 12593661]
    HCT-116 IC50
    0.8 3
    Compound: TSA
    Cytotoxicity against human HCT116 cells after 3 days by WST-1 assay
    Cytotoxicity against human HCT116 cells after 3 days by WST-1 assay
    		[PMID: 20452226]
    HCT-116 IC50
    <0.05 3
    Compound: TSA
    Inhibitory concentration required to reduce HCT 116 tumor cell growth by 50% in MTT assay
    Inhibitory concentration required to reduce HCT 116 tumor cell growth by 50% in MTT assay
    		[PMID: 12061890]
    HMEC IC50
    1.6 3
    Compound: TSA
    Inhibitory concentration required to reduce normal human epithelial cell line (HMEC), growth by 50% in MTT assay
    Inhibitory concentration required to reduce normal human epithelial cell line (HMEC), growth by 50% in MTT assay
    		[PMID: 12061890]
    HCT-116 IC50
    0.9 3
    Compound: TSA
    Inhibitory concentration against colon HCT116 cell line
    Inhibitory concentration against colon HCT116 cell line
    		[PMID: 12593661]
    HT-1080 IC50
    0.08 3
    Compound: TSA
    Antiproliferative activity against human HT1080 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human HT1080 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    SH-SY5Y IC50
    7.8 1
    Compound: Trichostatin A
    Inhibition of HDAC6 in human SHSY5Y cells using BATCP as substrate after 8 hrs by UHPLC-ESI-MS/MS analysis
    Inhibition of HDAC6 in human SHSY5Y cells using BATCP as substrate after 8 hrs by UHPLC-ESI-MS/MS analysis
    		[PMID: 27650925]
    HT-29 IC50
    3.8 1
    Compound: TSA
    Antiproliferative activity against human HT-29 cells in presence of isoCA-4 after 72 hrs by MTS assay relative to control
    Antiproliferative activity against human HT-29 cells in presence of isoCA-4 after 72 hrs by MTS assay relative to control
    		[PMID: 30004697]
    HCT-116 IC50
    13 1
    Compound: Trichostatin A
    Inhibitory activity against HCT116 human colon cell growth
    Inhibitory activity against HCT116 human colon cell growth
    		[PMID: 14521422]
    Sf21 IC50
    9 1
    Compound: TSA
    Inhibition of full length recombinant human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in baculovirus infected Sf21 insect cells using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate measured after 1 to 2 hrs by flu
    Inhibition of full length recombinant human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in baculovirus infected Sf21 insect cells using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate measured after 1 to 2 hrs by flu
    		[PMID: 32212730]
    HT-29 GI50
    34.1 1
    Compound: TSA
    Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay
    Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay
    		[PMID: 30004697]
    HCT-116 IC50
    < 0.05 3
    Compound: TSA
    Inhibitory concentration required to reduce HCT 116 tumor cell growth by 50% in MTT assay
    Inhibitory concentration required to reduce HCT 116 tumor cell growth by 50% in MTT assay
    		[PMID: 12061890]
    Sf9 IC50
    9 1
    Compound: TSA
    Inhibition of human recombinant HDAC10 expressed in baculovirus/sf9 cells using RHKKAc as substrate
    Inhibition of human recombinant HDAC10 expressed in baculovirus/sf9 cells using RHKKAc as substrate
    		[PMID: 23905680]
    HT-29 IC50
    55 1
    Compound: TSA
    Antiproliferative activity against human HT-29 cells after 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human HT-29 cells after 72 hrs by CellTiter Glo assay
    		[PMID: 35797900]
    SH-SY5Y IC50
    9.1 1
    Compound: Trichostatin A
    Inhibition of HDAC in human SHSY5Y cells using MAL as substrate after 8 hrs by UHPLC-ESI-MS/MS analysis
    Inhibition of HDAC in human SHSY5Y cells using MAL as substrate after 8 hrs by UHPLC-ESI-MS/MS analysis
    		[PMID: 27650925]
    HEK293 IC50
    0.16 3
    Compound: 5
    Cytotoxicity against human HEK293 cells after 96 hrs by MTT assay
    Cytotoxicity against human HEK293 cells after 96 hrs by MTT assay
    		[PMID: 25556102]
    HEK293 IC50
    0.16 3
    Compound: 5
    Cytotoxicity against human HEK293 cells after 96 hrs by MTT assay
    Cytotoxicity against human HEK293 cells after 96 hrs by MTT assay
    		[PMID: 25556102]
    Huh-7 IC50
    0.06 3
    Compound: TSA
    Antiproliferative activity against human HuH7 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human HuH7 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    HEK293 IC50
    34 1
    Compound: 1
    Inhibition of human recombinant HDAC4 expressed in 293 cells
    Inhibition of human recombinant HDAC4 expressed in 293 cells
    		[PMID: 17929798]
    HEK293 IC50
    81 1
    Compound: 1
    Inhibition of mouse recombinant HDAC6 expressed in 293 cells
    Inhibition of mouse recombinant HDAC6 expressed in 293 cells
    		[PMID: 17929798]
    Huh-7 IC50
    0.09 3
    Compound: Trichostatin A
    Cytotoxicity against human HuH7 cells assessed as cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human HuH7 cells assessed as cell viability after 72 hrs by CCK8 assay
    		10.1039/C3MD00371J
    HeLa IC50
    12 1
    Compound: TSA
    Inhibition of HDAC isolated from human HeLa cells by fluorimetric assay
    Inhibition of HDAC isolated from human HeLa cells by fluorimetric assay
    		10.1039/C4MD00211C
    HCT-116 IC50
    13 1
    Compound: Trichostatin A
    Inhibitory activity against HCT116 human colon cell growth
    Inhibitory activity against HCT116 human colon cell growth
    		[PMID: 14521422]
    Huh-7 IC50
    0.1 3
    Compound: TSA
    Cytotoxicity against human HuH7 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human HuH7 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    		[PMID: 24960627]
    HeLa EC50
    0.0052 3
    Compound: TSA
    Inhibition of HDAC6 in human HeLa cells assessed as inhibition of tubulin deacetylation incubated for overnight by cELISA
    Inhibition of HDAC6 in human HeLa cells assessed as inhibition of tubulin deacetylation incubated for overnight by cELISA
    		[PMID: 26611919]
    HL-60 GI50
    0.59 3
    Compound: TRICHOSTATIN A
    Antiproliferative activity against human HL60 cells after 24 hrs by MTT assay
    Antiproliferative activity against human HL60 cells after 24 hrs by MTT assay
    		[PMID: 29454918]
    HUVEC IC50
    20 1
    Compound: TSA, trichostatin A
    Inhibition of IL-1-beta-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of IL1-beta challenge by one stage clotting assay
    Inhibition of IL-1-beta-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of IL1-beta challenge by one stage clotting assay
    		[PMID: 17675290]
    HL-60 IC50
    0.03 3
    Compound: Trichostatin A
    Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by CCK8 assay
    		10.1039/C3MD00371J
    HUVEC IC50
    20 1
    Compound: TSA, trichostatin A
    Inhibition of HOSCN-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of HOSCN challenge by one stage clotting assay
    Inhibition of HOSCN-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of HOSCN challenge by one stage clotting assay
    		[PMID: 17675290]
    Sf9 IC50
    15.7 1
    Compound: Trichostatin A
    Inhibition of human recombinant GST-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells using MOCPAC as substrate after 4 hrs by UHPLC-ESI-MS/MS analysis
    Inhibition of human recombinant GST-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells using MOCPAC as substrate after 4 hrs by UHPLC-ESI-MS/MS analysis
    		[PMID: 27650925]
    HeLa IC50
    0.09 3
    Compound: TSA
    Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    HL-60 IC50
    0.08 3
    Compound: TSA
    Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    		[PMID: 24960627]
    HUVEC IC50
    20 1
    Compound: TSA, trichostatin A
    Inhibition of LPS-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of LPS challenge by one stage clotting assay
    Inhibition of LPS-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of LPS challenge by one stage clotting assay
    		[PMID: 17675290]
    HMEC IC50
    1.6 3
    Compound: TSA
    Inhibitory concentration required to reduce normal human epithelial cell line (HMEC), growth by 50% in MTT assay
    Inhibitory concentration required to reduce normal human epithelial cell line (HMEC), growth by 50% in MTT assay
    		[PMID: 12061890]
    HeLa IC50
    0.85 3
    Compound: 5
    Cytotoxicity against human HeLa cells after 96 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 96 hrs by MTT assay
    		[PMID: 25556102]
    HUVEC IC50
    30 1
    Compound: TSA, trichostatin A
    Inhibition of TNF-alpha-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of TNFalpha challenge by one stage clotting assay
    Inhibition of TNF-alpha-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of TNFalpha challenge by one stage clotting assay
    		[PMID: 17675290]
    K562 IC50
    0.12 3
    Compound: TSA
    Antiproliferative activity against human K562 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human K562 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    HeLa IC50
    0.1 3
    Compound: Trichostatin A
    Cytotoxicity against human HeLa cells assessed as cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human HeLa cells assessed as cell viability after 72 hrs by CCK8 assay
    		10.1039/C3MD00371J
    HMEC IC50
    32 3
    Compound: TSA
    Inhibitory concentration against normal epithelial HMEC cell line
    Inhibitory concentration against normal epithelial HMEC cell line
    		[PMID: 12593661]
    K562 IC50
    0.16 3
    Compound: Trichostatin A
    Cytotoxicity against human K562 cells assessed as cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human K562 cells assessed as cell viability after 72 hrs by CCK8 assay
    		10.1039/C3MD00371J
    HT-1080 IC50
    0.08 3
    Compound: TSA
    Antiproliferative activity against human HT1080 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human HT1080 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    HeLa IC50
    0.11 3
    Compound: TSA
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    		[PMID: 24960627]
    K562 IC50
    0.41 3
    Compound: TSA
    Cytotoxicity against human K562 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human K562 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    		[PMID: 24960627]
    HeLa IC50
    0.3 3
    Compound: TSA
    Inhibition of HDAC from human HeLa cells
    Inhibition of HDAC from human HeLa cells
    		[PMID: 18247554]
    K562 IC50
    260 1
    Compound: TSA
    Antiproliferative activity against human K562 cells after 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human K562 cells after 72 hrs by CellTiter Glo assay
    		[PMID: 35797900]
    HT-29 GI50
    34.1 1
    Compound: TSA
    Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay
    Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay
    		[PMID: 30004697]
    HeLa IC50
    0.3 3
    Compound: Trichostatin A
    Inhibition of HDAC from human HeLa cells by fluorogenic enzyme assay
    Inhibition of HDAC from human HeLa cells by fluorogenic enzyme assay
    		[PMID: 19457659]
    K562 GI50
    262 1
    Compound: TSA
    Antiproliferative activity against human K562 cells after 72 hrs by MTS assay
    Antiproliferative activity against human K562 cells after 72 hrs by MTS assay
    		[PMID: 30004697]
    HT-29 IC50
    3.8 1
    Compound: TSA
    Antiproliferative activity against human HT-29 cells in presence of isoCA-4 after 72 hrs by MTS assay relative to control
    Antiproliferative activity against human HT-29 cells in presence of isoCA-4 after 72 hrs by MTS assay relative to control
    		[PMID: 30004697]
    HeLa IC50
    0.0075 3
    Compound: Trichostatin A
    Inhibition of HDAC in human HeLa cell extract after 15 mins by fluorescence assay
    Inhibition of HDAC in human HeLa cell extract after 15 mins by fluorescence assay
    		[PMID: 25455492]
    K562 IC50
    560 1
    Compound: TSA
    Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
    Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
    		[PMID: 30245394]
    HeLa IC50
    0.02 3
    Compound: TSA
    Inhibition of HDAC in human HeLa cell nuclear extract assessed as inhibition of histone H4 deacetylation after 15 mins by fluorescence assay
    Inhibition of HDAC in human HeLa cell nuclear extract assessed as inhibition of histone H4 deacetylation after 15 mins by fluorescence assay
    		[PMID: 20381359]
    HT-29 IC50
    55 1
    Compound: TSA
    Antiproliferative activity against human HT-29 cells after 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human HT-29 cells after 72 hrs by CellTiter Glo assay
    		[PMID: 35797900]
    K562 IC50
    90 1
    Compound: TSA
    Antiproliferative activity against imatinib-resistant human K562 cells over expressing MDR1 after 72 hrs by CellTiter Glo assay
    Antiproliferative activity against imatinib-resistant human K562 cells over expressing MDR1 after 72 hrs by CellTiter Glo assay
    		[PMID: 35797900]
    HeLa IC50
    0.0011 3
    Compound: TSA
    Inhibition of HDAC2 in human HeLa cell nuclear extracts in presence of dithiothreitol by HDAC fluorescent assay
    Inhibition of HDAC2 in human HeLa cell nuclear extracts in presence of dithiothreitol by HDAC fluorescent assay
    		[PMID: 22465091]
    K-562R GI50
    88 1
    Compound: TSA
    Antiproliferative activity against human K562R cells after 72 hrs by MTS assay
    Antiproliferative activity against human K562R cells after 72 hrs by MTS assay
    		[PMID: 30004697]
    Sf9 IC50
    17.3 1
    Compound: TSA
    Inhibition of human recombinant HDAC11 expressed in baculovirus/sf9 cells using RHKKAc as substrate
    Inhibition of human recombinant HDAC11 expressed in baculovirus/sf9 cells using RHKKAc as substrate
    		[PMID: 23905680]
    HUVEC IC50
    20 1
    Compound: TSA, trichostatin A
    Inhibition of HOSCN-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of HOSCN challenge by one stage clotting assay
    Inhibition of HOSCN-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of HOSCN challenge by one stage clotting assay
    		[PMID: 17675290]
    L02 IC50
    0.21 3
    Compound: 5
    Cytotoxicity against human LO2 cells after 96 hrs by MTT assay
    Cytotoxicity against human LO2 cells after 96 hrs by MTT assay
    		[PMID: 25556102]
    HUVEC IC50
    20 1
    Compound: TSA, trichostatin A
    Inhibition of IL-1-beta-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of IL1-beta challenge by one stage clotting assay
    Inhibition of IL-1-beta-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of IL1-beta challenge by one stage clotting assay
    		[PMID: 17675290]
    Sf21 IC50
    17.9 1
    Compound: Trichostatin A
    Inhibition of recombinant human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in Sf21 insect cells by using RHK-K(Ac)-AMC as substrate measured after 60 mins by fluorescence assay
    Inhibition of recombinant human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in Sf21 insect cells by using RHK-K(Ac)-AMC as substrate measured after 60 mins by fluorescence assay
    		[PMID: 31924504]
    HUVEC IC50
    20 1
    Compound: TSA, trichostatin A
    Inhibition of LPS-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of LPS challenge by one stage clotting assay
    Inhibition of LPS-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of LPS challenge by one stage clotting assay
    		[PMID: 17675290]
    MCF7 IC50
    0.06 3
    Compound: Trichostatin A
    Cytotoxicity against human MCF7 cells assessed as cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human MCF7 cells assessed as cell viability after 72 hrs by CCK8 assay
    		10.1039/C3MD00371J
    HepG2 EC50
    0.38 3
    Compound: 5
    Up-regulation of transcriptional activity of human CLA-1 promoter region -1055 to -62bp transfected in HepG2 cells by luciferase reporter gene assay
    Up-regulation of transcriptional activity of human CLA-1 promoter region -1055 to -62bp transfected in HepG2 cells by luciferase reporter gene assay
    		[PMID: 25556102]
    HUVEC IC50
    30 1
    Compound: TSA, trichostatin A
    Inhibition of TNF-alpha-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of TNFalpha challenge by one stage clotting assay
    Inhibition of TNF-alpha-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of TNFalpha challenge by one stage clotting assay
    		[PMID: 17675290]
    MCF7 IC50
    0.06 3
    Compound: TSA
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    		[PMID: 24960627]
    SH-SY5Y IC50
    18.8 1
    Compound: Trichostatin A
    Inhibition of HDAC1 in human SHSY5Y cells using MOCPAC as substrate after 8 hrs by UHPLC-ESI-MS/MS analysis
    Inhibition of HDAC1 in human SHSY5Y cells using MOCPAC as substrate after 8 hrs by UHPLC-ESI-MS/MS analysis
    		[PMID: 27650925]
    HepG2 IC50
    0.96 3
    Compound: 5
    Cytotoxicity against human HepG2 cells after 96 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 96 hrs by MTT assay
    		[PMID: 25556102]
    MCF7 IC50
    0.07 3
    Compound: TSA
    Antiproliferative activity against human MCF7 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    HepG2 IC50
    0.38 3
    Compound: 4; TSA
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability
    		[PMID: 32005414]
    MCF7 IC50
    0.1 3
    Compound: TSA
    Inhibitory concentration required to reduce MCF-7 tumor cell growth by 50% in MTT assay
    Inhibitory concentration required to reduce MCF-7 tumor cell growth by 50% in MTT assay
    		[PMID: 12061890]
    MCF7 IC50
    1.7 3
    Compound: TSA
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 22465091]
    A549 IC50
    20 1
    Compound: TSA
    Antiproliferative activity against human A549 cells
    Antiproliferative activity against human A549 cells
    		[PMID: 30245394]
    MCF7 IC50
    141 1
    Compound: TSA
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 30245394]
    HUVEC IC50
    20 1
    Compound: TSA, trichostatin A
    Inhibition of HOSCN-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of HOSCN challenge by one stage clotting assay
    Inhibition of HOSCN-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of HOSCN challenge by one stage clotting assay
    		[PMID: 17675290]
    MCF7 IC50
    27.7 1
    Compound: 8; TSA
    Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition by SRB assay
    Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition by SRB assay
    		[PMID: 34826681]
    MCF7 IC50
    20 1
    Compound: TSA
    Antiproliferative activity against human MCF7 cells
    Antiproliferative activity against human MCF7 cells
    		[PMID: 30245394]
    MCF7 GI50
    45 1
    Compound: TSA
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay
    		[PMID: 30004697]
    MKN-45 IC50
    20 1
    Compound: TSA
    Antiproliferative activity against human MKN45 cells
    Antiproliferative activity against human MKN45 cells
    		[PMID: 30245394]
    MCF7 IC50
    54 1
    Compound: TSA
    Antiproliferative activity against human MCF7 cells after 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by CellTiter Glo assay
    		[PMID: 35797900]
    HL-60 GI50
    0.59 3
    Compound: TRICHOSTATIN A
    Antiproliferative activity against human HL60 cells after 24 hrs by MTT assay
    Antiproliferative activity against human HL60 cells after 24 hrs by MTT assay
    		[PMID: 29454918]
    HeLa EC50
    0.0052 3
    Compound: TSA
    Inhibition of HDAC6 in human HeLa cells assessed as inhibition of tubulin deacetylation incubated for overnight by cELISA
    Inhibition of HDAC6 in human HeLa cells assessed as inhibition of tubulin deacetylation incubated for overnight by cELISA
    		[PMID: 26611919]
    SK-BR-3 IC50
    20 1
    Compound: TSA
    Antiproliferative activity against human SKBR3 cells
    Antiproliferative activity against human SKBR3 cells
    		[PMID: 30245394]
    MDA-MB-231 IC50
    0.09 3
    Compound: TSA
    Inhibitory concentration required to reduce MDAmb 231 tumor cell growth by 50% in MTT assay
    Inhibitory concentration required to reduce MDAmb 231 tumor cell growth by 50% in MTT assay
    		[PMID: 12061890]
    HeLa IC50
    0.0011 3
    Compound: TSA
    Inhibition of HDAC2 in human HeLa cell nuclear extracts in presence of dithiothreitol by HDAC fluorescent assay
    Inhibition of HDAC2 in human HeLa cell nuclear extracts in presence of dithiothreitol by HDAC fluorescent assay
    		[PMID: 22465091]
    HL-60 IC50
    0.03 3
    Compound: Trichostatin A
    Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by CCK8 assay
    		10.1039/C3MD00371J
    MDA-MB-231 IC50
    91 1
    Compound: TSA
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by CellTiter Glo assay
    		[PMID: 35797900]
    HL-60 IC50
    0.08 3
    Compound: TSA
    Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    		[PMID: 24960627]
    HeLa IC50
    0.0075 3
    Compound: Trichostatin A
    Inhibition of HDAC in human HeLa cell extract after 15 mins by fluorescence assay
    Inhibition of HDAC in human HeLa cell extract after 15 mins by fluorescence assay
    		[PMID: 25455492]
    MDA-MB-435 GI50
    1.78 3
    Compound: TRICHOSTATIN A
    Antiproliferative activity against human MDA-MB-435 cells after 24 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-435 cells after 24 hrs by MTT assay
    		[PMID: 29454918]
    HMEC IC50
    32 3
    Compound: TSA
    Inhibitory concentration against normal epithelial HMEC cell line
    Inhibitory concentration against normal epithelial HMEC cell line
    		[PMID: 12593661]
    MDCK IC50
    0.008 3
    Compound: Trichostatin A
    Antiviral activity against Influenza A virus A/Hong Kong/8/68 H3N2 infected in MDCK cells assessed as reduction in virus-induced cytopathic effect after 3 days by CCK8 assay
    Antiviral activity against Influenza A virus A/Hong Kong/8/68 H3N2 infected in MDCK cells assessed as reduction in virus-induced cytopathic effect after 3 days by CCK8 assay
    		10.1039/C3MD00371J
    HeLa IC50
    0.02 3
    Compound: TSA
    Inhibition of HDAC in human HeLa cell nuclear extract assessed as inhibition of histone H4 deacetylation after 15 mins by fluorescence assay
    Inhibition of HDAC in human HeLa cell nuclear extract assessed as inhibition of histone H4 deacetylation after 15 mins by fluorescence assay
    		[PMID: 20381359]
    MIA PaCa-2 IC50
    200 1
    Compound: TSA
    Antiproliferative activity against human MIA PaCa-2 cells after 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human MIA PaCa-2 cells after 72 hrs by CellTiter Glo assay
    		[PMID: 35797900]
    HeLa IC50
    0.09 3
    Compound: TSA
    Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    HMEC IC50
    1.6 3
    Compound: TSA
    Inhibitory concentration required to reduce normal human epithelial cell line (HMEC), growth by 50% in MTT assay
    Inhibitory concentration required to reduce normal human epithelial cell line (HMEC), growth by 50% in MTT assay
    		[PMID: 12061890]
    HeLa IC50
    0.1 3
    Compound: Trichostatin A
    Cytotoxicity against human HeLa cells assessed as cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human HeLa cells assessed as cell viability after 72 hrs by CCK8 assay
    		10.1039/C3MD00371J
    MIA PaCa-2 GI50
    200 1
    Compound: TSA
    Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by MTS assay
    Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by MTS assay
    		[PMID: 30004697]
    NIH3T3 IC50
    21 1
    Compound: 1
    Inhibition of human recombinant HDAC1 expressed in NIH3T3 cells
    Inhibition of human recombinant HDAC1 expressed in NIH3T3 cells
    		[PMID: 17929798]
    HT-1080 IC50
    0.08 3
    Compound: TSA
    Antiproliferative activity against human HT1080 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human HT1080 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    MOLT-4 IC50
    0.02 3
    Compound: TSA
    Antiproliferative activity against human MOLT4 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human MOLT4 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    HeLa IC50
    0.11 3
    Compound: TSA
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    		[PMID: 24960627]
    MOLT-4 IC50
    0.03 3
    Compound: Trichostatin A
    Cytotoxicity against human MOLT4 cells assessed as cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human MOLT4 cells assessed as cell viability after 72 hrs by CCK8 assay
    		10.1039/C3MD00371J
    HeLa IC50
    0.3 3
    Compound: TSA
    Inhibition of HDAC from human HeLa cells
    Inhibition of HDAC from human HeLa cells
    		[PMID: 18247554]
    Huh-7 CC50
    1.587 3
    Compound: GNF-Pf-1011
    NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
    NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
    		[PMID: 18579783]
    MOLT-4 IC50
    0.03 3
    Compound: TSA
    Cytotoxicity against human MOLT4 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human MOLT4 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    		[PMID: 24960627]
    DMS-53 IC50
    25 1
    Compound: Trichostatin A
    Cytostatic activity against human DMS53 cells assessed as inhibition of cell proliferation after 2 days by MTT assay
    Cytostatic activity against human DMS53 cells assessed as inhibition of cell proliferation after 2 days by MTT assay
    		[PMID: 21504214]
    HeLa IC50
    0.3 3
    Compound: Trichostatin A
    Inhibition of HDAC from human HeLa cells by fluorogenic enzyme assay
    Inhibition of HDAC from human HeLa cells by fluorogenic enzyme assay
    		[PMID: 19457659]
    Sf21 IC50
    25 1
    Compound: TSA
    Inhibition of recombinant human GST-tagged HDAC2 (1 to 488 residues) expressed in baculovirus infected sf21 cells using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate measured after 1 to 2 hrs by fluorescence assay
    Inhibition of recombinant human GST-tagged HDAC2 (1 to 488 residues) expressed in baculovirus infected sf21 cells using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate measured after 1 to 2 hrs by fluorescence assay
    		[PMID: 32212730]
    NCI-H1975 IC50
    0.09 3
    Compound: Trichostatin A
    Cytotoxicity against human NCI-H1975 cells assessed as cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human NCI-H1975 cells assessed as cell viability after 72 hrs by CCK8 assay
    		10.1039/C3MD00371J
    HeLa IC50
    0.85 3
    Compound: 5
    Cytotoxicity against human HeLa cells after 96 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 96 hrs by MTT assay
    		[PMID: 25556102]
    HeLa IC50
    1.42 1
    Compound: TSA
    Inhibition of HDAC in human HeLa cell nuclear extract using BML-KI104 Fluor de Lys as substrate by fluorescence-based assay
    Inhibition of HDAC in human HeLa cell nuclear extract using BML-KI104 Fluor de Lys as substrate by fluorescence-based assay
    		[PMID: 26588603]
    NCI-H1975 IC50
    0.21 3
    Compound: TSA
    Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    		[PMID: 24960627]
    T47D IC50
    26.4 1
    Compound: 8; TSA
    Antiproliferative activity against human T47D cells assessed as cell growth inhibition by burton method
    Antiproliferative activity against human T47D cells assessed as cell growth inhibition by burton method
    		[PMID: 34826681]
    MCF7 IC50
    27.7 1
    Compound: 8; TSA
    Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition by SRB assay
    Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition by SRB assay
    		[PMID: 34826681]
    HeLa IC50
    12 1
    Compound: TSA
    Inhibition of HDAC isolated from human HeLa cells by fluorimetric assay
    Inhibition of HDAC isolated from human HeLa cells by fluorimetric assay
    		10.1039/C4MD00211C
    NCI-H446 IC50
    0.08 3
    Compound: TSA
    Inhibitory concentration required to reduce H446 tumor cell growth by 50% in MTT assay
    Inhibitory concentration required to reduce H446 tumor cell growth by 50% in MTT assay
    		[PMID: 12061890]
    Huh-7 IC50
    0.06 3
    Compound: TSA
    Antiproliferative activity against human HuH7 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human HuH7 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    HeLa IC50
    28.9 1
    Compound: TSA
    Inhibition of human HDAC in human HeLa cell nuclear extract after 15 mins by colorimetric assay
    Inhibition of human HDAC in human HeLa cell nuclear extract after 15 mins by colorimetric assay
    		[PMID: 20167479]
    NCI-H460 IC50
    0.1 3
    Compound: 1, TSA
    Growth inhibition of human H460 cells after 48 hrs by SRB assay
    Growth inhibition of human H460 cells after 48 hrs by SRB assay
    		[PMID: 21073160]
    NCI-H661 IC50
    0.085 3
    Compound: 7, TSA
    Antiproliferative activity against H661 cells after 48 hrs by XTT assay
    Antiproliferative activity against H661 cells after 48 hrs by XTT assay
    		[PMID: 17624773]
    HeLa IC50
    3 1
    Compound: TSA
    Inhibition of HDAC in human HeLa cell cytosolic extract after 30 mins by fluorimetric assay
    Inhibition of HDAC in human HeLa cell cytosolic extract after 30 mins by fluorimetric assay
    		[PMID: 19705846]
    Huh-7 IC50
    0.09 3
    Compound: Trichostatin A
    Cytotoxicity against human HuH7 cells assessed as cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human HuH7 cells assessed as cell viability after 72 hrs by CCK8 assay
    		10.1039/C3MD00371J
    HeLa IC50
    3 1
    Compound: TSA
    Inhibition of HDAC in human HeLa cell nuclear extract after 30 mins by fluorimetric assay
    Inhibition of HDAC in human HeLa cell nuclear extract after 30 mins by fluorimetric assay
    		[PMID: 19705846]
    Huh-7 IC50
    0.1 3
    Compound: TSA
    Cytotoxicity against human HuH7 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human HuH7 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    		[PMID: 24960627]
    NCI-H661 IC50
    0.085 3
    Compound: 1 (TSA)
    Antiproliferative activity against H661 cells after 48 hrs
    Antiproliferative activity against H661 cells after 48 hrs
    		[PMID: 17897824]
    HeLa IC50
    3 1
    Compound: TSA
    Inhibition of HDAC in human HeLa cells using Ac-Arg-Gly-Lys(Ac)-AMC as fluorescent substrate after 20 mins by fluorescence assay
    Inhibition of HDAC in human HeLa cells using Ac-Arg-Gly-Lys(Ac)-AMC as fluorescent substrate after 20 mins by fluorescence assay
    		[PMID: 21621883]
    NCI-H661 IC50
    0.1 3
    Compound: 1, TSA
    Antiproliferative activity against human NCI-H661 cells after 48 hrs by XTT assay
    Antiproliferative activity against human NCI-H661 cells after 48 hrs by XTT assay
    		[PMID: 19385600]
    HeLa IC50
    28.9 1
    Compound: TSA
    Inhibition of human HDAC in human HeLa cell nuclear extract after 15 mins by colorimetric assay
    Inhibition of human HDAC in human HeLa cell nuclear extract after 15 mins by colorimetric assay
    		[PMID: 20167479]
    HUVEC IC50
    30 1
    Compound: TSA, trichostatin A
    Inhibition of TNF-alpha-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of TNFalpha challenge by one stage clotting assay
    Inhibition of TNF-alpha-induced tissue factor activity in HUVEC preincubated for 4 hrs assessed after 4 hrs of TNFalpha challenge by one stage clotting assay
    		[PMID: 17675290]
    HeLa IC50
    39 1
    Compound: TSA
    Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
    Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
    		[PMID: 30245394]
    NCI-N87 IC50
    0.06 3
    Compound: TSA
    Antiproliferative activity against human NCI-N87 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human NCI-N87 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    NCI-N87 IC50
    58 1
    Compound: TSA
    Antiproliferative activity against human NCI-N87 cells after 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human NCI-N87 cells after 72 hrs by CellTiter Glo assay
    		[PMID: 35797900]
    HeLa IC50
    41 1
    Compound: TSA
    Inhibition of Histone deacetylase in HeLa cell nuclear extracts by fluorescence-based assay
    Inhibition of Histone deacetylase in HeLa cell nuclear extracts by fluorescence-based assay
    		[PMID: 17419603]
    JAM cell line IC50
    0.08 3
    Compound: 1a
    Cytotoxicity of compound against normal human ovarian JAM cell line
    Cytotoxicity of compound against normal human ovarian JAM cell line
    		[PMID: 15163181]
    NIH3T3 IC50
    0.006 3
    Compound: Trichostatin A
    Inhibition of HDAC1 in human NIH3T3 cells by radiometric histone deacetylation assay
    Inhibition of HDAC1 in human NIH3T3 cells by radiometric histone deacetylation assay
    		[PMID: 19457659]
    HeLa IC50
    5 1
    Compound: TSA
    Inhibition of human HDAC in HeLa cells by flour de lys assay
    Inhibition of human HDAC in HeLa cells by flour de lys assay
    		[PMID: 18397827]
    BT-474 IC50
    33.3 1
    Compound: 8; TSA
    Antiproliferative activity against human BT-474 cells assessed as cell growth inhibition by SRB assay
    Antiproliferative activity against human BT-474 cells assessed as cell growth inhibition by SRB assay
    		[PMID: 34826681]
    HeLa IC50
    5 1
    Compound: TSA
    Inhibition of HDAC in human HeLa cell nuclear extracts after 15 mins by fluorescence assay
    Inhibition of HDAC in human HeLa cell nuclear extracts after 15 mins by fluorescence assay
    		[PMID: 19914074]
    PANC-1 IC50
    0.1 3
    Compound: TSA
    Antiproliferative activity against human PANC1 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human PANC1 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    K562 IC50
    0.12 3
    Compound: TSA
    Antiproliferative activity against human K562 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human K562 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    PC-3 GI50
    387 1
    Compound: TSA
    Antiproliferative activity against human PC3 cells after 72 hrs by MTS assay
    Antiproliferative activity against human PC3 cells after 72 hrs by MTS assay
    		[PMID: 30004697]
    HEK293 IC50
    34 1
    Compound: 1
    Inhibition of human recombinant HDAC4 expressed in 293 cells
    Inhibition of human recombinant HDAC4 expressed in 293 cells
    		[PMID: 17929798]
    HeLa IC50
    5 1
    Compound: Trichostatin A
    Inhibition of histone deacetylase (HDAC) activity in HeLa cell nuclear extract
    Inhibition of histone deacetylase (HDAC) activity in HeLa cell nuclear extract
    		[PMID: 15109636]
    Sf21 IC50
    0.032 3
    Compound: TSA
    Inhibition of recombinant full length C-terminal FLAG/His-tagged human HDAC1 (1 to 482 residues) expressed in sf21 cells using RHK-K(Ac)-AMC as substrate by fluorimetric assay
    Inhibition of recombinant full length C-terminal FLAG/His-tagged human HDAC1 (1 to 482 residues) expressed in sf21 cells using RHK-K(Ac)-AMC as substrate by fluorimetric assay
    		[PMID: 30448419]
    HT-29 GI50
    34.1 1
    Compound: TSA
    Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay
    Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay
    		[PMID: 30004697]
    HeLa IC50
    54.5 1
    Compound: 15
    Inhibitory concentration against human histone deacetylase (HDAC) from HeLa cells with substrate 5a
    Inhibitory concentration against human histone deacetylase (HDAC) from HeLa cells with substrate 5a
    		[PMID: 15456267]
    K562 IC50
    0.16 3
    Compound: Trichostatin A
    Cytotoxicity against human K562 cells assessed as cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human K562 cells assessed as cell viability after 72 hrs by CCK8 assay
    		10.1039/C3MD00371J
    Sf21 IC50
    1.58 x 10-2 3
    Compound: Trichostatin A
    Inhibition of recombinant full length human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in baculovirus infected Sf21 cells using RHK-K(Ac)-AMC as substrate measured after 60 mins by fluorimetric assay
    Inhibition of recombinant full length human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in baculovirus infected Sf21 cells using RHK-K(Ac)-AMC as substrate measured after 60 mins by fluorimetric assay
    		[PMID: 31838329]
    Sf21 IC50
    17.9 1
    Compound: Trichostatin A
    Inhibition of recombinant human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in Sf21 insect cells by using RHK-K(Ac)-AMC as substrate measured after 60 mins by fluorescence assay
    Inhibition of recombinant human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in Sf21 insect cells by using RHK-K(Ac)-AMC as substrate measured after 60 mins by fluorescence assay
    		[PMID: 31924504]
    HCT-116 GI50
    35 1
    Compound: TSA
    Antiproliferative activity against human HCT-116 cells after 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human HCT-116 cells after 72 hrs by CellTiter Glo assay
    		[PMID: 35797900]
    HepG2 EC50
    0.38 3
    Compound: 5
    Up-regulation of transcriptional activity of human CLA-1 promoter region -1055 to -62bp transfected in HepG2 cells by luciferase reporter gene assay
    Up-regulation of transcriptional activity of human CLA-1 promoter region -1055 to -62bp transfected in HepG2 cells by luciferase reporter gene assay
    		[PMID: 25556102]
    Sf21 IC50
    25 1
    Compound: TSA
    Inhibition of recombinant human GST-tagged HDAC2 (1 to 488 residues) expressed in baculovirus infected sf21 cells using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate measured after 1 to 2 hrs by fluorescence assay
    Inhibition of recombinant human GST-tagged HDAC2 (1 to 488 residues) expressed in baculovirus infected sf21 cells using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate measured after 1 to 2 hrs by fluorescence assay
    		[PMID: 32212730]
    HCT-116 GI50
    35 1
    Compound: TSA
    Antiproliferative activity against human HCT116 cells after 72 hrs by MTS assay
    Antiproliferative activity against human HCT116 cells after 72 hrs by MTS assay
    		[PMID: 30004697]
    Sf21 IC50
    3.95 x 10-2 3
    Compound: Trichostatin A
    Inhibition of recombinant human C-terminal GST-tagged HDAC2 (1 to 488 residues) expressed in baculovirus infected sf21 cells using RHK-K(Ac)-AMC as substrate after 60 mins by fluorimetry assay
    Inhibition of recombinant human C-terminal GST-tagged HDAC2 (1 to 488 residues) expressed in baculovirus infected sf21 cells using RHK-K(Ac)-AMC as substrate after 60 mins by fluorimetry assay
    		[PMID: 31838329]
    HepG2 IC50
    0.38 3
    Compound: 4; TSA
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability
    		[PMID: 32005414]
    K562 IC50
    0.41 3
    Compound: TSA
    Cytotoxicity against human K562 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human K562 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    		[PMID: 24960627]
    HepG2 IC50
    0.96 3
    Compound: 5
    Cytotoxicity against human HepG2 cells after 96 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 96 hrs by MTT assay
    		[PMID: 25556102]
    Sf21 IC50
    6.574 1
    Compound: TSA
    Inhibition of full length human recombinant C-terminal FLAG-His-tagged HDAC1 (1 to 482 residues) expressed in Sf21 cells using RHK-K(Ac)-AMC as substrate incubated for 60 mins by fluorescence assay
    Inhibition of full length human recombinant C-terminal FLAG-His-tagged HDAC1 (1 to 482 residues) expressed in Sf21 cells using RHK-K(Ac)-AMC as substrate incubated for 60 mins by fluorescence assay
    		[PMID: 27060764]
    K562 IC50
    0.0046 3
    Compound: trichostatin
    Inhibitory activity against partially purified histone deacetylase of human leukemia K562 cells.
    Inhibitory activity against partially purified histone deacetylase of human leukemia K562 cells.
    		[PMID: 10425110]
    Sf21 IC50
    9 1
    Compound: TSA
    Inhibition of full length recombinant human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in baculovirus infected Sf21 insect cells using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate measured after 1 to 2 hrs by flu
    Inhibition of full length recombinant human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in baculovirus infected Sf21 insect cells using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate measured after 1 to 2 hrs by flu
    		[PMID: 32212730]
    Huh-7 CC50
    1.587 3
    Compound: GNF-Pf-1011
    NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
    NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
    		[PMID: 18579783]
    HeLa IC50
    39 1
    Compound: TSA
    Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
    Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
    		[PMID: 30245394]
    Sf9 IC50
    > 1 3
    Compound: TSA
    Inhibition of recombinant full length human HDAC4 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 1.5 hrs by electrophoretic mobility shift assay
    Inhibition of recombinant full length human HDAC4 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 1.5 hrs by electrophoretic mobility shift assay
    		[PMID: 31938464]
    Huh-7 IC50
    0.06 3
    Compound: TSA
    Antiproliferative activity against human HuH7 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human HuH7 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    HeLa IC50
    41 1
    Compound: TSA
    Inhibition of Histone deacetylase in HeLa cell nuclear extracts by fluorescence-based assay
    Inhibition of Histone deacetylase in HeLa cell nuclear extracts by fluorescence-based assay
    		[PMID: 17419603]
    Sf9 IC50
    > 1 3
    Compound: TSA
    Inhibition of recombinant human HDAC9 (604-1066 residues) expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 3 hrs by electrophoretic mobility shift assay
    Inhibition of recombinant human HDAC9 (604-1066 residues) expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 3 hrs by electrophoretic mobility shift assay
    		[PMID: 31938464]
    Huh-7 IC50
    0.09 3
    Compound: Trichostatin A
    Cytotoxicity against human HuH7 cells assessed as cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human HuH7 cells assessed as cell viability after 72 hrs by CCK8 assay
    		10.1039/C3MD00371J
    L02 IC50
    0.21 3
    Compound: 5
    Cytotoxicity against human LO2 cells after 96 hrs by MTT assay
    Cytotoxicity against human LO2 cells after 96 hrs by MTT assay
    		[PMID: 25556102]
    Sf9 IC50
    0.000681 3
    Compound: TSA
    Inhibition of recombinant full length human HDAC1 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by electrophoretic mobility shift assay
    Inhibition of recombinant full length human HDAC1 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by electrophoretic mobility shift assay
    		[PMID: 31938464]
    MCF7 GI50
    45 1
    Compound: TSA
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay
    		[PMID: 30004697]
    Huh-7 IC50
    0.1 3
    Compound: TSA
    Cytotoxicity against human HuH7 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human HuH7 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    		[PMID: 24960627]
    Sf9 IC50
    0.00161 3
    Compound: TSA
    Inhibition of recombinant full length human HDAC10 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by electrophoretic mobility shift assay
    Inhibition of recombinant full length human HDAC10 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by electrophoretic mobility shift assay
    		[PMID: 31938464]
    Jurkat IC50
    3.3 1
    Compound: TSA
    Tested for inhibitory concentration required to inhibit 50% of histone deacetylase (HDAC) from human T cell leukemia Jurkat cell
    Tested for inhibitory concentration required to inhibit 50% of histone deacetylase (HDAC) from human T cell leukemia Jurkat cell
    		[PMID: 11992774]
    SNU-16 IC50
    53 1
    Compound: TSA
    Inhibition of HDAC from human SNU16 cells
    Inhibition of HDAC from human SNU16 cells
    		[PMID: 18247554]
    Sf9 IC50
    0.002 3
    Compound: TSA
    Inhibition of recombinant N-terminal GST-tagged human HDAC6 (1 to 1215 residues) expressed in baculovirus infected sf9 insect cells using p53 (379 to 382 residues) derived fluorogenic peptide RHKKAc as substrate preincubated for 5 to 10 mins followed by s
    Inhibition of recombinant N-terminal GST-tagged human HDAC6 (1 to 1215 residues) expressed in baculovirus infected sf9 insect cells using p53 (379 to 382 residues) derived fluorogenic peptide RHKKAc as substrate preincubated for 5 to 10 mins followed by s
    		[PMID: 31414801]
    K-562R GI50
    88 1
    Compound: TSA
    Antiproliferative activity against human K562R cells after 72 hrs by MTS assay
    Antiproliferative activity against human K562R cells after 72 hrs by MTS assay
    		[PMID: 30004697]
    SNU-16 IC50
    53.29 1
    Compound: TSA (1)
    Inhibitory activity against Histone deacetylase (HDAC) from SNU-16 (human gastric adenocarcinoma) cells
    Inhibitory activity against Histone deacetylase (HDAC) from SNU-16 (human gastric adenocarcinoma) cells
    		[PMID: 14667227]
    Sf9 IC50
    0.00274 3
    Compound: TSA
    Inhibition of recombinant full length human HDAC2 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by electrophoretic mobility shift assay
    Inhibition of recombinant full length human HDAC2 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by electrophoretic mobility shift assay
    		[PMID: 31938464]
    K562 GI50
    262 1
    Compound: TSA
    Antiproliferative activity against human K562 cells after 72 hrs by MTS assay
    Antiproliferative activity against human K562 cells after 72 hrs by MTS assay
    		[PMID: 30004697]
    MCF7 IC50
    54 1
    Compound: TSA
    Antiproliferative activity against human MCF7 cells after 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by CellTiter Glo assay
    		[PMID: 35797900]
    HeLa IC50
    54.5 1
    Compound: 15
    Inhibitory concentration against human histone deacetylase (HDAC) from HeLa cells with substrate 5a
    Inhibitory concentration against human histone deacetylase (HDAC) from HeLa cells with substrate 5a
    		[PMID: 15456267]
    Sf9 IC50
    0.009 3
    Compound: TSA
    Inhibition of recombinant full length C-terminal His/FLAG tagged human HDAC1 (1 to 482 residues) expressed in baculovirus infected sf9 insect cells using p53 (379 to 382 residues) derived fluorogenic peptide RHKKAc as substrate preincubated for 5 to 10 mi
    Inhibition of recombinant full length C-terminal His/FLAG tagged human HDAC1 (1 to 482 residues) expressed in baculovirus infected sf9 insect cells using p53 (379 to 382 residues) derived fluorogenic peptide RHKKAc as substrate preincubated for 5 to 10 mi
    		[PMID: 31414801]
    K562 IC50
    0.0046 3
    Compound: trichostatin
    Inhibitory activity against partially purified histone deacetylase of human leukemia K562 cells.
    Inhibitory activity against partially purified histone deacetylase of human leukemia K562 cells.
    		[PMID: 10425110]
    Sf9 IC50
    0.482 3
    Compound: TSA
    Inhibition of recombinant full length human HDAC7 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 3 hrs by electrophoretic mobility shift assay
    Inhibition of recombinant full length human HDAC7 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 3 hrs by electrophoretic mobility shift assay
    		[PMID: 31938464]
    HT-29 IC50
    55 1
    Compound: TSA
    Antiproliferative activity against human HT-29 cells after 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human HT-29 cells after 72 hrs by CellTiter Glo assay
    		[PMID: 35797900]
    K562 IC50
    0.12 3
    Compound: TSA
    Antiproliferative activity against human K562 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human K562 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    Sf9 IC50
    0.776 3
    Compound: TSA
    Inhibition of recombinant full length human HDAC5 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 3 hrs by electrophoretic mobility shift assay
    Inhibition of recombinant full length human HDAC5 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 3 hrs by electrophoretic mobility shift assay
    		[PMID: 31938464]
    K562 IC50
    0.16 3
    Compound: Trichostatin A
    Cytotoxicity against human K562 cells assessed as cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human K562 cells assessed as cell viability after 72 hrs by CCK8 assay
    		10.1039/C3MD00371J
    NCI-N87 IC50
    58 1
    Compound: TSA
    Antiproliferative activity against human NCI-N87 cells after 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human NCI-N87 cells after 72 hrs by CellTiter Glo assay
    		[PMID: 35797900]
    Sf9 IC50
    0.9 1
    Compound: TSA
    Inhibition of human recombinant HDAC6 expressed in baculovirus/sf9 cells using RHKKAc as substrate
    Inhibition of human recombinant HDAC6 expressed in baculovirus/sf9 cells using RHKKAc as substrate
    		[PMID: 23905680]
    K562 IC50
    0.41 3
    Compound: TSA
    Cytotoxicity against human K562 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human K562 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    		[PMID: 24960627]
    MCF7 IC50
    1.7 3
    Compound: TSA
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 22465091]
    Sf9 IC50
    1.2 1
    Compound: TSA
    Inhibition of human recombinant HDAC6 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrate
    Inhibition of human recombinant HDAC6 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrate
    		[PMID: 23009203]
    K562 IC50
    260 1
    Compound: TSA
    Antiproliferative activity against human K562 cells after 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human K562 cells after 72 hrs by CellTiter Glo assay
    		[PMID: 35797900]
    MCF7 IC50
    0.07 3
    Compound: TSA
    Antiproliferative activity against human MCF7 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    Sf9 IC50
    1.716 1
    Compound: TSA
    Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells using RHK-K(Ac)-AMC as substrate incubated for 90 mins by fluorescence assay
    Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells using RHK-K(Ac)-AMC as substrate incubated for 90 mins by fluorescence assay
    		[PMID: 27060764]
    K562 IC50
    560 1
    Compound: TSA
    Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
    Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
    		[PMID: 30245394]
    MCF7 IC50
    0.06 3
    Compound: Trichostatin A
    Cytotoxicity against human MCF7 cells assessed as cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human MCF7 cells assessed as cell viability after 72 hrs by CCK8 assay
    		10.1039/C3MD00371J
    Sf9 IC50
    129 1
    Compound: TSA
    Inhibition of human recombinant HDAC8 expressed in baculovirus/sf9 cells using RHKAcKAc as substrate
    Inhibition of human recombinant HDAC8 expressed in baculovirus/sf9 cells using RHKAcKAc as substrate
    		[PMID: 23905680]
    MCF7 IC50
    0.3 3
    Compound: 4; TSA
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability
    		[PMID: 32005414]
    K562 IC50
    90 1
    Compound: TSA
    Antiproliferative activity against imatinib-resistant human K562 cells over expressing MDR1 after 72 hrs by CellTiter Glo assay
    Antiproliferative activity against imatinib-resistant human K562 cells over expressing MDR1 after 72 hrs by CellTiter Glo assay
    		[PMID: 35797900]
    Sf9 IC50
    15.7 1
    Compound: Trichostatin A
    Inhibition of human recombinant GST-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells using MOCPAC as substrate after 4 hrs by UHPLC-ESI-MS/MS analysis
    Inhibition of human recombinant GST-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells using MOCPAC as substrate after 4 hrs by UHPLC-ESI-MS/MS analysis
    		[PMID: 27650925]
    L02 IC50
    0.21 3
    Compound: 5
    Cytotoxicity against human LO2 cells after 96 hrs by MTT assay
    Cytotoxicity against human LO2 cells after 96 hrs by MTT assay
    		[PMID: 25556102]
    MCF7 IC50
    0.06 3
    Compound: TSA
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    		[PMID: 24960627]
    Sf9 IC50
    17.3 1
    Compound: TSA
    Inhibition of human recombinant HDAC11 expressed in baculovirus/sf9 cells using RHKKAc as substrate
    Inhibition of human recombinant HDAC11 expressed in baculovirus/sf9 cells using RHKKAc as substrate
    		[PMID: 23905680]
    MCF7 IC50
    0.02 3
    Compound: 1a
    Cytotoxicity of compound against normal human breast MCF-7 cell line
    Cytotoxicity of compound against normal human breast MCF-7 cell line
    		[PMID: 15163181]
    MCF7 GI50
    45 1
    Compound: TSA
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay
    		[PMID: 30004697]
    MCF7 IC50
    10 3
    Compound: TSA
    Inhibitory concentration against breast MCF-7 cell line
    Inhibitory concentration against breast MCF-7 cell line
    		[PMID: 12593661]
    Sf9 IC50
    5 1
    Compound: TSA
    Inhibition of human recombinant HDAC1 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrate
    Inhibition of human recombinant HDAC1 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrate
    		[PMID: 23009203]
    MCF7 IC50
    0.02 3
    Compound: 1a
    Cytotoxicity of compound against normal human breast MCF-7 cell line
    Cytotoxicity of compound against normal human breast MCF-7 cell line
    		[PMID: 15163181]
    Sf9 IC50
    5 1
    Compound: TSA
    Inhibition of human recombinant HDAC1 expressed in baculovirus/sf9 cells using RHKKAc as substrate
    Inhibition of human recombinant HDAC1 expressed in baculovirus/sf9 cells using RHKKAc as substrate
    		[PMID: 23905680]
    MCF7 IC50
    0.06 3
    Compound: TSA
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    		[PMID: 24960627]
    MCF7 IC50
    0.1 3
    Compound: TSA
    Inhibitory concentration required to reduce MCF-7 tumor cell growth by 50% in MTT assay
    Inhibitory concentration required to reduce MCF-7 tumor cell growth by 50% in MTT assay
    		[PMID: 12061890]
    Sf9 IC50
    5 1
    Compound: TSA
    Inhibition of human recombinant HDAC2 expressed in baculovirus/sf9 cells using RHKKAc as substrate
    Inhibition of human recombinant HDAC2 expressed in baculovirus/sf9 cells using RHKKAc as substrate
    		[PMID: 23905680]
    MCF7 IC50
    0.06 3
    Compound: Trichostatin A
    Cytotoxicity against human MCF7 cells assessed as cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human MCF7 cells assessed as cell viability after 72 hrs by CCK8 assay
    		10.1039/C3MD00371J
    MDA-MB-231 IC50
    3.5 3
    Compound: TSA
    Inhibitory concentration against breast MDA-MB-231 cell line
    Inhibitory concentration against breast MDA-MB-231 cell line
    		[PMID: 12593661]
    Sf9 IC50
    9 1
    Compound: TSA
    Inhibition of human recombinant HDAC10 expressed in baculovirus/sf9 cells using RHKKAc as substrate
    Inhibition of human recombinant HDAC10 expressed in baculovirus/sf9 cells using RHKKAc as substrate
    		[PMID: 23905680]
    MCF7 IC50
    0.07 3
    Compound: TSA
    Antiproliferative activity against human MCF7 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    MDA-MB-231 IC50
    0.09 3
    Compound: TSA
    Inhibitory concentration required to reduce MDAmb 231 tumor cell growth by 50% in MTT assay
    Inhibitory concentration required to reduce MDAmb 231 tumor cell growth by 50% in MTT assay
    		[PMID: 12061890]
    A549 GI50
    80 1
    Compound: TSA
    Antiproliferative activity against human A549 cells after 72 hrs by MTS assay
    Antiproliferative activity against human A549 cells after 72 hrs by MTS assay
    		[PMID: 30004697]
    MCF7 IC50
    0.1 3
    Compound: TSA
    Inhibitory concentration required to reduce MCF-7 tumor cell growth by 50% in MTT assay
    Inhibitory concentration required to reduce MCF-7 tumor cell growth by 50% in MTT assay
    		[PMID: 12061890]
    Sf9 IC50
    960 1
    Compound: 1, TSA
    Inhibition of N terminal hexahistidine-tagged human HDAC8 expressed in Sf9 cells after 1 hr by fluorescence assay
    Inhibition of N terminal hexahistidine-tagged human HDAC8 expressed in Sf9 cells after 1 hr by fluorescence assay
    		[PMID: 21723733]
    SGC-7901 IC50
    0.03 3
    Compound: TSA
    Antiproliferative activity against human SGC7901 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human SGC7901 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    A549 IC50
    80 1
    Compound: TSA
    Antiproliferative activity against human A549 cells after 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human A549 cells after 72 hrs by CellTiter Glo assay
    		[PMID: 35797900]
    MCF7 IC50
    0.3 3
    Compound: 4; TSA
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability
    		[PMID: 32005414]
    SH-SY5Y IC50
    18.8 1
    Compound: Trichostatin A
    Inhibition of HDAC1 in human SHSY5Y cells using MOCPAC as substrate after 8 hrs by UHPLC-ESI-MS/MS analysis
    Inhibition of HDAC1 in human SHSY5Y cells using MOCPAC as substrate after 8 hrs by UHPLC-ESI-MS/MS analysis
    		[PMID: 27650925]
    MCF7 IC50
    1.7 3
    Compound: TSA
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 22465091]
    MDA-MB-435 GI50
    1.78 3
    Compound: TRICHOSTATIN A
    Antiproliferative activity against human MDA-MB-435 cells after 24 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-435 cells after 24 hrs by MTT assay
    		[PMID: 29454918]
    SH-SY5Y IC50
    7.8 1
    Compound: Trichostatin A
    Inhibition of HDAC6 in human SHSY5Y cells using BATCP as substrate after 8 hrs by UHPLC-ESI-MS/MS analysis
    Inhibition of HDAC6 in human SHSY5Y cells using BATCP as substrate after 8 hrs by UHPLC-ESI-MS/MS analysis
    		[PMID: 27650925]
    MCF7 IC50
    10 3
    Compound: TSA
    Inhibitory concentration against breast MCF-7 cell line
    Inhibitory concentration against breast MCF-7 cell line
    		[PMID: 12593661]
    HEK293 IC50
    81 1
    Compound: 1
    Inhibition of mouse recombinant HDAC6 expressed in 293 cells
    Inhibition of mouse recombinant HDAC6 expressed in 293 cells
    		[PMID: 17929798]
    SH-SY5Y IC50
    9.1 1
    Compound: Trichostatin A
    Inhibition of HDAC in human SHSY5Y cells using MAL as substrate after 8 hrs by UHPLC-ESI-MS/MS analysis
    Inhibition of HDAC in human SHSY5Y cells using MAL as substrate after 8 hrs by UHPLC-ESI-MS/MS analysis
    		[PMID: 27650925]
    MCF7 IC50
    141 1
    Compound: TSA
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 30245394]
    K-562R GI50
    88 1
    Compound: TSA
    Antiproliferative activity against human K562R cells after 72 hrs by MTS assay
    Antiproliferative activity against human K562R cells after 72 hrs by MTS assay
    		[PMID: 30004697]
    SK-BR-3 IC50
    0.05 3
    Compound: TSA
    Antiproliferative activity against human SK-BR-3 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human SK-BR-3 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    MCF7 IC50
    20 1
    Compound: TSA
    Antiproliferative activity against human MCF7 cells
    Antiproliferative activity against human MCF7 cells
    		[PMID: 30245394]
    K562 IC50
    90 1
    Compound: TSA
    Antiproliferative activity against imatinib-resistant human K562 cells over expressing MDR1 after 72 hrs by CellTiter Glo assay
    Antiproliferative activity against imatinib-resistant human K562 cells over expressing MDR1 after 72 hrs by CellTiter Glo assay
    		[PMID: 35797900]
    SK-OV-3 IC50
    100 1
    Compound: TSA
    Antiproliferative activity against human SK-OV-3 cells after 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human SK-OV-3 cells after 72 hrs by CellTiter Glo assay
    		[PMID: 35797900]
    MCF7 IC50
    27.7 1
    Compound: 8; TSA
    Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition by SRB assay
    Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition by SRB assay
    		[PMID: 34826681]
    MDCK IC50
    0.008 3
    Compound: Trichostatin A
    Antiviral activity against Influenza A virus A/Hong Kong/8/68 H3N2 infected in MDCK cells assessed as reduction in virus-induced cytopathic effect after 3 days by CCK8 assay
    Antiviral activity against Influenza A virus A/Hong Kong/8/68 H3N2 infected in MDCK cells assessed as reduction in virus-induced cytopathic effect after 3 days by CCK8 assay
    		10.1039/C3MD00371J
    MDA-MB-231 IC50
    91 1
    Compound: TSA
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by CellTiter Glo assay
    		[PMID: 35797900]
    MCF7 IC50
    54 1
    Compound: TSA
    Antiproliferative activity against human MCF7 cells after 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by CellTiter Glo assay
    		[PMID: 35797900]
    SW48 IC50
    0.1 3
    Compound: TSA
    Inhibitory concentration required to reduce SW48 tumor cell growth by 50% in MTT assay
    Inhibitory concentration required to reduce SW48 tumor cell growth by 50% in MTT assay
    		[PMID: 12061890]
    MDA-MB-231 IC50
    0.09 3
    Compound: TSA
    Inhibitory concentration required to reduce MDAmb 231 tumor cell growth by 50% in MTT assay
    Inhibitory concentration required to reduce MDAmb 231 tumor cell growth by 50% in MTT assay
    		[PMID: 12061890]
    BXPC-3 GI50
    100 1
    Compound: TSA
    Antiproliferative activity against human BxPC3 cells after 72 hrs by MTS assay
    Antiproliferative activity against human BxPC3 cells after 72 hrs by MTS assay
    		[PMID: 30004697]
    T-24 IC50
    0.15 3
    Compound: TSA
    Inhibitory concentration required to reduce T24 tumor cell growth by 50% in MTT assay
    Inhibitory concentration required to reduce T24 tumor cell growth by 50% in MTT assay
    		[PMID: 12061890]
    T47D IC50
    26.4 1
    Compound: 8; TSA
    Antiproliferative activity against human T47D cells assessed as cell growth inhibition by burton method
    Antiproliferative activity against human T47D cells assessed as cell growth inhibition by burton method
    		[PMID: 34826681]
    MIA PaCa-2 IC50
    0.9 3
    Compound: 4; TSA
    Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability
    Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability
    		[PMID: 32005414]
    MDA-MB-231 IC50
    3.5 3
    Compound: TSA
    Inhibitory concentration against breast MDA-MB-231 cell line
    Inhibitory concentration against breast MDA-MB-231 cell line
    		[PMID: 12593661]
    MDA-MB-231 IC50
    91 1
    Compound: TSA
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by CellTiter Glo assay
    		[PMID: 35797900]
    U-251 IC50
    611.2 1
    Compound: 2
    Inhibition of SAP130 in VEGF-stimulated human U251 cells by PLAP reporter gene assay
    Inhibition of SAP130 in VEGF-stimulated human U251 cells by PLAP reporter gene assay
    		[PMID: 17643112]
    NCI-H1299 IC50
    100 1
    Compound: Trichostatin A
    Inhibitory activity against H1299 human lung carcinoma cell growth
    Inhibitory activity against H1299 human lung carcinoma cell growth
    		[PMID: 14521422]
    U2OS IC50
    14.93 3
    Compound: 5
    Cytotoxicity against human U2OS cells after 96 hrs by MTT assay
    Cytotoxicity against human U2OS cells after 96 hrs by MTT assay
    		[PMID: 25556102]
    MDA-MB-435 GI50
    1.78 3
    Compound: TRICHOSTATIN A
    Antiproliferative activity against human MDA-MB-435 cells after 24 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-435 cells after 24 hrs by MTT assay
    		[PMID: 29454918]
    MKN-45 IC50
    0.1 3
    Compound: TSA
    Antiproliferative activity against human MKN45 cells
    Antiproliferative activity against human MKN45 cells
    		[PMID: 18247554]
    U-87MG ATCC GI50
    1038 1
    Compound: TSA
    Antiproliferative activity against human U87 cells after 72 hrs by MTS assay
    Antiproliferative activity against human U87 cells after 72 hrs by MTS assay
    		[PMID: 30004697]
    MDCK IC50
    0.008 3
    Compound: Trichostatin A
    Antiviral activity against Influenza A virus A/Hong Kong/8/68 H3N2 infected in MDCK cells assessed as reduction in virus-induced cytopathic effect after 3 days by CCK8 assay
    Antiviral activity against Influenza A virus A/Hong Kong/8/68 H3N2 infected in MDCK cells assessed as reduction in virus-induced cytopathic effect after 3 days by CCK8 assay
    		10.1039/C3MD00371J
    SK-OV-3 IC50
    100 1
    Compound: TSA
    Antiproliferative activity against human SK-OV-3 cells after 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human SK-OV-3 cells after 72 hrs by CellTiter Glo assay
    		[PMID: 35797900]
    MIA PaCa-2 GI50
    200 1
    Compound: TSA
    Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by MTS assay
    Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by MTS assay
    		[PMID: 30004697]
    U-937 IC50
    0.04 3
    Compound: TSA
    Antiproliferative activity against human U937 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human U937 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    MKN-45 IC50
    0.1 3
    Compound: TSA (1)
    Compound was tested for antiproliferative activity against human MKN45 cancer cell lines
    Compound was tested for antiproliferative activity against human MKN45 cancer cell lines
    		[PMID: 14667227]
    U-937 IC50
    0.05 3
    Compound: Trichostatin A
    Cytotoxicity against human U937 cells assessed as cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human U937 cells assessed as cell viability after 72 hrs by CCK8 assay
    		10.1039/C3MD00371J
    MIA PaCa-2 IC50
    0.9 3
    Compound: 4; TSA
    Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability
    Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability
    		[PMID: 32005414]
    MM96L IC50
    0.03 3
    Compound: 1a
    Cytotoxicity against human melanoma MM96L cell line
    Cytotoxicity against human melanoma MM96L cell line
    		[PMID: 15163181]
    U-937 IC50
    0.1 3
    Compound: TSA
    Cytotoxicity against human U937 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human U937 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    		[PMID: 24960627]
    MM96L IC50
    0.03 3
    Compound: TSA
    Inhibition of human MM96L cells
    Inhibition of human MM96L cells
    		[PMID: 18247554]
    MIA PaCa-2 IC50
    200 1
    Compound: TSA
    Antiproliferative activity against human MIA PaCa-2 cells after 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human MIA PaCa-2 cells after 72 hrs by CellTiter Glo assay
    		[PMID: 35797900]
    Vero IC50
    0.6 3
    Compound: Trichostatin A
    Antiviral activity against EV71 infected in african green monkey Vero cells assessed as reduction in virus-induced cytopathic effect after 72 to 96 hrs by CCK8 assay
    Antiviral activity against EV71 infected in african green monkey Vero cells assessed as reduction in virus-induced cytopathic effect after 72 to 96 hrs by CCK8 assay
    		10.1039/C3MD00371J
    MKN-45 IC50
    0.1 3
    Compound: TSA
    Antiproliferative activity against human MKN45 cells
    Antiproliferative activity against human MKN45 cells
    		[PMID: 18247554]
    MOLT-4 IC50
    0.02 3
    Compound: TSA
    Antiproliferative activity against human MOLT4 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human MOLT4 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    Vero IC50
    41.2 14
    Compound: TSA
    Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs by Malstat reagent method
    Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs by Malstat reagent method
    		[PMID: 19914074]
    MKN-45 IC50
    0.1 3
    Compound: TSA (1)
    Compound was tested for antiproliferative activity against human MKN45 cancer cell lines
    Compound was tested for antiproliferative activity against human MKN45 cancer cell lines
    		[PMID: 14667227]
    MOLT-4 IC50
    0.03 3
    Compound: Trichostatin A
    Cytotoxicity against human MOLT4 cells assessed as cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human MOLT4 cells assessed as cell viability after 72 hrs by CCK8 assay
    		10.1039/C3MD00371J
    Vero IC50
    49.5 14
    Compound: TSA
    Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs by Malstat reagent method
    Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs by Malstat reagent method
    		[PMID: 19914074]
    MKN-45 IC50
    20 1
    Compound: TSA
    Antiproliferative activity against human MKN45 cells
    Antiproliferative activity against human MKN45 cells
    		[PMID: 30245394]
    MOLT-4 IC50
    0.03 3
    Compound: TSA
    Cytotoxicity against human MOLT4 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human MOLT4 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    		[PMID: 24960627]
    Vero IC50
    95 14
    Compound: TSA
    Cytotoxicity against african green monkey Vero cells after 1 to 2 days by neutral red assay
    Cytotoxicity against african green monkey Vero cells after 1 to 2 days by neutral red assay
    		[PMID: 19914074]
    MM96L IC50
    0.03 3
    Compound: 1a
    Cytotoxicity against human melanoma MM96L cell line
    Cytotoxicity against human melanoma MM96L cell line
    		[PMID: 15163181]
    Sf9 IC50
    129 1
    Compound: TSA
    Inhibition of human recombinant HDAC8 expressed in baculovirus/sf9 cells using RHKAcKAc as substrate
    Inhibition of human recombinant HDAC8 expressed in baculovirus/sf9 cells using RHKAcKAc as substrate
    		[PMID: 23905680]
    MM96L IC50
    0.03 3
    Compound: 1a
    Cytotoxicity against human melanoma MM96L cell line
    Cytotoxicity against human melanoma MM96L cell line
    		[PMID: 15163181]
    MCF7 IC50
    141 1
    Compound: TSA
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
    		[PMID: 30245394]
    MM96L IC50
    0.03 3
    Compound: TSA
    Inhibition of human MM96L cells
    Inhibition of human MM96L cells
    		[PMID: 18247554]
    MIA PaCa-2 GI50
    200 1
    Compound: TSA
    Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by MTS assay
    Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by MTS assay
    		[PMID: 30004697]
    MOLT-4 IC50
    0.02 3
    Compound: TSA
    Antiproliferative activity against human MOLT4 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human MOLT4 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    MIA PaCa-2 IC50
    200 1
    Compound: TSA
    Antiproliferative activity against human MIA PaCa-2 cells after 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human MIA PaCa-2 cells after 72 hrs by CellTiter Glo assay
    		[PMID: 35797900]
    MOLT-4 IC50
    0.03 3
    Compound: TSA
    Cytotoxicity against human MOLT4 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human MOLT4 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    		[PMID: 24960627]
    NFF IC50
    200 1
    Compound: TSA
    Cytotoxicity against human NFF cells
    Cytotoxicity against human NFF cells
    		[PMID: 30245402]
    MOLT-4 IC50
    0.03 3
    Compound: Trichostatin A
    Cytotoxicity against human MOLT4 cells assessed as cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human MOLT4 cells assessed as cell viability after 72 hrs by CCK8 assay
    		10.1039/C3MD00371J
    NCI-H1299 IC50
    0.1 3
    Compound: 1
    Antiproliferative activity against H1299 cells
    Antiproliferative activity against H1299 cells
    		[PMID: 16904890]
    MV4-11 EC50
    15.3 3
    Compound: Trichostatin A
    Antiproliferative activity against human MV4-11 cells assessed as cell viability by measuring amount of ATP after 72 hrs incubation by CellTiteer-Glo Cell viability assay
    Antiproliferative activity against human MV4-11 cells assessed as cell viability by measuring amount of ATP after 72 hrs incubation by CellTiteer-Glo Cell viability assay
    		[PMID: 39067437]
    NCI-H1975 IC50
    0.09 3
    Compound: Trichostatin A
    Cytotoxicity against human NCI-H1975 cells assessed as cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human NCI-H1975 cells assessed as cell viability after 72 hrs by CCK8 assay
    		10.1039/C3MD00371J
    NCI-H1299 IC50
    0.1 3
    Compound: 1
    Antiproliferative activity against H1299 cells
    Antiproliferative activity against H1299 cells
    		[PMID: 16904890]
    NCI-H1975 IC50
    0.21 3
    Compound: TSA
    Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    		[PMID: 24960627]
    NCI-H1299 IC50
    100 1
    Compound: Trichostatin A
    Inhibitory activity against H1299 human lung carcinoma cell growth
    Inhibitory activity against H1299 human lung carcinoma cell growth
    		[PMID: 14521422]
    NCI-H446 IC50
    1.5 3
    Compound: TSA
    Inhibitory concentration against lung H446 cell line
    Inhibitory concentration against lung H446 cell line
    		[PMID: 12593661]
    NCI-H446 IC50
    0.08 3
    Compound: TSA
    Inhibitory concentration required to reduce H446 tumor cell growth by 50% in MTT assay
    Inhibitory concentration required to reduce H446 tumor cell growth by 50% in MTT assay
    		[PMID: 12061890]
    NCI-H1975 IC50
    0.09 3
    Compound: Trichostatin A
    Cytotoxicity against human NCI-H1975 cells assessed as cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human NCI-H1975 cells assessed as cell viability after 72 hrs by CCK8 assay
    		10.1039/C3MD00371J
    K562 IC50
    260 1
    Compound: TSA
    Antiproliferative activity against human K562 cells after 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human K562 cells after 72 hrs by CellTiter Glo assay
    		[PMID: 35797900]
    NCI-H1975 IC50
    0.21 3
    Compound: TSA
    Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    		[PMID: 24960627]
    K562 GI50
    262 1
    Compound: TSA
    Antiproliferative activity against human K562 cells after 72 hrs by MTS assay
    Antiproliferative activity against human K562 cells after 72 hrs by MTS assay
    		[PMID: 30004697]
    NCI-H446 IC50
    0.08 3
    Compound: TSA
    Inhibitory concentration required to reduce H446 tumor cell growth by 50% in MTT assay
    Inhibitory concentration required to reduce H446 tumor cell growth by 50% in MTT assay
    		[PMID: 12061890]
    NCI-H460 IC50
    0.1 3
    Compound: 1, TSA
    Growth inhibition of human H460 cells after 48 hrs by SRB assay
    Growth inhibition of human H460 cells after 48 hrs by SRB assay
    		[PMID: 21073160]
    NCI-H446 IC50
    1.5 3
    Compound: TSA
    Inhibitory concentration against lung H446 cell line
    Inhibitory concentration against lung H446 cell line
    		[PMID: 12593661]
    NCI-H661 IC50
    <0.3 3
    Compound: 1
    Antiproliferative activity against H661 cells
    Antiproliferative activity against H661 cells
    		[PMID: 16904890]
    NCI-H460 IC50
    0.1 3
    Compound: 1, TSA
    Growth inhibition of human H460 cells after 48 hrs by SRB assay
    Growth inhibition of human H460 cells after 48 hrs by SRB assay
    		[PMID: 21073160]
    NCI-H661 IC50
    0.085 3
    Compound: 1 (TSA)
    Antiproliferative activity against H661 cells after 48 hrs
    Antiproliferative activity against H661 cells after 48 hrs
    		[PMID: 17897824]
    NCI-H661 IC50
    0.085 3
    Compound: 1 (TSA)
    Antiproliferative activity against H661 cells after 48 hrs
    Antiproliferative activity against H661 cells after 48 hrs
    		[PMID: 17897824]
    NCI-H661 IC50
    0.085 3
    Compound: 7, TSA
    Antiproliferative activity against H661 cells after 48 hrs by XTT assay
    Antiproliferative activity against H661 cells after 48 hrs by XTT assay
    		[PMID: 17624773]
    NCI-H661 IC50
    0.085 3
    Compound: 7, TSA
    Antiproliferative activity against H661 cells after 48 hrs by XTT assay
    Antiproliferative activity against H661 cells after 48 hrs by XTT assay
    		[PMID: 17624773]
    NCI-H661 IC50
    0.1 3
    Compound: 1, TSA
    Antiproliferative activity against human NCI-H661 cells after 48 hrs by XTT assay
    Antiproliferative activity against human NCI-H661 cells after 48 hrs by XTT assay
    		[PMID: 19385600]
    NCI-H661 IC50
    0.1 3
    Compound: 1, TSA
    Antiproliferative activity against human NCI-H661 cells after 48 hrs by XTT assay
    Antiproliferative activity against human NCI-H661 cells after 48 hrs by XTT assay
    		[PMID: 19385600]
    NCI-H661 IC50
    < 0.3 3
    Compound: 1
    Antiproliferative activity against H661 cells
    Antiproliferative activity against H661 cells
    		[PMID: 16904890]
    NCI-N87 IC50
    0.06 3
    Compound: TSA
    Antiproliferative activity against human NCI-N87 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human NCI-N87 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    NFF IC50
    0.2 3
    Compound: 1a
    Cytotoxicity of compound against human normal neonatal foreskin fibroblasts (NFF) cell line
    Cytotoxicity of compound against human normal neonatal foreskin fibroblasts (NFF) cell line
    		[PMID: 15163181]
    NCI-N87 IC50
    0.06 3
    Compound: TSA
    Antiproliferative activity against human NCI-N87 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human NCI-N87 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    NCI-N87 IC50
    58 1
    Compound: TSA
    Antiproliferative activity against human NCI-N87 cells after 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human NCI-N87 cells after 72 hrs by CellTiter Glo assay
    		[PMID: 35797900]
    NFF IC50
    6.7 3
    Compound: TSA
    Selectivity index, ratio of IC50 for human MM96L cells to IC50 for human NFF cells
    Selectivity index, ratio of IC50 for human MM96L cells to IC50 for human NFF cells
    		[PMID: 18247554]
    NFF IC50
    0.2 3
    Compound: 1a
    Cytotoxicity of compound against human normal neonatal foreskin fibroblasts (NFF) cell line
    Cytotoxicity of compound against human normal neonatal foreskin fibroblasts (NFF) cell line
    		[PMID: 15163181]
    NIH3T3 IC50
    0.006 3
    Compound: Trichostatin A
    Inhibition of HDAC1 in human NIH3T3 cells by radiometric histone deacetylation assay
    Inhibition of HDAC1 in human NIH3T3 cells by radiometric histone deacetylation assay
    		[PMID: 19457659]
    NFF IC50
    0.2 3
    Compound: 1a
    Cytotoxicity of compound against normal human normal neonatal foreskin fibroblasts (NFF)
    Cytotoxicity of compound against normal human normal neonatal foreskin fibroblasts (NFF)
    		[PMID: 15163181]
    PC-3 GI50
    387 1
    Compound: TSA
    Antiproliferative activity against human PC3 cells after 72 hrs by MTS assay
    Antiproliferative activity against human PC3 cells after 72 hrs by MTS assay
    		[PMID: 30004697]
    NFF IC50
    200 1
    Compound: TSA
    Cytotoxicity against human NFF cells
    Cytotoxicity against human NFF cells
    		[PMID: 30245402]
    PANC-1 IC50
    0.1 3
    Compound: TSA
    Antiproliferative activity against human PANC1 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human PANC1 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    K562 IC50
    560 1
    Compound: TSA
    Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
    Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
    		[PMID: 30245394]
    NFF IC50
    6.7 3
    Compound: TSA
    Selectivity index, ratio of IC50 for human MM96L cells to IC50 for human NFF cells
    Selectivity index, ratio of IC50 for human MM96L cells to IC50 for human NFF cells
    		[PMID: 18247554]
    WiDr IC50
    577.6 1
    Compound: 2
    Inhibition of SAP130 mediated cell growth in human WiDr cells
    Inhibition of SAP130 mediated cell growth in human WiDr cells
    		[PMID: 17643112]
    NIH3T3 IC50
    0.006 3
    Compound: Trichostatin A
    Inhibition of HDAC1 in human NIH3T3 cells by radiometric histone deacetylation assay
    Inhibition of HDAC1 in human NIH3T3 cells by radiometric histone deacetylation assay
    		[PMID: 19457659]
    U-251 IC50
    611.2 1
    Compound: 2
    Inhibition of SAP130 in VEGF-stimulated human U251 cells by PLAP reporter gene assay
    Inhibition of SAP130 in VEGF-stimulated human U251 cells by PLAP reporter gene assay
    		[PMID: 17643112]
    NIH3T3 IC50
    21 1
    Compound: 1
    Inhibition of human recombinant HDAC1 expressed in NIH3T3 cells
    Inhibition of human recombinant HDAC1 expressed in NIH3T3 cells
    		[PMID: 17929798]
    PANC-1 IC50
    0.1 3
    Compound: TSA
    Antiproliferative activity against human PANC1 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human PANC1 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    Sf21 IC50
    6.574 × 10-9 41
    Compound: TSA
    Inhibition of full length human recombinant C-terminal FLAG-His-tagged HDAC1 (1 to 482 residues) expressed in Sf21 cells using RHK-K(Ac)-AMC as substrate incubated for 60 mins by fluorescence assay
    Inhibition of full length human recombinant C-terminal FLAG-His-tagged HDAC1 (1 to 482 residues) expressed in Sf21 cells using RHK-K(Ac)-AMC as substrate incubated for 60 mins by fluorescence assay
    		[PMID: 27060764]
    Sf21 IC50
    0.032 3
    Compound: TSA
    Inhibition of recombinant full length C-terminal FLAG/His-tagged human HDAC1 (1 to 482 residues) expressed in sf21 cells using RHK-K(Ac)-AMC as substrate by fluorimetric assay
    Inhibition of recombinant full length C-terminal FLAG/His-tagged human HDAC1 (1 to 482 residues) expressed in sf21 cells using RHK-K(Ac)-AMC as substrate by fluorimetric assay
    		[PMID: 30448419]
    PC-3 GI50
    387 1
    Compound: TSA
    Antiproliferative activity against human PC3 cells after 72 hrs by MTS assay
    Antiproliferative activity against human PC3 cells after 72 hrs by MTS assay
    		[PMID: 30004697]
    Sf21 IC50
    1.58 × 10-8 41
    Compound: Trichostatin A
    Inhibition of recombinant full length human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in baculovirus infected Sf21 cells using RHK-K(Ac)-AMC as substrate measured after 60 mins by fluorimetric assay
    Inhibition of recombinant full length human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in baculovirus infected Sf21 cells using RHK-K(Ac)-AMC as substrate measured after 60 mins by fluorimetric assay
    		[PMID: 31838329]
    S2 IC50
    0.6 1
    Compound: 3, TSA
    Inhibition of Plasmodium falciparum HDAC1 expressed in Drosophila melanogaster S2 cells
    Inhibition of Plasmodium falciparum HDAC1 expressed in Drosophila melanogaster S2 cells
    		[PMID: 19317450]
    SGC-7901 IC50
    0.03 3
    Compound: TSA
    Antiproliferative activity against human SGC7901 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human SGC7901 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    Sf21 IC50
    3.95 × 10-8 41
    Compound: Trichostatin A
    Inhibition of recombinant human C-terminal GST-tagged HDAC2 (1 to 488 residues) expressed in baculovirus infected sf21 cells using RHK-K(Ac)-AMC as substrate after 60 mins by fluorimetry assay
    Inhibition of recombinant human C-terminal GST-tagged HDAC2 (1 to 488 residues) expressed in baculovirus infected sf21 cells using RHK-K(Ac)-AMC as substrate after 60 mins by fluorimetry assay
    		[PMID: 31838329]
    SH-SY5Y IC50
    18.8 1
    Compound: Trichostatin A
    Inhibition of HDAC1 in human SHSY5Y cells using MOCPAC as substrate after 8 hrs by UHPLC-ESI-MS/MS analysis
    Inhibition of HDAC1 in human SHSY5Y cells using MOCPAC as substrate after 8 hrs by UHPLC-ESI-MS/MS analysis
    		[PMID: 27650925]
    Sf9 IC50
    960 1
    Compound: 1, TSA
    Inhibition of N terminal hexahistidine-tagged human HDAC8 expressed in Sf9 cells after 1 hr by fluorescence assay
    Inhibition of N terminal hexahistidine-tagged human HDAC8 expressed in Sf9 cells after 1 hr by fluorescence assay
    		[PMID: 21723733]
    U-87MG ATCC GI50
    1038 1
    Compound: TSA
    Antiproliferative activity against human U87 cells after 72 hrs by MTS assay
    Antiproliferative activity against human U87 cells after 72 hrs by MTS assay
    		[PMID: 30004697]
    SH-SY5Y IC50
    7.8 1
    Compound: Trichostatin A
    Inhibition of HDAC6 in human SHSY5Y cells using BATCP as substrate after 8 hrs by UHPLC-ESI-MS/MS analysis
    Inhibition of HDAC6 in human SHSY5Y cells using BATCP as substrate after 8 hrs by UHPLC-ESI-MS/MS analysis
    		[PMID: 27650925]
    SH-SY5Y IC50
    9.1 1
    Compound: Trichostatin A
    Inhibition of HDAC in human SHSY5Y cells using MAL as substrate after 8 hrs by UHPLC-ESI-MS/MS analysis
    Inhibition of HDAC in human SHSY5Y cells using MAL as substrate after 8 hrs by UHPLC-ESI-MS/MS analysis
    		[PMID: 27650925]
    Sf9 IC50
    1.716 × 10-9 41
    Compound: TSA
    Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells using RHK-K(Ac)-AMC as substrate incubated for 90 mins by fluorescence assay
    Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells using RHK-K(Ac)-AMC as substrate incubated for 90 mins by fluorescence assay
    		[PMID: 27060764]
    SK-BR-3 IC50
    0.02 3
    Compound: TSA
    Antiproliferative activity against human SKBR3 cells
    Antiproliferative activity against human SKBR3 cells
    		[PMID: 18247554]
    Sf9 IC50
    0.009 3
    Compound: TSA
    Inhibition of recombinant full length C-terminal His/FLAG tagged human HDAC1 (1 to 482 residues) expressed in baculovirus infected sf9 insect cells using p53 (379 to 382 residues) derived fluorogenic peptide RHKKAc as substrate preincubated for 5 to 10 mi
    Inhibition of recombinant full length C-terminal His/FLAG tagged human HDAC1 (1 to 482 residues) expressed in baculovirus infected sf9 insect cells using p53 (379 to 382 residues) derived fluorogenic peptide RHKKAc as substrate preincubated for 5 to 10 mi
    		[PMID: 31414801]
    Sf9 IC50
    0.00161 3
    Compound: TSA
    Inhibition of recombinant full length human HDAC10 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by electrophoretic mobility shift assay
    Inhibition of recombinant full length human HDAC10 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by electrophoretic mobility shift assay
    		[PMID: 31938464]
    SK-BR-3 IC50
    0.02 3
    Compound: TSA (1)
    Compound was tested for antiproliferative activity against human SK-BR-3 cancer cell lines
    Compound was tested for antiproliferative activity against human SK-BR-3 cancer cell lines
    		[PMID: 14667227]
    SK-BR-3 IC50
    0.05 3
    Compound: TSA
    Antiproliferative activity against human SK-BR-3 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human SK-BR-3 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    Sf9 IC50
    0.00274 3
    Compound: TSA
    Inhibition of recombinant full length human HDAC2 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by electrophoretic mobility shift assay
    Inhibition of recombinant full length human HDAC2 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by electrophoretic mobility shift assay
    		[PMID: 31938464]
    SK-BR-3 IC50
    20 1
    Compound: TSA
    Antiproliferative activity against human SKBR3 cells
    Antiproliferative activity against human SKBR3 cells
    		[PMID: 30245394]
    Sf9 IC50
    >1 3
    Compound: TSA
    Inhibition of recombinant full length human HDAC4 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 1.5 hrs by electrophoretic mobility shift assay
    Inhibition of recombinant full length human HDAC4 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 1.5 hrs by electrophoretic mobility shift assay
    		[PMID: 31938464]
    SK-MEL-28 IC50
    0.28 3
    Compound: 1a
    Cytotoxicity of compound against normal human melanoma SK-MEL-28 cell line
    Cytotoxicity of compound against normal human melanoma SK-MEL-28 cell line
    		[PMID: 15163181]
    Sf9 IC50
    0.776 3
    Compound: TSA
    Inhibition of recombinant full length human HDAC5 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 3 hrs by electrophoretic mobility shift assay
    Inhibition of recombinant full length human HDAC5 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 3 hrs by electrophoretic mobility shift assay
    		[PMID: 31938464]
    SK-OV-3 IC50
    100 1
    Compound: TSA
    Antiproliferative activity against human SK-OV-3 cells after 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human SK-OV-3 cells after 72 hrs by CellTiter Glo assay
    		[PMID: 35797900]
    Sf9 IC50
    0.482 3
    Compound: TSA
    Inhibition of recombinant full length human HDAC7 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 3 hrs by electrophoretic mobility shift assay
    Inhibition of recombinant full length human HDAC7 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 3 hrs by electrophoretic mobility shift assay
    		[PMID: 31938464]
    SNU-16 IC50
    53 1
    Compound: TSA
    Inhibition of HDAC from human SNU16 cells
    Inhibition of HDAC from human SNU16 cells
    		[PMID: 18247554]
    Sf9 IC50
    0.002 3
    Compound: TSA
    Inhibition of recombinant N-terminal GST-tagged human HDAC6 (1 to 1215 residues) expressed in baculovirus infected sf9 insect cells using p53 (379 to 382 residues) derived fluorogenic peptide RHKKAc as substrate preincubated for 5 to 10 mins followed by s
    Inhibition of recombinant N-terminal GST-tagged human HDAC6 (1 to 1215 residues) expressed in baculovirus infected sf9 insect cells using p53 (379 to 382 residues) derived fluorogenic peptide RHKKAc as substrate preincubated for 5 to 10 mins followed by s
    		[PMID: 31414801]
    SNU-16 IC50
    53.29 1
    Compound: TSA (1)
    Inhibitory activity against Histone deacetylase (HDAC) from SNU-16 (human gastric adenocarcinoma) cells
    Inhibitory activity against Histone deacetylase (HDAC) from SNU-16 (human gastric adenocarcinoma) cells
    		[PMID: 14667227]
    SGC-7901 IC50
    0.03 3
    Compound: TSA
    Antiproliferative activity against human SGC7901 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human SGC7901 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    SK-BR-3 IC50
    0.02 3
    Compound: TSA
    Antiproliferative activity against human SKBR3 cells
    Antiproliferative activity against human SKBR3 cells
    		[PMID: 18247554]
    SQ20B IC50
    0.2 3
    Compound: TSA
    Inhibition of human SQ20B cells
    Inhibition of human SQ20B cells
    		[PMID: 18247554]
    SK-BR-3 IC50
    0.05 3
    Compound: TSA
    Antiproliferative activity against human SK-BR-3 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human SK-BR-3 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    SW-620 IC50
    2.454 3
    Compound: 11; TSA
    Antiproliferative activity against human SW620 cells
    Antiproliferative activity against human SW620 cells
    		[PMID: 38142509]
    SW48 IC50
    0.1 3
    Compound: TSA
    Inhibitory concentration required to reduce SW48 tumor cell growth by 50% in MTT assay
    Inhibitory concentration required to reduce SW48 tumor cell growth by 50% in MTT assay
    		[PMID: 12061890]
    SK-BR-3 IC50
    0.02 3
    Compound: TSA (1)
    Compound was tested for antiproliferative activity against human SK-BR-3 cancer cell lines
    Compound was tested for antiproliferative activity against human SK-BR-3 cancer cell lines
    		[PMID: 14667227]
    SK-MEL-28 IC50
    0.28 3
    Compound: 1a
    Cytotoxicity of compound against normal human melanoma SK-MEL-28 cell line
    Cytotoxicity of compound against normal human melanoma SK-MEL-28 cell line
    		[PMID: 15163181]
    SW48 IC50
    5 3
    Compound: TSA
    Inhibitory concentration against colon SW48 cell line
    Inhibitory concentration against colon SW48 cell line
    		[PMID: 12593661]
    SQ20B IC50
    0.2 3
    Compound: TSA
    Inhibition of human SQ20B cells
    Inhibition of human SQ20B cells
    		[PMID: 18247554]
    Sf21 IC50
    0.032 3
    Compound: TSA
    Inhibition of recombinant full length C-terminal FLAG/His-tagged human HDAC1 (1 to 482 residues) expressed in sf21 cells using RHK-K(Ac)-AMC as substrate by fluorimetric assay
    Inhibition of recombinant full length C-terminal FLAG/His-tagged human HDAC1 (1 to 482 residues) expressed in sf21 cells using RHK-K(Ac)-AMC as substrate by fluorimetric assay
    		[PMID: 30448419]
    Sf21 IC50
    1.58 x 10-8 41
    Compound: Trichostatin A
    Inhibition of recombinant full length human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in baculovirus infected Sf21 cells using RHK-K(Ac)-AMC as substrate measured after 60 mins by fluorimetric assay
    Inhibition of recombinant full length human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in baculovirus infected Sf21 cells using RHK-K(Ac)-AMC as substrate measured after 60 mins by fluorimetric assay
    		[PMID: 31838329]
    SW48 IC50
    5 3
    Compound: TSA
    Inhibitory concentration against colon SW48 cell line
    Inhibitory concentration against colon SW48 cell line
    		[PMID: 12593661]
    SW48 IC50
    0.1 3
    Compound: TSA
    Inhibitory concentration required to reduce SW48 tumor cell growth by 50% in MTT assay
    Inhibitory concentration required to reduce SW48 tumor cell growth by 50% in MTT assay
    		[PMID: 12061890]
    Sf21 IC50
    17.9 1
    Compound: Trichostatin A
    Inhibition of recombinant human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in Sf21 insect cells by using RHK-K(Ac)-AMC as substrate measured after 60 mins by fluorescence assay
    Inhibition of recombinant human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in Sf21 insect cells by using RHK-K(Ac)-AMC as substrate measured after 60 mins by fluorescence assay
    		[PMID: 31924504]
    Sf21 IC50
    25 1
    Compound: TSA
    Inhibition of recombinant human GST-tagged HDAC2 (1 to 488 residues) expressed in baculovirus infected sf21 cells using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate measured after 1 to 2 hrs by fluorescence assay
    Inhibition of recombinant human GST-tagged HDAC2 (1 to 488 residues) expressed in baculovirus infected sf21 cells using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate measured after 1 to 2 hrs by fluorescence assay
    		[PMID: 32212730]
    T-24 EC50
    0.01 3
    Compound: TSA
    Induction of alpha tubulin acetylation in human T24 cells
    Induction of alpha tubulin acetylation in human T24 cells
    		[PMID: 19111466]
    Sf21 IC50
    3.95 x 10-8 41
    Compound: Trichostatin A
    Inhibition of recombinant human C-terminal GST-tagged HDAC2 (1 to 488 residues) expressed in baculovirus infected sf21 cells using RHK-K(Ac)-AMC as substrate after 60 mins by fluorimetry assay
    Inhibition of recombinant human C-terminal GST-tagged HDAC2 (1 to 488 residues) expressed in baculovirus infected sf21 cells using RHK-K(Ac)-AMC as substrate after 60 mins by fluorimetry assay
    		[PMID: 31838329]
    T-24 EC50
    1 3
    Compound: 2 - TSA
    Inhibition of acetylation of histone-4 in human T-24 cancer cells
    Inhibition of acetylation of histone-4 in human T-24 cancer cells
    		[PMID: 14613312]
    T-24 EC50
    4 3
    Compound: 2 - TSA
    Inhibition of acetylation of histone-4 in human T-24 cancer cells
    Inhibition of acetylation of histone-4 in human T-24 cancer cells
    		[PMID: 14613312]
    Sf21 IC50
    6.574 x 10-9 41
    Compound: TSA
    Inhibition of full length human recombinant C-terminal FLAG-His-tagged HDAC1 (1 to 482 residues) expressed in Sf21 cells using RHK-K(Ac)-AMC as substrate incubated for 60 mins by fluorescence assay
    Inhibition of full length human recombinant C-terminal FLAG-His-tagged HDAC1 (1 to 482 residues) expressed in Sf21 cells using RHK-K(Ac)-AMC as substrate incubated for 60 mins by fluorescence assay
    		[PMID: 27060764]
    Sf21 IC50
    9 1
    Compound: TSA
    Inhibition of full length recombinant human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in baculovirus infected Sf21 insect cells using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate measured after 1 to 2 hrs by flu
    Inhibition of full length recombinant human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in baculovirus infected Sf21 insect cells using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as substrate measured after 1 to 2 hrs by flu
    		[PMID: 32212730]
    T-24 IC50
    4 3
    Compound: TSA
    Inhibitory concentration against bladder T24 cell line
    Inhibitory concentration against bladder T24 cell line
    		[PMID: 12593661]
    T-24 IC50
    0.15 3
    Compound: TSA
    Inhibitory concentration required to reduce T24 tumor cell growth by 50% in MTT assay
    Inhibitory concentration required to reduce T24 tumor cell growth by 50% in MTT assay
    		[PMID: 12061890]
    U2OS IC50
    14.93 3
    Compound: 5
    Cytotoxicity against human U2OS cells after 96 hrs by MTT assay
    Cytotoxicity against human U2OS cells after 96 hrs by MTT assay
    		[PMID: 25556102]
    U-937 IC50
    0.04 3
    Compound: TSA
    Antiproliferative activity against human U937 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human U937 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    Sf9 IC50
    0.00068 3
    Compound: TSA
    Inhibition of recombinant full length human HDAC1 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by electrophoretic mobility shift assay
    Inhibition of recombinant full length human HDAC1 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by electrophoretic mobility shift assay
    		[PMID: 31938464]
    U-937 IC50
    0.05 3
    Compound: Trichostatin A
    Cytotoxicity against human U937 cells assessed as cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human U937 cells assessed as cell viability after 72 hrs by CCK8 assay
    		10.1039/C3MD00371J
    Sf9 IC50
    0.00161 3
    Compound: TSA
    Inhibition of recombinant full length human HDAC10 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by electrophoretic mobility shift assay
    Inhibition of recombinant full length human HDAC10 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by electrophoretic mobility shift assay
    		[PMID: 31938464]
    U-937 IC50
    0.1 3
    Compound: TSA
    Cytotoxicity against human U937 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human U937 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    		[PMID: 24960627]
    Sf9 IC50
    0.002 3
    Compound: TSA
    Inhibition of recombinant N-terminal GST-tagged human HDAC6 (1 to 1215 residues) expressed in baculovirus infected sf9 insect cells using p53 (379 to 382 residues) derived fluorogenic peptide RHKKAc as substrate preincubated for 5 to 10 mins followed by s
    Inhibition of recombinant N-terminal GST-tagged human HDAC6 (1 to 1215 residues) expressed in baculovirus infected sf9 insect cells using p53 (379 to 382 residues) derived fluorogenic peptide RHKKAc as substrate preincubated for 5 to 10 mins followed by s
    		[PMID: 31414801]
    Sf9 IC50
    0.00274 3
    Compound: TSA
    Inhibition of recombinant full length human HDAC2 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by electrophoretic mobility shift assay
    Inhibition of recombinant full length human HDAC2 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by electrophoretic mobility shift assay
    		[PMID: 31938464]
    Vero IC50
    49.5 14
    Compound: TSA
    Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs by Malstat reagent method
    Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs by Malstat reagent method
    		[PMID: 19914074]
    Vero IC50
    41.2 14
    Compound: TSA
    Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs by Malstat reagent method
    Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs by Malstat reagent method
    		[PMID: 19914074]
    Sf9 IC50
    0.009 3
    Compound: TSA
    Inhibition of recombinant full length C-terminal His/FLAG tagged human HDAC1 (1 to 482 residues) expressed in baculovirus infected sf9 insect cells using p53 (379 to 382 residues) derived fluorogenic peptide RHKKAc as substrate preincubated for 5 to 10 mi
    Inhibition of recombinant full length C-terminal His/FLAG tagged human HDAC1 (1 to 482 residues) expressed in baculovirus infected sf9 insect cells using p53 (379 to 382 residues) derived fluorogenic peptide RHKKAc as substrate preincubated for 5 to 10 mi
    		[PMID: 31414801]
    Sf9 IC50
    0.482 3
    Compound: TSA
    Inhibition of recombinant full length human HDAC7 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 3 hrs by electrophoretic mobility shift assay
    Inhibition of recombinant full length human HDAC7 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 3 hrs by electrophoretic mobility shift assay
    		[PMID: 31938464]
    Vero IC50
    0.6 3
    Compound: Trichostatin A
    Antiviral activity against EV71 infected in african green monkey Vero cells assessed as reduction in virus-induced cytopathic effect after 72 to 96 hrs by CCK8 assay
    Antiviral activity against EV71 infected in african green monkey Vero cells assessed as reduction in virus-induced cytopathic effect after 72 to 96 hrs by CCK8 assay
    		10.1039/C3MD00371J
    Sf9 IC50
    0.776 3
    Compound: TSA
    Inhibition of recombinant full length human HDAC5 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 3 hrs by electrophoretic mobility shift assay
    Inhibition of recombinant full length human HDAC5 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 3 hrs by electrophoretic mobility shift assay
    		[PMID: 31938464]
    Vero IC50
    95 14
    Compound: TSA
    Cytotoxicity against african green monkey Vero cells after 1 to 2 days by neutral red assay
    Cytotoxicity against african green monkey Vero cells after 1 to 2 days by neutral red assay
    		[PMID: 19914074]
    Sf9 IC50
    0.9 1
    Compound: TSA
    Inhibition of human recombinant HDAC6 expressed in baculovirus/sf9 cells using RHKKAc as substrate
    Inhibition of human recombinant HDAC6 expressed in baculovirus/sf9 cells using RHKKAc as substrate
    		[PMID: 23905680]
    Sf9 IC50
    1.2 1
    Compound: TSA
    Inhibition of human recombinant HDAC6 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrate
    Inhibition of human recombinant HDAC6 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrate
    		[PMID: 23009203]
    Sf9 IC50
    1.716 x 10-9 41
    Compound: TSA
    Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells using RHK-K(Ac)-AMC as substrate incubated for 90 mins by fluorescence assay
    Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in sf9 cells using RHK-K(Ac)-AMC as substrate incubated for 90 mins by fluorescence assay
    		[PMID: 27060764]
    Sf9 IC50
    129 1
    Compound: TSA
    Inhibition of human recombinant HDAC8 expressed in baculovirus/sf9 cells using RHKAcKAc as substrate
    Inhibition of human recombinant HDAC8 expressed in baculovirus/sf9 cells using RHKAcKAc as substrate
    		[PMID: 23905680]
    Sf9 IC50
    15.7 1
    Compound: Trichostatin A
    Inhibition of human recombinant GST-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells using MOCPAC as substrate after 4 hrs by UHPLC-ESI-MS/MS analysis
    Inhibition of human recombinant GST-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells using MOCPAC as substrate after 4 hrs by UHPLC-ESI-MS/MS analysis
    		[PMID: 27650925]
    Sf9 IC50
    17.3 1
    Compound: TSA
    Inhibition of human recombinant HDAC11 expressed in baculovirus/sf9 cells using RHKKAc as substrate
    Inhibition of human recombinant HDAC11 expressed in baculovirus/sf9 cells using RHKKAc as substrate
    		[PMID: 23905680]
    Sf9 IC50
    5 1
    Compound: TSA
    Inhibition of human recombinant HDAC1 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrate
    Inhibition of human recombinant HDAC1 expressed in Sf9 cells incubated for 2 hrs using RHKK-Ac fluorogenic substrate
    		[PMID: 23009203]
    Sf9 IC50
    5 1
    Compound: TSA
    Inhibition of human recombinant HDAC1 expressed in baculovirus/sf9 cells using RHKKAc as substrate
    Inhibition of human recombinant HDAC1 expressed in baculovirus/sf9 cells using RHKKAc as substrate
    		[PMID: 23905680]
    Sf9 IC50
    5 1
    Compound: TSA
    Inhibition of human recombinant HDAC2 expressed in baculovirus/sf9 cells using RHKKAc as substrate
    Inhibition of human recombinant HDAC2 expressed in baculovirus/sf9 cells using RHKKAc as substrate
    		[PMID: 23905680]
    Sf9 IC50
    9 1
    Compound: TSA
    Inhibition of human recombinant HDAC10 expressed in baculovirus/sf9 cells using RHKKAc as substrate
    Inhibition of human recombinant HDAC10 expressed in baculovirus/sf9 cells using RHKKAc as substrate
    		[PMID: 23905680]
    Sf9 IC50
    960 1
    Compound: 1, TSA
    Inhibition of N terminal hexahistidine-tagged human HDAC8 expressed in Sf9 cells after 1 hr by fluorescence assay
    Inhibition of N terminal hexahistidine-tagged human HDAC8 expressed in Sf9 cells after 1 hr by fluorescence assay
    		[PMID: 21723733]
    Sf9 IC50
    > 1 3
    Compound: TSA
    Inhibition of recombinant full length human HDAC4 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 1.5 hrs by electrophoretic mobility shift assay
    Inhibition of recombinant full length human HDAC4 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 1.5 hrs by electrophoretic mobility shift assay
    		[PMID: 31938464]
    Sf9 IC50
    > 1 3
    Compound: TSA
    Inhibition of recombinant human HDAC9 (604-1066 residues) expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 3 hrs by electrophoretic mobility shift assay
    Inhibition of recombinant human HDAC9 (604-1066 residues) expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 3 hrs by electrophoretic mobility shift assay
    		[PMID: 31938464]
    T-24 EC50
    0.01 3
    Compound: TSA
    Induction of alpha tubulin acetylation in human T24 cells
    Induction of alpha tubulin acetylation in human T24 cells
    		[PMID: 19111466]
    T-24 EC50
    0.01 3
    Compound: TSA
    Induction of histone H3 acetylation in human T24 cells
    Induction of histone H3 acetylation in human T24 cells
    		[PMID: 19111466]
    T-24 EC50
    1 3
    Compound: 2 - TSA
    Inhibition of acetylation of histone-4 in human T-24 cancer cells
    Inhibition of acetylation of histone-4 in human T-24 cancer cells
    		[PMID: 14613312]
    T-24 EC50
    4 3
    Compound: 2 - TSA
    Inhibition of acetylation of histone-4 in human T-24 cancer cells
    Inhibition of acetylation of histone-4 in human T-24 cancer cells
    		[PMID: 14613312]
    T-24 IC50
    0.15 3
    Compound: TSA
    Inhibitory concentration required to reduce T24 tumor cell growth by 50% in MTT assay
    Inhibitory concentration required to reduce T24 tumor cell growth by 50% in MTT assay
    		[PMID: 12061890]
    T-24 IC50
    4 3
    Compound: TSA
    Inhibitory concentration against bladder T24 cell line
    Inhibitory concentration against bladder T24 cell line
    		[PMID: 12593661]
    T47D IC50
    26.4 1
    Compound: 8; TSA
    Antiproliferative activity against human T47D cells assessed as cell growth inhibition by burton method
    Antiproliferative activity against human T47D cells assessed as cell growth inhibition by burton method
    		[PMID: 34826681]
    U-251 IC50
    611.2 1
    Compound: 2
    Inhibition of SAP130 in VEGF-stimulated human U251 cells by PLAP reporter gene assay
    Inhibition of SAP130 in VEGF-stimulated human U251 cells by PLAP reporter gene assay
    		[PMID: 17643112]
    U-87MG ATCC GI50
    1038 1
    Compound: TSA
    Antiproliferative activity against human U87 cells after 72 hrs by MTS assay
    Antiproliferative activity against human U87 cells after 72 hrs by MTS assay
    		[PMID: 30004697]
    U-937 IC50
    0.04 3
    Compound: TSA
    Antiproliferative activity against human U937 cells after 72 hrs by CCK8 assay
    Antiproliferative activity against human U937 cells after 72 hrs by CCK8 assay
    		[PMID: 27427973]
    U-937 IC50
    0.05 3
    Compound: Trichostatin A
    Cytotoxicity against human U937 cells assessed as cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human U937 cells assessed as cell viability after 72 hrs by CCK8 assay
    		10.1039/C3MD00371J
    U-937 IC50
    0.1 3
    Compound: TSA
    Cytotoxicity against human U937 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    Cytotoxicity against human U937 cells assessed as reduction in cell viability after 72 hrs by CCK8 assay
    		[PMID: 24960627]
    U2OS IC50
    14.93 3
    Compound: 5
    Cytotoxicity against human U2OS cells after 96 hrs by MTT assay
    Cytotoxicity against human U2OS cells after 96 hrs by MTT assay
    		[PMID: 25556102]
    Vero IC50
    0.6 3
    Compound: Trichostatin A
    Antiviral activity against EV71 infected in african green monkey Vero cells assessed as reduction in virus-induced cytopathic effect after 72 to 96 hrs by CCK8 assay
    Antiviral activity against EV71 infected in african green monkey Vero cells assessed as reduction in virus-induced cytopathic effect after 72 to 96 hrs by CCK8 assay
    		10.1039/C3MD00371J
    Vero IC50
    41.2 14
    Compound: TSA
    Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs by Malstat reagent method
    Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs by Malstat reagent method
    		[PMID: 19914074]
    Vero IC50
    49.5 14
    Compound: TSA
    Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs by Malstat reagent method
    Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs by Malstat reagent method
    		[PMID: 19914074]
    Vero IC50
    95 14
    Compound: TSA
    Cytotoxicity against african green monkey Vero cells after 1 to 2 days by neutral red assay
    Cytotoxicity against african green monkey Vero cells after 1 to 2 days by neutral red assay
    		[PMID: 19914074]
    WiDr IC50
    577.6 1
    Compound: 2
    Inhibition of SAP130 mediated cell growth in human WiDr cells
    Inhibition of SAP130 mediated cell growth in human WiDr cells
    		[PMID: 17643112]
    In Vitro

    Trichostatin A is a potent and specific inhibitor of HDAC class I/II, with an IC50 value of 1.8 nM for HDAC. Trichostatin A (TSA) inhibits proliferation of eight breast carcinoma cell lines with mean±SD IC50 of 124.4±120.4 nM (range, 26.4-308.1 nM). HDAC inhibitory activity of Trichostatin A is similar in all cell lines with mean IC50 of 2.4±0.5 nM (range, 1.5-2.9 nM)[1]. Trichostatin A (330 nM) increases Gαs protein expression in human myometrial cells, but does not increase Gαs mRNA levels[2]. Trichostatin A (20-75 nM) induces minimal cytotoxicity to adipose-derived stem cells (ADSCs), and enhances the osteogenic differentiation capacity of ADSCs[3]. In addition, Trichostatin A (0, 10, 100, 500 nM) dose-dependently decreases HDAC class I/II activity[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Trichostatin A Related Antibodies
    In Vivo

    Trichostatin A (500 μg/kg, s.c.) pronounces antitumor activity without causing any measurable toxicity in doses of up to 5 mg/kg by s.c. injection, in randomized controlled efficacy studies using the N-methyl-N-nitrosourea carcinogen-induced rat mammary carcinoma model[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    302.37

    Formula

    C17H22N2O3
    CAS No.
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    CN(C1=CC=C(C=C1)C([C@@H](/C=C(/C=C/C(NO)=O)C)C)=O)C
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (165.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Methanol : 2 mg/mL (6.61 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.3072 mL 16.5360 mL 33.0721 mL
    5 mM 0.6614 mL 3.3072 mL 6.6144 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

    V1

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    Concentration (final)

    C2

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    Volume (final)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: 2.5 mg/mL (8.27 mM); Suspended solution; Need ultrasonic

      This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (8.27 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.91%

    SDS (393 KB)

    COA (243 KB) HNMR (263 KB) LCMS (265 KB) OR (170 KB) Elemental Analysis Report (101 KB)

    Handling Instructions (2659 KB)
    References
    Cell Assay
    [3]

    Cells are cultured in a 96-well plate at 1×103 cells per well with 100 μL complete DMEM in the presence or absence of a HDAC inhibitor Trichostatin A for 72 h. Cytotoxicity is measured by performing WST-8 assay using a CCK-8 cell proliferation kit. The 450 nm absorbance is measured with a microplate reader. All experiments are carried out in triplicate and 3 independent experiments are performed[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [1]

    Rats[1]
    Twelve rats are randomized to receive 500 μg/kg Trichostatin A in 50 μL DMSO, or 50 μL DMSO as vehicle control, by s.c. injection twice weekly for 4 weeks. In subsequent studies, 30 rats are randomized to receive Trichostatin A 500 μg/kg in 50 μL DMSO, or 50 μL DMSO as vehicle control, by s.c. injection daily for 4 weeks. Weekly tumor measurements, estimated tumor volumes, and body mass are recorded for each animal. Animals are sacrificed at the end of the 4-week study period; palpable tumors are resected and immediately snap-frozen in liquid nitrogen. Animals with tumors <2 cm in diameter or ulcerating tumors are withdrawn from study[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    Methanol / DMSO 1 mM 3.3072 mL 16.5360 mL 33.0721 mL 82.6802 mL
    5 mM 0.6614 mL 3.3072 mL 6.6144 mL 16.5360 mL
    DMSO 10 mM 0.3307 mL 1.6536 mL 3.3072 mL 8.2680 mL
    15 mM 0.2205 mL 1.1024 mL 2.2048 mL 5.5120 mL
    20 mM 0.1654 mL 0.8268 mL 1.6536 mL 4.1340 mL
    25 mM 0.1323 mL 0.6614 mL 1.3229 mL 3.3072 mL
    30 mM 0.1102 mL 0.5512 mL 1.1024 mL 2.7560 mL
    40 mM 0.0827 mL 0.4134 mL 0.8268 mL 2.0670 mL
    50 mM 0.0661 mL 0.3307 mL 0.6614 mL 1.6536 mL
    60 mM 0.0551 mL 0.2756 mL 0.5512 mL 1.3780 mL
    80 mM 0.0413 mL 0.2067 mL 0.4134 mL 1.0335 mL
    100 mM 0.0331 mL 0.1654 mL 0.3307 mL 0.8268 mL
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    Trichostatin A Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Trichostatin A58880-19-6TSAOrganoidHDACHistone deacetylasesInhibitorinhibitorinhibit

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