2. Cell Cycle/DNA Damage
    Epigenetics
  3. HDAC
  4. Tucidinostat

Tucidinostat  (Synonyms: Chidamide; HBI-8000; CS 055)

製品番号: HY-109015 純度: 99.82%
COA 取扱説明書

Tucidinostat (Chidamide) is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8 and HDAC11 (IC50s, 733 nM, 432 nM, respectively), and shows no effect on HDAC4/5/6/7/9.

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Tucidinostat 構造式

Tucidinostat 構造式

CAS 番号 : 1616493-44-7

容量 価格（税別） 在庫状況 数量
無料サンプル (0.1 - 0.5 mg)   今すぐ申し込む  
Solution
10 mM * 1 mL in DMSO USD 85 在庫あり
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 85 在庫あり
Estimated Time of Arrival: December 31
Solid
5 mg USD 77 在庫あり
Estimated Time of Arrival: December 31
10 mg USD 121 在庫あり
Estimated Time of Arrival: December 31
25 mg USD 242 在庫あり
Estimated Time of Arrival: December 31
50 mg USD 385 在庫あり
Estimated Time of Arrival: December 31
100 mg USD 616 在庫あり
Estimated Time of Arrival: December 31
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

カスタマーレビュー

Based on 17 publication(s) in Google Scholar

Other Forms of Tucidinostat:

Top Publications Citing Use of Products

HDAC アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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  • 純度とドキュメンテーション

  • 参考文献

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製品説明

Tucidinostat (Chidamide) is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8 and HDAC11 (IC50s, 733 nM, 432 nM, respectively), and shows no effect on HDAC4/5/6/7/9[1].

IC50 & Target

HDAC3

67 nM (IC50)

HDAC10

78 nM (IC50)

HDAC1

95 nM (IC50)

HDAC2

160 nM (IC50)

HDAC11

432 nM (IC50)

HDAC8

733 nM (IC50)

体外実験

Tucidinostat (Chidamide/CS055/HBI-8000) is a potent and orally bioavailable HDAC enzymes class I (HDAC1, 2, 3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8 and HDAC11 (IC50s, 733 nM, 432 nM, respectively), and shows no effect on HDAC4/5/6/7/9 (IC50s, >30 μM). Tucidinostat shows potent antitumor activity, and inhibits several human derived tumor cell lines, such as HL-60, U2OS, LNCaP with GI50s of 0.4 ± 0.1, 2.0 ± 0.6, and 4.0 ± 1.2 μM, respectively. In addition, Tucidinostat shows less toxic to normal cells from human fetal kidney (CCC-HEK) and liver (CCCHEL)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験

Tucidinostat (12.5-50 mg/kg, p.o.) dose-dependently reduces tumor size and tumor weight in mice bearing HCT-8 colorectal carcinoma, A549 lung carcinoma, BEL-7402 liver carcinoma, and MCF-7 breast carcinoma, and with no obvious body loss[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
臨床実験
分子量

390.41

Appearance

Solid

分子式

C22H19FN4O2
CAS 番号
SMILES

O=C(C1=CC=C(CNC(/C=C/C2=CN=CC=C2)=O)C=C1)NC(C=CC(F)=C3)=C3N
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : ≥ 50 mg/mL (128.07 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5614 mL 12.8070 mL 25.6141 mL
5 mM 0.5123 mL 2.5614 mL 5.1228 mL
10 mM 0.2561 mL 1.2807 mL 2.5614 mL
*Please refer to the solubility information to select the appropriate solvent.
体内:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.40 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.40 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.40 mM); Clear solution

*All of the co-solvents are available by MCE.
純度とドキュメンテーション

純度: 99.82%

COA (246 KB) HNMR (276 KB) LCMS (262 KB)

取扱説明書 (2659 KB)
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Tucidinostat1616493-44-7Chidamide HBI-8000 CS 055HBI8000HBI 8000HBI-8000CS055CS 055CS-055HDACHistone deacetylasesInhibitorinhibitorinhibit

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製品名:
Tucidinostat
製品番号:
HY-109015
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