2. Anti-infection Cell Cycle/DNA Damage Apoptosis Cytoskeleton Neuronal Signaling Autophagy
  3. Antibiotic DNA/RNA Synthesis Apoptosis Dynamin PINK1/Parkin Mitophagy
  4. Bleomycin A5

Bleomycin A5  (Synonyms: Pingyangmycin)

製品番号: HY-N10470 純度: 99.81%
COA 取扱説明書 Technical Support

Bleomycin A5 (Pingyangmycin) is a glycopeptide antibiotic with multiple biological activities, which can be isolated from Streptomyces. Bleomycin A5 exerts cytotoxic effects by binding to Fe2+ to form a complex, inducing single-strand and double-strand DNA breaks, and inhibiting DNA replication. Bleomycin A5 inhibits Drp1-mediated mitochondrial fission and suppresses PINK1/Parkin pathway-mediated mitophagy, ultimately triggering mitochondria-mediated cellular apoptosis. Bleomycin A5 can be used in cancer research.

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Bleomycin A5

Bleomycin A5 構造式

CAS 番号 : 11116-32-8

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 1212 在庫あり
Solution
10 mM * 1 mL in Water USD 1212 在庫あり
Solid
5 mg $450 在庫あり
10 mg $765 在庫あり
25 mg $1840 在庫あり
50 mg $3500 在庫あり
100 mg $6650 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

Other Forms of Bleomycin A5:

Bleomycin A5 関連抗体

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

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製品説明

Bleomycin A5 (Pingyangmycin) is a glycopeptide antibiotic with multiple biological activities, which can be isolated from Streptomyces. Bleomycin A5 exerts cytotoxic effects by binding to Fe2+ to form a complex, inducing single-strand and double-strand DNA breaks, and inhibiting DNA replication. Bleomycin A5 inhibits Drp1-mediated mitochondrial fission and suppresses PINK1/Parkin pathway-mediated mitophagy, ultimately triggering mitochondria-mediated cellular apoptosis. Bleomycin A5 can be used in cancer research[1][2][3][4][5].

IC50 & Target

Glycopeptide

 

体内実験

Bleomycin A5 (Pingyangmycin) (oral; 18 daily doses of 5 mg/kg) occurs anorexia, cachexia, skin ulcerations, and death and observes interstitial pneumonia, nephrosis and focal necrosis of the adrenal cortex[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1440.56

分子式

C57H89N19O21S2
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(N[C@H](C)[C@@H](O)[C@H](C)C(N[C@@H]([C@H](O)C)C(NCCC1=NC(C2=NC(C(NCCCNCCCCN)=O)=CS2)=CS1)=O)=O)[C@@H](NC(C3=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C3C)=O)[C@H](C4=CN=CN4)O[C@H](O[C@H]5CO)[C@H]([C@H]([C@@H]5O)O)O[C@H](O[C@@H]6CO)[C@H]([C@H]([C@@H]6O)OC(N)=O)O
Structure Classification
Initial Source

Penicillium avellaneum
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
体外: 

H2O : ≥ 100 mg/mL (69.42 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6942 mL 3.4709 mL 6.9417 mL
5 mM 0.1388 mL 0.6942 mL 1.3883 mL
10 mM 0.0694 mL 0.3471 mL 0.6942 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.6942 mL 3.4709 mL 6.9417 mL 17.3544 mL
5 mM 0.1388 mL 0.6942 mL 1.3883 mL 3.4709 mL
10 mM 0.0694 mL 0.3471 mL 0.6942 mL 1.7354 mL
15 mM 0.0463 mL 0.2314 mL 0.4628 mL 1.1570 mL
20 mM 0.0347 mL 0.1735 mL 0.3471 mL 0.8677 mL
25 mM 0.0278 mL 0.1388 mL 0.2777 mL 0.6942 mL
30 mM 0.0231 mL 0.1157 mL 0.2314 mL 0.5785 mL
40 mM 0.0174 mL 0.0868 mL 0.1735 mL 0.4339 mL
50 mM 0.0139 mL 0.0694 mL 0.1388 mL 0.3471 mL
60 mM 0.0116 mL 0.0578 mL 0.1157 mL 0.2892 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Bleomycin A5 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bleomycin A511116-32-8PingyangmycinBleomycin A 5Bleomycin A-5AntibioticDNA/RNA SynthesisApoptosisDynaminPINK1/ParkinMitophagyPTEN-induced kinase 1/ParkinMitochondrial AutophagyglycopeptideantibioticantineoplasticapoptosisbacterialcancerInhibitorinhibitorinhibit

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