11116-32-8
Chemical Structure
Bleomycin A5
Synonym(s): Pingyangmycin
- CAS No.: 11116-32-8
- Formula:C57H89N19O21S2
- Molecular Weight:1440.56
IUPAC Name: benzo[d]thiazol-2-ylmethyl 4-phenylpiperazine-1-carbodithioate
InChIKey: QYOAUOAXCQAEMW-DDZPZTJXSA-N
SMILES: O=C(N[C@H](C)[C@@H](O)[C@H](C)C(N[C@@H]([C@H](O)C)C(NCCC1=NC(C2=NC(C(NCCCNCCCCN)=O)=CS2)=CS1)=O)=O)[C@@H](NC(C3=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C3C)=O)[C@H](C4=CN=CN4)O[C@H](O[C@H]5CO)[C@H]([C@H]([C@@H]5O)O)O[C@H](O[C@@H]6CO)[C@H]([C@H]([C@@H]6O)OC(N)=O)O
Biological Activity: Bleomycin A5 (Pingyangmycin) is a glycopeptide antibiotic with multiple biological activities, which can be isolated from Streptomyces. Bleomycin A5 exerts cytotoxic effects by binding to Fe2+ to form a complex, inducing single-strand and double-strand DNA breaks, and inhibiting DNA replication. Bleomycin A5 inhibits Drp1-mediated mitochondrial fission and suppresses PINK1/Parkin pathway-mediated mitophagy, ultimately triggering mitochondria-mediated cellular apoptosis. Bleomycin A5 can be used in cancer research[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Bleomycin A5 | 99.81% | Bleomycin A5 (Pingyangmycin) is a glycopeptide antibiotic with multiple biological activities, which can be isolated from Streptomyces. Bleomycin A5 exerts cytotoxic effects by binding to Fe2+ to form a complex, inducing single-strand and double-strand DNA breaks, and inhibiting DNA replication. Bleomycin A5 inhibits Drp1-mediated mitochondrial fission and suppresses PINK1/Parkin pathway-mediated mitophagy, ultimately triggering mitochondria-mediated cellular apoptosis. Bleomycin A5 can be used in cancer research. | ||||||||||||||||||||
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- [1]. Yaowu Yang, et al. Bleomycin A5 sclerotherapy for cervicofacial lymphatic malformations. J Vasc Surg. 2011 Jan;53(1):150-5. [Content Brief]
- [2]. Wu F, et al. Bleomycin A5 suppresses Drp1‑mediated mitochondrial fission and induces apoptosis in human nasal polyp‑derived fibroblasts. Int J Mol Med. 2021;47(1):346-360. [Content Brief]
- [3]. Aouida M, et al. A new twist in cellular resistance to the anticancer drug bleomycin-A5. Curr Drug Metab. 2010;11(7):595-602. [Content Brief]
- [4]. Pan JB, et al. Rolipram attenuates bleomycin A5-induced pulmonary fibrosis in rats. Respirology. 2009;14(7):975-982. [Content Brief]
- [5]. Lan Y, et al. Pingyangmycin inhibits glycosaminoglycan sulphation in both cancer cells and tumour tissues. J Cell Mol Med. 2020;24(6):3419-3430. [Content Brief]
Keywords
