2. PI3K/Akt/mTOR Metabolic Enzyme/Protease Stem Cell/Wnt JAK/STAT Signaling Apoptosis Anti-infection
  3. PTEN Fatty Acid Synthase (FASN) STAT Apoptosis SARS-CoV
  4. Ginkgolic acid C17:1

Ginkgolic acid C17:1  (Synonyms: ギンコール酸C17:1)

製品番号: HY-N2116 純度: 99.80%
COA 取扱説明書 Technical Support

Ginkgolic acid C17:1 is a fatty acid synthase (FAS) inhibitor with an IC50 of 10.5 µM. Ginkgolic acid C17:1 shows anti-tumor activity by inhibiting the phosphorylation of STAT3 and inducing apoptosis. Ginkgolic acid C17:1 can block the interaction between S-RBD and ACE2, and has anti-SARS-CoV-2-S pseudovirus activity. Ginkgolic acid C17:1 inhibits the biofilm formation of enterohemorrhagic Escherichia coli and Staphylococcus aureus.

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Ginkgolic acid C17:1

Ginkgolic acid C17:1 構造式

CAS 番号 : 111047-30-4

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 295 在庫あり
Solution
10 mM * 1 mL in DMSO USD 295 在庫あり
Solid
5 mg $269 在庫あり
10 mg $457 在庫あり
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Based on 1 publication(s) in Google Scholar

Other Forms of Ginkgolic acid C17:1:

Ginkgolic acid C17:1 関連抗体

Top Publications Citing Use of Products

STAT アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
STAT3 STAT5 STAT6 STAT1

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製品説明

Ginkgolic acid C17:1 is a fatty acid synthase (FAS) inhibitor with an IC50 of 10.5 µM. Ginkgolic acid C17:1 shows anti-tumor activity by inhibiting the phosphorylation of STAT3 and inducing apoptosis. Ginkgolic acid C17:1 can block the interaction between S-RBD and ACE2, and has anti-SARS-CoV-2-S pseudovirus activity. Ginkgolic acid C17:1 inhibits the biofilm formation of enterohemorrhagic Escherichia coli and Staphylococcus aureus[1][2][3][4][5].

IC50 & Target[1]

STAT3

 

Cellular Effect
Cell Line Type Value Description References
A549 IC50
29.2 μg/mL
Compound: 6, phenolic acid C17:1
Growth inhibition of human A549 cells after 2 days by SRB assay
Growth inhibition of human A549 cells after 2 days by SRB assay
[PMID: 9677265]
HCT-15 IC50
8.39 μg/mL
Compound: 6, phenolic acid C17:1
Growth inhibition of human HCT15 cells after 2 days by SRB assay
Growth inhibition of human HCT15 cells after 2 days by SRB assay
[PMID: 9677265]
HT1197 IC50
28.14 μg/mL
Compound: 6, phenolic acid C17:1
Growth inhibition of human HT1197 cells after 2 days by SRB assay
Growth inhibition of human HT1197 cells after 2 days by SRB assay
[PMID: 9677265]
MCF7 IC50
5.06 μg/mL
Compound: 6, phenolic acid C17:1
Growth inhibition of human MCF7 cells after 2 days by SRB assay
Growth inhibition of human MCF7 cells after 2 days by SRB assay
[PMID: 9677265]
SK-OV-3 IC50
>50 μg/mL
Compound: 6, phenolic acid C17:1
Growth inhibition of human SKOV3 cells after 2 days by SRB assay
Growth inhibition of human SKOV3 cells after 2 days by SRB assay
[PMID: 9677265]
体外実験

Ginkgolic acid C17:1 (30-50 μM; 24 h) reduces the viability of U266 cells with an IC50 about 64 µM, but has no effect on PBMCs[1].
Ginkgolic acid C17:1 (30-50 μM; 1.5-24 h) inhibits the phosphorylation of STAT3, up-regulates the expression of PTEN and SHP-1, and induces apoptosis in multiple myeloma cells[1].
Ginkgolic acid C17:1 (10-500 μM; 25 h) inhibits SARS-CoV-2-S pseudovirus in hACE2/HEK293T cells with an IC50 of 79.43 μM and the maximum half cytotoxic concentration (CC50) of 130.8 μM[2].
Ginkgolic acid C17:1 (1-20 μg/mL; 24 h) significantly and dose-dependent inhibits the biofilm formation of enterohemorrhagic Escherichia coli (EHEC) and Staphylococcus aureus, but did not affect the growth of EHEC cells[3].
Ginkgolic acid C17:1 (0-30 μg/mL; 0-72 h) inhibits SMMC-7721 cells with an IC50 of 8.5 μg/mL, and induces apoptosis and inhibits cell migration[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ginkgolic acid C17:1 関連抗体

Cell Viability Assay[1]

Cell Line: U266 cells
Concentration: 30 and 50 μM
Incubation Time: 24 h
Result: Reduced cell viability of U266 in a concentration-dependent manner.

Western Blot Analysis[1]

Cell Line: U266 cells
Concentration: 30 and 50 μM
Incubation Time: 1.5 and 3 h
Result: Substantially suppressed phosphorylation of STAT3 in a dose- and time-dependent manner.

Western Blot Analysis[4]

Cell Line: U266 cells
Concentration: 0, 5, 10, 20 and 30 μg/mL
Incubation Time: 0, 24, 48 and 72 h
Result: Increased the Bax/Bcl-2 ratio by significantly increasing the expression of the pro-apoptotic protein Bax.
分子量

374.56

分子式

C24H38O3
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1=C(O)C=CC=C1CCCCCCCCC/C=C\CCCCCC
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (266.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6698 mL 13.3490 mL 26.6980 mL
5 mM 0.5340 mL 2.6698 mL 5.3396 mL
10 mM 0.2670 mL 1.3349 mL 2.6698 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (6.67 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (6.67 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 99.80%

COA (240 KB) HNMR (257 KB) LCMS (91 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6698 mL 13.3490 mL 26.6980 mL 66.7450 mL
5 mM 0.5340 mL 2.6698 mL 5.3396 mL 13.3490 mL
10 mM 0.2670 mL 1.3349 mL 2.6698 mL 6.6745 mL
15 mM 0.1780 mL 0.8899 mL 1.7799 mL 4.4497 mL
20 mM 0.1335 mL 0.6674 mL 1.3349 mL 3.3372 mL
25 mM 0.1068 mL 0.5340 mL 1.0679 mL 2.6698 mL
30 mM 0.0890 mL 0.4450 mL 0.8899 mL 2.2248 mL
40 mM 0.0667 mL 0.3337 mL 0.6674 mL 1.6686 mL
50 mM 0.0534 mL 0.2670 mL 0.5340 mL 1.3349 mL
60 mM 0.0445 mL 0.2225 mL 0.4450 mL 1.1124 mL
80 mM 0.0334 mL 0.1669 mL 0.3337 mL 0.8343 mL
100 mM 0.0267 mL 0.1335 mL 0.2670 mL 0.6674 mL
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Ginkgolic acid C17:1 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ginkgolic acid C17:1111047-30-4PTENFatty Acid Synthase (FASN)STATApoptosisSARS-CoVPhosphatase and tensin homologMMAC1SARS coronavirusU266 cellsPBMCsMultiple myeloma cellsSMMC-7721Inhibitorinhibitorinhibit

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