2. PI3K/Akt/mTOR
  3. PI3K
  4. iMDK

iMDK is a potent PI3K inhibitor and inhibits the growth factor MDK (also known as midkine or MK). iMDK suppresses non-small cell lung cancer (NSCLC) cooperatively with A MEK inhibitor without harming normal cells and mice.

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CAS No. : 881970-80-5

사이즈 가격 재고 수량
무료 샘플 (0.1 - 0.2 mg)   지금 신청하기  
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 5 publication(s) in Google Scholar

Other Forms of iMDK:

iMDK Related Antibodies

Top Publications Citing Use of Products

    iMDK purchased from MedChemExpress. Usage Cited in: Cell Discov. 2024 Oct 22;10(1):110.  [Abstract]

    iMDK (9 mg/kg, intraperitoneally injected, once a day from E7.5 to E12.5.). Placental efficiency as expressed by the ratio of fetal weight to placental weight (n = 24 for control, n = 41 for iMDK).

    iMDK purchased from MedChemExpress. Usage Cited in: Cell Discov. 2024 Oct 22;10(1):110.  [Abstract]

    iMDK (9 mg/kg, intraperitoneally injected, once a day from E7.5 to E12.5.). Measurements of the labyrinth area and JZ area and the ratio of the labyrinth area to the JZ area (n = 8 control, n = 14 iMDK).

    iMDK purchased from MedChemExpress. Usage Cited in: Cell Discov. 2024 Oct 22;10(1):110.  [Abstract]

    iMDK (9 mg/kg, intraperitoneally injected, once a day from E7.5 to E12.5.). Representative image of a cross-section through the labyrinth and JZ in a mid-section of a mouse placenta. The blue solid line outlines the labyrinth and JZ that was measured.

    iMDK purchased from MedChemExpress. Usage Cited in: Cell Discov. 2024 Oct 22;10(1):110.  [Abstract]

    iMDK (9 mg/kg, intraperitoneally injected, once a day from E7.5 to E12.5.). Real-time quantitative polymerase chain reaction (RT-qPCR) analysis of the expression of markers of SynT-I (Mct1) and endothelial cells (Cd31). RT-qPCR data were normalized to the reference gene Hprt.

    iMDK purchased from MedChemExpress. Usage Cited in: Cell Discov. 2024 Oct 22;10(1):110.  [Abstract]

    The CCK-8 assay was used to evaluate the proliferation of endothelial cells treated with iMDK (0.125-1 μM).

    View All PI3K Isoform Specific Products:

    View All Isoforms
    PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

    • Biological Activity

    • 순도&문서

    • References

    • 고객리뷰

    제품 설명

    iMDK is a potent PI3K inhibitor and inhibits the growth factor MDK (also known as midkine or MK). iMDK suppresses non-small cell lung cancer (NSCLC) cooperatively with A MEK inhibitor without harming normal cells and mice[1].

    In Vitro

    iMDK (50–500 nM) suppressed AKT phosphorylation in a dose-dependent manner in H441 lung adenocarcinoma cells after treatment for 72 h. In contrast, iMDK robustly increases p-ERK[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    iMDK Related Antibodies

    Cell Viability Assay[1]

    Cell Line: H441 (lung adenocarcinoma; KRASG12V), H2009 (non-small cell carcinoma; KRASG12A), A549 (lung carcinoma; KRASG12S) and H520 (lung squamous cell carcinoma; KRASWT)
    Concentration: iMDK (2.5 μM) and PD0325901 (0.5 μM) for H441 and H2009 cells
    iMDK (0.125 μM) and PD0325901 (0.25 μM) for H520 cells
    iMDK (0.25 μM) and PD0325901 (0.125 μM) for A549 cells
    Incubation Time: 72 hours
    Result: iMDK alone did not inhibit cell viability of A549 cells, the combinatorial treatment of iMDK with PD0325901 significantly inhibited that of A549 cells compared to the single treatment of PD0325901.

    Western Blot Analysis[1]

    Cell Line: H441 lung adenocarcinoma cells
    Concentration: 0-500 nM
    Incubation Time: 72 hours
    Result: Suppressed AKT phosphorylation in a dose-dependent manner.
    ERK1/2 phosphorylation was increased.
    In Vivo

    The combination treatment of iMDK ( (9 mg/kg/day; intraperitoneally injected with 100 μl) and PD0325901 (5 mg/kg; orally administered) effectively reduced lung tumor growth in a xenograft mouse model[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: female BALB/c nude mice (6 week old) bearing H441 human lung cancer xenografts[1]
    Dosage: iMDK (9 mg/kg) and PD0325901 (5 mg/kg)
    Administration: Intraperitoneally injected with 100 μL iMDK everyday and/or orally administered PD0325901 five times per week (on days 1, 2, 3, 4, 5, 7, 8, 9, 10, 11)
    Result: Reduced significantly volume of the tumors derived from H441 lung adenocarcinoma cells after the combination treatment with iMDK and PD0325901 compared to that of single compound in a xenograft mouse model.
    분자량

    376.40

    화학식

    C21H13FN2O2S
    CAS No.
    Appearance

    Solid

    Color

    Off-white to yellow

    SMILES

    O=C1C(C2=CN3C(SC(CC4=CC=C(F)C=C4)=C3)=N2)=CC5=CC=CC=C5O1
    선적

    Room temperature in continental US; may vary elsewhere.
    보관
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    용액&용해도
    In Vitro: 

    DMSO : 2 mg/mL (5.31 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.6567 mL 13.2837 mL 26.5675 mL
    5 mM 0.5313 mL 2.6567 mL 5.3135 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • 몰농도 계산기

    • 농도 희석 계산기

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration
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    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    =
    Concentration (final)

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    순도&문서

    Purity: 99.35%

    SDS (396 KB)

    COA (248 KB) HNMR (259 KB) RP-HPLC (254 KB) MS (68 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.6567 mL 13.2837 mL 26.5675 mL 66.4187 mL
    5 mM 0.5313 mL 2.6567 mL 5.3135 mL 13.2837 mL
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    iMDK Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    iMDK881970-80-5PI3KPhosphoinositide 3-kinasegrowthfactorMDKmidkine NSCLCInhibitorinhibitorinhibit

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    상품명:
    iMDK
    Cat. No.:
    HY-110171
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