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iMDK quarterhydrate 

Cat. No.: HY-110171A Purity: ≥99.0%
Handling Instructions

iMDK quarterhydrate, a MDK-positive H441 and H520 lung adenocarcinoma cells inhibitor, suppresses the growth of H441 cells by inhibiting the PI3 kinase (PI3K) pathway and inducing apoptosis. iMDK quarterhydrate decreases MDK-induced migration, angiogenesis of endothelial cells and abrogats the progression and metastasis of NSCLC cells.

For research use only. We do not sell to patients.

iMDK quarterhydrate Chemical Structure

iMDK quarterhydrate Chemical Structure

Size Price Stock Quantity
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

iMDK quarterhydrate, a MDK-positive H441 and H520 lung adenocarcinoma cells inhibitor, suppresses the growth of H441 cells by inhibiting the PI3 kinase (PI3K) pathway and inducing apoptosis[1]. iMDK quarterhydrate decreases MDK-induced migration, angiogenesis of endothelial cells and abrogats the progression and metastasis of NSCLC cells[2].

In Vitro

iMDK inhibits endogenous MDK expression in H441 lung adenocarcinoma cells, induces apoptosis in H441 lung adenocarcinoma cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: H441 cells
Concentration: 10, 50, 100, 500 nM
Incubation Time: 48 hours
Result: Suppression of H441 cells is dose-dependently observed 48 hours after treatment with iMDK.
Highly condenses and partly fragments nuclei are observed in H441 cells but not in normal NHLF cells after the treatment with iMDK.
In Vivo

iMDK (9mg/kg; 1 time/2 days) exhibits anti-tumor and anti-metastasis effects on a xenograft mouse model of NSCLC[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice (BALB/cAnNCrj-nu/nu)[2]
Dosage: 9 mg/kg
Administration: 1 time/2 days
Result: Exhibits anti-tumor and anti-metastasis effects on a xenograft mouse model of NSCLC.
Molecular Weight

380.91

Formula

C₂₁H₁₃FN₂O₂S.₁/₄H₂₀

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: ≥99.0%

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Product Name:
iMDK quarterhydrate
Cat. No.:
HY-110171A
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