2. Apoptosis GPCR/G Protein Immunology/Inflammation
  3. TNF Receptor Prostaglandin Receptor COX
  4. Licarin A

Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC50=12.6 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Anti-allergic effects. Licarin A reduces TNF-α and PGD2 production, and COX-2 expression.

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Licarin A

Licarin A Estructura química

No. CAS : 51020-86-1

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5 mg En stock
10 mg En stock
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100 mg   Obtener un presupuesto  

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Licarin A Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas TNF Receptor:

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TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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DP EP FP IP TXA2/TP TXB2

Ver todos los productos específicos de isoformas COX:

Ver todas las isoformas
COX COX-1 COX-2 COX-3

  • Actividad biológica

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Descripciòn

Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC50=12.6 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Anti-allergic effects. Licarin A reduces TNF-α and PGD2 production, and COX-2 expression[1].

IC50 & Target

DP

 

Cellular Effect
Cell Line Type Value Description References
Platelet IC50
165 3
Compound: 19
Antiplatelet activity in rabbit platelets assessed as inhibition of adenosin 5'-diphosphate-induced platelet aggregation
Antiplatelet activity in rabbit platelets assessed as inhibition of adenosin 5'-diphosphate-induced platelet aggregation
[PMID: 19880317]
Platelet IC50
556 3
Compound: 19
Antiplatelet activity in rabbit platelets assessed as inhibition of arachidonic acid-induced platelet aggregation
Antiplatelet activity in rabbit platelets assessed as inhibition of arachidonic acid-induced platelet aggregation
[PMID: 19880317]
Platelet IC50
>999 3
Compound: 19
Antiplatelet activity in rabbit platelets assessed as inhibition of platelet activating factor-induced platelet aggregation
Antiplatelet activity in rabbit platelets assessed as inhibition of platelet activating factor-induced platelet aggregation
[PMID: 19880317]
Platelet IC50
165 3
Compound: 19
Antiplatelet activity in rabbit platelets assessed as inhibition of adenosin 5'-diphosphate-induced platelet aggregation
Antiplatelet activity in rabbit platelets assessed as inhibition of adenosin 5'-diphosphate-induced platelet aggregation
[PMID: 19880317]
Platelet IC50
556 3
Compound: 19
Antiplatelet activity in rabbit platelets assessed as inhibition of arachidonic acid-induced platelet aggregation
Antiplatelet activity in rabbit platelets assessed as inhibition of arachidonic acid-induced platelet aggregation
[PMID: 19880317]
Platelet IC50
> 999 3
Compound: 19
Antiplatelet activity in rabbit platelets assessed as inhibition of platelet activating factor-induced platelet aggregation
Antiplatelet activity in rabbit platelets assessed as inhibition of platelet activating factor-induced platelet aggregation
[PMID: 19880317]
In Vitro

Licarin A is found in plants such as Aristolochia taliscana, Machilus thunbergii and Myristica fragrans, which are used as spices and in folk medicines for nervous and digestive disorders. Licarin A also exhibits anti-inflammatory effects[1].
Licarin A (5-20 μM) reduces TNF-α and prostaglandin D2 (PGD2) secretion via the inhibition of PKCα/βII and p38 MAPK pathways. Licarin A treatment tends to reduce phosphorylated PKCα/βII and p38 MAPK protein levels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Licarin A Related Antibodies
Peso molecular

326.39

Fòrmula

C20H22O4
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC=C([C@@H]2OC3=C(OC)C=C(/C=C/C)C=C3[C@H]2C)C=C1OC
Structure Classification
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvente y solubilidad
In Vitro: 

DMSO : ≥ 50 mg/mL (153.19 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0638 mL 15.3191 mL 30.6382 mL
5 mM 0.6128 mL 3.0638 mL 6.1276 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación

Purity: 99.83%

SDS (393 KB)

COA (247 KB) HNMR (82 KB) LCMS (106 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0638 mL 15.3191 mL 30.6382 mL 76.5955 mL
5 mM 0.6128 mL 3.0638 mL 6.1276 mL 15.3191 mL
10 mM 0.3064 mL 1.5319 mL 3.0638 mL 7.6595 mL
15 mM 0.2043 mL 1.0213 mL 2.0425 mL 5.1064 mL
20 mM 0.1532 mL 0.7660 mL 1.5319 mL 3.8298 mL
25 mM 0.1226 mL 0.6128 mL 1.2255 mL 3.0638 mL
30 mM 0.1021 mL 0.5106 mL 1.0213 mL 2.5532 mL
40 mM 0.0766 mL 0.3830 mL 0.7660 mL 1.9149 mL
50 mM 0.0613 mL 0.3064 mL 0.6128 mL 1.5319 mL
60 mM 0.0511 mL 0.2553 mL 0.5106 mL 1.2766 mL
80 mM 0.0383 mL 0.1915 mL 0.3830 mL 0.9574 mL
100 mM 0.0306 mL 0.1532 mL 0.3064 mL 0.7660 mL
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Licarin A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Licarin A51020-86-1(+)-Licarin ATNF ReceptorProstaglandin ReceptorCOXTumor Necrosis Factor ReceptorTNFRCyclooxygenaseneolignanTNF-αAnti-allergicPGD2COX-2nervousdigestivedisorderanti-inflammatoryInhibitorinhibitorinhibit

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Nombre del producto:
Licarin A
Cat. No.:
HY-N2252
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