MM41

Name: MM41
Brand: MedChemExpress
SKU: HY-16967
Rating: 4.5 (1 reviews)

Cat. No.: HY-16967 Purity: 98.89%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

MM41 is a quadruplex-interacting compound. MM41 binds tightly to quadruplexes encoded in the promoter sequences of the BCL-2 and k-RAS genes. MM41 reduces BCL-2 and k-RAS protein levels, increases caspase 3. MM41 has antitumor effects against pancreatic cancer.

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MM41 화학구조

CAS No. : 1429028-96-5

사이즈	재고	수량
무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

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View All Isoforms

Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

View All Ras Isoform Specific Products:

View All Isoforms

K-Ras H-Ras N-Ras Ras

View All Caspase Isoform Specific Products:

View All Isoforms

Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target^[1]

Caspase 3

Bcl-2

K-RAS

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	IC₅₀	0.32 μM Compound: 3d	Cytotoxicity against human 786-0 cells assessed as growth inhibition after 96 hrs by SRB assay Cytotoxicity against human 786-0 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 23514618]
A549	IC₅₀	19 nM Compound: MM41	Growth inhibition of human A549 cells after 96 hrs by SRB assay Growth inhibition of human A549 cells after 96 hrs by SRB assay	[PMID: 29356532]
A549	IC₅₀	< 0.01 μM Compound: 3d	Cytotoxicity against human A549 cells assessed as growth inhibition after 96 hrs by SRB assay Cytotoxicity against human A549 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 23514618]
MCF7	IC₅₀	0.07 μM Compound: 3d	Cytotoxicity against human MCF7 cells assessed as growth inhibition after 96 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 23514618]
MCF7	IC₅₀	70 nM Compound: MM41	Growth inhibition of human MCF7 cells after 96 hrs by SRB assay Growth inhibition of human MCF7 cells after 96 hrs by SRB assay	[PMID: 29356532]
MIA PaCa-2	IC₅₀	0.01 μM Compound: 3d	Cytotoxicity against human MIAPaCa2 cells assessed as growth inhibition after 96 hrs by SRB assay Cytotoxicity against human MIAPaCa2 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 23514618]
MIA PaCa-2	IC₅₀	11 nM Compound: MM41	Growth inhibition of human MIAPaCa2 cells after 96 hrs by SRB assay Growth inhibition of human MIAPaCa2 cells after 96 hrs by SRB assay	[PMID: 29356532]
PANC-1	IC₅₀	0.003 μM Compound: 2a	Cytotoxicity against human PANC1 cells after 96 hrs by SRB assay Cytotoxicity against human PANC1 cells after 96 hrs by SRB assay	[PMID: 23769166]
PANC-1	IC₅₀	3 nM Compound: MM41	Growth inhibition of human PANC1 cells after 96 hrs by SRB assay Growth inhibition of human PANC1 cells after 96 hrs by SRB assay	[PMID: 29356532]
RCC4	IC₅₀	0.56 μM Compound: 3d	Cytotoxicity against human RCC4 cells assessed as growth inhibition after 96 hrs by SRB assay Cytotoxicity against human RCC4 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 23514618]
WI-38	IC₅₀	0.23 μM Compound: 3d	Cytotoxicity against human WI38 cells assessed as growth inhibition after 96 hrs by SRB assay Cytotoxicity against human WI38 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 23514618]
WI-38	IC₅₀	230 nM Compound: MM41	Growth inhibition of human WI38 cells after 96 hrs by SRB assay Growth inhibition of human WI38 cells after 96 hrs by SRB assay	[PMID: 29356532]

In Vitro

MM41 (1 μM) stabilizes the BCL-2 promoter G-quadruplex with a ΔTₘ value of 26.4 °C, and also binds effectively to k-RAS1 and k-RAS2 promoter G-quadruplexes with ΔTₘ values of 22.5 °C and 19.8 °C respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MM41 (10-15 mg/kg; i.v.; twice weekly; 12 doses) shows dose-dependent anti-tumour activity in MIA PaCa-2 pancreatic cancer xenografts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female CD-1 nude mice (2-3 months old, weighing 20-25 g) bearing MIA PaCa-2 pancreatic cancer subcutaneous xenografts^[1]
Dosage:	10 mg/kg, 15 mg/kg
Administration:	Intravenous administration, twice weekly, 12 doses
Result:	Resulted in an average reduction of ca 80% in tumor growth by day 40 in mice, cessation of tumor regrowth from day 30 onwards, and complete tumor regression in two mice with no regrowth for 239 days (15 mg/kg). Showed weaker anti-tumour effect (10 mg/kg). Showed reduced BCL-2 and k-RAS protein levels in treated tumours. Showed that treated tumours, but not untreated ones, show high levels of caspase 3 staining.

분자량

831.06

화학식

C₄₄H₆₆N₁₀O₆

CAS No.

1429028-96-5

Appearance

Solid

Color

Blue to purple

SMILES

O=C1C2=CC(NCCCN3CCN(CC3)C)=C4C(N(CCCN5CCOCC5)C(C6=CC(NCCCN7CCN(CC7)C)=C(C2=C64)C(N1CCCN8CCOCC8)=O)=O)=O

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

1 M HCl : 100 mg/mL (120.33 mM; Need ultrasonic)

DMSO : 33.33 mg/mL (40.11 mM; ultrasonic and adjust pH to 8 with HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2033 mL	6.0164 mL	12.0328 mL
5 mM	0.2407 mL	1.2033 mL	2.4066 mL
10 mM	0.1203 mL	0.6016 mL	1.2033 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 98.89%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (250 KB) HNMR (294 KB) LCMS (99 KB)

Handling Instructions (2659 KB)

References

[1]. Ohnmacht SA, et al. A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer. Sci Rep. 2015 Jun 16;5:11385. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / 1 M HCl	1 mM	1.2033 mL	6.0164 mL	12.0328 mL	30.0821 mL
	5 mM	0.2407 mL	1.2033 mL	2.4066 mL	6.0164 mL
	10 mM	0.1203 mL	0.6016 mL	1.2033 mL	3.0082 mL
	15 mM	0.0802 mL	0.4011 mL	0.8022 mL	2.0055 mL
	20 mM	0.0602 mL	0.3008 mL	0.6016 mL	1.5041 mL
	25 mM	0.0481 mL	0.2407 mL	0.4813 mL	1.2033 mL
	30 mM	0.0401 mL	0.2005 mL	0.4011 mL	1.0027 mL
	40 mM	0.0301 mL	0.1504 mL	0.3008 mL	0.7521 mL
1 M HCl	50 mM	0.0241 mL	0.1203 mL	0.2407 mL	0.6016 mL
	60 mM	0.0201 mL	0.1003 mL	0.2005 mL	0.5014 mL
	80 mM	0.0150 mL	0.0752 mL	0.1504 mL	0.3760 mL
	100 mM	0.0120 mL	0.0602 mL	0.1203 mL	0.3008 mL

MM41 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MM411429028-96-5MM 41MM-41G-quadruplexBcl-2 FamilyRasCaspasePaCa-2pancreatic cancerA549RCC4,786-0cancer,stabilizerInhibitorinhibitorinhibit

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MM41

고객리뷰

MM41 Related Antibodies

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View All Caspase Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

MM41 Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

MM41 Related Classifications

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고객리뷰

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SAFETY DATA SHEET (SDS)

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