2. Neuronal Signaling GPCR/G Protein Epigenetics Cell Cycle/DNA Damage
  3. Adrenergic Receptor HDAC α-synuclein
  4. Oleuropein Aglycone

Oleuropein Aglycone  (Synonyms: 3,4-DHPEA-EA)

製品番号: HY-135115 純度: 98.46%
COA 取扱説明書 Technical Support

Oleuropein Aglycone (3,4-DHPEA-EA) is a polyphenol and the aglycone form of oleuropein (HY-N0292), formed by enzymatic, acidic or acetylated hydrolysis of oleuropein. Dietary intake of oleuropein Aglycone (50 mg/kg diet) increases the number of neuronal autophagic vesicles, reverses cognitive deficits in the TgCRND8 transgenic mouse model of Alzheimer's disease, and reduces the levels of histone deacetylase 2 (HDAC2) in the cortex and hippocampus. Oleuropein Aglycone increases urinary norepinephrine, interscapular brown adipose tissue epinephrine, and UCP1 protein levels, and reduced plasma leptin levels and total abdominal adipose tissue weight in a rat model of high-fat diet-induced obesity. Oleuropein Aglycone also reduced lung neutrophil infiltration, lipid peroxidation, and IL-1β levels in a mouse model of carrageenan-induced pleurisy.

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Oleuropein Aglycone

Oleuropein Aglycone 構造式

CAS 番号 : 31773-95-2

容量 価格（税別） 在庫状況 数量
Oil + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 528 在庫あり
Solution
10 mM * 1 mL in DMSO USD 528 在庫あり
Oil
1 mg $190 在庫あり
5 mg $480 在庫あり
10 mg $770 在庫あり
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100 mg   お問い合わせ  

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Oleuropein Aglycone 関連抗体

Top Publications Citing Use of Products

Adrenergic Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
α adrenergic receptor β adrenergic receptor

HDAC アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

α-synuclein アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
α-synuclein α-synuclein Aggregation α-synuclein/CHMP2B

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製品説明

Oleuropein Aglycone (3,4-DHPEA-EA) is a polyphenol and the aglycone form of oleuropein (HY-N0292), formed by enzymatic, acidic or acetylated hydrolysis of oleuropein. Dietary intake of oleuropein Aglycone (50 mg/kg diet) increases the number of neuronal autophagic vesicles, reverses cognitive deficits in the TgCRND8 transgenic mouse model of Alzheimer's disease, and reduces the levels of histone deacetylase 2 (HDAC2) in the cortex and hippocampus. Oleuropein Aglycone increases urinary norepinephrine, interscapular brown adipose tissue epinephrine, and UCP1 protein levels, and reduced plasma leptin levels and total abdominal adipose tissue weight in a rat model of high-fat diet-induced obesity. Oleuropein Aglycone also reduced lung neutrophil infiltration, lipid peroxidation, and IL-1β levels in a mouse model of carrageenan-induced pleurisy.

分子量

378.37

分子式

C19H22O8
CAS 番号
Appearance

Oil

Color

Off-white to light yellow

SMILES

O=C(OCCC1=CC=C(O)C(O)=C1)C[C@H]2/C([C@H](O)OC=C2C(OC)=O)=C\C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

DMSO : 50 mg/mL (132.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6429 mL 13.2146 mL 26.4292 mL
5 mM 0.5286 mL 2.6429 mL 5.2858 mL
10 mM 0.2643 mL 1.3215 mL 2.6429 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

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濃度 （終了）

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体積 （終了）

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In Vivo Dissolution Calculator
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純度とドキュメンテーション

純度: 98.46%

COA (247 KB) HNMR (266 KB) LCMS (100 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6429 mL 13.2146 mL 26.4292 mL 66.0729 mL
5 mM 0.5286 mL 2.6429 mL 5.2858 mL 13.2146 mL
10 mM 0.2643 mL 1.3215 mL 2.6429 mL 6.6073 mL
15 mM 0.1762 mL 0.8810 mL 1.7619 mL 4.4049 mL
20 mM 0.1321 mL 0.6607 mL 1.3215 mL 3.3036 mL
25 mM 0.1057 mL 0.5286 mL 1.0572 mL 2.6429 mL
30 mM 0.0881 mL 0.4405 mL 0.8810 mL 2.2024 mL
40 mM 0.0661 mL 0.3304 mL 0.6607 mL 1.6518 mL
50 mM 0.0529 mL 0.2643 mL 0.5286 mL 1.3215 mL
60 mM 0.0440 mL 0.2202 mL 0.4405 mL 1.1012 mL
80 mM 0.0330 mL 0.1652 mL 0.3304 mL 0.8259 mL
100 mM 0.0264 mL 0.1321 mL 0.2643 mL 0.6607 mL
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Oleuropein Aglycone Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oleuropein Aglycone31773-95-23,4-DHPEA-EAAdrenergic ReceptorHDACα-synucleinBeta ReceptorHistone deacetylasesα-SynInhibitorinhibitorinhibit

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製品名:
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製品番号:
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