Pyrrothiogatain

Name: Pyrrothiogatain
Brand: MedChemExpress
SKU: HY-138113
Rating: 4.5 (1 reviews)

製品番号: HY-138113 純度: 98.61%: Data Sheet SDS COA 取扱説明書
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Pyrrothiogatain is a transcription factor GATA3 inhibitor with an IC₅₀ of 54.7 μM. Pyrrothiogatain inhibits the DNA-binding activity of GATA3 and inhibits the T helper 2 (Th2) cell differentiation and expression of Th2 cytokines. Pyrrothiogatain shows anti-infection effect by inhibiting ACE2 expression. Pyrrothiogatain can be used for the researches of inflammation, immunology, infection and cancer, such as colon cancer and SARS-CoV-2 infection.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Pyrrothiogatain 構造式

CAS 番号 : 477888-48-5

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 55	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 55	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$50	在庫あり	Estimated Time of Arrival: December 31
10 mg	$80	在庫あり	Estimated Time of Arrival: December 31
25 mg	$150	在庫あり	Estimated Time of Arrival: December 31
50 mg	$240	在庫あり	Estimated Time of Arrival: December 31
100 mg	$360	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

顧客検証

•Cell Rep. 2026 Feb 24;45(2):116952.

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

Interleukin Related アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

TNF Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target^[1]^[2]^[3]^[4]

GATA3

54.7 μM (IC₅₀)

IL-4

IL-5

IL-6

IL-13

ACE

体外実験

Pyrrothiogatain (50-100 μM) inhibits the DNA-binding activity of GATA3^[1].
Pyrrothiogatain (0-100 μM, 3 days) does not influence cell viability in Jurkat cells^[1].
Pyrrothiogatain (10-30 μM) suppresses GATA3-dependent transcriptional activation of the IL-5 promoter in HEK293T cells^[1].
Pyrrothiogatain (30-80 μM, 5 days) inhibits Th2 cell differentiation in CD4⁺ T cells^[1].
Pyrrothiogatain (80 μM, 2 days) inhibits GATA3 binding to Th2 cytokine gene locus in CD4⁺ T cells^[1].
Pyrrothiogatain (50 μM, 4 days) decreases cell ount in both NT and GATA-3 knockout 3T3L1 cells^[2].
Pyrrothiogatain (50 μM) reduces IL-6 and TNF-α levels in 3T3L-1 preadipocytes^[2].
Pyrrothiogatain (50-500 μM) reduces ACE2 and in HEK293T cells^[3].
Pyrrothiogatain (500 μM, 48 h) reduces SARS-CoV-2 viral load in Calu-3 cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Differentiation Assay^[1]

Cell Line:	CD4⁺ T cells
Concentration:	30 and 80 μM
Incubation Time:	5 days
Result:	Inhibited generation of IL-4-, IL-5-, and IL-13-producing Th2 cells. Decreased production and mRNA expression of IL-4, IL-5 and IL-13.

体内実験

Pyrrothiogatain (60 mg/kg, i.p., once a day) inhibits MC38 tumor growth in Cdc42^+/+Foxp3^YFP-Cre mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Cdc42^+/+Foxp3^YFP-Cre mice with MC38 tumor^[4]
Dosage:	60 mg/kg
Administration:	Intraperitoneally injection, once a day
Result:	Reduced tumor volume.

分子量

221.28

分子式

C₁₁H₁₁NO₂S

CAS 番号

477888-48-5

Appearance

Solid

Color

Light yellow to orange

SMILES

O=C(C1=C(N2C(C)=CC=C2C)C=CS1)O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 125 mg/mL (564.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.5192 mL	22.5958 mL	45.1916 mL
5 mM	0.9038 mL	4.5192 mL	9.0383 mL
10 mM	0.4519 mL	2.2596 mL	4.5192 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 98.61%

Select Batch:

データシート (283 KB) SDS (393 KB)

COA (259 KB) HNMR (237 KB) LCMS (97 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Nomura S, et al. Pyrrothiogatain acts as an inhibitor of GATA family proteins and inhibits Th2 cell differentiation in vitro. Sci Rep. 2019 Nov 22;9(1):17335. [Content Brief]

[2]. Almuraikhy S, et al. Targeted Inhibition of GATA-3 by Pyrrothiogatain: Implications for Adipocyte Biology and Inflammatory Response. Cells. 2025 Jan 10;14(2):100. [Content Brief]

[3]. Israeli M, et al. Genome-wide CRISPR screens identify GATA6 as a proviral host factor for SARS-CoV-2 via modulation of ACE2. Nat Commun. 2022 Apr 25;13(1):2237. [Content Brief]

[4]. Kalim KW, et al. Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity. J Immunother Cancer. 2022 Nov;10(11):e004806. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.5192 mL	22.5958 mL	45.1916 mL	112.9790 mL
	5 mM	0.9038 mL	4.5192 mL	9.0383 mL	22.5958 mL
	10 mM	0.4519 mL	2.2596 mL	4.5192 mL	11.2979 mL
	15 mM	0.3013 mL	1.5064 mL	3.0128 mL	7.5319 mL
	20 mM	0.2260 mL	1.1298 mL	2.2596 mL	5.6490 mL
	25 mM	0.1808 mL	0.9038 mL	1.8077 mL	4.5192 mL
	30 mM	0.1506 mL	0.7532 mL	1.5064 mL	3.7660 mL
	40 mM	0.1130 mL	0.5649 mL	1.1298 mL	2.8245 mL
	50 mM	0.0904 mL	0.4519 mL	0.9038 mL	2.2596 mL
	60 mM	0.0753 mL	0.3766 mL	0.7532 mL	1.8830 mL
	80 mM	0.0565 mL	0.2824 mL	0.5649 mL	1.4122 mL
	100 mM	0.0452 mL	0.2260 mL	0.4519 mL	1.1298 mL