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Results for "

Autophagy-IN-2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Autophagy (35) Mitophagy (2) ADC Cytotoxin (4) Akt (3) AMPK (2) Antibiotic (3) Apoptosis (19) Aryl Hydrocarbon Receptor (1) Bacterial (2) Bcl-2 Family (2) DNA Alkylator/Crosslinker (2) DNA-PK (2) EBV (1) Endogenous Metabolite (1) ERK (1) Ferroptosis (2) Filovirus (1) FXR (3) GSK-3 (3) HBV (2) HIV (2) IKK (1) JAK (1) JNK (1) LPL Receptor (3) MEK (1) Microtubule/Tubulin (3) MMP (1) mTOR (3) NF-κB (1) Organoid (4) Parasite (2) PDK-1 (2) PERK (1) PI3K (3) Proteasome (1) PTEN (1) Reactive Oxygen Species (1) SGK (1) SphK (3) STAT (1) Topoisomerase (2) TRP Channel (1) Wnt (3) β-catenin (3)
By Research Areas:	Cancer (35) Cardiovascular Disease (4) Infection (4) Inflammation/Immunology (6) Metabolic Disease (2)

By Targets:

Autophagy (35)

Mitophagy (2)

ADC Cytotoxin (4)

Akt (3)

AMPK (2)

Antibiotic (3)

Apoptosis (19)

Aryl Hydrocarbon Receptor (1)

Bacterial (2)

Bcl-2 Family (2)

DNA Alkylator/Crosslinker (2)

DNA-PK (2)

EBV (1)

Endogenous Metabolite (1)

ERK (1)

Ferroptosis (2)

Filovirus (1)

FXR (3)

GSK-3 (3)

HBV (2)

HIV (2)

IKK (1)

JAK (1)

JNK (1)

LPL Receptor (3)

MEK (1)

Microtubule/Tubulin (3)

MMP (1)

mTOR (3)

NF-κB (1)

Organoid (4)

Parasite (2)

PDK-1 (2)

PERK (1)

PI3K (3)

Proteasome (1)

PTEN (1)

Reactive Oxygen Species (1)

SGK (1)

SphK (3)

STAT (1)

Topoisomerase (2)

TRP Channel (1)

Wnt (3)

β-catenin (3)

By Research Areas:

Cancer (35)

Cardiovascular Disease (4)

Infection (4)

Inflammation/Immunology (6)

Metabolic Disease (2)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Autophagy AUTACs Mitophagy Atg4 Atg8/LC3 AIM2 NEKs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-117357

SI-113

SGK Cancer

SI-113 is a SGK1 inhibitor, with an IC₅₀ of 600 nM. SI113 induces autophagy .

SI-113	SGK	Cancer
SI-113 is a SGK1 inhibitor, with an IC₅₀ of 600 nM. SI113 induces autophagy .

HY-17394

Cisplatin Maximum Cited Publications 383 Publications Verification cis-PlatINum; CDDP; cis-DiamINodichloroplatINum	DNA Alkylator/Crosslinker Ferroptosis Autophagy	Cancer
Cisplatin (CDDP) is an antineoplastic chemotherapy agent by cross-linking with DNA and causing DNA damage in cancer cells. Cisplatin activates ferroptosis and induces *autophagy* .

HY-N0706

Gracillin 1 Publications Verification	Apoptosis Autophagy	Cancer
Gracillin is a steroidal saponin that can be extracted from the roots of the plant and has anti-tumor properties. Gracillin can induce cancer cell apoptosis and autophagy .

HY-150757

*Autophagy-IN-2*	Autophagy Apoptosis	Cancer
Autophagy-IN-2 (Compound 7h) is an autophagic flux inhibitor. Autophagy-IN-2 induces cancer cell apoptosis and can be used for triple-negative breast cancer research .

HY-144637

*Autophagy inducer 2*	Apoptosis Autophagy	Cancer
Autophagy inducer 2 (Compound 11i) is a potent autophagy inducer. Autophagy inducer 2 exhibits apparent antiproliferative activity against the MCF-7 cell line with an IC₅₀ value of 1.31 μM and remarkably inhibits the colony formation of the MCF-7 cells. Autophagy inducer 2 arrests the MCF-7 cells in the G2/M phase by regulating the cell-cycle-related proteins Cdk-1 and Cyclin B1. Autophagy inducer 2 has the potential for the research of breast cancer .

HY-B0015

Paclitaxel 175+ Cited Publications	Microtubule/Tubulin ADC Cytotoxin Apoptosis Autophagy	Cancer
Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces *autophagy* .

HY-12222

Obeticholic acid 55+ Cited Publications INT-747; 6-ECDCA; 6-Ethylchenodeoxycholic acid	FXR Autophagy	Others
Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC₅₀ of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces *autophagy* .

HY-15531

Venetoclax 120+ Cited Publications ABT-199; GDC-0199; RG7601	Bcl-2 Family Autophagy	Cancer
Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable *Bcl-2* inhibitor with a K_i of less than 0.01 nM. Venetoclax induces *autophagy* .

HY-N2117

Isoginkgetin 10+ Cited Publications	MMP Akt NF-κB Proteasome Apoptosis Autophagy	Inflammation/Immunology Cancer
Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates *autophagy* .

HY-N2959

Brevilin A 3 Publications Verification	JAK STAT Apoptosis Autophagy	Cancer
Brevilin A is an orally active STAT3/JAK inhibitor (STAT3 IC₅₀= 10.6 µM). Brevilin A shows anti-tumor activity, anti-proliferative activity to cancer cells, and can induce apoptosis and *autophagy* .

HY-110067

VO-OHPic	PTEN Apoptosis Autophagy	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
VO-OHPic is a reversible, noncompetitive and selective PTEN inhibitor with an IC₅₀ of 46 nM. VO-OHPic attenuates apoptosis, adverse cardiac remodeling, and pro-inflammatory M1 macrophages in doxorubicin-induced cardiomyopathy. VO-OHPic inhibits *autophagy* .

HY-17394R

Cisplatin (Standard) cis-PlatINum (Standard); CDDP (Standard); cis-DiamINodichloroplatINum (Standard)	DNA Alkylator/Crosslinker Ferroptosis Autophagy	Cancer
Cisplatin (Standard) is the analytical standard of Cisplatin. This product is intended for research and analytical applications. Cisplatin (CDDP) is an antineoplastic chemotherapy agent by cross-linking with DNA and causing DNA damage in cancer cells. Cisplatin activates ferroptosis and induces *autophagy* .

HY-B0015S1

Paclitaxel-d5 (benzoyloxy)	Microtubule/Tubulin ADC Cytotoxin Apoptosis Autophagy	Cancer
Paclitaxel-d₅ (benzoyloxy) is the deuterium labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy[1][2].

HY-10358

MK-2206 dihydrochloride 285+ Cited Publications MK-2206 (2HCl)	Organoid Akt Autophagy Apoptosis	Cancer
MK-2206 dihydrochloride (MK-2206 (2HCl)) is an orally active, BBB-penetrated allosteric AKT inhibitor with IC₅₀s of 5 nM, 12 nM, and 65 nM for AKT1, *AKT2, and AKT3, respectively. MK-2206 dihydrochloride induces autophagy* .

HY-12222S

Obeticholic acid-d5 INT-747-d₅; 6-ECDCA-d₅; 6-Ethylchenodeoxycholic acid-d₅	FXR Autophagy	Others
Obeticholic acid-d₅ is the deuterium labeled Obeticholic acid. Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC50 of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy[1][2][3].

HY-12222S1

Obeticholic Acid-d4	FXR Autophagy	Others
Obeticholic Acid-d₄ is the deuterium labeled Obeticholic acid. Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC50 of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy[1][2][3].

HY-15531S

Venetoclax-d8 ABT-199-d₈; GDC-0199-d₈; RG7601-d₈	Bcl-2 Family Autophagy	Cancer
Venetoclax-d₈ is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy[1][2][3].

HY-122571

Retro-2	Filovirus Parasite Autophagy	Infection Cancer
Retro-2 is a selective inhibitor of retrograde protein trafficking at the endosome-trans-Golgi network interface. Retro-2 is an ebolavirus (EBOV) infection inhibitor with an EC₅₀ of 12.2 µM in HeLa cells. Retro-2 induces cell *autophagy* .

HY-161102

[Ru(phen)2(xant)] hexafluorophosphate	Autophagy	Cancer
[Ru(phen)2(xant)] hexafluorophosphate is an inducer of *Autophagy*. [Ru(phen)2(xant)] hexafluorophosphate eliminates CRC stem cells by targeting the chaperone Hsp90. [Ru(phen)2(xant)] hexafluorophosphate reduces cell migration and invasion .

HY-N0585

(Rac)-Norcantharidin (Rac)-NCTD	Endogenous Metabolite	Cancer
(Rac)-Norcantharidin ((Rac)-NCTD) is the isoform of Norcantharidin, which is a synthetic and demethylated anticancer agent derived from Cantharidin (HY-N0209). Norcantharidin has lighter side effects and stronger bioactivity than Cantharidin. And Norcantharidin inhibits cell proliferation, migration and metastasis, and causes apoptosis and autophagy .

HY-100973A

Adenosine 5′-diphosphoribose sodium 2 Publications Verification ADP ribose sodium
Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD ⁺) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca ²⁺-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance *autophagy* .

HY-12661A

AMG PERK 44 3 Publications Verification	PERK Autophagy	Cancer
AMG PERK 44 is an orally active and highly selective PERK inhibitor with an IC₅₀ of 6 nM. AMG PERK 44 has 1000-fold and 160-fold selectivity over GCN2 (IC₅₀=7300 nM) and B-Raf (IC₅₀ >1000 nM), respectively. AMG PERK 44 induces *autophagy* .

HY-15311

Avermectin B1 4 Publications Verification AbamectIN; AvermectIN B1a-AvermectIN B1b mixt.	Parasite Autophagy Apoptosis Reactive Oxygen Species Antibiotic	Infection Inflammation/Immunology
Avermectin B1 (Abamectin) is a mixture of two similar segments of avermectin. Avermectin B1 is an orally anti-infection agent, which can be used in the research of parasitic worms, insect pests, agriculture and animal husbandry. Avermectin B1 can also induce the production of ROS and induces cytotoxicity, apoptosis and *autophagy* .

HY-N0047

Polyphyllin I 1 Publications Verification	JNK mTOR Akt PDK-1 Autophagy Apoptosis	Cancer
Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces *autophagy*, G2/M phase arrest and apoptosis ^[2] .

HY-15142

Doxorubicin hydrochloride 360+ Cited Publications HydroxydaunorubicIN hydrochloride	Topoisomerase ADC Cytotoxin AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial	Infection Cancer
Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy .

HY-149577

EBV lytic cycle inducer-1	EBV	Cancer
Epstein-Barr virus (EBV) lytic cycle inducer-1 Dp44mT (compound C7) is an iron-chelatoe-like compound. Dp44mT cooperates with HDAC inhibitor Romidespin (HY-15149) and SAHA to induce EBV lytic cycle. Dp44mT reactivates EBV lytic cycle by activating the *ERK1/2-autophagy* axis in epithelial cancers ^[2].

HY-157320

Tubulin/PARP-IN-2	Microtubule/Tubulin Apoptosis	Cancer
Tubulin/PARP-IN-2 (compound 14) is a dual PARP-Tubulin inhibitor. Tubulin/PARP-IN-2 inhibits PARP1, PARP2, and tubulin activity with IC₅₀ values of 74 nM, 109 nM, and 1.4 µM, respectively. Tubulin/PARP-IN-2 induces apoptosis as well as *autophagy*. Tubulin/PARP-IN-2 causes cell cycle arrest at the G2/M phase .

HY-10514

BX795 20+ Cited Publications	PDK-1 IKK Autophagy	Cancer
BX795 is a potent and selective inhibitor of PDK1, with an IC₅₀ of 6 nM. BX795 is also a potent and relatively specific inhibitor of TBK1 and IKKε, with an IC₅₀ of 6 and 41 nM, respectively. BX795 blocks phosphorylation of S6K1, Akt, PKCδ, and GSK3β, and has lower selectivity over PKA, PKC, c-Kit, GSK3β etc. BX795 modulates *autophagy* .

HY-10115

PI-103 15+ Cited Publications	PI3K mTOR DNA-PK Autophagy Apoptosis	Cancer
PI-103 is a potent PI3K and mTOR inhibitor with IC₅₀s of 8 nM, 88 nM, 48 nM, 150 nM, 20 nM, and 83 nM for p110α, p110β, p110δ, p110γ, mTORC1, and *mTORC2. PI-103 also inhibits DNA-PK* with an IC50 of 2 nM. PI-103 induces *autophagy* .

HY-10115A

PI-103 Hydrochloride 15+ Cited Publications	PI3K mTOR DNA-PK Autophagy Apoptosis	Cancer
PI-103 Hydrochloride is a dual PI3K and mTOR inhibitor with IC₅₀s of 8 nM, 88 nM, 48 nM, 150 nM, 20 nM, and 83 nM for p110α, p110β, p110δ, p110γ, mTORC1, and *mTORC2. PI-103 Hydrochloride also inhibits DNA-PK* with an IC50 of 2 nM. PI-103 Hydrochloride induces *autophagy* .

HY-15142A

Doxorubicin HydroxydaunorubicIN	ADC Cytotoxin Antibiotic Bacterial Topoisomerase AMPK HIV Autophagy Mitophagy Apoptosis HBV	Infection Cancer
Doxorubicin (Hydroxydaunorubicin), a broad-spectrum anthracycline antibiotic with cytotoxic properties, is an anti-cancer chemotherapy agent. Doxorubicin has fluorescence properties. Doxorubicin inhibits topoisomerase II with an IC₅₀ of 2.67 μM, thus stopping DNA replication. Doxorubicin reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin induces apoptosis and *autophagy* . Doxorubicin inhibits human DNA topoisomerase I with an IC₅₀ of 0.8 μM .

HY-139426A

(rel)-ML-SI3 trans-ML-SI3	TRP Channel Autophagy	Cancer
(rel)-ML-SI3 is the isomer of ML-SI3 (HY-139426). ML-SI3 is a TRPML Channel Inhibitor. ML-SI3 blocks TRPML1 and TRPML2 with IC₅₀s of 4.7 μM and 1.7 μM, respectively. ML-SI3 prevents lysosomal calcium efflux and blocks downstream TRPML1-mediated induction of *autophagy* .

HY-10182

Laduviglusib 140+ Cited Publications CHIR-99021; CT99021	Organoid GSK-3 Wnt β-catenin Autophagy	Metabolic Disease Cancer
Laduviglusib (CHIR-99021) is a potent, selective and orally active GSK-3α/β inhibitor with IC₅₀s of 10 nM and 6.7 nM. Laduviglusib shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib enhances mouse and human embryonic stem cells self-renewal. Laduviglusib induces *autophagy* .

HY-10182B

Laduviglusib trihydrochloride 140+ Cited Publications CHIR-99021 trihydrochloride; CT99021 trihydrochloride	Organoid GSK-3 Wnt β-catenin Autophagy	Cancer
Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3α/β inhibitor with IC₅₀s of 10 nM and 6.7 nM. Laduviglusib trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib trihydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib trihydrochloride induces *autophagy* .

HY-15425

PF-543 5+ Cited Publications SphINgosINe KINase 1 INhibitor II	SphK LPL Receptor Apoptosis Autophagy	Cardiovascular Disease Inflammation/Immunology Cancer
PF-543 (Sphingosine Kinase 1 Inhibitor II) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC₅₀ of 2 nM and a K_i of 3.6 nM. PF-543 is >100-fold selectivity for SPHK1 over SPHK2. PF-543 is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC₅₀ of 26.7 nM. PF-543 induces apoptosis, necrosis, and *autophagy* .

HY-15425B

PF-543 hydrochloride SphINgosINe KINase 1 INhibitor II hydrochloride	SphK LPL Receptor Apoptosis Autophagy	Cardiovascular Disease Inflammation/Immunology Cancer
PF-543 hydrochloride (Sphingosine Kinase 1 Inhibitor II hydrochloride) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC₅₀ of 2 nM and a K_i of 3.6 nM. PF-543 hydrochloride is >100-fold selectivity for SPHK1 over SPHK2. PF-543 hydrochloride is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC₅₀ of 26.7 nM. PF-543 hydrochloride induces apoptosis, necrosis, and *autophagy* .

HY-15425A

PF-543 Citrate 5+ Cited Publications SphINgosINe KINase 1 INhibitor II Citrate	SphK LPL Receptor Apoptosis Autophagy	Cardiovascular Disease Inflammation/Immunology Cancer
PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC₅₀ of 2 nM and a K_i of 3.6 nM. PF-543 Citrate is >100-fold selectivity for SPHK1 over SPHK2. PF-543 Citrate is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC₅₀ of 26.7 nM. PF-543 Citrate induces apoptosis, necrosis, and *autophagy* .

HY-10182A

Laduviglusib monohydrochloride 140+ Cited Publications CHIR-99021 monohydrochloride; CT99021 monohydrochloride	Organoid GSK-3 Wnt β-catenin Autophagy	Cancer
Laduviglusib (CHIR-99021) monohydrochloride is a potent and selective GSK-3α/β inhibitor with IC₅₀s of 10 nM and 6.7 nM. Laduviglusib monohydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib monohydrochloride is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib monohydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib monohydrochloride induces *autophagy* .

HY-12028

PD98059 280+ Cited Publications	MEK ERK Aryl Hydrocarbon Receptor Autophagy	Cancer
PD98059 is a potent and selective MEK inhibitor with an IC₅₀ of 5 µM. PD98059 binds to the inactive form of MEK, thereby preventing the activation of MEK1 (IC₅₀ of 2-7 µM) and *MEK2* (IC₅₀ of 50 µM) by upstream kinases. PD98059 is a *ERK1/2* signaling inhibitor. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR), and suppresses TCDD binding (IC₅₀ of 4 μM) and AHR transformation (IC₅₀ of 1 μM). PD98059 also inhibits Mycobacterium bovis Bacillus CalmetteGuerin (BCG)-induced *autophagy* .

HY-12795

Vps34-IN-1 5+ Cited Publications	PI3K Autophagy	Cancer
Vps34-IN-1 is a potent and selective inhibitor of class III Vps34 PI3K. Vps34-IN-1 inhibits phosphorylation of PtdIns by recombinant insect cell expressed Vps34-Vps15 complex with an IC₅₀ of ~25 nM. Vps34-IN-1 can suppress SGK3 activation by reducing PtdIns(3)P levels via lowering phosphorylation of T-loop and hydrophobic motifs. Vps34-IN-1 modulates *autophagy* .

Autophagy Compound Library	1371 compounds
Autophagy is a lysosomal degradation pathway that is essential for cell survival, differentiation, development, and homeostasis. The process of autophagy in mammalian cells is as follows: a portion of cytoplasm, including organelles, is enclosed by a phagophore or isolation membrane to form an autophagosome. The outer membrane of the autophagosome subsequently fuses with the endosome and then the lysosome, and the internal material is degraded. Autophagy plays a wide variety of physiological and pathophysiological roles. Defective autophagy contributes to various pathologies, including infections, cancer, neurodegeneration, aging, and heart disease. MCE provides a unique collection of 1371 autophagy pathway-related compounds that is a useful tool for the research of autophagy-related regulation and diseases.

Cat. No.	Product Name	Category	Target	Chemical Structure