1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
    Apoptosis
    Autophagy
  2. JAK
    STAT
    Apoptosis
    Autophagy
  3. Brevilin A

Brevilin A 

Cat. No.: HY-N2959 Purity: >99.0%
Handling Instructions

Brevilin A is a sesquiterpene lactone isolated from Centipeda minima with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50 = 10.6 µM) in Cancer Cells. Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26.

For research use only. We do not sell to patients.

Brevilin A Chemical Structure

Brevilin A Chemical Structure

CAS No. : 16503-32-5

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5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 430 In-stock
Estimated Time of Arrival: December 31
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Description

Brevilin A is a sesquiterpene lactone isolated from Centipeda minima with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50 = 10.6 µM) in Cancer Cells. Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26[1][2].

IC50 & Target

IC50: 10.6 µM (STAT3 signaling)[1]

Molecular Weight

346.42

Formula

C₂₀H₂₆O₅

CAS No.

16503-32-5

SMILES
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Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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Brevilin A
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