2. Autophagy
  3. Autophagy
  4. Licochalcone A

Licochalcone A (LCA), a flavonoid isolated, presents obvious anti-cancer effects, displays broad-spectrum inhibition against UDP-glucuronosyltransferases (UGTs). Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC50 and Ki values lower than 5 μM) .

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CAS No. : 58749-22-7

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Customer Review

Based on 19 publication(s) in Google Scholar

Other Forms of Licochalcone A:

Licochalcone A Related Antibodies

Top Publications Citing Use of Products

    Licochalcone A purchased from MedChemExpress. Usage Cited in: Exploration (Beijing). 2025 May 25;5(5):20240198.

    SPR analysis verifies direct binding between LCA and STIP1. Sensorgram shows response over time as Licochalcone A (LCA; 0.6215, 1.25, 2.5, 5, 10, 20 μM) passes over STIP1-conjugated chip.

    Licochalcone A purchased from MedChemExpress. Usage Cited in: Exploration (Beijing). 2025 May 25;5(5):20240198.

    After treat various doses of Licochalcone A (LCA; 0, 0.5, 5, 10 μM) , AHCY, LDHA, PKM2 and ALDOA protein level were measured by western blot in KYSE30, KYSE450 cells.

    Licochalcone A purchased from MedChemExpress. Usage Cited in: Exploration (Beijing). 2025 May 25;5(5):20240198.

    Licochalcone A (LCA; 0, 10 μM) decreased glucose consumption, lactate secretion in KYSE30, KYSE450 cells.

    Licochalcone A purchased from MedChemExpress. Usage Cited in: Exploration (Beijing). 2025 May 25;5(5):20240198.

    Licochalcone A (LCA; 0, 10 μM) decreased ECAR reflective of glycolytic flux in KYSE30 cells, reflecting impaired glycolysis.

    Licochalcone A purchased from MedChemExpress. Usage Cited in: Exploration (Beijing). 2025 May 25;5(5):20240198.

    Licochalcone A (LCA; 0, 0.5， 5，10 μM； 24, 48, 72 h) dose-dependently reduces ESCC cell proliferation by MTT assay.

    Licochalcone A purchased from MedChemExpress. Usage Cited in: Exploration (Beijing). 2025 May 25;5(5):20240198.

    Licochalcone A (LCA； 10, 20 mg/kg; po; four times per week) for in 6‐week‐old female NOD/SCID mice ( fresh surgical ESCC tissues) significantly decreased tumor volumes and weights in two ESCC PDX models.

    Licochalcone A purchased from MedChemExpress. Usage Cited in: Exploration (Beijing). 2025 May 25;5(5):20240198.

    Licochalcone A (LCA; 10, 20 mg/kg; po; four times per week) for in 6‐week‐old female NOD/SCID mice ( fresh surgical ESCC tissues) decreased proliferation marker Ki67 and increased apoptosis marker Bax of of PDX tumors.

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    Description

    Licochalcone A (LCA), a flavonoid isolated, presents obvious anti-cancer effects, displays broad-spectrum inhibition against UDP-glucuronosyltransferases (UGTs)[1]. Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC50 and Ki values lower than 5 μM) [2].

    Cellular Effect
    Cell Line Type Value Description References
    BV-2 IC50
    0.625 μg/mL
    Compound: 142
    Antiinflammatory activity in LPS-induced mouse BV-2 cells assessed as reduction in COX-2 protein expression by Western blot analysis
    Antiinflammatory activity in LPS-induced mouse BV-2 cells assessed as reduction in COX-2 protein expression by Western blot analysis
    		[PMID: 37683361]
    CHO-K1 IC50
    508.3 μM
    Compound: 118
    Cytotoxicity against CHO-K1 cells incubated for 24 hrs by colorimetric assay
    Cytotoxicity against CHO-K1 cells incubated for 24 hrs by colorimetric assay
    		[PMID: 33479649]
    Erythrocyte IC50
    1.43 μg/mL
    Compound: 61
    Antiplasmodial activity against mixture of chloroquine resistant Plasmodium falciparum RKL 303-chloroquine sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as inhibition of parasite growth incubated for 48 hrs by Giemsa staining based microscopic analysis
    Antiplasmodial activity against mixture of chloroquine resistant Plasmodium falciparum RKL 303-chloroquine sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as inhibition of parasite growth incubated for 48 hrs by Giemsa staining based microscopic analysis
    		[PMID: 35985254]
    GES1 IC50
    > 180 μM
    Compound: Licochalcone A
    Cytotoxicity against human GES-1 cells
    Cytotoxicity against human GES-1 cells
    		[PMID: 32347726]
    HEK-293T IC50
    4.2 μg/mL
    Compound: 2
    Inhibition of oseltamivir-resistant H1N1 swine influenza virus neuraminidase H274Y mutant activity expressed in HEK293T cells after 2 hrs by spectrofluorometry
    Inhibition of oseltamivir-resistant H1N1 swine influenza virus neuraminidase H274Y mutant activity expressed in HEK293T cells after 2 hrs by spectrofluorometry
    		[PMID: 21123068]
    HEK-293T IC50
    5.42 μg/mL
    Compound: 2
    Inhibition of wild type H1N1 swine influenza virus neuraminidase activity expressed in HEK293T cells after 2 hrs by spectrofluorometry
    Inhibition of wild type H1N1 swine influenza virus neuraminidase activity expressed in HEK293T cells after 2 hrs by spectrofluorometry
    		[PMID: 21123068]
    HEK293 IC50
    0.28 nM
    Compound: Licochalcone A
    Effect on etoposide-induced cytotoxicity against HEK293 cells by measuring etoposide IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb =0.21 +/- 0.04 uM)
    Effect on etoposide-induced cytotoxicity against HEK293 cells by measuring etoposide IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb =0.21 +/- 0.04 uM)
    		[PMID: 32347726]
    HEK293 IC50
    0.3 nM
    Compound: Licochalcone A
    Effect on etoposide-induced cytotoxicity against HEK293 cells by measuring etoposide IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb =0.21 +/- 0.04 uM)
    Effect on etoposide-induced cytotoxicity against HEK293 cells by measuring etoposide IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb =0.21 +/- 0.04 uM)
    		[PMID: 32347726]
    HEK293 IC50
    0.3 nM
    Compound: Licochalcone A
    Effect on etoposide-induced cytotoxicity against HEK293 cells by measuring etoposide IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb =0.21 +/- 0.04 uM)
    Effect on etoposide-induced cytotoxicity against HEK293 cells by measuring etoposide IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb =0.21 +/- 0.04 uM)
    		[PMID: 32347726]
    HEK293 IC50
    0.31 nM
    Compound: Licochalcone A
    Effect on etoposide-induced cytotoxicity against HEK293 cells by measuring etoposide IC50 at 0.5 uM after 72 hrs by CCK8 assay (Rvb =0.21 +/- 0.04 uM)
    Effect on etoposide-induced cytotoxicity against HEK293 cells by measuring etoposide IC50 at 0.5 uM after 72 hrs by CCK8 assay (Rvb =0.21 +/- 0.04 uM)
    		[PMID: 32347726]
    HEK293 IC50
    10 μM
    Compound: Licochalcone A
    Cytotoxicity against HEK293 cells after 72 hrs by CCK8 assay
    Cytotoxicity against HEK293 cells after 72 hrs by CCK8 assay
    		[PMID: 32347726]
    HEK293 IC50
    10 μM
    Compound: Licochalcone A
    Cytotoxicity against HEK293 cells overexpressing human ABCG2 after 72 hrs by CCK8 assay
    Cytotoxicity against HEK293 cells overexpressing human ABCG2 after 72 hrs by CCK8 assay
    		[PMID: 32347726]
    HEK293 IC50
    24.72 nM
    Compound: Licochalcone A
    Effect on topotecan-induced cytotoxicity against HEK293 cells by measuring topotecan IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 24.60 +/- 5.98 nM)
    Effect on topotecan-induced cytotoxicity against HEK293 cells by measuring topotecan IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 24.60 +/- 5.98 nM)
    		[PMID: 32347726]
    HEK293 IC50
    25.55 nM
    Compound: Licochalcone A
    Effect on topotecan-induced cytotoxicity against HEK293 cells by measuring topotecan IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 24.60 +/- 5.98 nM)
    Effect on topotecan-induced cytotoxicity against HEK293 cells by measuring topotecan IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 24.60 +/- 5.98 nM)
    		[PMID: 32347726]
    HEK293 IC50
    25.89 nM
    Compound: Licochalcone A
    Effect on topotecan-induced cytotoxicity against HEK293 cells by measuring topotecan IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 24.60 +/- 5.98 nM)
    Effect on topotecan-induced cytotoxicity against HEK293 cells by measuring topotecan IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 24.60 +/- 5.98 nM)
    		[PMID: 32347726]
    HEK293 IC50
    26.83 nM
    Compound: Licochalcone A
    Effect on topotecan-induced cytotoxicity against HEK293 cells by measuring topotecan IC50 at 0.5 uM after 72 hrs by CCK8 assay (Rvb = 24.60 +/- 5.98 nM)
    Effect on topotecan-induced cytotoxicity against HEK293 cells by measuring topotecan IC50 at 0.5 uM after 72 hrs by CCK8 assay (Rvb = 24.60 +/- 5.98 nM)
    		[PMID: 32347726]
    HEK293 IC50
    4.6 nM
    Compound: Licochalcone A
    Effect on mitoxantrone-induced cytotoxicity against HEK293 cells by measuring mitoxantrone IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 4.70 +/- 0.99 nM)
    Effect on mitoxantrone-induced cytotoxicity against HEK293 cells by measuring mitoxantrone IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 4.70 +/- 0.99 nM)
    		[PMID: 32347726]
    HEK293 IC50
    4.74 nM
    Compound: Licochalcone A
    Effect on mitoxantrone-induced cytotoxicity against HEK293 cells by measuring mitoxantrone IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 4.70 +/- 0.99 nM)
    Effect on mitoxantrone-induced cytotoxicity against HEK293 cells by measuring mitoxantrone IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 4.70 +/- 0.99 nM)
    		[PMID: 32347726]
    HEK293 IC50
    4.78 nM
    Compound: Licochalcone A
    Effect on mitoxantrone-induced cytotoxicity against HEK293 cells by measuring mitoxantrone IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 4.70 +/- 0.99 nM)
    Effect on mitoxantrone-induced cytotoxicity against HEK293 cells by measuring mitoxantrone IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 4.70 +/- 0.99 nM)
    		[PMID: 32347726]
    HEK293 IC50
    5.11 nM
    Compound: Licochalcone A
    Effect on mitoxantrone-induced cytotoxicity against HEK293 cells by measuring mitoxantrone IC50 at 0.5 uM after 72 hrs by CCK8 assay (Rvb = 4.70 +/- 0.99 nM)
    Effect on mitoxantrone-induced cytotoxicity against HEK293 cells by measuring mitoxantrone IC50 at 0.5 uM after 72 hrs by CCK8 assay (Rvb = 4.70 +/- 0.99 nM)
    		[PMID: 32347726]
    HEK293 IC50
    7.99 nM
    Compound: Licochalcone A
    Effect on Colchicine-induced cytotoxicity against HEK293 cells by measuring colchicine IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 8.42 +/- 3 nM)
    Effect on Colchicine-induced cytotoxicity against HEK293 cells by measuring colchicine IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 8.42 +/- 3 nM)
    		[PMID: 32347726]
    HEK293 IC50
    8.67 nM
    Compound: Licochalcone A
    Effect on Colchicine-induced cytotoxicity against HEK293 cells by measuring colchicine IC50 at 0.5 uM after 72 hrs by CCK8 assay (Rvb = 8.42 +/- 3 nM)
    Effect on Colchicine-induced cytotoxicity against HEK293 cells by measuring colchicine IC50 at 0.5 uM after 72 hrs by CCK8 assay (Rvb = 8.42 +/- 3 nM)
    		[PMID: 32347726]
    HEK293 IC50
    8.9 nM
    Compound: Licochalcone A
    Effect on Colchicine-induced cytotoxicity against HEK293 cells by measuring colchicine IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 8.42 +/- 3 nM)
    Effect on Colchicine-induced cytotoxicity against HEK293 cells by measuring colchicine IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 8.42 +/- 3 nM)
    		[PMID: 32347726]
    HEK293 IC50
    9.03 nM
    Compound: Licochalcone A
    Effect on Colchicine-induced cytotoxicity against HEK293 cells by measuring colchicine IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 8.42 +/- 3 nM)
    Effect on Colchicine-induced cytotoxicity against HEK293 cells by measuring colchicine IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 8.42 +/- 3 nM)
    		[PMID: 32347726]
    HK-2 IC50
    88.7 μM
    Compound: 4
    Cytotoxicity against human HK2 cells assessed as reduction in cell viability after 24 to 48 hrs by MTT assay
    Cytotoxicity against human HK2 cells assessed as reduction in cell viability after 24 to 48 hrs by MTT assay
    		[PMID: 31539776]
    HT-1080 IC50
    10.75 μM
    Compound: Licochalcone A
    Antiproliferative activity against human HT1080 cells harboring IDH1-R132C mutation incubated for 48 hrs
    Antiproliferative activity against human HT1080 cells harboring IDH1-R132C mutation incubated for 48 hrs
    		[PMID: 31836442]
    HeLa IC50
    48.5 μM
    Compound: 4
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay
    Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay
    		[PMID: 31539776]
    Hepatocyte IC50
    0.927 nM
    Compound: Licochalcone A
    Antimicrobial activity against Plasmodium yoelii 265 liver infected in mammalian hepatocytes after 48 hrs
    Antimicrobial activity against Plasmodium yoelii 265 liver infected in mammalian hepatocytes after 48 hrs
    		[PMID: 18212104]
    MCF7 IC50
    22 μM
    Compound: 4
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 24 to 48 hrs by MTS assay
    Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 24 to 48 hrs by MTS assay
    		[PMID: 31539776]
    MDA-MB-231 IC50
    22 μM
    Compound: 4
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 24 to 48 hrs by MTS assay
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 24 to 48 hrs by MTS assay
    		[PMID: 31539776]
    MSTO-211H IC50
    26 μM
    Compound: 4
    Cytotoxicity against human MSTO-211H cells assessed as reduction in cell viability after 24 to 48 hrs by MTS assay
    Cytotoxicity against human MSTO-211H cells assessed as reduction in cell viability after 24 to 48 hrs by MTS assay
    		[PMID: 31539776]
    NCI-H28 IC50
    30 μM
    Compound: 4
    Cytotoxicity against human NCI-H28 cells assessed as reduction in cell viability after 24 to 48 hrs by MTS assay
    Cytotoxicity against human NCI-H28 cells assessed as reduction in cell viability after 24 to 48 hrs by MTS assay
    		[PMID: 31539776]
    NCI-H460 IC50
    10 μM
    Compound: Licochalcone A
    Cytotoxicity against human H460 cells after 72 hrs by MTT assay
    Cytotoxicity against human H460 cells after 72 hrs by MTT assay
    		[PMID: 32347726]
    NCI-H460 IC50
    19.84 nM
    Compound: Licochalcone A
    Effect on mitoxantrone-induced cytotoxicity against human H460 cells by measuring mitoxantrone IC50 at 1 uM after 72 hrs by MTT assay (Rvb = 21.61 +/- 5.85 nM)
    Effect on mitoxantrone-induced cytotoxicity against human H460 cells by measuring mitoxantrone IC50 at 1 uM after 72 hrs by MTT assay (Rvb = 21.61 +/- 5.85 nM)
    		[PMID: 32347726]
    NCI-H460 IC50
    20.1 nM
    Compound: Licochalcone A
    Effect on mitoxantrone-induced cytotoxicity against human H460 cells by measuring mitoxantrone IC50 at 2 uM after 72 hrs by MTT assay (Rvb = 21.61 +/- 5.85 nM)
    Effect on mitoxantrone-induced cytotoxicity against human H460 cells by measuring mitoxantrone IC50 at 2 uM after 72 hrs by MTT assay (Rvb = 21.61 +/- 5.85 nM)
    		[PMID: 32347726]
    NCI-H460 IC50
    20.34 nM
    Compound: Licochalcone A
    Effect on mitoxantrone-induced cytotoxicity against human H460 cells by measuring mitoxantrone IC50 at 3 uM after 72 hrs by MTT assay (Rvb = 21.61 +/- 5.85 nM)
    Effect on mitoxantrone-induced cytotoxicity against human H460 cells by measuring mitoxantrone IC50 at 3 uM after 72 hrs by MTT assay (Rvb = 21.61 +/- 5.85 nM)
    		[PMID: 32347726]
    NCI-H460 IC50
    21.69 nM
    Compound: Licochalcone A
    Effect on topotecan-induced cytotoxicity against human H460 cells by measuring topotecan IC50 at 2 uM after 72 hrs by MTT assay (Rvb = 37.42 +/- 5.45 nM)
    Effect on topotecan-induced cytotoxicity against human H460 cells by measuring topotecan IC50 at 2 uM after 72 hrs by MTT assay (Rvb = 37.42 +/- 5.45 nM)
    		[PMID: 32347726]
    NCI-H460 IC50
    22.41 nM
    Compound: Licochalcone A
    Effect on topotecan-induced cytotoxicity against human H460 cells by measuring topotecan IC50 at 1 uM after 72 hrs by MTT assay (Rvb = 37.42 +/- 5.45 nM)
    Effect on topotecan-induced cytotoxicity against human H460 cells by measuring topotecan IC50 at 1 uM after 72 hrs by MTT assay (Rvb = 37.42 +/- 5.45 nM)
    		[PMID: 32347726]
    NCI-H460 IC50
    22.52 nM
    Compound: Licochalcone A
    Effect on topotecan-induced cytotoxicity against human H460 cells by measuring topotecan IC50 at 3 uM after 72 hrs by MTT assay (Rvb = 37.42 +/- 5.45 nM)
    Effect on topotecan-induced cytotoxicity against human H460 cells by measuring topotecan IC50 at 3 uM after 72 hrs by MTT assay (Rvb = 37.42 +/- 5.45 nM)
    		[PMID: 32347726]
    NCI-H460 IC50
    25.54 nM
    Compound: Licochalcone A
    Effect on topotecan-induced cytotoxicity against human H460 cells by measuring topotecan IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 37.42 +/- 5.45 nM)
    Effect on topotecan-induced cytotoxicity against human H460 cells by measuring topotecan IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 37.42 +/- 5.45 nM)
    		[PMID: 32347726]
    NCI-H460 IC50
    25.91 nM
    Compound: Licochalcone A
    Effect on mitoxantrone-induced cytotoxicity against human H460 cells by measuring mitoxantrone IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 21.61 +/- 5.85 nM)
    Effect on mitoxantrone-induced cytotoxicity against human H460 cells by measuring mitoxantrone IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 21.61 +/- 5.85 nM)
    		[PMID: 32347726]
    RBL-2H3 IC50
    17 μM
    Compound: LicoA
    Antiinflammatory activity in RBL2H3 cells assessed as inhibition of degranulation
    Antiinflammatory activity in RBL2H3 cells assessed as inhibition of degranulation
    		[PMID: 24316124]
    S1 IC50
    10 μM
    Compound: Licochalcone A
    Cytotoxicity against human S1 cells after 72 hrs by MTT assay
    Cytotoxicity against human S1 cells after 72 hrs by MTT assay
    		[PMID: 32347726]
    S1 IC50
    10.7 nM
    Compound: Licochalcone A
    Effect on topotecan-induced cytotoxicity against human S1 cells by measuring topotecan IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 9.21 +/- 1.45 nM)
    Effect on topotecan-induced cytotoxicity against human S1 cells by measuring topotecan IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 9.21 +/- 1.45 nM)
    		[PMID: 32347726]
    S1 IC50
    11.01 nM
    Compound: Licochalcone A
    Effect on topotecan-induced cytotoxicity against human S1 cells by measuring topotecan IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 9.21 +/- 1.45 nM)
    Effect on topotecan-induced cytotoxicity against human S1 cells by measuring topotecan IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 9.21 +/- 1.45 nM)
    		[PMID: 32347726]
    S1 IC50
    11.74 nM
    Compound: Licochalcone A
    Effect on topotecan-induced cytotoxicity against human S1 cells by measuring topotecan IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 9.21 +/- 1.45 nM)
    Effect on topotecan-induced cytotoxicity against human S1 cells by measuring topotecan IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 9.21 +/- 1.45 nM)
    		[PMID: 32347726]
    S1 IC50
    4.44 nM
    Compound: Licochalcone A
    Effect on mitoxantrone-induced cytotoxicity against human S1 cells by measuring mitoxantrone IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 4.83 +/- 0.83 nM)
    Effect on mitoxantrone-induced cytotoxicity against human S1 cells by measuring mitoxantrone IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 4.83 +/- 0.83 nM)
    		[PMID: 32347726]
    S1 IC50
    4.53 nM
    Compound: Licochalcone A
    Effect on mitoxantrone-induced cytotoxicity against human S1 cells by measuring mitoxantrone IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 4.83 +/- 0.83 nM)
    Effect on mitoxantrone-induced cytotoxicity against human S1 cells by measuring mitoxantrone IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 4.83 +/- 0.83 nM)
    		[PMID: 32347726]
    S1 IC50
    4.55 nM
    Compound: Licochalcone A
    Effect on mitoxantrone-induced cytotoxicity against human S1 cells by measuring mitoxantrone IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 4.83 +/- 0.83 nM)
    Effect on mitoxantrone-induced cytotoxicity against human S1 cells by measuring mitoxantrone IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 4.83 +/- 0.83 nM)
    		[PMID: 32347726]
    S1 IC50
    4.73 nM
    Compound: Licochalcone A
    Effect on mitoxantrone-induced cytotoxicity against human S1 cells by measuring mitoxantrone IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 4.83 +/- 0.83 nM)
    Effect on mitoxantrone-induced cytotoxicity against human S1 cells by measuring mitoxantrone IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 4.83 +/- 0.83 nM)
    		[PMID: 32347726]
    S1 IC50
    9.73 nM
    Compound: Licochalcone A
    Effect on topotecan-induced cytotoxicity against human S1 cells by measuring topotecan IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 9.21 +/- 1.45 nM)
    Effect on topotecan-induced cytotoxicity against human S1 cells by measuring topotecan IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 9.21 +/- 1.45 nM)
    		[PMID: 32347726]
    S1-M1-80 IC50
    0.31 μM
    Compound: Licochalcone A
    Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by measuring topotecan IC50 at 3 uM after 72 hrs by MTT assay (Rvb = 10.14 +/- 2.820 uM)
    Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by measuring topotecan IC50 at 3 uM after 72 hrs by MTT assay (Rvb = 10.14 +/- 2.820 uM)
    		[PMID: 32347726]
    S1-M1-80 IC50
    0.41 μM
    Compound: Licochalcone A
    Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by measuring topotecan IC50 at 2 uM after 72 hrs by MTT assay (Rvb = 10.14 +/- 2.820 uM)
    Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by measuring topotecan IC50 at 2 uM after 72 hrs by MTT assay (Rvb = 10.14 +/- 2.820 uM)
    		[PMID: 32347726]
    S1-M1-80 IC50
    0.61 μM
    Compound: Licochalcone A
    Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by measuring topotecan IC50 at 1 uM after 72 hrs by MTT assay (Rvb = 10.14 +/- 2.820 uM)
    Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by measuring topotecan IC50 at 1 uM after 72 hrs by MTT assay (Rvb = 10.14 +/- 2.820 uM)
    		[PMID: 32347726]
    S1-M1-80 IC50
    1.03 μM
    Compound: Licochalcone A
    Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by measuring topotecan IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 10.14 +/- 2.820 uM)
    Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by measuring topotecan IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 10.14 +/- 2.820 uM)
    		[PMID: 32347726]
    S1-M1-80 IC50
    1.53 μM
    Compound: Licochalcone A
    Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 3 uM after 72 hrs by MTT assay (Rvb = 73.62 +/- 7.20 uM)
    Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 3 uM after 72 hrs by MTT assay (Rvb = 73.62 +/- 7.20 uM)
    		[PMID: 32347726]
    S1-M1-80 IC50
    10 μM
    Compound: Licochalcone A
    Cytotoxicity against human S1-M1-80 cells harboring ABCG2 (unknown origin) after 72 hrs by MTT assay
    Cytotoxicity against human S1-M1-80 cells harboring ABCG2 (unknown origin) after 72 hrs by MTT assay
    		[PMID: 32347726]
    S1-M1-80 IC50
    2.63 μM
    Compound: Licochalcone A
    Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 2 uM after 72 hrs by MTT assay (Rvb = 73.62 +/- 7.20 uM)
    Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 2 uM after 72 hrs by MTT assay (Rvb = 73.62 +/- 7.20 uM)
    		[PMID: 32347726]
    S1-M1-80 IC50
    39.47 μM
    Compound: Licochalcone A
    Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 73.62 +/- 7.20 uM)
    Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 73.62 +/- 7.20 uM)
    		[PMID: 32347726]
    S1-M1-80 IC50
    6.8 μM
    Compound: Licochalcone A
    Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 1 uM after 72 hrs by MTT assay (Rvb = 73.62 +/- 7.20 uM)
    Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 1 uM after 72 hrs by MTT assay (Rvb = 73.62 +/- 7.20 uM)
    		[PMID: 32347726]
    SiHa IC50
    42.2 μM
    Compound: 4
    Cytotoxicity against human SiHa cells assessed as reduction in cell viability after 24 hrs by MTT assay
    Cytotoxicity against human SiHa cells assessed as reduction in cell viability after 24 hrs by MTT assay
    		[PMID: 31539776]
    U-87MG ATCC IC50
    > 50 μM
    Compound: Licochalcone A
    Cytotoxicity against human U87MG cells harboring wild type IDH1 incubated for 48 hrs
    Cytotoxicity against human U87MG cells harboring wild type IDH1 incubated for 48 hrs
    		[PMID: 31836442]
    WI-38 IC50
    90.2 μM
    Compound: 4
    Cytotoxicity against human WI38 cells assessed as reduction in cell viability after 24 to 48 hrs by MTT assay
    Cytotoxicity against human WI38 cells assessed as reduction in cell viability after 24 to 48 hrs by MTT assay
    		[PMID: 31539776]
    In Vitro

    Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC50 and Ki values lower than 5 μM)[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Licochalcone A Related Antibodies
    Clinical Trial
    Molecular Weight

    338.40

    Formula

    C21H22O4
    CAS No.
    Appearance

    Solid

    Color

    Yellow to orange

    SMILES

    O=C(C1=CC=C(O)C=C1)/C=C/C2=CC(C(C)(C)C=C)=C(O)C=C2OC
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 125 mg/mL (369.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.9551 mL 14.7754 mL 29.5508 mL
    5 mM 0.5910 mL 2.9551 mL 5.9102 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (7.39 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

    • Protocol 2

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: 2.08 mg/mL (6.15 mM); Suspended solution; Need ultrasonic

      This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.76%

    SDS (393 KB)

    COA (246 KB) HNMR (267 KB) LCMS (94 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.9551 mL 14.7754 mL 29.5508 mL 73.8771 mL
    5 mM 0.5910 mL 2.9551 mL 5.9102 mL 14.7754 mL
    10 mM 0.2955 mL 1.4775 mL 2.9551 mL 7.3877 mL
    15 mM 0.1970 mL 0.9850 mL 1.9701 mL 4.9251 mL
    20 mM 0.1478 mL 0.7388 mL 1.4775 mL 3.6939 mL
    25 mM 0.1182 mL 0.5910 mL 1.1820 mL 2.9551 mL
    30 mM 0.0985 mL 0.4925 mL 0.9850 mL 2.4626 mL
    40 mM 0.0739 mL 0.3694 mL 0.7388 mL 1.8469 mL
    50 mM 0.0591 mL 0.2955 mL 0.5910 mL 1.4775 mL
    60 mM 0.0493 mL 0.2463 mL 0.4925 mL 1.2313 mL
    80 mM 0.0369 mL 0.1847 mL 0.3694 mL 0.9235 mL
    100 mM 0.0296 mL 0.1478 mL 0.2955 mL 0.7388 mL
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Licochalcone A Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Licochalcone A58749-22-7AutophagyInhibitorinhibitorinhibit

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