1. Apoptosis
    Autophagy
  2. Bcl-2 Family
    Autophagy
  3. Venetoclax-d8

Venetoclax-d8 (Synonyms: ABT-199-d8; GDC-0199-d8)

Cat. No.: HY-15531S
Handling Instructions

Venetoclax-d8 is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy.

For research use only. We do not sell to patients.

Venetoclax-d8 Chemical Structure

Venetoclax-d8 Chemical Structure

CAS No. : 1257051-06-1

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Description

Venetoclax-d8 is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

876.49

Formula

C45H42D8ClN7O7S

CAS No.
SMILES

O=C(NS(=O)(C1=CC=C(NCC2CCOCC2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N4C([2H])([2H])C([2H])([2H])N(CC5=C(C6=CC=C(Cl)C=C6)CC(C)(C)CC5)C([2H])([2H])C4([2H])[2H])C=C3OC7=CN=C(NC=C8)C8=C7

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Venetoclax-d8
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