Venetoclax-d₈ (Synonyms: ABT-199-d₈; GDC-0199-d₈; RG7601-d₈)

Cat. No.: HY-15531S: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Venetoclax-d₈ is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy[1][2][3].

For research use only. We do not sell to patients.

Venetoclax-d<sub>8</sub> Chemical Structure

Venetoclax-d₈ Chemical Structure

CAS No. : 1257051-06-1

Size	Price	Stock
1 mg	USD 390	Ask For Quote & Lead Time
5 mg	USD 980	Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of Venetoclax-d₈:

Venetoclax In-stock

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

876.49

Formula

C₄₅H₄₂D₈ClN₇O₇S

CAS No.

1257051-06-1

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NS(=O)(C1=CC=C(NCC2CCOCC2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N4C([2H])([2H])C([2H])([2H])N(CC5=C(C6=CC=C(Cl)C=C6)CC(C)(C)CC5)C([2H])([2H])C4([2H])[2H])C=C3OC7=CN=C(NC=C8)C8=C7

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (142.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1409 mL	5.7046 mL	11.4091 mL
5 mM	0.2282 mL	1.1409 mL	2.2818 mL
10 mM	0.1141 mL	0.5705 mL	1.1409 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.05%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (253 KB) HNMR (303 KB) RP-HPLC (81 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Souers AJ, et al. ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med. 2013 Feb;19(2):202-8. [Content Brief]

[3]. Peirs S, et al. ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia. Blood. 2014 Dec 11;124(25):3738-47. [Content Brief]

[4]. Bi C, et al. Inhibition of 4EBP phosphorylation mediates the cytotoxic effect of mechanistic target of rapamycin kinase inhibitors in aggressive B-cell lymphomas. Haematologica. 2017 Apr;102(4):755-764. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1409 mL	5.7046 mL	11.4091 mL	28.5229 mL
	5 mM	0.2282 mL	1.1409 mL	2.2818 mL	5.7046 mL
	10 mM	0.1141 mL	0.5705 mL	1.1409 mL	2.8523 mL
	15 mM	0.0761 mL	0.3803 mL	0.7606 mL	1.9015 mL
	20 mM	0.0570 mL	0.2852 mL	0.5705 mL	1.4261 mL
	25 mM	0.0456 mL	0.2282 mL	0.4564 mL	1.1409 mL
	30 mM	0.0380 mL	0.1902 mL	0.3803 mL	0.9508 mL
	40 mM	0.0285 mL	0.1426 mL	0.2852 mL	0.7131 mL
	50 mM	0.0228 mL	0.1141 mL	0.2282 mL	0.5705 mL
	60 mM	0.0190 mL	0.0951 mL	0.1902 mL	0.4754 mL
	80 mM	0.0143 mL	0.0713 mL	0.1426 mL	0.3565 mL
	100 mM	0.0114 mL	0.0570 mL	0.1141 mL	0.2852 mL

Venetoclax-d₈ Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Venetoclax-d₈1257051-06-1ABT-199-d₈ GDC-0199-d₈ RG7601-d₈Bcl-2 FamilyAutophagyInhibitorinhibitorinhibit

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Venetoclax-d8 (Synonyms: ABT-199-d8; GDC-0199-d8; RG7601-d8)

Other Forms of Venetoclax-d8:

Venetoclax-d8 Related Antibodies