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Results for "

TNF-alpha-IN-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	TNF Receptor (20) Adrenergic Receptor (3) Akt (1) AMPK (1) Apoptosis (1) Autophagy (1) Bacterial (2) Bcl-2 Family (1) Caspase (1) COX (3) EGFR (1) Epigenetic Reader Domain (1) Histone Demethylase (1) Interleukin Related (16) Isotope-Labeled Compounds (1) Keap1-Nrf2 (2) MMP (1) mTOR (1) NF-κB (1) NO Synthase (4) NOD-like Receptor (NLR) (1) p38 MAPK (2) Parasite (1) PARP (1) Phosphodiesterase (PDE) (1) PI3K (1) PKA (1) PKC (1) Reactive Oxygen Species (4) ROS Kinase (1) Toll-like Receptor (TLR) (1) Tyrosinase (2) VEGFR (3)
By Research Areas:	Cancer (9) Cardiovascular Disease (3) Infection (1) Inflammation/Immunology (34) Metabolic Disease (1) Neurological Disease (1)

By Targets:

TNF Receptor (20)

Adrenergic Receptor (3)

Akt (1)

AMPK (1)

Apoptosis (1)

Autophagy (1)

Bacterial (2)

Bcl-2 Family (1)

Caspase (1)

COX (3)

EGFR (1)

Epigenetic Reader Domain (1)

Histone Demethylase (1)

Interleukin Related (16)

Isotope-Labeled Compounds (1)

Keap1-Nrf2 (2)

MMP (1)

mTOR (1)

NF-κB (1)

NO Synthase (4)

NOD-like Receptor (NLR) (1)

p38 MAPK (2)

Parasite (1)

PARP (1)

Phosphodiesterase (PDE) (1)

PI3K (1)

PKA (1)

PKC (1)

Reactive Oxygen Species (4)

ROS Kinase (1)

Toll-like Receptor (TLR) (1)

Tyrosinase (2)

VEGFR (3)

By Research Areas:

Cancer (9)

Cardiovascular Disease (3)

Infection (1)

Inflammation/Immunology (34)

Metabolic Disease (1)

Neurological Disease (1)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: TNF Receptor 5 alpha Reductase IFNAR α-synuclein PGC-1α AIM2 NEKs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112275

TNF-α-IN-1

1 Publications Verification

TNF Receptor Inflammation/Immunology Cancer

TNF-α-IN-1 is a TNF-α inhibitor extracted from patent US20030096841A1, compound example I-7.

**TNF-α-IN-1** 1 Publications Verification	TNF Receptor	Inflammation/Immunology Cancer
TNF-α-IN-1 is a *TNF-α* inhibitor extracted from patent US20030096841A1, compound example I-7.

HY-118694

TAPI-0	TNF Receptor MMP Bacterial	Infection Cancer
TAPI-0 is a *TACE (TNF-α converting enzyme; ADAM17)* inhibitor with an IC₅₀ of 100 nM. TAPI-0 is a MMP inhibitor and also attenuates TNF-α processing .

HY-101041

(E)-AG 556

(E)-TyrphostIN AG 556

(E)-AG 556 is a highly selective EGFR inhibitor and also blocks LPS-induced TNF-α production .

(E)-AG 556 (E)-TyrphostIN AG 556
(E)-AG 556 is a highly selective EGFR inhibitor and also blocks LPS-induced TNF-α production .

HY-N0358

1,4-Dicaffeoylquinic acid 1 Publications Verification 1,4-DCQA	TNF Receptor Interleukin Related	Inflammation/Immunology
1,4-Dicaffeoylquinic acid (1,4-DCQA) is a phenylpropanoid from Xanthii fructus, inhibits LPS-stimulated TNF-α production .

HY-160027

*TNF-alpha-IN-1*	TNF Receptor	Inflammation/Immunology
TNF-alpha-IN-1 (compound 202) is an orally active inhibitor of *TNF-alpha*. TNF-alpha-IN-1 has anti-inflammatory activity which can used in study rheumatoid arthritis, psoriasis, and asthma .

HY-N9315

Episappanol	TNF Receptor Interleukin Related	Inflammation/Immunology
Episappanol is a natural compound isolated from Caesalpinia sappan heartwood with anti-inflammatory activity. Episappanol significantly inhibits the IL-6 and *TNF-α* secretion .

HY-126414

Methylenedihydrotanshinquinone	Others	Inflammation/Immunology
Methylenedihydrotanshinquinone is a natural product that can be isolated from the dried root of S. miltiorrhiza. Methylenedihydrotanshinquinone has anti-inflammatory effect by inhibiting expression of TNF-α, IL-1β, and IL-8 .

HY-126114

Lupeol acetate 1 Publications Verification	COX Interleukin Related	Inflammation/Immunology
Lupeol acetate, a derivative of Lupeol, suppresses the progression of rheumatoid arthritis (RA) by inhibiting the activation of macrophages and osteoclastogenesis through downregulations of TNF-α, IL-1β, MCP-1, COX-2, VEGF and granzyme B .

HY-N3552

Catalposide	NF-κB	Inflammation/Immunology
Catalposide, an iridoid glycoside that could be isolated from Catalpa ovate G. Don (Bignoniaceae), inhibits TNF-α, IL-1β, and IL-6 productions and NF-κB (p65) activation in lipopolysaccharide-activated RAW 264.7 macrophages .

HY-N0569

Madecassic acid 1 Publications Verification	NO Synthase COX TNF Receptor Interleukin Related	Inflammation/Immunology
Madecassic acid is isolated from Centella asiatica (Umbelliferae). Madecassic acid has anti-inflammatory properties caused by iNOS, COX-2, *TNF-alpha, IL-1beta*, and IL-6 inhibition via the downregulation of NF-κB activation in RAW 264.7 macrophage cells .

HY-134950

(E)-C-HDMAPP ammonium	TNF Receptor	Inflammation/Immunology
(E)-C-HDMAPP ammonium, is a potent phosphoantigen in ammonium form as well as a pyrophosphonate form of (E)-HDMAPP. (E)-C-HDMAPP is also an effective activator of γδ-T cells, induces T-cell stimulatory responses in vitro (EC₅₀=0.91 nM for TNF-α release) .

HY-156060

NCI126224	Toll-like Receptor (TLR)	Inflammation/Immunology
NCI126224 is a TLR4 signaling inhibitor. NCI126224 suppress LPS (HY-D1056)-induced production of NF-κB, TNF-α, IL-1β, and NO in the nanomolar-low micromolar range. NCI126224 can be used for the research of inflammatory diseases .

HY-W010201

Citronellol 1 Publications Verification (±)-Citronellol; (±)-β-Citronellol	Reactive Oxygen Species	Cancer
Citronellol ((±)-Citronellol) is a monoterpene Pelargonium graveolens. Citronellol ((±)-Citronellol) induces necroptosis of cancer cell via up-regulating TNF-α, RIP1/RIP3 activities, down-regulating caspase-3/caspase-8 activities and increasing ROS (reactive oxygen species) accumulation .

HY-N6927

Isoforskolin Coleonol B	TNF Receptor Interleukin Related	Inflammation/Immunology
Isoforskolin is the principle active component of C. forskohlii native to China. Isoforskolin reduces the secretion of lipopolysaccharide (LPS)-induced cytokines, namely *TNF-α, IL-1β*, IL-6 and IL-8, in human mononuclear leukocytes. Isoforskolin acts as an anti-inflammatory agent for the treatment of Lyme arthritis .

HY-N1940

β-Anhydroicaritin 1 Publications Verification
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties . β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats . β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca ²⁺, and markedly decreases iNOS protein expression .

HY-15507

VGX-1027 1 Publications Verification GIT 27	Interleukin Related TNF Receptor	Metabolic Disease Inflammation/Immunology
VGX-1027 is an orally active isoxazole compound that exhibits various immunomodulatory properties. VGX-1027 targets macrophages, reducing the production of the proinflammatory mediators TNF-α, IL-1β, IL-10. VGX-1027 has antidiabetogenic effects by limiting cytokine-mediated immunoinflammatory events .

HY-151188

DHU-Se1	NO Synthase TNF Receptor	Inflammation/Immunology
DHU-Se1 is a potent anti-inflammatory agent. DHU-Se1 can stimulate macrophages to release the reactive selenium compound and reduce the expression of cellular inflammatory factors (eg: iNOS and *TNF-α*). DHU-Se1 alleviate the process of inflammation by blocking the polarization of macrophages from M0 to M1 .

HY-N12042

Taxamairin B	TNF Receptor PI3K Reactive Oxygen Species Interleukin Related	Inflammation/Immunology
Taxamairin B is a potent anti-inflammatory agent. Taxamairin B decreases proinflammatory cytokines (TNF-α, IL-1β and IL-6) expression and the production of NO and ROS in LPS-induced RAW264.7 cells. Taxamairin B exhibits significant protective effects in LPS-induced acute lung injury in mice .

HY-B0446

Naphazoline hydrochloride NaphthazolINe hydrochloride	Adrenergic Receptor TNF Receptor Interleukin Related VEGFR	Cardiovascular Disease Inflammation/Immunology
Naphazoline (Naphthazoline) hydrochloride is a potent α-adrenergic receptor agonist. Naphazoline hydrochloride reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline hydrochloride reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF。Naphazoline hydrochloride can be used for non-bacterial conjunctivitis research .

HY-147697

LSD1-IN-21	Histone Demethylase TNF Receptor	Inflammation/Immunology Cancer
LSD1-IN-21 (compound 5a) is a potent and BBB-penetrated LSD1 (Lysine specific demethylase-1) inhibitor, with an IC₅₀ of 0.956 µM. LSD1-IN-21 significantly reduces the pro-inflammatory cytokine *TNF-α*. LSD1-IN-21 shows good anticancer and anti-inflammatory activity .

HY-146765

AMS-17	NOD-like Receptor (NLR)	Neurological Disease Inflammation/Immunology
AMS-17 is a potent NLRP3 inhibitor, inhibiting microglia activation in vitro and in vivo. AMS-17 also inhibits cytokines such as caspase-1, TNF-α, IL-1β and inducible nitric oxide synthase (iNOS) in N9 cells. AMS-17 can be used for researching inflammation-associated neurological disorders .

HY-111326

Naphazoline NaphthazolINe	Adrenergic Receptor TNF Receptor Interleukin Related VEGFR	Cardiovascular Disease Inflammation/Immunology
Naphazoline (Naphthazoline) is a potent α-adrenergic receptor agonist. Naphazoline reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF。Naphazoline can be used for non-bacterial conjunctivitis research .

HY-15509

Semapimod CNI-1493 free base; CPSI-2364	Interleukin Related TNF Receptor p38 MAPK	Inflammation/Immunology Cancer
Semapimod, an inhibitor of proinflammatory cytokine production, can inhibit *TNF-α, IL-1β*, and IL-6. Semapimod inhibits TLR4 signaling (IC₅₀≈0.3 μM). Semapimod inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod has potential in a variety of inflammatory and autoimmune disorders .

HY-152213

BET-IN-13	Epigenetic Reader Domain	Inflammation/Immunology
BET-IN-13 is a potent BET inhibitor with an IC₅₀ value of 1.6 nM. BET-IN-13 reduces LPS-induced TNF-α, IL-1β, IL-6, and NOS2 mRNA expression levels. BET-IN-13 shows anti-inflammatory activity. BET-IN-13 has the potential for the research of acute liver injury .

HY-N0569R

Madecassic acid (Standard)	NO Synthase COX TNF Receptor Interleukin Related	Inflammation/Immunology
Madecassic acid (Standard) is the analytical standard of Madecassic acid. This product is intended for research and analytical applications. Madecassic acid is isolated from Centella asiatica (Umbelliferae). Madecassic acid has anti-inflammatory properties caused by iNOS, COX-2, *TNF-alpha, IL-1beta*, and IL-6 inhibition via the downregulation of NF-κB activation in RAW 264.7 macrophage cells .

HY-111326A

Naphazoline nitrate NaphthazolINe nitrate	Adrenergic Receptor TNF Receptor Interleukin Related VEGFR	Cardiovascular Disease Inflammation/Immunology
Naphazoline (Naphthazoline) nitrate is an α-adrenergic receptor agonist. Naphazoline nitrate reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline nitrate reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF。Naphazoline nitrate can be used for non-bacterial conjunctivitis research .

HY-W010201R

Citronellol (Standard) (±)-Citronellol (Standard); (±)-β-Citronellol (Standard)	Reactive Oxygen Species	Cancer
Citronellol (Standard) is the analytical standard of Citronellol. This product is intended for research and analytical applications. Citronellol ((±)-Citronellol) is a monoterpene Pelargonium graveolens. Citronellol ((±)-Citronellol) induces necroptosis of cancer cell via up-regulating TNF-α, RIP1/RIP3 activities, down-regulating caspase-3/caspase-8 activities and increasing ROS (reactive oxygen species) accumulation .

HY-155199

PDE1-IN-5	Phosphodiesterase (PDE)	Inflammation/Immunology
PDE1-IN-5 (Compound 10c) is a selective PDE1C inhibitor (IC₅₀: 15 nM). PDE1-IN-5 has anti- inflammatory activity, and inhibits expression of iNOS, TNF-α, IL-1α, IL-1β, and IL-6 induced by LPS. PDE1-IN-5 has anti-inflammatory bowel disease (IBD) effects in the dextran sodium sulfate (DSS)-Induced colitis mice model. PDE1-IN-5 can be used for research of IBD .

HY-W505984

TPNA10168 KM05073	Keap1-Nrf2	Inflammation/Immunology
TPNA10168 is an Nrf-2 activator that activates the Keap1-Nrf2-ARE pathway. TPNA10168 is neuroprotective against oxidative stress-induced damage. TPNA10168 significantly reduces the transcription of inflammatory genes, including TNF-α, IL-1β, IL-6, and iNOS. TPNA10168 can be used in research on anti-inflammatory and neurological diseases .

HY-N0619

Mulberroside A 2 Publications Verification	TNF Receptor Interleukin Related Tyrosinase	Inflammation/Immunology
Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of *TNF-α, IL-1β*, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

HY-15509A

Semapimod tetrahydrochloride 1 Publications Verification CNI-1493; CPSI-2364 tetrahydrochloride	TNF Receptor Interleukin Related p38 MAPK	Inflammation/Immunology Cancer
Semapimod tetrahydrochloride (CNI-1493), an inhibitor of proinflammatory cytokine production, can inhibit *TNF-α, IL-1β*, and IL-6. Semapimod tetrahydrochloride inhibits TLR4 signaling (IC₅₀≈0.3 μM). Semapimod tetrahydrochloride inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod tetrahydrochloride has potential in a variety of inflammatory and autoimmune disorders .

HY-110246

Quin C1	Others	Inflammation/Immunology
Quin C1 is a highly specific and potent agonist for formyl peptide receptor 2 (FPR2/ALX). Quin-C1 significantly reduces the neutrophil and lymphocyte counts in BALF, diminishes expression of TNF-α, IL-1β, KC, and TGF-β1, and decreases collagen deposition in lung tissue. Quin C1 has the potential for the research of lung injury .

HY-W015879S

2-Heptanol-d5	Bacterial Isotope-Labeled Compounds	Inflammation/Immunology
2-Heptanol-d₅ is deuterated labeled Citronellol (HY-W010201). Citronellol ((±)-Citronellol) is a monoterpene Pelargonium graveolens. Citronellol ((±)-Citronellol) induces necroptosis of cancer cell via up-regulating TNF-α, RIP1/RIP3 activities, down-regulating caspase-3/caspase-8 activities and increasing ROS (reactive oxygen species) accumulation .

HY-N0619A

cis-Mulberroside A Mulberroside D	TNF Receptor Interleukin Related Tyrosinase	Inflammation/Immunology
cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of *TNF-α, IL-1β*, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

HY-156025

HCAR2 agonist 1	Others	Inflammation/Immunology
HCAR2 agonist 1 (Compound 9n) is a G_i protein-biased allosteric modulator of HCAR2. HCAR2 agonist 1 activates the G_i protein signaling pathway. HCAR2 agonist 1 shows anti-inflammatory effect, and reduces mRNA level of pro-inflammatory cytokine (TNF-α, IL-1β, IL-6, and MCP-1). HCAR2 agonist 1 enhances anti-inflammatory effects of orthosteric agonists in the mouse model of colitis .

HY-110133

JTE-607 1 Publications Verification	Interleukin Related	Inflammation/Immunology
JTE-607, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 inhibits inflammatory cytokine production, including *TNF-α, IL-1β*, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC₅₀s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively . Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) is the target of JTE-607 .

HY-147924

Keap1-Nrf2-IN-11	Keap1-Nrf2 NO Synthase ROS Kinase	Inflammation/Immunology
Keap1-Nrf2-IN-11 (compound 6k) is a Keap1-Nrf2 inhibitor with K_D2 value of 0.21 nM. Keap1-Nrf2-IN-11 inhibits the productions of ROS and NO and the expression of TNF-α. Keap1-Nrf2-IN-11 relieves inflammations by increasing the Nrf2 nuclear translocation. Keap1-Nrf2-IN-11 can be used for anti-inflammatory research .

HY-19744

T6167923 Maximum Cited Publications 11 Publications Verification
T6167923 is a selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity, and improves anti-inflammatory activity with IC₅₀s of 2.7 μM, 2.9 μM, 2.66 μM and 2.66 μM for IFN-γ, IL-1β, IL-6 and TNF-α, respectively .

HY-N0281

Daphnetin 2 Publications Verification 7,8-DihydroxycoumarIN	EGFR PKA PKC Autophagy Apoptosis AMPK Akt mTOR Reactive Oxygen Species Caspase Bcl-2 Family PARP Parasite	Inflammation/Immunology Cancer
Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC₅₀s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1ß, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research .

HY-155759

HMGB1-IN-2	Others	Inflammation/Immunology Cancer
HMGB1-IN-2 (compound 15) is an inhibitor of highly conserved nuclear protein (HMGB1), showing NO inhibitory effect with IC₅₀ value of 20.2 μM in RAW264.7 cells. HMGB1-IN-2 (30 μM) decreases the level of IL-1 β, TNF-α, caspase-1 p20, inhibits the phosphorylation of NF-κB p65, exhibits anti-apoptotic activity. HMGB1-IN-2 (15 mg/kg; ip) relives kidney injury in septic acute kidney injury mouse. HMGB1-IN-2 inhibits Huh7 cells and A549 cells with IC₅₀s of 77.0 μM, and 82.0 μM, respectively .

TAPI-0	TNF Receptor MMP Bacterial	Infection Cancer
TAPI-0 is a *TACE (TNF-α converting enzyme; ADAM17)* inhibitor with an IC₅₀ of 100 nM. TAPI-0 is a MMP inhibitor and also attenuates TNF-α processing .

Cat. No.	Product Name	Category	Target	Chemical Structure