Search Result

Results for "

arginine methyltransferase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Histone Methyltransferase (69) AP-1 (2) Apoptosis (8) Autophagy (1) Biochemical Assay Reagents (1) c-Myc (1) CDK (2) Discoidin Domain Receptor (1) DNA/RNA Synthesis (1) Early 2 Factor (E2F) (1) Fungal (1) GLP Receptor (1) Histone Acetyltransferase (1) Histone Demethylase (2) KLF (1) MDM-2/p53 (2) NF-κB (2) Parasite (3) Phosphodiesterase (PDE) (3) PKA (2) PROTACs (4) Reactive Oxygen Species (ROS) (1) Reference Standards (7) SARS-CoV (2) Sirtuin (1)
By Research Areas:	Cancer (68) Infection (6) Inflammation/Immunology (7) Metabolic Disease (3)

By Targets:

Histone Methyltransferase (69)

AP-1 (2)

Apoptosis (8)

Autophagy (1)

Biochemical Assay Reagents (1)

c-Myc (1)

CDK (2)

Discoidin Domain Receptor (1)

DNA/RNA Synthesis (1)

Early 2 Factor (E2F) (1)

Fungal (1)

GLP Receptor (1)

Histone Acetyltransferase (1)

Histone Demethylase (2)

KLF (1)

MDM-2/p53 (2)

NF-κB (2)

Parasite (3)

Phosphodiesterase (PDE) (3)

PKA (2)

PROTACs (4)

Reactive Oxygen Species (ROS) (1)

Reference Standards (7)

SARS-CoV (2)

Sirtuin (1)

By Research Areas:

Cancer (68)

Infection (6)

Inflammation/Immunology (7)

Metabolic Disease (3)

Inhibitors & Agonists

Screening Libraries

Peptides

Recombinant Proteins

Antibodies

Targets Recommended: SRPK Protein Arginine Deiminase Histone Methyltransferase Amine N-methyltransferase METTL3 COMT ICMT RNA MTase DNA Methyltransferase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101563

GSK3326595 Maximum Cited Publications 31 Publications Verification EPZ015938	Histone Methyltransferase SARS-CoV MDM-2/p53 CDK Apoptosis	Infection Cancer
GSK3326595 is a protein arginine methyltransferase 5 (PRMT5) inhibitor. GSK3326595 decreases SARS-CoV-2 infection, inhibits cancer cell proliferation and induces pro-inflammatory macrophage polarization and increases hepatic triglyceride levels without affecting atherosclerosis. GSK3326595 can be used for research of relapsed/refractory mantle cell lymphoma .

HY-101564

Onametostat 5+ Cited Publications JNJ-64619178	Histone Methyltransferase	Cancer
Onametostat (JNJ-64619178) is a selective, orally active and pseudo-irreversible *protein arginine* methyltransferase 5 (PRMT5) inhibitor with an IC₅₀** of 0.14 nM. Onametostat has potent activity in lung cancer .

HY-19615

MS023 20+ Cited Publications	Histone Methyltransferase	Cancer
MS023, a chemical probe, is a potent, selective, and cell-active inhibitor of human *type I protein arginine* methyltransferases (PRMTs) inhibitor, with IC₅₀s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8**, respectively .

HY-19715

SGC707 10+ Cited Publications	Histone Methyltransferase	Metabolic Disease
SGC707, a chemical probe, is a potent, selective, and non-competitive PRMT3 (*protein arginine* methyltransferase 3) inhibitor (IC₅₀=31 nM, K_d**=53 nM).

HY-128717A

GSK3368715 dihydrochloride 15+ Cited Publications EPZ019997 dihydrochloride	Histone Methyltransferase	Cancer
GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive *type I protein arginine* methyltransferases (PRMTs) inhibitor (IC₅₀*=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) produces a shift in arginine* methylation states, alters exon usage, and has strong anti-cancer activity .

HY-128717

GSK3368715 15+ Cited Publications EPZ019997	Histone Methyltransferase	Cancer
GSK3368715 (EPZ019997) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive *type I protein arginine* methyltransferases (PRMTs) inhibitor (IC₅₀*=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 (EPZ019997) produces a shift in arginine* methylation states, alters exon usage, and has strong anti-cancer activity .

HY-107777

LLY-283 5+ Cited Publications	Histone Methyltransferase	Cancer
LLY-283, a chemical probe, is a potent, selective and oral protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC₅₀ of 22 nM and a K_d of 6 nM for PRMT5:MEP50 complex, and shows antitumor activity .

HY-107574

TC-E 5003 3 Publications Verification	Histone Methyltransferase AP-1 NF-κB PKA	Metabolic Disease Inflammation/Immunology Cancer
TC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC₅₀ of 1.5 µM against hPRMT1. TC-E 5003 modulates the lipopolysaccharide (LPS) (HY-D1056)-induced AP-1 and NF-κB signaling pathways with anti-inflammatory properties. TC-E 5003 also upregulates the expression of Ucp1 and Fgf21, activates protein kinase A signaling and lipolysis in primary subcutaneous adipocytes from both mouse and humans. TC-E 5003 is promising for research of obesity and associated metabolic disorders, oxidative stress, inflammation and cancers .

HY-18962

AMI-1 5+ Cited Publications	Histone Methyltransferase	Cancer
AMI-1 is a potent, cell-permeable and reversible inhibitor of *protein arginine* N-methyltransferases (PRMTs), with IC₅₀**s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 exerts PRMTs inhibitory effects by blocking peptide-substrate binding .

HY-110137

Furamidine dihydrochloride 3 Publications Verification DB75 dihydrochloride; NSC 305831 dihydrochloride	Histone Methyltransferase Phosphodiesterase (PDE) Parasite	Infection Inflammation/Immunology Cancer
Furamidine dihydrochloride (DB75 dihydrochloride) is a selective *protein arginine* methyltransferase 1 (PRMT1) inhibitor with an IC₅₀ of 9.4 μM. Furamidine dihydrochloride is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC₅₀s of 166 µM, 283 µM, and >400 µM, respectively). Furamidine dihydrochloride is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1** by Furamidine dihydrochloride is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine dihydrochloride is also an antiparasite agent .

HY-100565

SGC2085 1 Publications Verification	Histone Methyltransferase	Cancer
SGC2085 is a potent and selective inhibitor of coactivator associated arginine methyltransferase 1 (CARM1) with an IC₅₀ of 50 nM. SGC2085 also selectively inhibits PRMT6 with an IC₅₀ value of 5.2 μM, but not other PRMT proteins .

HY-100025A

HLCL-61 hydrochloride 2 Publications Verification	Histone Methyltransferase Apoptosis	Cancer
HLCL-61 hydrochloride is a first-in-class inhibitor of *protein arginine* methyltransferase 5 (PRMT5)**.

HY-19615B

MS023 dihydrochloride 20+ Cited Publications	Histone Methyltransferase	Cancer
MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human *type I protein arginine* methyltransferases (PRMTs) inhibitor, with IC₅₀s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8**, respectively .

HY-111213

PRMT5-IN-20	Histone Methyltransferase	Cancer
PRMT5-IN-20 is a selective protein arginine methyltransferase 5 (PRMT5) inhibitor with anti-tumor activity .

HY-109963

PR5-LL-CM01	Histone Methyltransferase	Cancer
PR5-LL-CM01 is a potent protein arginine methyltransferase 5 (PRMT5) inhibitor (IC₅₀= 7.5 μM). Anti-tumor activies .

HY-133740

MS117	Histone Methyltransferase	Cancer
MS117 is a first-in-class and cell-active irreversible *protein arginine* methyltransferase 6 (PRMT6) covalent inhibitor, with an IC₅₀** of 18 nM .

HY-112165

PRMT5-IN-2	Histone Methyltransferase	Cancer
PRMT5-IN-2 is a *rotein arginine* methyltransferase 5 (PRMT5)** inhibitor extracted from patent WO2018130840A1, compound 3 .

HY-122096

DCLX069 1 Publications Verification	Histone Methyltransferase	Cancer
DCLX069 is a selective *protein arginine* methyltransferase 1 (PRMT1) inhibitor with an IC₅₀** value of 17.9 µM. DCLX069 shows less active against PRMT4 and PRMT6. DCLX069 has anticancer effects .

HY-124131

DS-437 1 Publications Verification	Histone Methyltransferase	Inflammation/Immunology Cancer
DS-437 is a dual PRMT5/7 inhibitor (IC₅₀s of PRMT5/7=6 μM). DS-437 is selective for PRMT5 and PRMT7 over 29 other human protein-, DNA-, and RNA-methyltransferases. DS-437 is a S-adenosylmethionine (SAM)-competitive inhibitor of PRMT5. DS-437 also inhibits DNMT3A and DNMT3B, with IC₅₀s of 52 and 62 μM, respectively. DS-437 inhibits the methylation of FOXP3 .

HY-156152A

CARM1 degrader-1 hydrochloride	PROTACs Histone Methyltransferase	Cancer
CARM1 degrader-1 hydrochloride is a CARM1 PROTAC degrader (DC₅₀ = 8.1 nM) with high selectivity over other protein arginine methyltransferases. CARM1 degrader-1 hydrochloride degrades CARM1 in a VHL- and proteasome-dependent manner. CARM1 degrader-1 hydrochloride downregulates the methylation level of CARM1 substrates in cell-based assays. CARM1 degrader-1 hydrochloride inhibits cancer cell migration in cell-based assays. CARM1 degrader-1 hydrochloride can be used in breast cancer research .

HY-Q36691

PRMT5-IN-30	Histone Methyltransferase	Cancer
PRMT5-IN-30 (compound 17) is a potent and selective *protein arginine* methyltransferase 5 (PRMT5) inhibitor with an IC₅₀ of 0.33 μM and a K_d** of 0.987 μM. PRMT5-IN-30 exhibits a broad selectivity against a panel of other methyltransferases. PRMT5-IN-30 inhibits PRMT5 mediated SmD3 methylation .

HY-128579

DW14800	Histone Methyltransferase	Cancer
DW14800 is a protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC₅₀ of 17 nM. DW14800 reduces H4R3me2s levels and enhances the transcription of HNF4α, but does not alter PRMT5 expression. Anti-cancer activity .

HY-126256A

PRMT5-IN-1 hydrochloride	Histone Methyltransferase	Cancer
PRMT5 IN-1 hydrochloride (compound 9), a hemiaminal, is a potent, selective *protein arginine* methyltransferase 5 (PRMT5) inhibitor with an IC₅₀** of 11 nM for PRMT5/MEP50. PRMT5 IN-1 hydrochloride can be converted to aldehydes and react with C449 to form covalent adducts under physiological conditions .

HY-18962A

AMI-1 free acid 5+ Cited Publications	Histone Methyltransferase	Cancer
AMI-1 free acid is a potent, cell-permeable and reversible inhibitor of *protein arginine* N-methyltransferases (PRMTs), with IC₅₀**s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 free acid exerts PRMTs inhibitory effects by blocking peptide-substrate binding .

HY-159728

PROTAC PRMT3 degrader 1	PROTACs Histone Methyltransferase Apoptosis Early 2 Factor (E2F) c-Myc	Cancer
PROTAC PRMT3 degrader 1 is a selective PRMT3 PROTAC degrader with a DC₅₀ of 2.566 μM. PROTAC PRMT3 degrader 1 forms a ternary complex with MDM2 E3 ubiquitin ligase to induce proteasomal and neddylation-dependent degradation of PRMT3. PROTAC PRMT3 degrader 1 activates intrinsic apoptosis, endoplasmic reticulum stress signaling pathways. PROTAC PRMT3 degrader 1 downregulates E2F, MYC, oxidative phosphorylation pathways. PROTAC PRMT3 degrader 1 reduces cellular asymmetric dimethylarginine (ADMA) levels. PROTAC PRMT3 degrader 1 inhibits acute leukemia cell growth. PROTAC PRMT3 degrader 1 acts with glycolysis inhibitor 2-DG to reduce ATP production, induce intrinsic apoptosis, drive synergistic antiproliferative effects. PROTAC PRMT3 degrader 1 can be used for the research of acute leukemia .

HY-110137A

Furamidine DB75; NSC 305831	Histone Methyltransferase Phosphodiesterase (PDE) Parasite	Infection Inflammation/Immunology Cancer
Furamidine (DB75) is a selective *protein arginine* methyltransferase 1 (PRMT1) inhibitor with an IC₅₀ of 9.4 μM. Furamidine is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC₅₀s of 166 µM, 283 µM, and >400 µM, respectively). Furamidine is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1** by Furamidine is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine is also an antiparasite agent .

HY-156152

CARM1 degrader-1	PROTACs Histone Methyltransferase	Cancer
CARM1 degrader-1 is a CARM1 PROTAC degrader (DC₅₀ = 8.1 nM) with high selectivity over other protein arginine methyltransferases. CARM1 degrader-1 degrades CARM1 in a VHL- and proteasome-dependent manner. CARM1 degrader-1 downregulates the methylation level of CARM1 substrates in cell-based assays. CARM1 degrader-1 inhibits cancer cell migration in cell-based assays. CARM1 degrader-1 can be used for the research of breast cancer .

HY-15214A

CARM1-IN-3 dihydrochloride	Histone Methyltransferase	Cancer
CARM1-IN-3 dihydrochloride (compound 17b) is a potent and selective *co-activator associated arginine* methyltransferase (CARM1) inhibitor with IC₅₀** values of 0.07, >25 µM for CARM1 and CARM3, respectively .

HY-100565A

SGC2085 hydrochloride	Histone Methyltransferase	Cancer
SGC2085 hydrochloride is a potent and selective inhibitor of coactivator associated arginine methyltransferase 1 (CARM1) with an IC₅₀ of 50 nM. SGC2085 hydrochloride also selectively inhibits PRMT6 with an IC₅₀ value of 5.2 μM, but not other PRMT proteins .

HY-136809

PRMT6-IN-2	Histone Methyltransferase	Cancer
PRMT6-IN-2 (compound 2) is a dual inhibitor of protein arginine methyltransferase PRMT6 and CARM1 with an IC50 of 30 nM. PRMT6 is abnormally expressed in many cancer cells, and PRMT6-IN-2-based derivatives have potential anticancer activity.

HY-126256

PRMT5-IN-1	Histone Methyltransferase	Cancer
PRMT5 IN-1, a hemiaminal, is a potent, selective *protein arginine* methyltransferase 5 (PRMT5) inhibitor with an IC₅₀** of 11 nM for PRMT5/MEP50. PRMT5 IN-1 can be converted to aldehydes and react with C449 to form covalent adducts under physiological conditions .

HY-172769

CM112	Histone Methyltransferase	Cancer
CM112 is a selective protein arginine methyltransferase 1 (PRMT1) degrader by tethering hydrophobic tag, adamantane, to MS023 with a 5-PEG linker. CM112 induces the degradation of PRMT1 in various solid cancer cell lines. CM112 can also target the nonenzymatic function of PRMT1 by downregulating the stability of the orphan receptor TR3. CM112 is promising for research of cancers .

HY-176534

PRMT5-IN-52	Histone Methyltransferase	Cancer
PRMT5-IN-52 (Compound 17) is a non-nucleoside *Protein Arginine* Methyltransferase 5 (PRMT5)** inhibitor with inhibitory rates of 20.2% at 10 μM. PRMT5-IN-52 has potent antitumor activity, promising for research of cancers, including lung, prostate cancer, and colorectal carcinoma .

HY-117927

EPZ0025654 GSK3536023	Histone Methyltransferase	Cancer
EPZ0025654 (GSK3536023) is an inhibitor for protein arginine methyltransferases 4 (PRMT4) (which is also known as coactivator associated arginine methyltransferase 1 CARM1), with IC₅₀ of 3 nM .

HY-176701

PRMT5-MTA-IN-4	Histone Methyltransferase	Cancer
PRMT5-MTA-IN-4 (Compound 30) is a potent irreversible protein arginine methyltransferase 5 (PRMT5) inhibitor (IC₅₀=8 nM). PRMT5-MTA-IN-4 blocks arginine methylation, inhibiting ribosomal RNA processing and cell cycle-related protein expression. PRMT5-MTA-IN-4 exhibits antiproliferative activity in multiple tumor cell lines (e.g., IC₅₀=0.3 μM in DLD-1 cells). PRMT5-MTA-IN-4 is promising for research of hematological malignancies, such as acute myeloid leukemia, diffuse large B-cell lymphoma .

HY-175821

PRMT1-IN-3	Histone Methyltransferase Apoptosis	Cancer
PRMT1-IN-3 is a potent protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC₅₀ of 4.11 μM. PRMT1-IN-3 inhibits PRMT6 and PRMT8 with IC₅₀s of 23.3 and 30.1 μM. PRMT1-IN-3 suppresses asymmetric dimethylarginine (ADMA) levels and histone H4R3me2a modification in triple-negative breast cancer (TNBC) cells. PRMT1-IN-3 induces cell cycle arrest, apoptosis, and inhibits migration and colony formation in MDA-MB-231 cells. PRMT1-IN-3 acts as chemotherapeutic sensitizers for Paclitaxel (HY-B0015). PRMT1-IN-3 can be used for the study of TNBC .

HY-178378

G9a-IN-4	Histone Methyltransferase GLP Receptor Reactive Oxygen Species (ROS) Autophagy Apoptosis	Cancer
G9a-IN-4 is a G9a inhibitor with high selectivity (IC₅₀ = 32 nM). G9a-IN-4 shows high selectivity against the other tested lysine/arginine methyltransferases. G9a-IN-4 exhibits high enzymatic activity against G9a and more potent antiproliferative effects against all tested cancer cells. G9a-IN-4 significantly suppresses the H3K9me2 level. G9a-IN-4 triggers autophagy by inducing the production of ROS, thus leading to cell apoptosis and cell cycle arrest at G0/G1 in CT26 colon cells. G9a-IN-4 can be used for the study of colon cancer .

HY-144188

PRMT5-IN-17	Histone Methyltransferase	Cancer
PRMT5-IN-17 (Compound 6) is a PRMT5 inhibitor with anti-tumor activity. PRMT5 is a type of protein arginine methyltransferase, and is a new anti-tumor target related to epigenetic modification .

HY-144187

PRMT5-IN-16	Histone Methyltransferase	Cancer
PRMT5-IN-16 (Compound 20) is a PRMT5 inhibitor with anti-tumor activity. PRMT5 is a type of protein arginine methyltransferase, and is a new anti-tumor target related to epigenetic modification .

HY-P3822

PRMT5-IN-23	Histone Methyltransferase	Cancer
PRMT5-IN-23 (compound 50) is an inhibitor of *protein arginine* methyltransferase 5 (PRMT5) with anti-tumor activity. PRMT5** is a type of protein arginine methyltransferase, and is a new anti-tumor target related to epigenetic modification .

HY-110158

UNC2327	Histone Methyltransferase	Cancer
UNC2327 is an allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3).

HY-141875

PRMT5-IN-13	Histone Methyltransferase	Cancer
PRMT5-IN-13 is a selective inhibitor of *protein arginine* methyltransferase 5 (prmt5)**.

HY-100025

HLCL-61	Histone Methyltransferase	Cancer
HLCL-61 is a first-in-class small-molecule inhibitor of *protein arginine* methyltransferase 5 (PRMT5)**.

HY-P2556

Histone H3 (21-44)	Biochemical Assay Reagents	Others
Histone H3 (21-44), derived from histone H3 21-44 amino acids, is usually used as a substrate (such as protein arginine methyltransferases) for methylation assays .

HY-155154A

PRMT4-IN-3	Histone Methyltransferase	Cancer
PRMT4-IN-3 (compound 56) is a potent inhibitor of class I protein arginine methyltransferase (PRMT), targeting PRMT4 (IC₅₀: 37 nM) and PRMT4 (IC₅₀: 253 nM) .

HY-111030

PRMT1-IN-2	Histone Methyltransferase	Cancer
PRMT1-IN-2 (RM65) is a potent PRMT1 inhibitor with an IC₅₀ of 55.4 μM. PRMT1-IN-2 shows histone hypomethylation in HepG2 cells .

HY-164497

NSC 641396	DNA/RNA Synthesis Histone Methyltransferase	Cancer
NSC 641396 is a ribonucleotide reductase (RNR) inhibitor with an IC₅₀ value of 1.2 μM. NSC 641396 is also a protein arginine N-methyltransferase 9 (PRMT9) inhibitor. NSC 641396 has antitumor activity .

HY-15214

CARM1-IN-3	Histone Methyltransferase	Cancer
CARM1-IN-3 (compound 17b) is a potent and selective *co-activator associated arginine* methyltransferase (CARM1) inhibitor with IC₅₀** values of 0.07, >25 µM for CARM1 and CARM3, respectively .

HY-128717C

GSK3368715 hydrochloride EPZ019997 hydrochloride	Histone Methyltransferase	Cancer
GSK3368715 (EPZ019997) hydrochloride is an orally active, reversible, SAM-noncompetitive type I protein arginine methyltransferase (PRMT) inhibitor with IC₅₀ values of 3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), and 1.7 nM (PRMT8). GSK3368715 hydrochloride induces a shift in arginine methylation states, alters exon usage, and exhibits potent anticancer activity .

HY-153421

PRMT5-IN-28	Histone Methyltransferase	Cancer
PRMT5-IN-28 (compound 36) is an inhibitor of *protein arginine* methyltransferase 5 (PRMT5*) enzyme. Protein arginine* methylation is a common post-translational modification involved in gene transcription, mRNA splicing, DNA repair, protein cellular localization, cell fate determination and signal transduction, etc. Abnormal PRMT5 can promote cancer cell proliferation, resist apoptosis, enhance invasion and metastasis, and affect immune escape .

Cat. No.	Product Name

HY-L024

Histone Modification Research Compound Library

904 compounds

A histone modification, a covalent post-translational modification (PTM) to histone proteins, includes methylation, phosphorylation, acetylation, ubiquitylation, and sumoylation, etc. In general, histone modifications are catalyzed by specific enzymes that act predominantly at the histone N-terminal tails involving amino acids such as lysine or arginine, as well as serine, threonine, tyrosine, etc. The PTMs made to histones can impact gene expression by altering chromatin structure or recruiting histone modifiers. Histone modifications act in diverse biological processes such as transcriptional activation/inactivation, chromosome packaging, and DNA damage/repair. Deregulation of histone modification contributes to many diseases, including cancer and autoimmune diseases.

MCE owns a unique collection of 904 bioactive compounds targeting Epigenetic Reader Domain, HDAC, Histone Acetyltransferase, Histone Demethylase, Histone Methyltransferase, Sirtuin, etc. Histone Modification Research Compound Library is a useful tool for histone modification research and drug screening.

Cat. No.	Product Name	Target	Research Area

HY-P3822

PRMT5-IN-23	Histone Methyltransferase	Cancer
PRMT5-IN-23 (compound 50) is an inhibitor of *protein arginine* methyltransferase 5 (PRMT5) with anti-tumor activity. PRMT5** is a type of protein arginine methyltransferase, and is a new anti-tumor target related to epigenetic modification .

HY-P2556

Histone H3 (21-44)	Biochemical Assay Reagents	Others
Histone H3 (21-44), derived from histone H3 21-44 amino acids, is usually used as a substrate (such as protein arginine methyltransferases) for methylation assays .

Species:	Human (4)
Tag:	His (4) Flag (2)
Source:	HEK293 (2) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P790095

	CARM1 Protein, Human (His) Histone-arginine methyltransferase CARM1; Coactivator-associated arginine methyltransferase 1; Protein arginine N-methyltransferase 4; CARM1; PRMT4	Human	E. coli
	CARM1 Protein, Human (His) is the recombinant human-derived CARM1, expressed by E. coli , with C-10*His labeled tag.

HY-P76551

	PRMT3 Protein, Human (His) Protein arginine N-methyltransferase 3; PRMT3; HRMT1L3	Human	E. coli
	PRMT3 protein is a multifunctional protein arginine N-methyltransferase. As a type I methyltransferase, it catalyzes monomethylation and asymmetric dimethylation of arginine residues in target proteins. In addition to its methyltransferase role, PRMT3 may also regulate retinoic acid synthesis and signaling by inhibiting ALDH1A1 retinal dehydrogenase activity. PRMT3 Protein, Human (His) is the recombinant human-derived PRMT3 protein, expressed by E. coli , with N-10*His labeled tag.

HY-P75983

	PRMT6 Protein, Human (HEK293, His-Flag) Protein arginine N-methyltransferase 6; PRMT6; HRMT1L6	Human	HEK293
	PRMT6 is a multifunctional arginine methyltransferase that prefers the formation of asymmetric dimethylarginine (aDMA) and methylates arginine residues within glycine- and arginine-rich domains change. It coordinates asymmetric dimethylation of histone H3 "Arg-2" to generate H3R2me2a, a unique epigenetic tag associated with transcriptional repression. PRMT6 Protein, Human (HEK293, His-Flag) is the recombinant human-derived PRMT6 protein, expressed by HEK293 , with N-Flag, C-His labeled tag.

HY-P77152

	PRMT5 Protein, Human (HEK293, His-Flag) Protein arginine N-methyltransferase 5; 72 kDa ICln-binding protein; SKB1Hs; HRMT1L5; IBP72; JBP1; SKB1	Human	HEK293
	PRMT5 protein, an enzyme from the methyltransferase family, methylates arginine in target proteins like histones, p53, and transcription factors. It regulates transcription and small nuclear ribonucleoprotein assembly. Alternative splicing generates diverse PRMT5 transcript variants. It is widely expressed, particularly in the thyroid, ovary, and other tissues, emphasizing its crucial role in cellular processes. PRMT5 Protein, Human (HEK293, His-Flag) is the recombinant human-derived PRMT5, expressed by HEK293, with N-Flag, C-His labeled tag.

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Host:	Mouse (4) Rabbit (1)
Reactivity:	Human (5) Rat (3) Mouse (4) Rabbit (1) Dog (1)
Application:	IHC-P (3) ICC/IF (2) IP (2) WB (5)
Isotype:	IgG (1)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (5) Recombinant (1)
Modification:	Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85492

	CARM1 Antibody (YA5184) carm1; CARM1_HUMAN; Coactivator associated arginine methyltransferase 1; Coactivator-associated arginine methyltransferase 1; Histone arginine methyltransferase CARM 1; Histone arginine methyltransferase CARM1; Histone-arginine methyltransferase CARM1; PRMT 4; PRMT4; Protein arginine methyltransferase; Protein arginine N methyltransferase 4; Protein arginine N-methyltransferase 4.	WB, IP	Human, Mouse
	CARM1 Antibody (YA5184) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CARM1.

HY-P85335

	CARM1 Antibody (YA5027) CARM1; PRMT4; Histone-arginine methyltransferase CARM1; Coactivator-associated arginine methyltransferase 1; Protein arginine N-methyltransferase 4	WB, IHC-P, IP	Human, Mouse, Rat
	CARM1 Antibody (YA5027) is a Rabbit-derived and non-conjugated recombinant monoclonal antibody, targeting to CARM1.

HY-P85496

	PRMT6 Antibody (YA5188) ANM6_HUMAN; Chromobox protein homolog 7; FLJ10559; FLJ51477; Heterogeneous nuclear ribonucleoprotein methyltransferase like protein 6; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6; Histone-arginine N-methyltransferase PRMT6; HMT1 hnRNP methyltransferase like 6.; HRMT1L6; OTTHUMP00000012633; PRMT 6; prmt6; Protein arginine methyltransferase 6; Protein arginine N methyltransferase 6; Protein arginine N-methyltransferase 6.	WB, IHC-P, ICC/IF	Human
	PRMT6 Antibody (YA5188) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PRMT6.

HY-P85460

	PRMT6 Antibody (YA5152) PRMT6; HRMT1L6; Protein arginine N-methyltransferase 6; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6; Histone-arginine N-methyltransferase PRMT6	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	PRMT6 Antibody (YA5152) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PRMT6.

HY-P85459

	PRMT1 Antibody (YA5151) PRMT1; HMT2; HRMT1L2; IR1B4; Protein arginine N-methyltransferase 1; Histone-arginine N-methyltransferase PRMT1; Interferon receptor 1-bound protein 4	WB	Human, Mouse, Rat, Dog, Rabbit
	PRMT1 Antibody (YA5151) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PRMT1.

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