2. Epigenetics
  3. Histone Methyltransferase
  4. UNC2327

UNC2327 is an allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3).

For research use only. We do not sell to patients.

UNC2327 Chemical Structure

UNC2327 Chemical Structure

CAS No. : 1426152-53-5

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Based on 1 publication(s) in Google Scholar

UNC2327 Related Antibodies

Top Publications Citing Use of Products

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • Biological Activity

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  • Customer Review

Description

UNC2327 is an allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3).

IC50 & Target

PRMT3

 

Molecular Weight

319.38

Formula

C14H17N5O2S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NCC(N1CCCCC1)=O)NC2=CC3=C(N=NS3)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : 10 mg/mL (31.31 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1311 mL 15.6553 mL 31.3107 mL
5 mM 0.6262 mL 3.1311 mL 6.2621 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.70%

COA (245 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 3.1311 mL 15.6553 mL 31.3107 mL 78.2767 mL
5 mM 0.6262 mL 3.1311 mL 6.2621 mL 15.6553 mL
10 mM 0.3131 mL 1.5655 mL 3.1311 mL 7.8277 mL
15 mM 0.2087 mL 1.0437 mL 2.0874 mL 5.2184 mL
20 mM 0.1566 mL 0.7828 mL 1.5655 mL 3.9138 mL
25 mM 0.1252 mL 0.6262 mL 1.2524 mL 3.1311 mL
30 mM 0.1044 mL 0.5218 mL 1.0437 mL 2.6092 mL
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UNC2327 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UNC23271426152-53-5UNC 2327UNC-2327Histone MethyltransferaseInhibitorinhibitorinhibit

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