1. Epigenetics
  2. Histone Methyltransferase
  3. SGC707

SGC707 

Cat. No.: HY-19715 Purity: 99.31%
Handling Instructions

SGC707 is a first-in-class PRMT3 chemical probe which is a potent, selective, and cell-active allosteric inhibitor of PRMT3 with IC50 of 31 nM.

For research use only. We do not sell to patients.

SGC707 Chemical Structure

SGC707 Chemical Structure

CAS No. : 1687736-54-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1  mL in DMSO USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 65 In-stock
Estimated Time of Arrival: December 31
50 mg USD 225 In-stock
Estimated Time of Arrival: December 31
100 mg USD 450 In-stock
Estimated Time of Arrival: December 31
500 mg USD 1750 In-stock
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    SGC707 purchased from MCE. Usage Cited in: FASEB J. 2020 Jul 8.

    The effect of SGC707 on the key antiviral gene expression after SVCV and GCRV infection in ZFL cells is examined by qRT‐PCR assays. The addition of SGC707 enhances poly (I:C), and SVCV‐ induced IFN activation in EPC cells. SGC707 also enhances the antiviral gene expression by SVCV infection or GCRV infection.
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    Description

    SGC707 is a first-in-class PRMT3 chemical probe which is a potent, selective, and cell-active allosteric inhibitor of PRMT3 with IC50 of 31 nM. IC50 value: 31 nM Target: PRMT3 in vitro: SGC707 is the first PRMT3 chemical probe. SGC707 is a potent PRMT3 inhibitor (IC50=31±2 nM, KD=53±2 nM) with outstanding selectivity (selective against 31 other methyltransferases and more than 250 non-epigenetic targets). SGC707 can engage PRMT3 and effectively inhibit its catalytic activity in cells and that overexpressed PRMT3 can methylate histone H4 in cells. SGC707 stabilizes PRMT3 in both HEK293 and A549 cells with EC50 values of 1.3 μM and 1.6 μM in PRMT3 InCELL Hunter Assays. in vivo: SGC707 is bioavailable and suitable for animal studies. This well characterized chemical probe is an excellent tool to further study the role of PRMT3 in health and disease. We assessed in vivo pharmacokinetic (PK) properties of SGC707. Intraperitoneal injection of SGC707 at 30 mg/kg gave good plasma exposure in CD-1 male mice over 6 h with the peak plasma level of 38000 nM. The plasma level of SGC707 at 6 h post injection was 208 nM, more than 2-fold higher than its IC50 value in the cellular assay and the half-life of SGC707 was about 1 h. This mdose was well tolerated by the test animals. These results suggest that SGC707 is suitable for animal studies in addition to cell-based studies.

    Molecular Weight

    298.34

    Formula

    C₁₆H₁₈N₄O₂

    CAS No.

    1687736-54-4

    SMILES

    O=C(NCC(N1CCCC1)=O)NC2=CC=C3C=NC=CC3=C2

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (335.19 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.3519 mL 16.7594 mL 33.5188 mL
    5 mM 0.6704 mL 3.3519 mL 6.7038 mL
    10 mM 0.3352 mL 1.6759 mL 3.3519 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 3 mg/mL (10.06 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 3 mg/mL (10.06 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 3 mg/mL (10.06 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Keywords:

    SGC707SGC 707SGC-707Histone MethyltransferaseInhibitorinhibitorinhibit

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    Product Name:
    SGC707
    Cat. No.:
    HY-19715
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