1. Epigenetics
  2. Histone Methyltransferase
  3. SGC707

SGC707 

Cat. No.: HY-19715 Purity: 99.39%
COA Handling Instructions

SGC707 is a potent, selective, and non-competitive PRMT3 (protein arginine methyltransferase 3) inhibitor (IC50=31 nM, Kd=53 nM).

For research use only. We do not sell to patients.

SGC707 Chemical Structure

SGC707 Chemical Structure

CAS No. : 1687736-54-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 79 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 72 In-stock
Estimated Time of Arrival: December 31
50 mg USD 248 In-stock
Estimated Time of Arrival: December 31
100 mg USD 495 In-stock
Estimated Time of Arrival: December 31
500 mg USD 1925 In-stock
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

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Customer Review

Based on 6 publication(s) in Google Scholar

Top Publications Citing Use of Products

    SGC707 purchased from MCE. Usage Cited in: FASEB J. 2020 Aug;34(8):10212-10227.  [Abstract]

    The effect of SGC707 on the key antiviral gene expression after SVCV and GCRV infection in ZFL cells is examined by qRT‐PCR assays. The addition of SGC707 enhances poly (I:C), and SVCV‐ induced IFN activation in EPC cells. SGC707 also enhances the antiviral gene expression by SVCV infection or GCRV infection.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    SGC707 is a potent, selective, and non-competitive PRMT3 (protein arginine methyltransferase 3) inhibitor (IC50=31 nM, Kd=53 nM).

    IC50 & Target

    PRMT3

    31 nM (IC50)

    In Vitro

    SGC707 (0-10 μM; 6 h) binds to PRMT3 in both HEK293 and A549 cells[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[1]

    Cell Line: HEK293 and A549 cells
    Concentration: 0-10 μM
    Incubation Time: 6 hours
    Result: Stabilized PRMT3 in both HEK293 and A549 cells with EC50 values of 1.3 μM and 1.6 μM, respectively.
    In Vivo

    SGC707 (intraperitoneal injection; 10 mg/kg; 3 times per week; 3 w) treatment reduces hepatic steatosis and plasma triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Western-type diet-fed LDL (lipoprotein) receptor knockout mice[2]
    Dosage: 10 mg/kg
    Administration: Intraperitoneal injection; 10 mg/kg; 3 times per week; 3 weeks
    Result: Exhibited 50% lower liver triglyceride stores as well as 32% lower plasma triglyceride levels.
    Molecular Weight

    298.34

    Formula

    C16H18N4O2

    CAS No.
    SMILES

    O=C(NCC(N1CCCC1)=O)NC2=CC=C3C=NC=CC3=C2

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (335.19 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.3519 mL 16.7594 mL 33.5188 mL
    5 mM 0.6704 mL 3.3519 mL 6.7038 mL
    10 mM 0.3352 mL 1.6759 mL 3.3519 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 3 mg/mL (10.06 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 3 mg/mL (10.06 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 3 mg/mL (10.06 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation
    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

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    Product Name:
    SGC707
    Cat. No.:
    HY-19715
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