1. Epigenetics
  2. Histone Methyltransferase
  3. EPZ020411

EPZ020411 

Cat. No.: HY-12970
Handling Instructions

EPZ020411 is a potent and selective inhibitor of PRMT6 with IC50 of 10 nM, has >10 fold selectivity for PRMT6 over PRMT1 and PRMT8.

For research use only. We do not sell to patients.

EPZ020411 Chemical Structure

EPZ020411 Chemical Structure

CAS No. : 1700663-41-7

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Description

EPZ020411 is a potent and selective inhibitor of PRMT6 with IC50 of 10 nM, has >10 fold selectivity for PRMT6 over PRMT1 and PRMT8. IC50 value: 10 nM Target: PRMT6 in vitro: EPZ020411 inhibits methylation of PRMT6 substrates in cells. EPZ020411 does-dependently inhibits H3R2 methylation in PRMT6-overexpressing cells. in vivo: EPZ020411 shows good bioavailability following subcutaneous (SC) dosing in rats making it a suitable tool for in vivo studies.

Molecular Weight

442.59

Formula

C₂₅H₃₈N₄O₃

CAS No.

1700663-41-7

SMILES

CNCCN(C)CC1=CNN=C1C2=CC=C(O[[email protected]]3C[[email protected]](OCCC4CCOCC4)C3)C=C2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

EPZ020411EPZ 020411EPZ-020411Histone MethyltransferaseInhibitorinhibitorinhibit

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EPZ020411
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HY-12970
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