1. Epigenetics
  2. Histone Methyltransferase
  3. EPZ020411 hydrochloride

EPZ020411 hydrochloride 

Cat. No.: HY-12970A Purity: 97.33%
Handling Instructions

EPZ020411 hydrochloride is a potent and selective inhibitor of PRMT6 with IC50 of 10 nM, has >10 fold selectivity for PRMT6 over PRMT1 and PRMT8.

For research use only. We do not sell to patients.

EPZ020411 hydrochloride Chemical Structure

EPZ020411 hydrochloride Chemical Structure

CAS No. : 2070015-25-5

Size Price Stock Quantity
10 mM * 1 mL in Water USD 202 In-stock
Estimated Time of Arrival: December 31
2 mg USD 120 In-stock
Estimated Time of Arrival: December 31
5 mg USD 192 In-stock
Estimated Time of Arrival: December 31
10 mg USD 312 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1140 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1740 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

EPZ020411 hydrochloride is a potent and selective inhibitor of PRMT6 with IC50 of 10 nM, has >10 fold selectivity for PRMT6 over PRMT1 and PRMT8. IC50 value: 10 nM Target: PRMT6 in vitro: EPZ020411 inhibits methylation of PRMT6 substrates in cells. EPZ020411 does-dependently inhibits H3R2 methylation in PRMT6-overexpressing cells. in vivo: EPZ020411 shows good bioavailability following subcutaneous (SC) dosing in rats making it a suitable tool for in vivo studies.

Molecular Weight

479.06

Formula

C₂₅H₃₉ClN₄O₃

CAS No.

2070015-25-5

SMILES

CNCCN(C)CC1=CNN=C1C2=CC=C(O[[email protected]]3C[[email protected]](OCCC4CCOCC4)C3)C=C2.Cl[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (104.37 mM; Need ultrasonic)

H2O : ≥ 41 mg/mL (85.58 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0874 mL 10.4371 mL 20.8742 mL
5 mM 0.4175 mL 2.0874 mL 4.1748 mL
10 mM 0.2087 mL 1.0437 mL 2.0874 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.22 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.22 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.22 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 97.33%

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Keywords:

EPZ020411EPZ 020411EPZ-020411Histone MethyltransferaseInhibitorinhibitorinhibit

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Product name:
EPZ020411 hydrochloride
Cat. No.:
HY-12970A
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