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Cat. No.: HY-101563R

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Pemrametostat (Standard)

Name: Pemrametostat (Standard)
Brand: MedChemExpress
SKU: HY-101563R
Price: 125.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: GSK3326595 (Standard); EPZ015938 (Standard))

Pemrametostat (Standard) (GSK3326595 (Standard); EPZ015938 (Standard)) is the analytical standard of Pemrametostat (HY-101563). This product is intended for research and analytical applications. Pemrametostat (GSK3326595) is a protein arginine methyltransferase 5 (PRMT5) inhibitor. Pemrametostat decreases SARS-CoV-2 infection, inhibits cancer cell proliferation and induces pro-inflammatory macrophage polarization and increases hepatic triglyceride levels without affecting atherosclerosis. Pemrametostat can be used for research of relapsed/refractory mantle cell lymphoma.

For research use only. We do not sell to patients.

Purity : 98%
CAS No.: 1616392-22-3
Formula: C₂₄H₃₂N₆O₃
Molecular Weight:452.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Pemrametostat (Standard) Chemical Structure

CAS No.: 1616392-22-3

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Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 1616392-22-3
Molecular Weight 452.55
Formula C₂₄H₃₂N₆O₃
SMILES

O=C(C)N1CCC(NC2=NC=NC(C(NC[C@H](O)CN3CCC(C=CC=C4)=C4C3)=O)=C2)CC1
Synonyms

GSK3326595 (Standard); EPZ015938 (Standard)
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Che Y, et al. Exploiting PRMT5 as a target for combination therapy in mantle cell lymphoma characterized by frequent ATM and TP53 mutations [J]. Blood cancer journal, 2023, 13(1): 27. [Content Brief]

[2]. Fedoriw A, et al. Anti-tumor activity of the type I PRMT inhibitor, GSK3368715, synergizes with PRMT5 inhibition through MTAP loss [J]. Cancer cell, 2019, 36(1): 100-114. e25.

[3]. Zhang Y, et al. PRMT5 inhibition induces pro‐inflammatory macrophage polarization and increased hepatic triglyceride levels without affecting atherosclerosis in mice [J]. Journal of Cellular and Molecular Medicine, 2023, 27(8): 1056-1068.

[4]. Li Z, et al. GSK3326595 is a promising drug to prevent SARS-CoV-2 Omicron and other variants infection by inhibiting ACE2-R671 di-methylation [J]. Journal of Medical Virology, 2023, 95(1): e28158.

[5]. Luo Y, et al. Myelocytomatosis-protein arginine N-methyltransferase 5 Axis defines the tumorigenesis and immune response in hepatocellular carcinoma [J]. Hepatology, 2021, 74(4): 1932-1951. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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