1. Epigenetics
  2. Histone Methyltransferase
  3. PRMT5-IN-2

PRMT5-IN-2 is a rotein arginine methyltransferase 5 (PRMT5) inhibitor extracted from patent WO2018130840A1, compound 3.

For research use only. We do not sell to patients.

PRMT5-IN-2 Chemical Structure

PRMT5-IN-2 Chemical Structure

CAS No. : 1989620-04-3

Size Price Stock Quantity
5 mg USD 420 In-stock
10 mg USD 690 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

PRMT5-IN-2 is a rotein arginine methyltransferase 5 (PRMT5) inhibitor extracted from patent WO2018130840A1, compound 3[1].

IC50 & Target

PRMT5[1]

Molecular Weight

394.78

Formula

C17H16ClFN4O4

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O[C@H]1[C@@H](O[C@@]([C@@H](C2=CC(F)=C(Cl)C=C2)O)([H])[C@H]1O)N3C4=NC=NC(N)=C4C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (316.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5331 mL 12.6653 mL 25.3306 mL
5 mM 0.5066 mL 2.5331 mL 5.0661 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5331 mL 12.6653 mL 25.3306 mL 63.3264 mL
5 mM 0.5066 mL 2.5331 mL 5.0661 mL 12.6653 mL
10 mM 0.2533 mL 1.2665 mL 2.5331 mL 6.3326 mL
15 mM 0.1689 mL 0.8444 mL 1.6887 mL 4.2218 mL
20 mM 0.1267 mL 0.6333 mL 1.2665 mL 3.1663 mL
25 mM 0.1013 mL 0.5066 mL 1.0132 mL 2.5331 mL
30 mM 0.0844 mL 0.4222 mL 0.8444 mL 2.1109 mL
40 mM 0.0633 mL 0.3166 mL 0.6333 mL 1.5832 mL
50 mM 0.0507 mL 0.2533 mL 0.5066 mL 1.2665 mL
60 mM 0.0422 mL 0.2111 mL 0.4222 mL 1.0554 mL
80 mM 0.0317 mL 0.1583 mL 0.3166 mL 0.7916 mL
100 mM 0.0253 mL 0.1267 mL 0.2533 mL 0.6333 mL
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PRMT5-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
PRMT5-IN-2
Cat. No.:
HY-112165
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