Search Result

Results for "

collagen-induced+arthritis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (5) Apoptosis (4) Bacterial (2) Btk (1) c-Fms (1) Caspase (2) COX (2) Drug Derivative (1) Drug Intermediate (1) Drug Isomer (1) Endogenous Metabolite (1) FAP (1) Fungal (1) HDAC (1) Heme Oxygenase (HO) (1) Interleukin Related (5) IRAK (3) JAK (2) JNK (1) Kallikrein (1) LPL Receptor (2) LXR (1) MMP (3) Molecular Glues (1) mTOR (1) NF-κB (1) NO Synthase (1) p38 MAPK (2) Phospholipase (1) PPAR (1) Prostaglandin Receptor (3) PROTACs (1) PTHR (1) Reactive Oxygen Species (ROS) (3) Reference Standards (1) ROR (2) STAT (2) TNF Receptor (6) TREM receptor (1)
By Research Areas:	Cancer (11) Infection (7) Inflammation/Immunology (40) Metabolic Disease (1) Neurological Disease (4)

By Targets:

Antibiotic (5)

Apoptosis (4)

Bacterial (2)

Btk (1)

c-Fms (1)

Caspase (2)

COX (2)

Drug Derivative (1)

Drug Intermediate (1)

Drug Isomer (1)

Endogenous Metabolite (1)

FAP (1)

Fungal (1)

HDAC (1)

Heme Oxygenase (HO) (1)

Interleukin Related (5)

IRAK (3)

JAK (2)

JNK (1)

Kallikrein (1)

LPL Receptor (2)

LXR (1)

MMP (3)

Molecular Glues (1)

mTOR (1)

NF-κB (1)

NO Synthase (1)

p38 MAPK (2)

Phospholipase (1)

PPAR (1)

Prostaglandin Receptor (3)

PROTACs (1)

PTHR (1)

Reactive Oxygen Species (ROS) (3)

Reference Standards (1)

ROR (2)

STAT (2)

TNF Receptor (6)

TREM receptor (1)

By Research Areas:

Cancer (11)

Infection (7)

Inflammation/Immunology (40)

Metabolic Disease (1)

Neurological Disease (4)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-168625

VAV1 degrader-3	Molecular Glues	Inflammation/Immunology
VAV1 degrader-3 (Example 185) is an orally active VAV1 molecular glue degrader (DC₅₀: 7 nM). VAV1 degrader-3 reduces immune cell activation, immune cell proliferation and the production of various cytokines. VAV1 degrader-3 can be used for research of inflammatory or autoimmune disorder. VAV1 degrader-3 inhibits disease progression in experimntal autoimmune encephalomyelitis (EAE) mouse model, Collagen-induced arthritis (CIA) mouse model, etc. .

HY-P990151

Anti-Mouse TL1A/TNFSF15 Antibody (5G4.6)	TNF Receptor	Inflammation/Immunology
Anti-Mouse TL1A/TNFSF15 Antibody (5G4.6) is an anti-mouse TL1A/TNFSF15 IgG monoclonal antibody. Anti-Mouse TL1A/TNFSF15 Antibody (5G4.6) can reduce TL1A levels and block TL1A-DR3 interactions. Anti-Mouse TL1A/TNFSF15 Antibody (5G4.6) can be used for research on inflammation conditions such as colitis and collagen-induced arthritis (CIA) .

HY-108559

L-161982 1 Publications Verification	Prostaglandin Receptor	Inflammation/Immunology
L-161982 is a selective EP4 receptor antagonist. L-161982 completely blocks PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. L-161982 alleviates collagen-induced arthritis in mice .

HY-110177

SP-100030 1 Publications Verification	NF-κB	Inflammation/Immunology
SP-100030 is a potent NF-κB and activator protein-1 (AP-1) double inhibitor (IC₅₀s=50 and 50 nM, respectively). SP-100030 inhibits IL-2, IL-8, and TNF-alpha production in Jurkat and other T cell lines. SP-100030 decreases murine collagen-induced arthritis (CIA) .

HY-114495

Caerulomycin A 3 Publications Verification Cerulomycin; Caerulomycin	Fungal Antibiotic	Infection Inflammation/Immunology
Caerulomycin A is an orally active immunomodulator and antimicrobial agent. Caerulomycin A targets Smad3, STAT1 and GATA-3. Caerulomycin A downregulates GATA-3 expression, inhibits Th2 cell differentiation and Th2 cytokine production, reduces IgE levels, and alleviates pulmonary inflammatory responses and eosinophil infiltration. Caerulomycin A ameliorates collagen-induced arthritis symptoms, reduces joint inflammation and synovitis, and decreases the levels of proinflammatory cytokines in joints. Caerulomycin A inhibits the growth of some filamentous fungi, yeasts and specific bacteria. Caerulomycin A can be used in research related to arthritis and asthma .

HY-101448

TMI-1 1 Publications Verification WAY-171318	MMP Apoptosis Interleukin Related TNF Receptor Caspase	Infection Neurological Disease Inflammation/Immunology Cancer
TMI-1 (WAY-171318) inhibits TNF converting enzyme (TACE) (IC₅₀ of 8.4 nM), ADAM-TS-4, ADAM-17 and various MMPs with oral activity. TMI-1 significantly suppresses the secretion of TNF-α , alleviating collagen-induced arthritis in mice. TMI-1 inhibits cancer cell proliferation, induces apoptosis through a caspase-dependent pathway. TMI-1 also reverses TRPV1 upregulation and lowers the levels of inflammatory factors (TNF-α、IL-1β、IL-6) in nerve cells, protecting against paclitaxel-induced neurotoxicity. TMI-1 leads to changes in pro-atherogenic lipoprotein profiles, but does not affect the progression of early lesions .

HY-P10086

TREM-1 inhibitory peptide GF9 1 Publications Verification Human TREM-1(213-221)	TREM receptor TNF Receptor Interleukin Related c-Fms	Neurological Disease Inflammation/Immunology Cancer
TREM-1 inhibitory peptide GF9 (Human TREM-1 (213-221)) is a TREM-1 inhibitor. TREM-1 inhibitory peptide GF9 blocks the TREM-1 signaling pathway via a ligand-independent mechanism, spontaneously inserts into the cell membrane to dissociate TREM-1 from DAP-12, and functions through the Signaling Chain Homooligomerization (SCHOOL) model. TREM-1 inhibitory peptide GF9 reduces the levels of TNFα, IL-1β, IL-6, and M-CSF. TREM-1 inhibitory peptide GF9 inhibits tumor growth, prolongs the survival of mice with pancreatic cancer models, ameliorates collagen-induced arthritis, and exerts protective effects on bone and cartilage simultaneously. TREM-1 inhibitory peptide GF9 can be used in research related to arthritis, pancreatic cancer, retinopathy, alcoholic liver disease, and liver cancer .

HY-P5003

Collagen Type II Fragment	MMP	Inflammation/Immunology
Collagen Type II Fragment is an anti-inflammatory peptide that potently inhibits collagen-induced arthritis (CIA) in mice. Collagen Type II Fragment can be used for research on inflammation and immunity .

HY-136990

GLPG0259	p38 MAPK	Cancer
GLPG0259 is a ATP-competitive inhibitor of MAPK-activated protein kinase 5 (MK5) with oral activity. GLPG0259 reduces inflammation and bone destruction in a mouse model of collagen-induced arthritis. GLPG0259 also inhibited the metastasis of prostate cancer (PCa) cells .

HY-N9794

Isoboldine	Others	Inflammation/Immunology
Isoboldine is a pyridine alkaloid. Isoboldine effectively alleviates inflammation and joint destruction in collagen-induced arthritis in mice .

HY-123133

PKSI-527	Kallikrein	Inflammation/Immunology
PKSI-527 is a new, highly selective plasma kallikrein inhibitor. PKSI-527 can suppress collagen-induced arthritis (CIA) by modifying the kallikrein-kinin system .

HY-177435

FAPI-800CW	FAP	Inflammation/Immunology
FAPI-800CW is a near-infrared (NIR) fluorescent-labeled fibroblast activation protein (FAP) inhibitor. FAPI-800CW shows specific uptake in inflamed paws in collagen-induced arthritis (CIA) model mice. FAPI-800CW can be used for in vivo molecular imaging of FAP expression in inflammatory diseases such as rheumatoid arthritis (RA) to monitor joint inflammation and disease activity .

HY-18164

TASP0277308	LPL Receptor	Inflammation/Immunology
TASP0277308 is a highly selective S1P₁ antagonist. TASP0277308 possesses immunomodulatory activities, including lymphopenia, a block in T cell egress from the thymus, marginal zone B cell displacement, and the upregulation of CD69 expression on lymphocytes. TASP0277308 can be used for the research of collagen-induced arthritis in mice .

HY-167692

JI069	STAT	Others
JI069 is a novel JAK-STAT inhibitor that demonstrates potent activity in suppressing Th1, Th2, and Th17 differentiation while promoting iTreg differentiation. JI069 effectively inhibits STAT3 activation as well as the activation of other STATs, including STAT1, STAT5, and STAT6. JI069 has shown significant therapeutic potential in alleviating symptoms of collagen-induced arthritis in mice while inhibiting cytokine production from T cells and the phosphorylation of STAT3 in synovial cells.

HY-138007

SR-1903	ROR PPAR LXR	Metabolic Disease Inflammation/Immunology
SR-1903 is an inverse agonist of RORγ and PPARγ (IC₅₀ of ∼100 nM and 209 nM for RORγ and PPARγ, respectively) and a LXR agonist. SR-1903 exhibits anti-inflammatory and anti-diabetic efficacy in collagen-induced arthritis and diet-induced obesity mouse models .

HY-178012

GLPG4471	IRAK TNF Receptor	Inflammation/Immunology
GLPG4471 is a selective and orally active IRAK4 inhibitor with an IC₅₀ of 1.7 nM. GLPG4471 exhibits potent inhibition of cytokine (TNFα and IFNα) secretion in cellular and whole blood phenotypic assays. GLPG4471 displays significant activity in a mouse model of collagen-induced arthritis. GLPG4471 can be used for the study of arthritis .

HY-W004681

5-Hydroxy-2-methylpyridine 6-Methyl-3-pyridinol	Drug Intermediate	Inflammation/Immunology
6-Methyl-3-pyridinol (5-hydroxy-2-methylpyridine) is a starting compound for the synthesis of L-azatyrosine (HY-W048303). 6-Methyl-3-pyridinol can be isolated from cigarette smoke condensate. 6-Methyl-3-pyridinol aggravates Collagen-induced arthritis in mice .

HY-120041

ND-2158	IRAK	Cancer
ND-2158 is a competitive IRAK4 inhibitor, with the K_i of 1.3 nM. ND-2158 suppresses LPS-induced TNF production in human white blood cells, alleviated collagen-induced arthritis, and blocked gout formation in mouse models. ND-2158 has antitumor activity in vivo .

HY-117622

ND-2110	IRAK	Inflammation/Immunology Cancer
ND-2110 is a selective IRAK4 inhibitor (K_i: 7.5 nM). ND-2110 binds to the ATP pocket of IRAK4. ND-2110 targets the subset of activated B cell-like (ABC) subtype of diffuse large B cell lymphoma (DLBCL) cell lines with MYD88 L265P mutations,. ND-2110 inhibits LPS-induced TNF production, alleviates collagen-induced arthritis, and blocks gout formation in mouse models .

HY-120050

GK470	Phospholipase	Inflammation/Immunology
GK470 (compound 28) is an inhibitor of group IVA cytosolic phospholipase A2 (GIVA cPLA₂) with an IC₅₀ of 300 nM in vesicle assays. GK470 has anti-inflammatory activity, inhibiting the release of arachidonic acid in SW982 fibroblast-like synoviocytes with an IC₅₀ value of 0.6 μM. GK470 exhibits comparable anti-inflammatory effects to Methotrexate (HY-14519) in a preventive collagen-induced arthritis model and significantly reduces plasma PGE₂ levels .

HY-153321A

(R,R)-Bexobrutideg (R,R)-NX-5948; (R,R)-BTK-IN-24	Drug Isomer PROTACs Btk	Inflammation/Immunology Cancer
(R,R)-Bexobrutideg is the (R,R)-enantiomer of Bexobrutideg (HY-153321). Bexobrutideg (NX-5948) is an orally active PROTAC that induces specific BTK protein degradation via a cereblon E3 ligase (CRBN) complex without degrading other cereblon neo substrates. Bexobrutideg mediates potent anti-inflammatory activity through BTK degradation, thereby inhibiting B cell activation. Bexobrutideg exhibits potent tumor growth inhibition in TMD8 xenograft models containing wild-type BTK or BTKi resistance mutations. Bexobrutideg is effective in a mouse model of collagen-induced arthritis (CIA). Bexobrutideg can cross the blood-brain barrier. NX-5948 consists of a target protein ligand, a linker, and a VHL E3 ubiquitin ligase (Red: BTK ligand (HY-170324); Blue: CRBN ligand (HY-171893); Black: linker) .

HY-111749

JAK-IN-4	JAK	Inflammation/Immunology
JAK-IN-4 is a proagent of a JAK inhibitor, effective in murine collagen induced arthritis model .

HY-N14973

Epoxyquinomicin D	Antibiotic	Infection Inflammation/Immunology
Epoxyquinomicin D is an antibiotic that can be isolated from Amycolatopsis sp. Epoxyquinomicin D exhibits anti-inflammatory effects against collagen-induced arthritis .

HY-N14977

Epoxyquinomicin C	Antibiotic	Infection Inflammation/Immunology
Epoxyquinomicin C is an antibiotic that can be isolated from Amycolatopsis sp. Epoxyquinomicin C exhibits anti-inflammatory effects against collagen-induced arthritis. Epoxyquinomicin C can be designed for synthesis of the NF-κB Inhibitor DHMEQ .

HY-N12141

Flaccidoside II	Apoptosis	Inflammation/Immunology
Flaccidoside II inhibits proliferation and induces apoptosis in Malignant peripheral nerve sheath tumors (MPNSTs) cell lines. Flaccidoside II ameliorates collagen-induced arthritis in mice. Flaccidoside II is an active triterpenoid saponin constituent from Anemone flaccida rhizome .

HY-P4684

Osteostatin PTHrP (107–111)	PTHR	Inflammation/Immunology
Osteostatin, a fragment of parathyroid hormone-related protein (PTHrP) 107-111, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis, inhibits collagen-induced arthritis and inhibits osteoclastic bone resorption directly. Osteostatin can be used for inflammation and immunology research .

HY-155031

MCI	Reactive Oxygen Species (ROS) COX	Inflammation/Immunology Cancer
MCI alleviates inflammation by macrophage reprogramming via targeting ROS scavenging and COX-2 downregulation. MCI inhibits COX-2 with an IC₅₀ value of 1.23 μM. MCI has significant anti-inflammatory effects in collagen-induced arthritis (CIA) models. MCI can be used in research for rheumatoid arthritis (RA) .

HY-163651

(R)-Vorbipiprant (R)-CR6086	Prostaglandin Receptor	Inflammation/Immunology
(R)-Vorbipiprant ((R)-CR6086) is an orally active antagonist for prostaglandin E2 receptor 4 (EP4) with K_i of 16.6 nM for human EP4. (R)-Vorbipiprant inhibits PGE2 (HY-101952)-induced cAMP production with an IC₅₀ of 22 nM. (R)-Vorbipiprant exhibits immunomodulatory and anti-angiogenic activities, and ameliorates the collagen-induced arthritis in mice .

HY-N14238

Epoxyquinomicin B	Antibiotic Bacterial	Infection Inflammation/Immunology Cancer
Epoxyquinomicin B is an antibiotic that can be isolated from Amycolatopsis sp. Epoxyquinomicin B exhibits inhibitory activity against Micrococcus luteus, Bacillus subtilis, Pasteurella piscicida and Staphylococcus aureus with a MIC of 6.25-12.5 µg/mL. Epoxyquinomicin B exhibits cytotoxicity in cancer cell L1210 with IC₅₀ of 16.3 µg/mL. Epoxyquinomicin B exhibits anti-inflammatory effects against collagen-induced arthritis .

HY-112863

RORγt inhibitor 3	ROR	Inflammation/Immunology
RORγt inhibitor 3 is an orally active and potent retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor. RORγt inhibitor 3 shows high binding affinity and inhibitory activity of Th17 cell differentiation. RORγt inhibitor 3 also shows efficacy in both mouse experimental autoimmune encephalomyelitis (EAE) and collagen induced arthritis (CIA) models .

HY-108559R

L-161982 (Standard)	Prostaglandin Receptor	Inflammation/Immunology
L-161982 (Standard) is the analytical standard of L-161982. This product is intended for research and analytical applications. L-161982 is a selective EP4 receptor antagonist. L-161982 completely blocks PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. L-161982 alleviates collagen-induced arthritis in mice .

HY-N14237

Epoxyquinomicin A	Antibiotic Bacterial	Infection Inflammation/Immunology Cancer
Epoxyquinomicin A is an antibiotic that can be isolated from Amycolatopsis sp. Epoxyquinomicin A exhibits inhibitory activity against Micrococcus luteus, Bacillus subtilis, Pasteurella piscicida and Staphylococcus aureus with a MIC of 3-12.5 µg/mL. Epoxyquinomicin A exhibits cytotoxicity in cancer cell L1210, B16 and S180 with IC₅₀ of 2-8 µg/mL. Epoxyquinomicin A exhibits anti-inflammatory effects against collagen-induced arthritis .

HY-179216

KTT-1	HDAC	Neurological Disease Inflammation/Immunology
KTT-1 is a kinetically selective and orally active HDAC2 inhibitor. KTT-1 exhibits high HDAC2-selectivity over HDAC1. KTT-1 inhibits osteoclast differentiation at an early stage by downregulating c-Fos expression. KTT-1 effectively suppresses arthritis symptoms in the collagen-induced arthritis (CIA) mouse model. KTT-1 can be used for the research of rheumatoid arthritis and neurodegenerative diseases .

HY-N16371

6-Methoxy-8-hydroxyisocoumarin-3-carboxylic acid	Endogenous Metabolite	Inflammation/Immunology Cancer
6-Methoxy-8-hydroxyisocoumarin-3-carboxylic acid (Compound MC-1), an isocoumarin, is a metabolite of Cytogenin (HY-19606). 6-Methoxy-8-hydroxyisocoumarin-3-carboxylic acid has anti-angiogenic activity in S-180 implanted dorsal air sac mice model. 6-Methoxy-8-hydroxyisocoumarin-3-carboxylic acid also modifies collagen-induced arthritis. 6-Methoxy-8-hydroxyisocoumarin-3-carboxylic acid can be used for cancers and inflammatory diseases research .

HY-N16465

Cinnamtannin D1	Apoptosis Reactive Oxygen Species (ROS) STAT	Inflammation/Immunology
Cinnamtannin D1 is an orally active polyphenolic compound with immunosuppressive activity. Cinnamtannin D1 regulates the balance of Th17/Treg cells by inhibiting AHR expression. Cinnamtannin D1 reduces apoptosis and ROS in INS-1 cells and primary cultured murine islets induced by Palmitic acid (PA) (HY-N0830). Cinnamtannin D1 reduces Th17 cell differentiation via downregulating p-STAT3/RORγt and promotes Treg cell differentiation via upregulating p-STAT5/Foxp3. Cinnamtannin D1 exerts excellent anti-arthritic efficacy in collagen-induced arthritis (CIA) model of mice. Cinnamtannin D1 can be used for the study of rheumatoid arthritis (RA) .

HY-173518

SIN 14	Heme Oxygenase (HO) Reactive Oxygen Species (ROS) NO Synthase COX Interleukin Related	Inflammation/Immunology
SIN 14, a derivative of Sinomenine (HY-15122), is an orally active HO-1 activator (K_D = 17.2 μM). SIN 14 binds to the catalytic core domain of HO-1 and induces HO-1 activation in catalysis. SIN 14 significantly increases HO-1 stability. SIN 14 has anti-inflammatory effects and inhibits M1 macrophage polarization while promoting M2 polarization in LPS (Lipopolysaccharides)(HY-D1056)-induced RAW264.7 cells. SIN 14 inhibits inflammatory mediator production (eg: NO, IL-6, IL-1β and CCL2, inhibits production of ROS and down-regulates the expression of COX-2 and iNOS. SIN 14 can inhibit RA-related inflammatory edema in collagen-induced arthritis (ClA) mice .

HY-117767

CZ830	mTOR	Inflammation/Immunology
CZ830 is a mTOR kinase inhibitor with an IC₅₀ of < 1 μM. CZ830 is applicable to the research of collagen-induced arthritis .

HY-171296

p38 Kinase inhibitor 8	p38 MAPK JNK	Inflammation/Immunology
p38 Kinase inhibitor 8 (Compound CCLXXVIII) is the orally active inhibitor for p38β and JNK2α2 with IC₅₀s of 6.3 nM and 53.6 nM. p38 Kinase inhibitor 8 exhibits anti-inflammatory effect in rats collagen-induced arthritis models .

HY-14371

LX2932	Drug Derivative LPL Receptor	Inflammation/Immunology
LX2932 is an orally active LX2931 (HY-14370) analogue and S1P/S1PR signaling axis modulator. LX2932 yields a dose-dependent decrease in circulating lymphocyte numbers. LX2932 improves collagen-induced arthritis .

HY-P992000

F8-IL-4	Interleukin Related	Inflammation/Immunology
F8-IL-4 is an immune cytokine targeting IL-4. F8-IL-4 specifically delivers IL-4 to inflammatory sites via binding to targets expressed on neovascular vessels. F8-IL-4 alleviates collagen-induced arthritis in mice by regulating T cell subsets and macrophage polarization. When combined with Dexamethasone (HY-14648), F8-IL-4 produces a synergistic and long-lasting therapeutic effect, and prevents arthritis recurrence after drug withdrawal by maintaining anti-inflammatory cell phenotypes and cytokine profiles. F8-IL-4 can be used in the research of collagen-induced arthritis .

HY-182884

TNF-α-IN-29	TNF Receptor	Inflammation/Immunology
TNF-α-IN-29 is an orally active and selective TNF-α inhibitor, with IC₅₀ values of 123.0 nM against human targets, and a human K_d of 45.9 nM. TNF-α-IN-29 blocks TNF-α-TNFR1 protein-protein interactions and inhibits TNF-α-mediated inflammatory signaling pathways. TNF-α-IN-29 exhibits anti-inflammatory effects in a mouse model of collagen-induced arthritis and promotes articular cartilage repair. TNF-α-IN-29 can be used for the research of rheumatoid arthritis .

HY-181929

RAI-20 H018	JAK	Inflammation/Immunology
RAI-20 (H018) is an orally active JAK1/JAK2 dual inhibitor (IC₅₀=15.1 and 22.7 nM). RAI-20 exhibits excellent pharmacokinetic properties, including plasma stability, systemic exposure, and a long half-life. In a collagen-induced arthritis rat model, RAI-20 shows significant anti-inflammatory and anti-arthritic activities, effectively reducing paw swelling volume and arthritis index. RAI-20 can be used for research on the pathogenesis of rheumatoid arthritis .

HY-101448R

TMI-1 (Standard) WAY-171318 (Standard)	MMP Reference Standards Apoptosis Interleukin Related TNF Receptor Caspase	Infection Neurological Disease Inflammation/Immunology Cancer
TMI-1 (Standard) is the analytical standard of TMI-1 (HY-101448). This product is intended for research and analytical applications. TMI-1 (WAY-171318) inhibits TNF converting enzyme (TACE) (IC50 of 8.4 nM), ADAM-TS-4, ADAM-17 and various MMPs with oral activity. TMI-1 significantly suppresses the secretion of TNF-α , alleviating collagen-induced arthritis in mice. TMI-1 inhibits cancer cell proliferation, induces apoptosis through a caspase-dependent pathway. TMI-1 also reverses TRPV1 upregulation and lowers the levels of inflammatory factors (TNF-α、IL-1β、IL-6) in nerve cells, protecting against paclitaxel-induced neurotoxicity. TMI-1 leads to changes in pro-atherogenic lipoprotein profiles, but does not affect the progression of early lesions .

Cat. No.	Product Name	Target	Research Area