JI069
Based on 1 Customer Validation
JI069 is a novel JAK-STAT inhibitor that demonstrates potent activity in suppressing Th1, Th2, and Th17 differentiation while promoting iTreg differentiation. JI069 effectively inhibits STAT3 activation as well as the activation of other STATs, including STAT1, STAT5, and STAT6. JI069 has shown significant therapeutic potential in alleviating symptoms of collagen-induced arthritis in mice while inhibiting cytokine production from T cells and the phosphorylation of STAT3 in synovial cells.
For research use only. We do not sell to patients.
- Purity: 98.03%
- CAS No.: 850019-35-1
- Formula: C15H12Cl2N2O4S
- Molecular Weight:387.24
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Immunology/Inflammation Compound Library
HY-L007
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JAK/STAT Compound Library
HY-L008
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Kinase Inhibitor Library
HY-L009
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Stem Cell Signaling Compound Library
HY-L017
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Anti-Aging Compound Library
HY-L034
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Differentiation Inducing Compound Library
HY-L038
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Anti-Breast Cancer Compound Library
HY-L074
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Anti-Lung Cancer Compound Library
HY-L075
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Anti-Pancreatic Cancer Compound Library
HY-L077
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Anti-Blood Cancer Compound Library
HY-L079
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Anti-Obesity Compound Library
HY-L087
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Transcription Factor-Targeted Library
HY-L090
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Cancer Stem Cells Compound Library
HY-L135
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Coagulation and Anti-coagulation Compound Library
HY-L136
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Anti-Hematopathy Compound Library
HY-L171
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Cell Proliferation Compound Library
HY-L201
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
Chemical Information
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CAS No. 850019-35-1
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Appearance Solid
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Molecular Weight 387.24
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Formula C15H12Cl2N2O4S
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Color Light yellow to light brown
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SMILES
O=C(C1=C(NC(COC(CC2=C(Cl)C=CC=C2Cl)=O)=O)SC=C1)N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (322.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5824 mL | 12.9119 mL | 25.8238 mL | 64.5594 mL |
| 5 mM | 0.5165 mL | 2.5824 mL | 5.1648 mL | 12.9119 mL | |
| 10 mM | 0.2582 mL | 1.2912 mL | 2.5824 mL | 6.4559 mL | |
| 15 mM | 0.1722 mL | 0.8608 mL | 1.7216 mL | 4.3040 mL | |
| 20 mM | 0.1291 mL | 0.6456 mL | 1.2912 mL | 3.2280 mL | |
| 25 mM | 0.1033 mL | 0.5165 mL | 1.0330 mL | 2.5824 mL | |
| 30 mM | 0.0861 mL | 0.4304 mL | 0.8608 mL | 2.1520 mL | |
| 40 mM | 0.0646 mL | 0.3228 mL | 0.6456 mL | 1.6140 mL | |
| 50 mM | 0.0516 mL | 0.2582 mL | 0.5165 mL | 1.2912 mL | |
| 60 mM | 0.0430 mL | 0.2152 mL | 0.4304 mL | 1.0760 mL | |
| 80 mM | 0.0323 mL | 0.1614 mL | 0.3228 mL | 0.8070 mL | |
| 100 mM | 0.0258 mL | 0.1291 mL | 0.2582 mL | 0.6456 mL |
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