Cinnamtannin D1
Cinnamtannin D1 is an orally active polyphenolic compound with immunosuppressive activity. Cinnamtannin D1 regulates the balance of Th17/Treg cells by inhibiting AHR expression. Cinnamtannin D1 reduces apoptosis and ROS in INS-1 cells and primary cultured murine islets induced by Palmitic acid (PA) (HY-N0830). Cinnamtannin D1 reduces Th17 cell differentiation via downregulating p-STAT3/RORγt and promotes Treg cell differentiation via upregulating p-STAT5/Foxp3. Cinnamtannin D1 exerts excellent anti-arthritic efficacy in collagen-induced arthritis (CIA) model of mice. Cinnamtannin D1 can be used for the study of rheumatoid arthritis (RA).
For research use only. We do not sell to patients.
- CAS No.: 97233-06-2
- Formula: C45H36O18
- Molecular Weight:864.76
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Cinnamtannin D1 (40 μM, 72 h) significantly inhibits Th17 cell differentiation and promotes Treg cell differentiation in naive CD4+T cells from BALB/c mice under Th17 or Treg polarization conditions[1].
Cinnamtannin D1 (40 μM, 72 h) reduces IL-17A level in Th17 cell supernatant and increases IL-10 level in Treg cell supernatant[1].
Cinnamtannin D1 (72 h) significantly inhibits 6-formylindolo[3,2-b] carbazole (FICZ) (HY-12451)-induced Th17 cell differentiation in splenocytes from BALB/c mice[1].
Cinnamtannin D1(20-40 μM, 96 h) dose-dependently inhibits Th17 cell differentiation and decreases AHR protein expression in naive CD4+T cells from BALB/c mice under Th17 polarization conditions[1].
Cinnamtannin D1 (1.56-50 μM, 48 h) dose-dependently increases cell viability in INS-1 cells treated with Palmitic acid (PA) (HY-N0830)[2].
Cinnamtannin D1 (25-50 μM, 48 h) significantly reduces the apoptotic rate and ROS and NO production of INS-1 cells and primary cultured murine islets induced by PA[2].
Cinnamtannin D1 (25-50 μM, 48 h) significantly reduces the phosphorylation of NF-κB and c-Jun N-terminal kinase (JNK) in INS-1 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:INS-1 cells
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Concentration:25, 50 μM
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Incubation Time:48 h
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Result:Reduced the phosphorylation of NF-κB and c-Jun N-terminal kinase (JNK) in INS-1 cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Bovine collagen type II was intradermally injected into the base of the tail of 6-8-week-old male DBA/1 mice for primary immunization[1]
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Dosage:50 mg/kg
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Administration:p.o., daily, 4 weeks
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Result:Achieved significant alleviation of collagen-induced arthritis (CIA) severity.
Alleviated joint inflammatory cell infiltration and cartilage damage.
Decreased serum levels of CII-specific IgG, IgG2a, IgG3, and inflammatory cytokines (IL-17, IL-6, IL-1β).
Increased serum levels of anti-inflammatory cytokines (IL-10, TGF-β).
reduced the number of IL-17-secreting cells in spleen and draining lymph nodes.
Decreased splenic Th17 cell (CD4+IL-17A+) frequency.
Elevated splenic Treg cell (CD4+CD25+Foxp3+) frequency.
Decreased phospho-STAT3 (Tyr705) expression.
Increased phospho-STAT5 (Tyr649) expression.
Downregulated mRNA levels of Rorc, Il17, Ccr6, Ahr, and Il22.
Upregulated mRNA levels of Foxp3, Il10, and Tgfb.
Chemical Information
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CAS No. 97233-06-2
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Molecular Weight 864.76
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Formula C45H36O18
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SMILES
O[C@H]1[C@](OC2=CC(O)=C3)(C(C=C4)=CC(O)=C4O)OC(C=C5O)=C(C(O[C@@H]6C(C=C7)=CC(O)=C7O)=C5[C@H](C(C(O)=C8)=C(O[C@H](C(C=C9)=CC(O)=C9O)[C@H]%10O)C(C%10)=C8O)[C@H]6O)[C@@]1([H])C2=C3O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Shi C, et al. Cinnamtannin D1 attenuates autoimmune arthritis by regulating the balance of Th17 and treg cells through inhibition of aryl hydrocarbon receptor expression. Pharmacol Res. 2020 Jan;151:104513. [Content Brief]
[2]. Wang T, et al. Cinnamtannin D-1 protects pancreatic β-cells from palmitic acid-induced apoptosis by attenuating oxidative stress. J Agric Food Chem. 2014 Jun 4;62(22):5038-45. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cinnamtannin D1 Related Classifications
HY-N16465 Related Classifications
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