97233-06-2
Chemical Structure
Cinnamtannin D1
- CAS No.: 97233-06-2
- Formula:C45H36O18
- Molecular Weight:864.76
SMILES: O[C@H]1[C@](OC2=CC(O)=C3)(C(C=C4)=CC(O)=C4O)OC(C=C5O)=C(C(O[C@@H]6C(C=C7)=CC(O)=C7O)=C5[C@H](C(C(O)=C8)=C(O[C@H](C(C=C9)=CC(O)=C9O)[C@H]%10O)C(C%10)=C8O)[C@H]6O)[C@@]1([H])C2=C3O
Biological Activity: Cinnamtannin D1 is an orally active polyphenolic compound with immunosuppressive activity. Cinnamtannin D1 regulates the balance of Th17/Treg cells by inhibiting AHR expression. Cinnamtannin D1 reduces apoptosis and ROS in INS-1 cells and primary cultured murine islets induced by Palmitic acid (PA) (HY-N0830). Cinnamtannin D1 reduces Th17 cell differentiation via downregulating p-STAT3/RORγt and promotes Treg cell differentiation via upregulating p-STAT5/Foxp3. Cinnamtannin D1 exerts excellent anti-arthritic efficacy in collagen-induced arthritis (CIA) model of mice. Cinnamtannin D1 can be used for the study of rheumatoid arthritis (RA)[1][2].
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Cinnamtannin D1 | Cinnamtannin D1 is an orally active polyphenolic compound with immunosuppressive activity. Cinnamtannin D1 regulates the balance of Th17/Treg cells by inhibiting AHR expression. Cinnamtannin D1 reduces apoptosis and ROS in INS-1 cells and primary cultured murine islets induced by Palmitic acid (PA) (HY-N0830). Cinnamtannin D1 reduces Th17 cell differentiation via downregulating p-STAT3/RORγt and promotes Treg cell differentiation via upregulating p-STAT5/Foxp3. Cinnamtannin D1 exerts excellent anti-arthritic efficacy in collagen-induced arthritis (CIA) model of mice. Cinnamtannin D1 can be used for the study of rheumatoid arthritis (RA). | |||||||||||||||||||||
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References
- [1]. Shi C, et al. Cinnamtannin D1 attenuates autoimmune arthritis by regulating the balance of Th17 and treg cells through inhibition of aryl hydrocarbon receptor expression. Pharmacol Res. 2020 Jan;151:104513. [Content Brief]
- [2]. Wang T, et al. Cinnamtannin D-1 protects pancreatic β-cells from palmitic acid-induced apoptosis by attenuating oxidative stress. J Agric Food Chem. 2014 Jun 4;62(22):5038-45. [Content Brief]
