2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease
  4. PKSI-527

PKSI-527 is a new, highly selective plasma kallikrein inhibitor. PKSI-527 can suppress collagen-induced arthritis (CIA) by modifying the kallikrein-kinin system.

For research use only. We do not sell to patients.

PKSI-527 Chemical Structure

PKSI-527 Chemical Structure

CAS No. : 128837-71-8

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 115 In-stock
Solution
10 mM * 1 mL in DMSO USD 115 In-stock
Solid
5 mg USD 110 In-stock
10 mg USD 190 In-stock
25 mg USD 400 In-stock
50 mg USD 640 In-stock
100 mg USD 1025 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

PKSI-527 Related Antibodies

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Description

PKSI-527 is a new, highly selective plasma kallikrein inhibitor. PKSI-527 can suppress collagen-induced arthritis (CIA) by modifying the kallikrein-kinin system[1].

Molecular Weight

473.99

Formula

C25H32ClN3O4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

NC[C@@H]1CC[C@H](CC1)C(N[C@H](C(NC2=CC=C(C=C2)CC(O)=O)=O)CC3=CC=CC=C3)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (210.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1097 mL 10.5487 mL 21.0975 mL
5 mM 0.4219 mL 2.1097 mL 4.2195 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1097 mL 10.5487 mL 21.0975 mL 52.7437 mL
5 mM 0.4219 mL 2.1097 mL 4.2195 mL 10.5487 mL
10 mM 0.2110 mL 1.0549 mL 2.1097 mL 5.2744 mL
15 mM 0.1406 mL 0.7032 mL 1.4065 mL 3.5162 mL
20 mM 0.1055 mL 0.5274 mL 1.0549 mL 2.6372 mL
25 mM 0.0844 mL 0.4219 mL 0.8439 mL 2.1097 mL
30 mM 0.0703 mL 0.3516 mL 0.7032 mL 1.7581 mL
40 mM 0.0527 mL 0.2637 mL 0.5274 mL 1.3186 mL
50 mM 0.0422 mL 0.2110 mL 0.4219 mL 1.0549 mL
60 mM 0.0352 mL 0.1758 mL 0.3516 mL 0.8791 mL
80 mM 0.0264 mL 0.1319 mL 0.2637 mL 0.6593 mL
100 mM 0.0211 mL 0.1055 mL 0.2110 mL 0.5274 mL
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PKSI-527 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PKSI-527128837-71-8PKSI527PKSI 527Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesplasma kallikreincollagen-induced arthritis (CIA)kallikrein-kinin systemInhibitorinhibitorinhibit

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