Search Result
Results for "
neurites
" in MedChemExpress (MCE) Product Catalog:
2
Biochemical Assay Reagents
1
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-149500
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- HY-133101
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Others
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Cancer
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14-Norpseurotin is a compound isolated from the culture of Aspergillus fumigatus. 14-Norpseurotin significantly induces neurite outgrowth of rat pheochromocytoma cells (PC12) at a 10.0 microM concentration .
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- HY-N9096
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Others
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Neurological Disease
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Gentiside B has neuritogenic activity and induce neurite outgrowth. Gentiside B can be isolated from the root and rhizome of Gentiana rigescens. Gentiana has hepatoprotective, anti-inflammatory, analgesic, antiproliferative and antimicrobial effects .
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- HY-162330
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HDAC
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Neurological Disease
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HDAC6-IN-36 (compound 11d) is an inhibitor of HDAC6 with IC50 value of 8.64 nM. HDAC6-IN-36 induces neurite outgrowth of PC12 cells without producing toxic effects.
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- HY-116392E
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- HY-N0857
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- HY-N12170
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Others
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Neurological Disease
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Kissoone C (compound 3) is a three-membered ring sesquiterpene isolated from valerian root. Kissoone C can enhance the activity of nerve growth factor (NGF)-mediated neurite outgrowth in PC12D cells .
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- HY-107116
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Microtubule/Tubulin
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Neurological Disease
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MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 binds in vitro to microtubule-associated protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents .
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- HY-N4285
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- HY-158131
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FKBP
HSP
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Neurological Disease
Cancer
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FKBP51-Hsp90-IN-2 (Compound E08) is a selective FKBP51-Hsp90 protein-protein interaction inhibitor with IC50 values of 0.4 µM and 5 µM for FKBP51 and FKBP52, respectively. FKBP51-Hsp90-IN-2 also effectively stimulates cellular energy metabolism and neurite growth. FKBP51-Hsp90-IN-2 can be used in research on neurodegenerative diseases and cancer .
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- HY-P4322
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ERK
Akt
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Neurological Disease
Cancer
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H-Ile-Lys-Val-Ala-Val-OH is one of the most potent active sites of laminin-1. H-Ile-Lys-Val-Ala-Val-OH promotes cell adhesion, neurite outgrowth, and tumor growth. H-Ile-Lys-Val-Ala-Val-OH stimulates BMMSC population growth and proliferation by activating MAPK/ERK1/2 and PI3K/Akt signalling pathways .
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- HY-N10325
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Others
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Others
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Scabronine M is a novel inhibitor of NGF-induced neurite outgrowth from PC12 cells.
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- HY-110155
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Neurotensin Receptor
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Neurological Disease
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LM11A-31 dihydrochloride, a non-peptide p75 NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist. LM11A-31 dihydrochloride is an amino acid derivative with high blood-brain barrier permeability and blocks p75-mediated cell death. M11A-31 dihydrochloride reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression .
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- HY-120553
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Apoptosis
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Neurological Disease
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B355252, a phenoxy thiophene sulfonamide small molecule, is a potent NGF receptor agonist. B355252 potentiates NGF-induced neurite outgrowth. B355252 protects ischemic neurons from neuronal loss by attenuating DNA damage, reducing ROS production and the LDH level, and preventing neuronal apoptosis. B355252 has anti-apoptotic effects in glutamate-induced excitotoxicity, as well as in a murine hippocampal cell line (HT22) model of Parkinson disease (PD) .
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- HY-E70043
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Sialidase isoenzyme S; AuSialidase S
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Endogenous Metabolite
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Metabolic Disease
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Ganglioside sialidase (AuSialidase S) is an endogenous metabolite. Ganglioside sialidases have been implicated in neuronal differentiation processes, including neurite outgrowth .
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- HY-112798
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Others
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Neurological Disease
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PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells that could rescue impairments of mitochondrial motility and neurite outgrowth.
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- HY-N3482
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Others
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Neurological Disease
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Isogarciniaxanthone E (compound 1) is a natural product that can be found in Garcinia xanthochymus. Isogarciniaxanthone E enhances nerve growth factor-mediated neurite outgrowth .
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- HY-N11001
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Others
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Neurological Disease
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Erinacine U is a cyanogen diterpene isolated from Hericium erinaceus, which has neurotrophic activity and has obvious neurite growth-promoting effect on PC12 cells .
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- HY-N9085
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Bacterial
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Neurological Disease
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Neuchromenin is a microbial melabolite that can be isolated from the culture broth of Eupenicillium javanicum var. meloforme PFll81. Neuchromenin induces neurite outgrowth of PC12 cells .
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- HY-114616
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Others
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Neurological Disease
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PBB3, a selective PET ligand, recognizes tau pathology in Alzheimer's disease brains, where dystrophic neurites and diffuse neurofibrils are more clearly detected Tangles with calcification .
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- HY-18314
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- HY-161327
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HBV
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Infection
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HBV-IN-44 (Compound (S)-2a) is a HBV inhibitor with a IC50 value of 23 nM for HbsAg. HBV-IN-44 is less toxic to the neurite growth of HT22 cells and DRG neurons in vitro .
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- HY-124401
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BT-13
2 Publications Verification
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RET
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Neurological Disease
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BT-13 is a potent and selective glial cell line-derived neurotrophic factor (GDNF) receptor RET agonist independently of GFLs, promoting neurite growth from sensory neurons in vitro and attenuates experimental neuropathy in the Rat .
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- HY-N3928
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Others
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Neurological Disease
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Garciniaxanthone E is a xanthone compound. Garciniaxanthone E significantly enhances cellular nerve growth factor (NGF)-mediated neurite outgrowth in PC12D cells. Garciniaxanthone E contributes to basic research and medicinal development in neurodegenerative diseases .
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- HY-117517
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Others
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Cancer
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NG-012, potentiator of nerve growth factor (NGF), were isolated from the culture broth of Penicillium verruculosum F-4542. NG-012 potentiates the neurite outgrowth induced by NGF in rat pheochromocytoma cell line (PC12) .
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- HY-N8303
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ERK
PAK
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Neurological Disease
Inflammation/Immunology
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Gardenin A is an orally active and synthetic PMF analogue with the neurotrophic effect for neurite outgrowth and neuronal differentiation. Gardenin A promotes neuritogenesis via activating MAPK/ERK, PKC, and PKA, but not TrkA, CREB signaling pathways. Gardenin A also has sedative, anxiolytic, antidepressant, and anticonvulsant effects .
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- HY-W127502
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1-Hex-GPA
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Biochemical Assay Reagents
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Others
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1-Hexadecyl lysophosphatidic acid is an ether analog of lysophosphatidic acid (LPA) containing a hexadecyl group in the sn-1 position. LPA binds to five different G protein-coupled receptors and mediates a variety of biological responses, including cell proliferation, smooth muscle contraction, platelet aggregation, neurite contraction, and cell motility.
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- HY-107116S
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Microtubule/Tubulin
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MAP4343-d4 is the deuterium labeled MAP4343. MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 binds in vitro to microtubule-associated protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents[1][2][3].
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- HY-P4439
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Amino Acid Derivatives
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Neurological Disease
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H-Met-Val-OH is a dipeptide containing free N-terminal methionine. H-Met-Val-OH exhibits activity against cDNA expressing Flavin-containing monooxygenase (FMO) 1 and FMO3. H-Met-Val-OH has potential applications in the growth of neuritis .
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- HY-N0380
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Others
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Neurological Disease
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Nardosinone, isolated from Nardostachys chinensis, is the first enhancer of the neuritogenic action of dbcAMP and staurosporine. Nardosinone may become a useful pharmacological tool for studying the mechanism of action of not only nerve growth factor (NGF) but also both the neuritogenic substances .
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- HY-146678
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HDAC
Amyloid-β
Cholinesterase (ChE)
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Neurological Disease
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HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-5 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity .
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- HY-146679
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HDAC
Amyloid-β
Cholinesterase (ChE)
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Neurological Disease
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HDAC6-IN-6 (compound 6a) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-6 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-6 can enhance neurite outgrowth without significant neurotoxicity .
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- HY-P5754B
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Apoptosis
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Neurological Disease
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TAT-NEP1-40 acetate is a therapeutic candidate for axonal regeneration and functional recovery after stroke. TAT-NEP1-40 acetate can protect PC12 cells against oxygen and glucose deprivation (OGD) and promote neurite outgrowth. TAT-NEP1-40 acetate protects the brain against ischemia/reperfusion injury through inhibition of neuronal apoptosis. TAT-NEP1-40 acetate can be efficiently delivered into the rat brains .
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- HY-P5754
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Apoptosis
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Neurological Disease
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TAT-NEP1-40 is a BBB-penatrable peptide. TAT-NEP1-40 protects PC12 cells against oxygen and glucose deprivation (OGD), and promotes neurite outgrowth. TAT-NEP1-40 also improves ischemia-induced neurologic outcomes by inhibiting cell apoptosis in ischemic brains. TAT-NEP1-40 can be used for research of CNS injuries, such as axonal regeneration and functional recovery after stroke .
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- HY-15780
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OPC-34712
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5-HT Receptor
Dopamine Receptor
Adrenergic Receptor
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Neurological Disease
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Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM) .
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- HY-15780A
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OPC-34712 hydrochloride
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5-HT Receptor
Dopamine Receptor
Adrenergic Receptor
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Neurological Disease
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Brexpiprazole (OPC-34712) hydrochloride, an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole hydrochloride is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Brexpiprazole hydrochloride also shows potent antagonist activity at human noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM) .
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- HY-N12172
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Others
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Others
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Kissoone A (compound 1) is a three-membered ring sesquiterpene isolated from valerian root .
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- HY-16594
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Proteasome
Apoptosis
ROS Kinase
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Infection
Cardiovascular Disease
Neurological Disease
Cancer
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Lactacystin is a potent, orally active, irreversible, cell-permeable, selective 20S proteasome inhibitor (IC50 = 4.8 μM). Lactacystin also inhibits the lysosomal enzyme cathepsin A. Lactacystin inhibits cell growth and induces apoptosisand cell cycle arrest, and has antiviral and antioxidative activity. Lactacystin induces neurite outgrowth and hypertension. Lactacystin has the potential for the research of cancer, Neurological Disease, hypertension and Malaria, and so on [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] .
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- HY-P5754A
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Apoptosis
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Neurological Disease
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TAT-NEP1-40 TFA is a BBB-penatrable peptide. TAT-NEP1-40 TFA protects PC12 cells against oxygen and glucose deprivation (OGD), and promotes neurite outgrowth. TAT-NEP1-40 TFA also improves ischemia-induced neurologic outcomes by inhibiting cell apoptosis in ischemic brains. TAT-NEP1-40 TFA can be used for research of CNS injuries, such as axonal regeneration and functional recovery after stroke .
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- HY-16663
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ITX3
2 Publications Verification
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Others
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Others
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ITX3 is a specific and nontoxic inhibitor of TrioN (N-terminal GEF domain of the multidomain Trio protein) with an IC50 value of 76 μM. ITX3 can be used for the research of agent .
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- HY-110155A
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Others
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Neurological Disease
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(Rac)-LM11A-31 dihydrochloride is an isomer of LM11A-31 dihydrochloride. LM11A-31 dihydrochloride, a non-peptide p75 NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist .
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Cat. No. |
Product Name |
Type |
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- HY-E70043
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Sialidase isoenzyme S; AuSialidase S
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Biochemical Assay Reagents
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Ganglioside sialidase (AuSialidase S) is an endogenous metabolite. Ganglioside sialidases have been implicated in neuronal differentiation processes, including neurite outgrowth .
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- HY-W127502
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1-Hex-GPA
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Cell Assay Reagents
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1-Hexadecyl lysophosphatidic acid is an ether analog of lysophosphatidic acid (LPA) containing a hexadecyl group in the sn-1 position. LPA binds to five different G protein-coupled receptors and mediates a variety of biological responses, including cell proliferation, smooth muscle contraction, platelet aggregation, neurite contraction, and cell motility.
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Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P4322
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ERK
Akt
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Neurological Disease
Cancer
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H-Ile-Lys-Val-Ala-Val-OH is one of the most potent active sites of laminin-1. H-Ile-Lys-Val-Ala-Val-OH promotes cell adhesion, neurite outgrowth, and tumor growth. H-Ile-Lys-Val-Ala-Val-OH stimulates BMMSC population growth and proliferation by activating MAPK/ERK1/2 and PI3K/Akt signalling pathways .
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- HY-P5118A
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Peptides
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Neurological Disease
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Tat-peptide 190-208 TFA is a cell-permeable and Tat-labeled fusion peptide, corresponding to residues 190-208 of rat G3BP1. Tat sequence from HIV, is placed at the least conserved end of the sequence, for cell permeability. Tat-peptide 190-208 TFA increases axon growth and increases the number of neurites per neuron. Tat-peptide 190-208 TFA likely exhibits an axon intrinsic mechanism. Tat-peptide 190-208 TFA can be used for ischemic protection during endovascular repair for intracranial aneurysms .
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- HY-P5119
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Peptides
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Neurological Disease
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Tat-peptide 168-189 is a cell-permeable and Tat-labeled fusion peptide, corresponding to residues 168-189 of rat G3BP1. Tat sequence from HIV, is placed at the least conserved end of the sequence, for cell permeability. Tat-peptide 168-189 is the negtive control of Tat-peptide 190-208 (HY-P5118), as Tat-peptide 190-208 increases axon growth and increases the number of neurites per neuron .
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- HY-P5119A
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Peptides
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Neurological Disease
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Tat-peptide 168-189 is a cell-permeable and Tat-labeled fusion peptide, corresponding to residues 168-189 of rat G3BP1. Tat sequence from HIV, is placed at the least conserved end of the sequence, for cell permeability. Tat-peptide 168-189 is the negtive control of Tat-peptide 168-189 TFA (HY-P5118A), as Tat-peptide 168-189 TFA increases axon growth and increases the number of neurites per neuron .
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- HY-P5118
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Peptides
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Neurological Disease
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Tat-peptide 190-208 is a cell-permeable and Tat-labeled fusion peptide, corresponding to residues 190-208 of rat G3BP1. Tat sequence from HIV, is placed at the least conserved end of the sequence, for cell permeability. Tat-peptide 190-208 increases axon growth and increases the number of neurites per neuron. Tat-peptide 190-208 likely exhibits an axon intrinsic mechanism. Tat-peptide 190-208 can be used for ischemic protection during endovascular repair for intracranial aneurysms .
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- HY-P5353
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IKVAV sequence; Laminin A-chain fragment
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Peptides
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Others
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PA22-2 (IKVAV sequence; Laminin A-chain fragment) is a biological active peptide. (This peptide is derived from mouse laminin a1 . Cell matrix substrate constituted with this peptide can promote neurite outgrowth.)
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- HY-P2697
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Cys-Laminin A chain 2091-2108
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Peptides
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Others
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PA22-2 (free acid) (Cys-Laminin A chain 2091-2108) is a peptide that supports neurite outgrowth and stimulates neuronal-like process formation. PA22-2 (free acid) can be used to culture human adenoid cystic carcinoma cells, and in the preparation of peptide-functionalized supported phospholipid bilayers .
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- HY-P4439
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Amino Acid Derivatives
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Neurological Disease
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H-Met-Val-OH is a dipeptide containing free N-terminal methionine. H-Met-Val-OH exhibits activity against cDNA expressing Flavin-containing monooxygenase (FMO) 1 and FMO3. H-Met-Val-OH has potential applications in the growth of neuritis .
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- HY-P5754B
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Apoptosis
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Neurological Disease
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TAT-NEP1-40 acetate is a therapeutic candidate for axonal regeneration and functional recovery after stroke. TAT-NEP1-40 acetate can protect PC12 cells against oxygen and glucose deprivation (OGD) and promote neurite outgrowth. TAT-NEP1-40 acetate protects the brain against ischemia/reperfusion injury through inhibition of neuronal apoptosis. TAT-NEP1-40 acetate can be efficiently delivered into the rat brains .
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- HY-P5754
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Apoptosis
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Neurological Disease
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TAT-NEP1-40 is a BBB-penatrable peptide. TAT-NEP1-40 protects PC12 cells against oxygen and glucose deprivation (OGD), and promotes neurite outgrowth. TAT-NEP1-40 also improves ischemia-induced neurologic outcomes by inhibiting cell apoptosis in ischemic brains. TAT-NEP1-40 can be used for research of CNS injuries, such as axonal regeneration and functional recovery after stroke .
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- HY-P5754A
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Apoptosis
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Neurological Disease
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TAT-NEP1-40 TFA is a BBB-penatrable peptide. TAT-NEP1-40 TFA protects PC12 cells against oxygen and glucose deprivation (OGD), and promotes neurite outgrowth. TAT-NEP1-40 TFA also improves ischemia-induced neurologic outcomes by inhibiting cell apoptosis in ischemic brains. TAT-NEP1-40 TFA can be used for research of CNS injuries, such as axonal regeneration and functional recovery after stroke .
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Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P99213
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GSK1223249
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Inhibitory Antibodies
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Neurological Disease
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Ozanezumab (GSK1223249) is an anti-Nogo-A (neurite outgrowth inhibitor A) monoclonal antibody. Ozanezumab can be used in amyotrophic lateral sclerosis (ALS) and multiple sclerosis research .
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Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
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- HY-107116S
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MAP4343-d4 is the deuterium labeled MAP4343. MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 binds in vitro to microtubule-associated protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents[1][2][3].
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