2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC6-IN-36

HDAC6-IN-36 (compound 11d) is an inhibitor of HDAC6 with IC50 value of 8.64 nM. HDAC6-IN-36 induces neurite outgrowth of PC12 cells without producing toxic effects.

For research use only. We do not sell to patients.

HDAC6-IN-36 Chemical Structure

HDAC6-IN-36 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

HDAC6-IN-36 Related Antibodies

Top Publications Citing Use of Products

View All HDAC Isoform Specific Products:

View All Isoforms

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

HDAC6-IN-36 (compound 11d) is an inhibitor of HDAC6 with IC50 value of 8.64 nM. HDAC6-IN-36 induces neurite outgrowth of PC12 cells without producing toxic effects.

IC50 & Target

HDAC1

1284 nM (IC50)

HDAC6

8.64 nM (IC50)

In Vitro

HDAC6-IN-36 (1 μM, 24 h) increases the acetylation level of histone H3 and ɑ-tubulin in the PC12 cell line.
HDAC6-IN-36 (1-10 μM, 48 h) stimulates neurite outgrowth induced by NGF (20 ng/mL) in PC12 cells.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC6-IN-36 Related Antibodies

Western Blot Analysis[1]

Cell Line: PC12 cell
Concentration: 0.1, 0.5 and 1 μM
Incubation Time: 24 h
Result: Increased the acetylation level of α-tubulin in a dose-dependent manner.
Molecular Weight

529.03

Formula

C30H29ClN4O3
SMILES

O=C(NCC1=CC=C(C(NO)=O)C=C1)[C@H](C2)N(CC3CC3)[C@H](C4=CC=C(Cl)C=C4)C5=C2C6=CC=CC=C6N5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

HDAC6-IN-36 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6-IN-36HDACHistone deacetylasesHDAC6 inhibitorNeurite outgrowthInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
HDAC6-IN-36
Cat. No.:
HY-162330
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.