PBB3
Based on 1 Customer Validation
PBB3 is a tracer of tau PET. PBB3 can be used to detect levels of tau protein in Alzheimer's disease and non-Alzheimer's disease.
For research use only. We do not sell to patients.
- Purity: 96.21%
- CAS No.: 1565796-97-5
- Formula: C17H15N3OS
- Molecular Weight:309.39
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
PBB3 (56.5 µM) labels Alzheimer's disease patient-originated brain pathological changes by fluorescent labeling[1].
PBB3 (56.5 µM) labels neuropil threads and plaque neurites in hippocampal derived from an Alzheimer’s disease patient[1].
PBB3 bound
to primitive plaques, which is accumulation ofabnormally swollen neurites without cores of
extracellular amyloid[1].
PBB3 clearly detects dystrophic neurites in
brains of Alzheimer's disease and diffuse neurofibrillary tangles with calcification
characterized by accumulation of all six tau isoforms[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1565796-97-5
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Appearance Solid
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Molecular Weight 309.39
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Formula C17H15N3OS
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Color Yellow to orange
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SMILES
OC1=CC=C2N=C(SC2=C1)/C=C/C=C/C3=CN=C(C=C3)NC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (323.22 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2322 mL | 16.1608 mL | 32.3217 mL | 80.8042 mL |
| 5 mM | 0.6464 mL | 3.2322 mL | 6.4643 mL | 16.1608 mL | |
| 10 mM | 0.3232 mL | 1.6161 mL | 3.2322 mL | 8.0804 mL | |
| 15 mM | 0.2155 mL | 1.0774 mL | 2.1548 mL | 5.3869 mL | |
| 20 mM | 0.1616 mL | 0.8080 mL | 1.6161 mL | 4.0402 mL | |
| 25 mM | 0.1293 mL | 0.6464 mL | 1.2929 mL | 3.2322 mL | |
| 30 mM | 0.1077 mL | 0.5387 mL | 1.0774 mL | 2.6935 mL | |
| 40 mM | 0.0808 mL | 0.4040 mL | 0.8080 mL | 2.0201 mL | |
| 50 mM | 0.0646 mL | 0.3232 mL | 0.6464 mL | 1.6161 mL | |
| 60 mM | 0.0539 mL | 0.2693 mL | 0.5387 mL | 1.3467 mL | |
| 80 mM | 0.0404 mL | 0.2020 mL | 0.4040 mL | 1.0101 mL | |
| 100 mM | 0.0323 mL | 0.1616 mL | 0.3232 mL | 0.8080 mL |
PBB3 Related Classifications
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