H-Ile-Lys-Val-Ala-Val-OH
Based on 1 publication(s) in Google Scholar
H-Ile-Lys-Val-Ala-Val-OH is one of the most potent active sites of laminin-1. H-Ile-Lys-Val-Ala-Val-OH promotes cell adhesion, neurite outgrowth, and tumor growth. H-Ile-Lys-Val-Ala-Val-OH stimulates BMMSC population growth and proliferation by activating MAPK/ERK1/2 and PI3K/Akt signalling pathways.
For research use only. We do not sell to patients.
- Purity: 99.35%
- CAS No.: 131167-89-0
- Formula: C25H48N6O6
- Molecular Weight:528.69
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) H-Ile-Lys-Val-Ala-Val-OH
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Biological Activity
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ERK1 |
ERK2 |
Akt |
H-Ile-Lys-Val-Ala-Val-OH (0-2.5 mM, 0-48 h) induces proliferation and proliferating cell nuclear antigen (PCNA) synthesis of bone marrow mesenchymal stem cell (BMMSC)[2].
H-Ile-Lys-Val-Ala-Val-OH (5 mM, 24 h) induces the BMMSC cell cycle for cells to enter S phase from G0/G1 and arrests them from entering G2/M phase[2].
H-Ile-Lys-Val-Ala-Val-OH (0-2.5 mM, 0-48 h) activats MAPK/ERK and PI3K/Akt signalling pathways by enhancing phosphorylation levels of ERK1/2 and Akt in the BMMSCs[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BMMSC
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Concentration:0, 0.004, 0.02, 0.1, 0.5 and 2.5 mM
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Incubation Time:0, 12, 24, 36, 48 h
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Result:Stimulated proliferating cell nuclear antigen (PCNA) synthesis and induced proliferation of bone marrow mesenchymal stem cell (BMMSC) in a dose- and time-dependent manner.
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Cell Line:BMMSC
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Concentration:5 mM
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Incubation Time:24 h
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Result:Induced the BMMSC cell cycle for cells to enter S phase from G0/G1 and arrested them from entering G2/M phase; the increased proportion of S phase in cell cycle was considered to be a sign of BMMSC proliferation.
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Cell Line:BMMSC
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Concentration:0, 0.004, 0.02, 0.1, 0.5 and 2.5 mM
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Incubation Time:0, 12, 24, 36, 48 h
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Result:Increased significantly the levels of p-ERK1/2 and p-Akt in a dose- and time-dependent manner.
Chemical Information
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CAS No. 131167-89-0
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Appearance Solid
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Molecular Weight 528.69
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Formula C25H48N6O6
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Color White to off-white
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Sequence
H-Ile-Lys-Val-Ala-Val-OH
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Sequence Shortening
IKVAV
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Int J Mol Sci
miR-107 Targets NSG1 to Regulate Hypopharyngeal Squamous Cell Carcinoma Progression through ERK Pathway. [Abstract]2024 May 29;25(11):5961. PMID: 38892156
Solvent & Solubility
H2O : 100 mg/mL (189.15 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Nomizu M, et al. The all-D-configuration segment containing the IKVAV sequence of laminin A chain has similar activities to the all-L-peptide in vitro and in vivo. J Biol Chem. 1992 Jul 15;267(20):14118-21. [Content Brief]
[2]. Li B, et al. IKVAV regulates ERK1/2 and Akt signalling pathways in BMMSC population growth and proliferation. Cell Prolif. 2014 Apr;47(2):133-45. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.8915 mL | 9.4573 mL | 18.9147 mL | 47.2867 mL |
| 5 mM | 0.3783 mL | 1.8915 mL | 3.7829 mL | 9.4573 mL | |
| 10 mM | 0.1891 mL | 0.9457 mL | 1.8915 mL | 4.7287 mL | |
| 15 mM | 0.1261 mL | 0.6305 mL | 1.2610 mL | 3.1524 mL | |
| 20 mM | 0.0946 mL | 0.4729 mL | 0.9457 mL | 2.3643 mL | |
| 25 mM | 0.0757 mL | 0.3783 mL | 0.7566 mL | 1.8915 mL | |
| 30 mM | 0.0630 mL | 0.3152 mL | 0.6305 mL | 1.5762 mL | |
| 40 mM | 0.0473 mL | 0.2364 mL | 0.4729 mL | 1.1822 mL | |
| 50 mM | 0.0378 mL | 0.1891 mL | 0.3783 mL | 0.9457 mL | |
| 60 mM | 0.0315 mL | 0.1576 mL | 0.3152 mL | 0.7881 mL | |
| 80 mM | 0.0236 mL | 0.1182 mL | 0.2364 mL | 0.5911 mL | |
| 100 mM | 0.0189 mL | 0.0946 mL | 0.1891 mL | 0.4729 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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