1. MAPK/ERK Pathway
    Stem Cell/Wnt
    Apoptosis
  2. ERK
    Apoptosis
  3. DMU-212

DMU-212 

Cat. No.: HY-137977 Purity: 99.91%
Handling Instructions

DMU-212 is a methylated derivative of Resveratrol (HY-16561), with antimitotic, anti-proliferative, antioxidant and apoptosis promoting activities. DMU-212 induces mitotic arrest via induction of apoptosis and activation of ERK1/2 protein. DMU-212 has orally active.

For research use only. We do not sell to patients.

DMU-212 Chemical Structure

DMU-212 Chemical Structure

CAS No. : 134029-62-2

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 88 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 88 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 80 In-stock
Estimated Time of Arrival: December 31
25 mg USD 160 In-stock
Estimated Time of Arrival: December 31
50 mg USD 280 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

DMU-212 is a methylated derivative of Resveratrol (HY-16561), with antimitotic, anti-proliferative, antioxidant and apoptosis promoting activities. DMU-212 induces mitotic arrest via induction of apoptosis and activation of ERK1/2 protein. DMU-212 has orally active[1][2].

In Vitro

DMU-212 (0.3125-40 μM) inhibits growth of A375, MeWo, Bro and M5 human melanoma cells[1].
DMU-212 (30-50 μM; 24 hours) induces upregulation of cell cycle inhibitors, apoptosis and ERK activation in A375 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: A375 cells, MeWo cells, M5 cells, Bro cells
Concentration: 0.3125 μM, 0,625 μM, 1.25 μM, 2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM
Incubation Time: 96 hours
Result: Inhibited the cellular proliferation of human melanoma cells at submicromolar or micromolar concentrations (IC50=0.5 μM for A375 and Bro and IC50= 1.25 μM for MeWo and M5 cells).

Cell Cycle Analysis[1]

Cell Line: A375 cells
Concentration: 20 μM, 30 μM, 50 μM
Incubation Time: 24 hours
Result: Caused a marked increase in the levels of p21, p53 and cyclin B1 proteins with a concomitant decrease in the levels of cyclin A2.

Western Blot Analysis[1]

Cell Line: A375 cells
Concentration: 20 μM, 30 μM, 50 μM
Incubation Time: 24 hours
Result: Significant upregulated Bax, caspase 3 and caspase 9 protein levels, while decreased the levels of the anti-apoptotic protein Bcl-2.

Apoptosis Analysis[1]

Cell Line: A375 cells
Concentration: 10 μM, 20 μM
Incubation Time: 24 hours, 36 hours
Result: Induced apoptosis.
In Vivo

DMU-212 (50 mg/kg; i.g.; three times a week; for 14 days) inhibits tumor growth in xenograft model of human ovarian cancer[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-weeks-old SCID female mice (20-24 g), with ovarian cancer xenografts[2]
Dosage: 50 mg/kg
Administration: Oral gavage, three times a week, for 14 days
Result: Lowered tumor burden.
Molecular Weight

300.35

Formula

C18H20O4

CAS No.
SMILES

COC1=CC=C(/C=C/C2=CC(OC)=C(OC)C(OC)=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (66.59 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3294 mL 16.6472 mL 33.2945 mL
5 mM 0.6659 mL 3.3294 mL 6.6589 mL
10 mM 0.3329 mL 1.6647 mL 3.3294 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2 mg/mL (6.66 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Product Name:
DMU-212
Cat. No.:
HY-137977
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