1. MAPK/ERK Pathway
    Stem Cell/Wnt
    Apoptosis
  2. ERK
    Apoptosis
  3. DMU-212

DMU-212 

Cat. No.: HY-137977
Handling Instructions

DMU-212 is a methylated derivative of Resveratrol (HY-16561), with antimitotic, anti-proliferative, antioxidant and apoptosis promoting activities. DMU-212 induces mitotic arrest via induction of apoptosis and activation of ERK1/2 protein. DMU-212 has orally active.

For research use only. We do not sell to patients.

DMU-212 Chemical Structure

DMU-212 Chemical Structure

CAS No. : 134029-62-2

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Description

DMU-212 is a methylated derivative of Resveratrol (HY-16561), with antimitotic, anti-proliferative, antioxidant and apoptosis promoting activities. DMU-212 induces mitotic arrest via induction of apoptosis and activation of ERK1/2 protein. DMU-212 has orally active[1][2].

In Vitro

DMU-212 (0.3125-40 μM) inhibits growth of A375, MeWo, Bro and M5 cells human melanoma cells[1].
DMU-212 (30-50 μM; 24 hours) induces upregulation of cell cycle inhibitors, apoptosis and ERK activation in A375 cells[1].
DMU-212 induces upregulation of cell cycle inhibitors, apoptosis and ERK activation in A375 cells[1].
DMU-212 induces G2/M arrest and apoptosis in cancer cells[1].
DMU-212 induces mitotic arrest, apoptosis and activation of ERK1/2 protein[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: A375 cells, MeWo cells, M5 cells, Bro cells
Concentration: 0.3125 μM, 0,625 μM, 1.25 μM, 2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM
Incubation Time: 96 hours
Result: Inhibited the cellular proliferation of human melanoma cells at submicromolar or micromolar concentrations (IC50=0.5 μM for A375 and Bro and IC50= 1.25 μM for MeWo and M5 cells).

Cell Cycle Analysis[1]

Cell Line: A375 cells
Concentration: 20 μM, 30 μM, 50 μM
Incubation Time: 24 hours
Result: Caused a marked increase in the levels of p21, p53 and cyclin B1 proteins with a concomitant decrease in the levels of cyclin A2.

Western Blot Analysis[1]

Cell Line: A375 cells
Concentration: 20 μM, 30 μM, 50 μM
Incubation Time: 24 hours
Result: Significant upregulation of Bax, caspase 3 and caspase 9 protein levels, while the levels of the anti-apoptotic protein Bcl-2 were decreased.
In Vivo

DMU-212 (50 mg/kg; i.g.; three times a week; for 14 days) inhibits tumor growth in xenograft model of human ovarian cancer[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-weeks-old SCID female mice (20-24 g), with ovarian cancer xenografts[2]
Dosage: 50 mg/kg
Administration: Oral gavage, three times a week, for 14 days
Result: Lower tumor burden.
Molecular Weight

300.35

Formula

C₁₈H₂₀O₄

CAS No.

134029-62-2

SMILES

COC1=CC=C(/C=C/C2=CC(OC)=C(OC)C(OC)=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DMU-212DMU212DMU 212ERKApoptosisExtracellular signal regulated kinasesResveratrolanticancerantimitoticantioxidantapoptosisInhibitorinhibitorinhibit

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DMU-212
Cat. No.:
HY-137977
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