1. Protein Tyrosine Kinase/RTK
  2. RET
  3. BT-13

BT-13 

Cat. No.: HY-124401 Purity: >99.0%
Handling Instructions

BT-13 is a potent and selective glial cell line-derived neurotrophic factor (GDNF) receptor RET agonist independently of GFLs, promoting neurite growth from sensory neurons in vitro and attenuates experimental neuropathy in the Rat.

For research use only. We do not sell to patients.

BT-13 Chemical Structure

BT-13 Chemical Structure

CAS No. : 924537-98-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 205 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 280 In-stock
Estimated Time of Arrival: December 31
50 mg USD 850 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

BT-13 is a potent and selective glial cell line-derived neurotrophic factor (GDNF) receptor RET agonist independently of GFLs, promoting neurite growth from sensory neurons in vitro and attenuates experimental neuropathy in the Rat[1].

IC50 & Target

GDNF receptor RET[1].

In Vitro

BT-13 stimulates phosphorylation of RET, as well as RET-dependent intracellular signaling, but activated neither NGF receptor TrkA nor BDNF receptor TrkB nor intracellular signaling in the absence of RET[1].

In Vivo

BT-13 (20 and 25mg/kg in rats induced by ligation of left L5 and L6 spinal nerves) has a slight antinociceptive/antihyperalgesic effect and protected DRG neurons in rats with surgery-induced neuropathy[1].

Animal Model: Rats induced by ligation of left L5 and L6 spinal nerves[1].
Dosage: 5-25 mg/kg, dissolved in sesame oil containing 5% DMSO.
Administration: Subcutaneous injections on post-surgical day 1, 3, 5, 8, 10, and 12.
Result: 20 and 25mg/kg decreased mechanical hypersensitivity and normalized expression of sensory neuron markers in dorsal root ganglia.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References
Molecular Weight

517.54

Formula

C₂₃H₂₇F₄N₃O₄S

CAS No.

924537-98-4

SMILES

O=S(C1=CC=C(OC)C(N2CCN(C(C3=CC=C(F)C=C3C(F)(F)F)=O)CC2)=C1)(N(CC)CC)=O

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Room temperature in continental US; may vary elsewhere

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Product Name:
BT-13
Cat. No.:
HY-124401
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BT-13

Cat. No.: HY-124401