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Nardosinone 

Cat. No.: HY-N0380 Purity: 99.37%
Handling Instructions

Nardosinone, isolated from Nardostachys chinensis, is the first enhancer of the neuritogenic action of dbcAMP and staurosporine. Nardosinone may become a useful pharmacological tool for studying the mechanism of action of not only nerve growth factor (NGF) but also both the neuritogenic substances.

For research use only. We do not sell to patients.

Nardosinone Chemical Structure

Nardosinone Chemical Structure

CAS No. : 23720-80-1

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5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
20 mg USD 180 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Nardosinone, isolated from Nardostachys chinensis, is the first enhancer of the neuritogenic action of dbcAMP and staurosporine. Nardosinone may become a useful pharmacological tool for studying the mechanism of action of not only nerve growth factor (NGF) but also both the neuritogenic substances[1].

In Vitro

Nardosinone (0.1-100 microM) enhanced dibutyryl cyclic AMP (dbcAMP, 0.3 mM)- and staurosporine (10 nM)-induced neurite outgrowth from PC12D cells in a concentration-dependent manner. Nardosinone enhances a downstream step of MAP kinase in the MAP kinase-dependent signaling pathway[1].

Molecular Weight

250.33

Formula

C₁₅H₂₂O₃

CAS No.

23720-80-1

SMILES

O=C1C[[email protected]@]2([H])OOC(C)(C)[[email protected]@]2([H])[[email protected]@]3(C)[[email protected]](C)CCC=C13

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (998.68 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9947 mL 19.9736 mL 39.9473 mL
5 mM 0.7989 mL 3.9947 mL 7.9895 mL
10 mM 0.3995 mL 1.9974 mL 3.9947 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

NardosinoneOthersNeuriteoutgrowth-promotingPC12DcellsneuritogenicsubstancesMAPKInhibitorinhibitorinhibit

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Nardosinone
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HY-N0380
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