2. Natural Products
  3. Disease Research Fields Plants Terpenoids
  4. Valerianaceae Neurological Disease Sesquiterpenes
  5. Nardostachys jatamansi (D. Don) DC.
  6. Nardosinone

Nardosinone, isolated from Nardostachys chinensis, is the first enhancer of the neuritogenic action of dbcAMP and staurosporine. Nardosinone may become a useful pharmacological tool for studying the mechanism of action of not only nerve growth factor (NGF) but also both the neuritogenic substances.

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Nardosinone Chemical Structure

Nardosinone Chemical Structure

CAS No. : 23720-80-1

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Based on 1 publication(s) in Google Scholar

Nardosinone Related Antibodies

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Description

Nardosinone, isolated from Nardostachys chinensis, is the first enhancer of the neuritogenic action of dbcAMP and staurosporine. Nardosinone may become a useful pharmacological tool for studying the mechanism of action of not only nerve growth factor (NGF) but also both the neuritogenic substances[1].

In Vitro

Nardosinone (0.1-100 microM) enhanced dibutyryl cyclic AMP (dbcAMP, 0.3 mM)- and staurosporine (10 nM)-induced neurite outgrowth from PC12D cells in a concentration-dependent manner. Nardosinone enhances a downstream step of MAP kinase in the MAP kinase-dependent signaling pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nardosinone Related Antibodies
Molecular Weight

250.33

Formula

C15H22O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C[C@@]2([H])OOC(C)(C)[C@@]2([H])[C@@]3(C)[C@H](C)CCC=C13
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (998.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9947 mL 19.9736 mL 39.9473 mL
5 mM 0.7989 mL 3.9947 mL 7.9895 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9947 mL 19.9736 mL 39.9473 mL 99.8682 mL
5 mM 0.7989 mL 3.9947 mL 7.9895 mL 19.9736 mL
10 mM 0.3995 mL 1.9974 mL 3.9947 mL 9.9868 mL
15 mM 0.2663 mL 1.3316 mL 2.6632 mL 6.6579 mL
20 mM 0.1997 mL 0.9987 mL 1.9974 mL 4.9934 mL
25 mM 0.1598 mL 0.7989 mL 1.5979 mL 3.9947 mL
30 mM 0.1332 mL 0.6658 mL 1.3316 mL 3.3289 mL
40 mM 0.0999 mL 0.4993 mL 0.9987 mL 2.4967 mL
50 mM 0.0799 mL 0.3995 mL 0.7989 mL 1.9974 mL
60 mM 0.0666 mL 0.3329 mL 0.6658 mL 1.6645 mL
80 mM 0.0499 mL 0.2497 mL 0.4993 mL 1.2484 mL
100 mM 0.0399 mL 0.1997 mL 0.3995 mL 0.9987 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nardosinone23720-80-1OthersNeuriteoutgrowth-promotingPC12DcellsneuritogenicsubstancesMAPKInhibitorinhibitorinhibit

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