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    Cytoskeleton
  2. Microtubule/Tubulin
  3. MAP4343

MAP4343 

Cat. No.: HY-107116 Purity: 98.09%
Handling Instructions

MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 binds in vitro to microtubule-associated protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents.

For research use only. We do not sell to patients.

MAP4343 Chemical Structure

MAP4343 Chemical Structure

CAS No. : 511-26-2

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 110 In-stock
Estimated Time of Arrival: December 31
5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 170 In-stock
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25 mg USD 350 In-stock
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50 mg USD 570 In-stock
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100 mg USD 900 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 binds in vitro to microtubule-associated protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents[1][2].

In Vitro

MAP4343 (40 μM; 15 or 30 min) stimulates microtubule polymerization in vitro[1].
MAP4343 (30 μM; 2-8 d) stimulates nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells[1].
MAP4343 (20 μM; 1 h) protects against microtubule depolymerization induced by Nocodazole in PC12 cells[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MAP4343 (12 mg/kg; daily s.c. for 28 d) improves the recovery of locomotor function after spinal cord injury (SCI) in rats[2].
MAP4343 (4 mg/kg; daily s.c. for 6 d) increases MAP2 levels in spinal cord after SCI in rats[2].
MAP4343 (4 mg/kg; daily s.c. for 6 d) increases the size of lumbar spinal motoneurons' dendrite arbours after SCI in rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult Sprague-Dawley male rats with spinal cord injury[2]
Dosage: 12 mg/kg
Administration: Daily s.c. for 28 days
Result: Increased the number of animals able to walk with weight-supported plantar steps.
Showed forelimb-hindlimb coordination at the end of the study.
Clinical Trial
Molecular Weight

330.50

Formula

C₂₂H₃₄O₂

CAS No.

511-26-2

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (75.64 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0257 mL 15.1286 mL 30.2572 mL
5 mM 0.6051 mL 3.0257 mL 6.0514 mL
10 mM 0.3026 mL 1.5129 mL 3.0257 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (7.56 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.56 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

MAP4343MAP 4343MAP-4343Microtubule/TubulinPregnenolonemicrotubule-associatedprotein2MAP2polymerizationtubulinneuritesInhibitorinhibitorinhibit

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Product Name:
MAP4343
Cat. No.:
HY-107116
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