1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Microtubule/Tubulin
  3. MAP4343

MAP4343 

Cat. No.: HY-107116
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MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 binds in vitro to microtubule-associated protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents.

For research use only. We do not sell to patients.

MAP4343 Chemical Structure

MAP4343 Chemical Structure

CAS No. : 511-26-2

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Description

MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 binds in vitro to microtubule-associated protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents[1][2].

In Vitro

MAP4343 (40 μM; 15 or 30 min) stimulates microtubule polymerization in vitro[1].
MAP4343 (30 μM; 2-8 d) stimulates nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells[1].
MAP4343 (20 μM; 1 h) protects against microtubule depolymerization induced by Nocodazole in PC12 cells[1]

In Vivo

MAP4343 (12 mg/kg; daily s.c. for 28 d) improves the recovery of locomotor function after spinal cord injury (SCI) in rats[2].
MAP4343 (4 mg/kg; daily s.c. for 6 d) increases MAP2 levels in spinal cord after SCI in rats[2].
MAP4343 (4 mg/kg; daily s.c. for 6 d) increases the size of lumbar spinal motoneurons' dendrite arbours after SCI in rats[2].

Animal Model: Adult Sprague-Dawley male rats with spinal cord injury[2]
Dosage: 12 mg/kg
Administration: Daily s.c. for 28 days
Result: Increased the number of animals able to walk with weight-supported plantar steps.
Showed forelimb-hindlimb coordination at the end of the study.
Molecular Weight

330.50

Formula

C₂₂H₃₄O₂

CAS No.

511-26-2

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Keywords:

MAP4343MAP 4343MAP-4343Microtubule/TubulinPregnenolonemicrotubule-associatedprotein2MAP2polymerizationtubulinneuritesInhibitorinhibitorinhibit

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MAP4343
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