Cefonicid sodium

Cat. No.: HY-B1300 Purity: 95.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Cefonicid sodium is a long-acting cephalosporin antibiotic. Cefonicid sodium also acts as a noncompetitive class I β-lactamase inhibitor with a K_i value of 0.8 μM. Cefonicid sodium exhibits broad-spectrum antimicrobial activity and is effective against a variety of Gram-positive and Gram-negative bacteria. Cefonicid sodium can be used for research on infections.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Cefonicid sodium 화학구조

CAS No. : 61270-78-8

사이즈	재고	수량

무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

Other Forms of Cefonicid sodium:

Cefonicid 견적 받기
Cefonicid monosodium 견적 받기
Cefonicid sodium (Standard) 견적 받기

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Metallo-β-lactamase (MBL) Serine β-lactamase (SBL)

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vitro

Cefonicid sodium (25-200 mg/L; 3-6 days) dose-dependently inhibits the proliferation of human PBMCs stimulated by FLU, XENO, ALLO, and PHA (HY-N7038)^[1].
Cefonicid sodium (0-200 mg/L; 7 days) dose-dependently inhibits IL-2 production by human PBMC stimulated with FLU, XENO and ALLO^[1].
Cefonicid sodium (0-24 h) exhibits concentration-dependent bactericidal activity against Klebsiella pneumoniae strain 2603 in vitro, with an MIC of 0.25 mg/L^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cefonicid sodium (15 mg/kg; i.p.; 2 doses) significantly reduces the pulmonary bacterial load in guinea pigs infected with K. pneumoniae^[3].
Cefonicid sodium (40 mg/kg; single dose) exhibits excellent protective effects against S. aureus, E. coli, P. mirabilis, and K. pneumoniae infections in mice^[4].
Cefonicid sodium exerts excellent preventive protective effects against surgical wound infections in mice, with an ED₅₀ value of ≤2.1 mg/kg against Gram-negative bacilli and an ED₅₀ value ranging from 3.7 to 8.7 mg/kg against S. aureus^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Hartley (female, 220-250 g)^[3]
Dosage:	15 mg/kg
Administration:	i.p.; 2 doses (immediately and 24 hours post-challenge)
Result:	Showed similar lung bacterial counts to infected untreated controls at 0 and 1 hour post-challenge. Reduced lung bacterial counts significantly compared to infected untreated controls starting at 6 hours post-challenge, with significant reductions also seen at 24 and 48 hours post-challenge.

분자량

586.53

화학식

C₁₈H₁₆N₆Na₂O₈S₃

CAS No.

61270-78-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(C(N12)=C(CSC3=NN=NN3CS(=O)(O[Na])=O)CS[C@]2([H])[C@H](NC([C@H](O)C4=CC=CC=C4)=O)C1=O)O[Na]

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

용액&용해도

In Vitro:

DMSO : 116.67 mg/mL (198.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 100 mg/mL (170.49 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7049 mL	8.5247 mL	17.0494 mL
5 mM	0.3410 mL	1.7049 mL	3.4099 mL
10 mM	0.1705 mL	0.8525 mL	1.7049 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 95.0%

Select Batch:

Data Sheet (278 KB) SDS (419 KB)

COA (256 KB) HNMR (291 KB) MS (71 KB)

Handling Instructions (2659 KB)

References

[1]. Villa ML, et al. Interference of cephalosporins with immune response: effects of cefonicid on human T-helper cells. Int J Immunopharmacol. 1991;13(8):1099-1107. [Content Brief]

[2]. MEHTA R J, et al. Cefonicid: a stable β-lactamase inhibitor. The Journal of Antibiotics, 1981, 34(2): 202-205.

[3]. Drago L, et al. Evaluation of antibacterial activity of cefodizime, ceftriaxone and cefonicid in Klebsiella pneumoniae-infected guinea pigs. Clinical microbiology and infection, 1999, 5(6): 371-373.

[4]. Saltiel E, et al. Cefonicid. A review of its antibacterial activity, pharmacological properties and therapeutic use. Drugs. 1986;32(3):222-259. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	1.7049 mL	8.5247 mL	17.0494 mL	42.6236 mL
	5 mM	0.3410 mL	1.7049 mL	3.4099 mL	8.5247 mL
	10 mM	0.1705 mL	0.8525 mL	1.7049 mL	4.2624 mL
	15 mM	0.1137 mL	0.5683 mL	1.1366 mL	2.8416 mL
	20 mM	0.0852 mL	0.4262 mL	0.8525 mL	2.1312 mL
	25 mM	0.0682 mL	0.3410 mL	0.6820 mL	1.7049 mL
	30 mM	0.0568 mL	0.2842 mL	0.5683 mL	1.4208 mL
	40 mM	0.0426 mL	0.2131 mL	0.4262 mL	1.0656 mL
	50 mM	0.0341 mL	0.1705 mL	0.3410 mL	0.8525 mL
	60 mM	0.0284 mL	0.1421 mL	0.2842 mL	0.7104 mL
	80 mM	0.0213 mL	0.1066 mL	0.2131 mL	0.5328 mL
	100 mM	0.0170 mL	0.0852 mL	0.1705 mL	0.4262 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.