2. Apoptosis Immunology/Inflammation Metabolic Enzyme/Protease
  3. TNF Receptor Interleukin Related Tyrosinase
  4. Mulberroside A

Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.). Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects. Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC50 of 53.6 μM.

For research use only. We do not sell to patients.

CAS No. : 102841-42-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
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1 mg In-stock
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25 mg In-stock
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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of Mulberroside A:

Mulberroside A Related Antibodies

Top Publications Citing Use of Products

    Mulberroside A purchased from MedChemExpress. Usage Cited in: J Inflamm (Lond). 2024 Aug 28;21(1):32.  [Abstract]

    The viability of NPCs intervened with different Mulberroside A (MA) concentrations (0, 20, 40, 80, and 160 µM) for 24 h was evaluated by a CCK-8 kit.

    Mulberroside A purchased from MedChemExpress. Usage Cited in: J Inflamm (Lond). 2024 Aug 28;21(1):32.  [Abstract]

    A Calcein /PI double staining of NPCs after intervention with IL-1β (5 ng/mL) alone or with different Mulberroside A (MA) concentrations (20, 40, and 80 µM) for 24 h.

    Mulberroside A purchased from MedChemExpress. Usage Cited in: J Inflamm (Lond). 2024 Aug 28;21(1):32.  [Abstract]

    The inflammatory proteins expressions (Inos, Cox-2, and Il-6) in NPCs shown in western blotting treated with Mulberroside A (MA) (20, 40, 80 μM).

    Mulberroside A purchased from MedChemExpress. Usage Cited in: J Inflamm (Lond). 2024 Aug 28;21(1):32.  [Abstract]

    The mRNA expression levels of inflammatory genes (Inos and Cox-2) were analyzed by RT-qPCR treated with Mulberroside A (MA) (20, 40, 80 μM).

    Mulberroside A purchased from MedChemExpress. Usage Cited in: J Inflamm (Lond). 2024 Aug 28;21(1):32.  [Abstract]

    IHC images of Aggrecan, Mmp13, Collagen II, Ppar-γ treated with Mulberroside A (MA) (80 μM).

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.)[1]. Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects[2]. Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC50 of 53.6 μM[3].

    IC50 & Target[1][2][3]

    IL-1β

     

    IL-6

     

    In Vivo

    Mulberroside A (10, 20, and 40 mg/kg) decreases serum uric acid levels and increases urinary urate excretion and fractional excretion of uric acid in hyperuricemic micem[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male Kun-Ming mice (20±2 g)[4]
    Dosage: 5, 10, 20, and 40 mg/kg; the dose volume 10 mL/kg body weight
    Administration: Orally initiated at 9:00 a.m.
    Result: 10, 20, and 40 mg/kg significantly increased urinary urate excretion in 24 h, resulting in a remarkable elevation of fractional excretion of uric acid (FEUA), and the highest dose completely reversed FEUA alteration of hyperuricemic mice to normal.
    Molecular Weight

    568.52

    Formula

    C26H32O14
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O[C@H]([C@@H](O)[C@@H]1O)[C@@H](O[C@@H]1CO)OC2=CC(/C=C/C(C=CC(O[C@@H]([C@@H]([C@@H](O)[C@@H]3O)O)O[C@@H]3CO)=C4)=C4O)=CC(O)=C2
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (87.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7590 mL 8.7948 mL 17.5895 mL
    5 mM 0.3518 mL 1.7590 mL 3.5179 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (4.40 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (4.40 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  0.5% CMC-Na/saline water

      Solubility: 10 mg/mL (17.59 mM); Suspended solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.92%

    SDS (393 KB)

    COA (249 KB) HNMR (323 KB) LCMS (94 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.7590 mL 8.7948 mL 17.5895 mL 43.9738 mL
    5 mM 0.3518 mL 1.7590 mL 3.5179 mL 8.7948 mL
    10 mM 0.1759 mL 0.8795 mL 1.7590 mL 4.3974 mL
    15 mM 0.1173 mL 0.5863 mL 1.1726 mL 2.9316 mL
    20 mM 0.0879 mL 0.4397 mL 0.8795 mL 2.1987 mL
    25 mM 0.0704 mL 0.3518 mL 0.7036 mL 1.7590 mL
    30 mM 0.0586 mL 0.2932 mL 0.5863 mL 1.4658 mL
    40 mM 0.0440 mL 0.2199 mL 0.4397 mL 1.0993 mL
    50 mM 0.0352 mL 0.1759 mL 0.3518 mL 0.8795 mL
    60 mM 0.0293 mL 0.1466 mL 0.2932 mL 0.7329 mL
    80 mM 0.0220 mL 0.1099 mL 0.2199 mL 0.5497 mL
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    Mulberroside A Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Mulberroside A102841-42-9TNF ReceptorInterleukin RelatedTyrosinaseTumor Necrosis Factor ReceptorTNFRILInhibitorinhibitorinhibit

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