Norepinephrine hydrochloride (Synonyms: Levarterenol hydrochloride; L-Noradrenaline hydrochloride; L-ノルエピネフリン塩酸塩)

Name: Norepinephrine hydrochloride
Brand: MedChemExpress
SKU: HY-13715A
Rating: 5.0 (61 reviews)

製品番号: HY-13715A 純度: 99.45%: Data Sheet SDS COA 取扱説明書
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Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α₁, α₂, β₁ receptors.

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CAS 番号 : 329-56-6

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 71	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 71	在庫あり	Estimated Time of Arrival: December 31
Solid
500 mg	$65	在庫あり	Estimated Time of Arrival: December 31
1 g		お問い合わせ
5 g		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 61 publication(s) in Google Scholar

Other Forms of Norepinephrine hydrochloride:

Norepinephrine 在庫あり
Norepinephrine bitartrate monohydrate 在庫あり
Norepinephrine tartrate 在庫あり
Norepinephrine hydrochloride (Standard) 在庫あり

顧客検証

Cell Proliferation/Viability Assay

Bio/Physico-chemical Assay

Flow Cytometry

Cell Imaging/Staining

RT-PCR

: Norepinephrine hydrochloride purchased from MedChemExpress. Usage Cited in: Cell. 2026 Mar 5;189(5):1323-1340.e25. [Abstract]; Norepinephrine bitartrate monohydrate (NE) (0.5 mM; 12 h) decreased CXCL16 level in mouse and human cultured keratinocytes.

: Norepinephrine hydrochloride purchased from MedChemExpress. Usage Cited in: Cell. 2026 Mar 5;189(5):1323-1340.e25. [Abstract]; Norepinephrine bitartrate monohydrate (NE) (2 mM; 100 μL; i.d.) caused a pronounced decrease in keratinocyte CXCL16 expression in C57BL/6J mice.

: Norepinephrine hydrochloride purchased from MedChemExpress. Usage Cited in: Cell. 2026 Mar 5;189(5):1323-1340.e25. [Abstract]; Norepinephrine bitartrate monohydrate (NE) (0.5 mM; 12 h) decreased Cxcl16 and Tgfb3 expression in cultured mouse keratinocytes.

: Norepinephrine hydrochloride purchased from MedChemExpress. Usage Cited in: Cell. 2026 Mar 5;189(5):1323-1340.e25. [Abstract]; Norepinephrine bitartrate monohydrate (NE) (2 mM; 100 μL; i.d.) led to a significant reduction of skin CD8⁺ T_RM cells in C57BL/6J mice.

: Norepinephrine hydrochloride purchased from MedChemExpress. Usage Cited in: Cell. 2026 Mar 5;189(5):1323-1340.e25. [Abstract]; Norepinephrine bitartrate monohydrate (NE) (0.5 mM; 12 h) decreased Cxcl16 and Tgfb3 expression in cultured human keratinocytes.

: Norepinephrine hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 6:e04817. [Abstract]; Atenolol (ATN, 1 µM, 72 h) rescued the Norepinephrine (NE, 10 µM)-induced decrease in TM4 cell viability.

: Norepinephrine hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 6:e04817. [Abstract]; Atenolol (ATN, 1 µM, 48 h) restored the Norepinephrine (NE, 10 µM)-induced increase in intracellular ferrous ion concentration in TM4 cells.

: Norepinephrine hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 6:e04817. [Abstract]; Atenolol (ATN, 1 µM, 48 h) restored the Norepinephrine (NE, 10 µM)-induced decrease in mitochondrial membrane potential in TM4 cells.

: Norepinephrine hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 6:e04817. [Abstract]; Atenolol (ATN, 1 µM, 48 h) reversed Norepinephrine (NE,10 μM）-induced alterations in the expression of SLC7A11, GPX4, and ACSL4 in TM4 cells.

: Norepinephrine hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 6:e04817. [Abstract]; Atenolol (ATN, 1 µM, 48 h) reversed Norepinephrine (NE,10 μM）-induced alterations in the expression of SLC7A11, GPX4, and ACSL4 in TM4 cells.

: Norepinephrine hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 May 7;15(1):3834. [Abstract]; Representative images of DLAT oligomer immunofluorescence imaging by confocal microscopy. Scale bar = 20 μm. HL-1 cells were treated with 10 µM CuCl2 in the presence of solvent (DMSO), 1 µM NE or 10 µM NE for 24 h.

: Norepinephrine hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2023 Feb;20(2):175-188. [Abstract]; Effects of epinephrine (EPI) and norepinephrine (NE) on virus-induced transcription of antiviral genes. THP1 cells (1 × 106) were treated with EPI or NE (10 μM) and then uninfected or infected with SeV or HSV-1 (MOI = 1), and at the indicated times, qPCR analysis was performed to determine the levels of the indicated mRNAs.

: Norepinephrine hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2023 Feb;20(2):175-188. [Abstract]; Effects of EPI/NE/isoprenaline (ISO) on virus-induced transcription of antiviral genes. THP1 cells (1 × 106) were treated with EPI, NE or ISO (10 μM) and uninfected or infected with EMCV (MOI = 1). Ten hours later, qPCR analysis was performed to determine the levels of the indicated mRNAs.

: Norepinephrine hydrochloride purchased from MedChemExpress. Usage Cited in: Cardiovasc Res. 2018 Feb 1;114(2):300-311. [Abstract]; Knockdown of GATA4 ameliorated morphology and functional changes in a Meox1 cell line with NE stimulation. Immunodetection of actin in HL-1 cells. Actin staining appeared green, and sections are counterstained blue with DAPI (40,6-diamidino-2-phenylindole).

: Norepinephrine hydrochloride purchased from MedChemExpress. Usage Cited in: J Nutr Biochem. 2018 Aug:58:110-118. [Abstract]; PASMCs are pretreated with or not Norepinephrine (50 μM) or ICI 118,551 (5 nM), and α-SMA (D) are analyzed.

Adrenergic Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

α adrenergic receptor β adrenergic receptor

Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Human Endogenous Metabolite Microbial Metabolite

生物活性
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純度とドキュメンテーション
参考文献
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製品説明

Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α₁, α₂, β₁ receptors^[1]^[2]^[3]^[4].

IC₅₀ & Target^[1]^[2]

α1-adrenergic receptor

α2-adrenergic receptor

Beta-1 adrenergic receptor

Microbial Metabolite

Human Endogenous Metabolite

体外実験

Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride is generally considered to be a β₁-subtype selective adrenergic agonist over β₂-adrenoceptor. Norepinephrine(NE) hydrochloride also has direct activity at the β₂-adrenoceptor in higher concentrations^[2].
Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 μM) with or without CGP (10 nM) co-treatment.
Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effect
Norepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly attenuated with CGP co-treatment in mouse iWA^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

Norepinephrine hydrochloride can be used to induce cardiomyopathy^[5]^[6]

Induced Cardiomyopathy Model^[5]^[6]

Background

Norepinephrine hydrochloride is a potent growth factor for cardiomyocytes. Long-term infusion of subhyperbaric doses of Norepinephrine hydrochloride in animals can cause increases in myocardial mass and left ventricular wall thickness. Norepinephrine hydrochloride activates the Raf-1 kinase/MAP kinase cascade through α1- and β-adrenergic stimulation, and signaling pathways from both receptors synergistically induce cardiomyocyte hypertrophy.

Specific Modeling Methods

Rat: Spragues-Dawley rats • adult (6 months old) • male Administration: Continuously injected via an osmotic minipump • 100 μg/kg/h or 200 μg/kg/h (Norepinephrine)

Modeling Indicators

Molecular changes: Left ventricular Dnmt activity ↑; ROS generation ↑; lactate dehydrogenase release ↑; dystrophin expression ↑; FHL2 protein expression ↓

Gene Expression: Expression of Dnmt1, 3a, and 3b ↑; mRNA expression of fetal genes ANP, BNP, and βMHC in left ventricle ↑

Phenotypic observation: Myocardial infarction area ↑; blood pressure continues to rise; left ventricular mass ↑; left ventricular development pressure ↓; cardiac contractility ↓. Cardiac hypertrophy.

Opposite Product(s): 5-Aza-2’-deoxycytidine (HY-A0004), Prazosin (HY-B0193), Propranolol (HY-B0573B)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

205.64

分子式

C₈H₁₂ClNO₃

CAS 番号

329-56-6

Appearance

Solid

Color

Off-white to yellow

SMILES

OC1=CC=C([C@@H](O)CN)C=C1O.Cl

Structure Classification

Initial Source

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

溶剤 & 溶解度

体外:

H₂O : 100 mg/mL (486.29 mM; Need ultrasonic)

DMSO : 50 mg/mL (243.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.8629 mL	24.3143 mL	48.6287 mL
5 mM	0.9726 mL	4.8629 mL	9.7257 mL
10 mM	0.4863 mL	2.4314 mL	4.8629 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (12.16 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (12.16 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (12.16 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 33.33 mg/mL (162.08 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: 99.95%

Select Batch:

データシート (282 KB) SDS (480 KB)

COA (248 KB) HNMR (247 KB) RP-HPLC (244 KB) LCMS (296 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Brian P Ramos, et al. Adrenergic pharmacology and cognition: focus on the prefrontal cortex. Pharmacol Ther. 2007 Mar;113(3):523-36. [Content Brief]

[2]. MacGregor DA, et al. Relative efficacy and potency of beta-adrenoceptor agonists for generating cAMP in human lymphocytes. Chest. 1996 Jan;109(1):194-200. [Content Brief]

[3]. Littlejohn NK, et al. Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. Cell Rep. 2016 Aug 9;16(6):1548-60. [Content Brief]

[4]. Xinyu Xu, et al. Binding pathway determines norepinephrine selectivity for the human β 1 AR over β 2 AR. Cell Res. 2021 May;31(5):569-579. [Content Brief]

細胞実験
^[2]

Subcutaneous preadipocytes derived from a 38-year old non-diabetic female donor are immortalized with TERT and HPV E6/E7. For the current studies, a stable diploid clone (referred to as clone B) with consistent differentiation capacity is isolated by ring cloning. Cells are grown in preadipocyte PGM2 media. Once cells are confluent, differentiation is induced by incubation in differentiation media consisting of dexamethasone, IBMX, indomethacin, and additional insulin. Cells are differentiated for 10 days. Prior to treatment, media is replaced with PGM2 media for one day and then switched to serum-free media overnight for treatments. Adipocytes are treated for 6 hours with vehicle, Norepinephrine (NE, 10 μM), CGP (10 nM), or Norepinephrine (NE) and CGP^[2].

MedChemExpress (MCE) はこれらの方法の精度を確認していません。こちらは参照専用です。

参考文献

[1]. Brian P Ramos, et al. Adrenergic pharmacology and cognition: focus on the prefrontal cortex. Pharmacol Ther. 2007 Mar;113(3):523-36. [Content Brief]

[2]. MacGregor DA, et al. Relative efficacy and potency of beta-adrenoceptor agonists for generating cAMP in human lymphocytes. Chest. 1996 Jan;109(1):194-200. [Content Brief]

[3]. Littlejohn NK, et al. Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. Cell Rep. 2016 Aug 9;16(6):1548-60. [Content Brief]

[4]. Xinyu Xu, et al. Binding pathway determines norepinephrine selectivity for the human β 1 AR over β 2 AR. Cell Res. 2021 May;31(5):569-579. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	4.8629 mL	24.3143 mL	48.6287 mL	121.5717 mL
	5 mM	0.9726 mL	4.8629 mL	9.7257 mL	24.3143 mL
	10 mM	0.4863 mL	2.4314 mL	4.8629 mL	12.1572 mL
	15 mM	0.3242 mL	1.6210 mL	3.2419 mL	8.1048 mL
	20 mM	0.2431 mL	1.2157 mL	2.4314 mL	6.0786 mL
	25 mM	0.1945 mL	0.9726 mL	1.9451 mL	4.8629 mL
	30 mM	0.1621 mL	0.8105 mL	1.6210 mL	4.0524 mL
	40 mM	0.1216 mL	0.6079 mL	1.2157 mL	3.0393 mL
	50 mM	0.0973 mL	0.4863 mL	0.9726 mL	2.4314 mL
	60 mM	0.0810 mL	0.4052 mL	0.8105 mL	2.0262 mL
	80 mM	0.0608 mL	0.3039 mL	0.6079 mL	1.5196 mL
	100 mM	0.0486 mL	0.2431 mL	0.4863 mL	1.2157 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Norepinephrine hydrochloride Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Norepinephrine329-56-6LevarterenolL-NoradrenalineAdrenergic ReceptorAutophagyEndogenous MetaboliteBeta Receptoradrenergic receptorα1α2β1Inhibitorinhibitorinhibit

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Norepinephrine hydrochloride (Synonyms: Levarterenol hydrochloride; L-Noradrenaline hydrochloride; L-ノルエピネフリン塩酸塩)

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Other Forms of Norepinephrine hydrochloride:

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生物活性

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純度とドキュメンテーション

参考文献

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Molarity Calculator

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Complete Stock Solution Preparation Table

Norepinephrine hydrochloride Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

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Norepinephrine hydrochloride (Synonyms: Levarterenol hydrochloride; L-Noradrenaline hydrochloride; L-ノルエピネフリン 塩酸塩)

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Other Forms of Norepinephrine hydrochloride:

Norepinephrine hydrochloride 関連抗体

顧客検証

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

Adrenergic Receptor アイソフォーム固有の製品をすべて表示:

Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

生物活性

プロトコル

純度とドキュメンテーション

参考文献

カスタマーレビュー

Norepinephrine hydrochloride 関連抗体

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Norepinephrine hydrochloride Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

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Norepinephrine hydrochloride (Synonyms: Levarterenol hydrochloride; L-Noradrenaline hydrochloride; L-ノルエピネフリン塩酸塩)