2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. BRL-44408 maleate

BRL-44408 maleate is an α2A-adrenoceptor antagonist (Ki: 8.5 nM). BRL-44408 maleate has antidepressant and analgesic activity. BRL-44408 also improves cecal ligation puncture (CLP)-induced acute lung injury.

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BRL-44408 maleate Chemical Structure

BRL-44408 maleate Chemical Structure

CAS No. : 681806-46-2

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BRL-44408 maleate Related Antibodies

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Description

BRL-44408 maleate is an α2A-adrenoceptor antagonist (Ki: 8.5 nM). BRL-44408 maleate has antidepressant and analgesic activity. BRL-44408 also improves cecal ligation puncture (CLP)-induced acute lung injury[1][2].

IC50 & Target

Ki: 8.5 nM (α2A-adrenoceptor)[1]
Molecular Weight

331.37

Formula

C17H21N3O4
CAS No.
Appearance

Solid

Color

Light brown to brown

SMILES

CC1N(CC2=NCCN2)CC3=C1C=CC=C3.O=C(O)/C=C\C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (90.53 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0178 mL 15.0889 mL 30.1777 mL
5 mM 0.6036 mL 3.0178 mL 6.0355 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Purity: ≥99.0%

COA (260 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0178 mL 15.0889 mL 30.1777 mL 75.4444 mL
5 mM 0.6036 mL 3.0178 mL 6.0355 mL 15.0889 mL
10 mM 0.3018 mL 1.5089 mL 3.0178 mL 7.5444 mL
15 mM 0.2012 mL 1.0059 mL 2.0118 mL 5.0296 mL
20 mM 0.1509 mL 0.7544 mL 1.5089 mL 3.7722 mL
25 mM 0.1207 mL 0.6036 mL 1.2071 mL 3.0178 mL
30 mM 0.1006 mL 0.5030 mL 1.0059 mL 2.5148 mL
40 mM 0.0754 mL 0.3772 mL 0.7544 mL 1.8861 mL
50 mM 0.0604 mL 0.3018 mL 0.6036 mL 1.5089 mL
60 mM 0.0503 mL 0.2515 mL 0.5030 mL 1.2574 mL
80 mM 0.0377 mL 0.1886 mL 0.3772 mL 0.9431 mL
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BRL-44408 maleate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRL-44408681806-46-2BRL44408BRL 44408Adrenergic ReceptorBeta ReceptorantidepressantanalgesicCLPlung injuryInhibitorinhibitorinhibit

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