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Results for "

exo-

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (8) Antibiotic (1) Apoptosis (1) Arf Family GTPase (2) Bacterial (4) Biochemical Assay Reagents (36) Cannabinoid Receptor (5) Cytochrome P450 (1) DNA/RNA Synthesis (8) Drug Derivative (1) Drug Intermediate (1) Drug Metabolite (1) Drug-Linker Conjugates for ADC (4) Endogenous Metabolite (6) Endonuclease (1) Epigenetic Reader Domain (1) Exosomes (2) FLAP (2) Fluorescent Dye (7) Fungal (2) Gli (1) Glycosidase (3) Hedgehog (1) Isotope-Labeled Compounds (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) Nucleoside Antimetabolite/Analog (1) Phytohormone (1) PROTAC Linkers (4) Ras (1) Reference Standards (3) Small Interfering RNA (siRNA) (5) Smo (1) STAT (1) Virus Protease (1) Wnt (2)
By Research Areas:	Cancer (30) Endocrinology (2) Infection (10) Inflammation/Immunology (2) Metabolic Disease (5) Neurological Disease (4)
Click Chemistry:	Labeling and Fluorescence Imaging (5) DBCO (1) PROTAC Synthesis (4) BCN (18)
Oligonucleotides:	Thymine Nucleotide (1) Adenosine (1) Nucleoside Analogs (1) Nucleotide Analogs (2) Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (2) Adenine Nucleotide (1) siRNAs (5)

112

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-120821

Endosidin-2 2 Publications Verification ES2	Exosomes	Others
Endosidin-2 (ES2) is a selective inhibitor targeting the conserved exosome subunit *EXO70. Endosidin-2 binds to the C-terminal domain of EXO70, inhibiting exocytosis and endosomal recycling, while promoting vacuolar trafficking in plant cells. Endosidin-2 interferes with the EXO70-mediated vesicle-to-plasma membrane anchoring process, leading to abnormal aggregation of auxin transporters (such as PIN2*) in the cytoplasm and redirected to vacuolar degradation, while causing abnormal Golgi structure (such as cup-shaped or ring-shaped vesicles cisternae formation). Endosidin-2 can inhibit exocytosis in plant and mammalian cells and is mainly used to study the dynamic regulation of membrane trafficking (such as polar growth, vesicle sorting) .

HY-112670

Exo1 Maximum Cited Publications 8 Publications Verification	Arf Family GTPase	Others
Exo1 is a chemical inhibitor of the exocytic pathway.

HY-P2988

Neuraminidase, Microorganism 1 Publications Verification exo-α-sialidase	Endogenous Metabolite	Infection
Neuraminidase, Microorganism (Exo-α-sialidase) is an exosialidase, is often used in biochemical studies. Neuraminidase cleaves α-ketosidic linkage between the sialic (N-acetylneuraminic) acid and an adjacent sugar residue. Neuraminidase, derived from mucosal pathogens, is a virulence factor that modifies the host's response to infection .

HY-174143

EXO1-IN-1	Apoptosis	Cancer
EXO1-IN-1 is a human exonuclease 1 (EXO1) inhibitor (IC₅₀ = 15.7 μM). EXO1-IN-1 inhibits DNA end resection, promotes the accumulation of DNA double-strand breaks, and triggers S-phase polyamylation. EXO1-IN-1 induces apoptosis (Apoptosis) in BRCA1-deficient breast cancer cells. EXO1-IN-1 suppresses the growth of BRCA1-deficient breast cancer xenografts. EXO1-IN-1 can be used in research related to BRCA1-deficient breast cancer .

HY-W754588

exo-BCN-L-Lysine	PROTAC Linkers	Others
exo-BCN-L-Lysine is a Click Amino Acid that can be used as a linker in the synthesis of PROTAC molecules. exo-BCN-L-Lysine contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-P3187

exo-β-1,4-Xylosidase, Cellulosimicrobium cellulans sp. 21	DNA/RNA Synthesis	Others
Exo-1,4-β-xylosidase is an exonuclease that specifically acts on the β-1,4 glycosidic bonds at the non-reducing ends of xylan and xylooligosaccharides. Exo-1,4-β-xylosidase is Ca ²⁺-dependent and reversibly binds to metal ions to catalyze the hydrolysis of β-1,4 glycosidic bonds, thereby degrading xylan to produce xylose. Exo-1,4-β-xylosidase can be used in research fields such as lignocellulose bioconversion, bioethanol production, and optimization of xylan saccharification processes .

HY-133402

*BCN-exo-PEG3-NH2*	PROTAC Linkers	Cancer
BCN- exo- PEG3- NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . BCN- exo- PEG3- NH2 is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-W096149

exo-BCN-NHS carbonate	Biochemical Assay Reagents	Others
exo-BCN-NHS carbonate carbonate contains BCN group. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-137975

Exo2	Bacterial	Endocrinology
Exo2 is a secretion inhibitor. Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network. Exo2 blocks secretory cargo exit from the ER (endoplasmic reticulum) and disrupts the Golgi apparatus, but does not affect the morphology of the TGN (trans-Golgi network) Exo2 can stimulate calcium-dependent exocytosis in permeabilized adrenal chromaff in cells .

HY-133406

exo BCN-O-PNB	PROTAC Linkers	Cancer
exo BCN-O-PNB is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . exo BCN-O-PNB is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-169322

APL-1081 Mal-exo-EVC-MMAE	Drug-Linker Conjugates for ADC Microtubule/Tubulin	Cancer
APL-1081 (Mal-Exo-EVC-MMAE) is part of an antibody-conjugated active molecule (ADC). APL-1081 is conjugated with an ADC linker (peptide Mal-Exo-EEVC) and a potent tubulin polymerization inhibitor, MMAE (HY-15162) .

HY-134734

*BCN-exo-PEG7-maleimide*	ADC Linker	Cancer
BCN-exo-PEG7-maleimide is an ADC Linker containing 7 PEG units. BCN-exo-PEG7-maleimide contains the lyophilic bidentate macrocyclic ligand BCN, which allows for further synthesis of macrocyclic complexes. In click chemistry, BCN reacts with molecules containing azide groups to form stable triazoles in the absence of catalysts. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.

HY-156305

*Coumarin-C2-exo-BCN*	Fluorescent Dye	Others
Coumarin-C2-exoBCN is a dye derivative of Coumarin (HY-N0709). Coumarin-C2-exoBCN contains the lyophilic bidentate macrocyclic ligand exo-BCN, which can further synthesize macrocyclic complexes. In click chemistry, exo-BCN can react with molecules containing azide groups to generate stable triazoles under catalyst-free conditions.

HY-156322

*BCN-exo-PEG3-maleimide*	ADC Linker	Cancer
BCN-exo-PEG3-maleimide is an ADC Linker containing 3 PEG units. BCN-exo-PEG3-maleimide contains the lyophilic bidentate macrocyclic ligand BCN, which enables the further synthesis of macrocyclic complexes. In click chemistry, BCN reacts with molecules containing azide groups to form stable triazoles in the absence of catalysts. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.

HY-108437

exo-IWR-1	Wnt	Infection Cancer
exo-IWR-1, an inactive stereoisomer of Endo-IWR-1, is a negative control of IWR-1 (HY-12238). IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway .

HY-175888

APL-1082 Mc-exo-EVC-Exatecan	Drug-Linker Conjugates for ADC	Cancer
APL-1082 is a drug-Linker conjugate that can be used for ADC synthesis. APL-1082 contains Exatecan (HY-13631) and Linker (HY-175929). APL-1082 reduces aggregation and hydrophobicity in Trastuzumab (HY-P9907) ADCs, enables production of high-DAR (10) ADCs with homogeneity and defined physicochemical properties. APL-1082 forms a Trastuzumab ADC with enhanced stability, showing greater DAR retention over time. APL-1082 can be used for the research of gastric cancer .

HY-P10862A

AH-D peptide TFA	Exosomes Virus Protease	Infection Cancer
AH-D peptide TFA is an antiviral peptide that selectively disrupts membrane structures within the size range of exosomes, inducing T-EXO depletion and enhancing cancer immunotherapy .

HY-P3261

Inulinase	Biochemical Assay Reagents	Others
Inulinase is expressed in various microorganisms, including yeasts, fungi, mesophilic bacteria. Inulinase can be used to produce inulooligosaccharides from inulin and inulin-containing materials. Inulinase produced by yeast has hydrolysing capability towards sucrose, inulin, levan type fructans exo-wise .

HY-170845

MU1409	Endonuclease	Cancer
MU1409 is an inhibitor of MRE11 nuclease with an IC₅₀ of 12.1 μM. Additionally, MU1409 also inhibits FEN1 and *EXO1, with IC₅₀* values of 24.2 and 176.4 μM, respectively. MU1409 affects DNA repair in cells, preventing the degradation of stalled replication forks in BRCA2-deficient cells, making it a promising candidate for research on BRCA2 mutation-induced cancers .

HY-169323

APL-1091 Mal-exo-EEVC-MMAE	Drug-Linker Conjugates for ADC	Cancer
APL-1091 (Mal-Exo-EEVC-MMAE) is part of a Drug-linker conjugate for ADC. APL-1091 contains a Mal-Exo-EEVC (HY-169353) linker and MMAE (HY-15162) (Microtubule inhibitor). APL-1091 can be used for ADC synthesis .

HY-156320

*BCN-exo-PEG2-maleimide*	ADC Linker	Cancer
BCN-exo-PEG2-maleimide is an ADC Linker containing 2 PEG units. BCN-exo-PEG2-maleimide contains the lyophilic bidentate macrocyclic ligand BCN, which allows for further synthesis of macrocyclic complexes. In click chemistry, BCN reacts with molecules containing azide groups to form stable triazoles in the absence of catalysts. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.

HY-164416

DBCO-Dextran sulfate (MW 40000)	Drug Intermediate	Inflammation/Immunology
DBCO-Dextran sulfate (MW 40000) can be used to construct DS-EXOs in cells via click chemistry, that can be used for the research of rheumatoid arthritis (RA) .

HY-175883

FEN1-IN-8	FLAP	Cancer
FEN1-IN-8 (compund 15) is a selective FEN1 inhibitor, with IC₅₀ values of < 100 nM for FEN1 and 100 nM to 1 μM for *EXO1*, respectively. FEN1-IN-8 can be used for study of colorectal cancer and gastric cancer .

HY-D1275

CAY10731	Fluorescent Dye	Others
CAY10731 (compound 3) is a highly selective fluorescent probe for detection of hydrogen sulfide (H₂S). CAY10731 is used to monitor exo- and endogenous H₂S in both cancer and normal cells. CAY10731 is applied for imaging of H₂S in living tissues at variable depths and in nematodes .

HY-P2802D

exo-α-Glucosidase, Bacteroides thetaiotaomicron	Glycosidase	Others
exo-α-Glucosidase,Bacteroides thetaiotaomicron (EC.3.2.1.20) is a α-Glucosidase. exo-α-Glucosidase, using maltose as a donor, exhibits excellent transglycosidic activity towards various receptors .

HY-E70404

*FastTaq DNA Polymerase(5'→3' exo-)*	DNA/RNA Synthesis Biochemical Assay Reagents	Others
FastTaq DNA Polymerase (5'→3' exo-) is a modified DNA polymerase based on Taq DNA Polymerase. FastTaq DNA Polymerase (5'→3' exo-) lacks the 5'→3' exonuclease activity of wild-type Taq. It retains the 5'→3' DNA polymerase activity of wild-type Taq .

HY-132177H

exo-α-Fucosidase, Bacteroides fragilis	Biochemical Assay Reagents	Others
exo-α-Fucosidase, Bacteroides fragilis (EC 3.2.1.51) is a glycoside hydrolase that would release free fucose .

HY-P3187B

exo-β-1,4-xylosidase, Bacteroides ovatus	DNA/RNA Synthesis	Others
exo-β-1,4-xylosidase, Bacteroides ovatus (EC.3.2.1.37) is an exonuclease that specifically acts on the β-1,4 glycosidic bonds at the non-reducing ends of xylan and xylooligosaccharides. exo-β-1,4-xylosidase is Ca ²⁺-dependent and reversibly binds to metal ions to catalyze the hydrolysis of β-1,4 glycosidic bonds, thereby degrading xylan to produce xylose. exo-β-1,4-xylosidase can be used in research fields such as lignocellulose bioconversion, bioethanol production, and optimization of xylan saccharification processes .

HY-P3187A

exo-β-1,4-xylosidase, Clostridium stercorarium	DNA/RNA Synthesis	Others
exo-β-1,4-xylosidase,Clostridium stercorarium (EC.3.2.1.37) is an exonuclease that specifically acts on the β-1,4 glycosidic bonds at the non-reducing ends of xylan and xylooligosaccharides. exo-β-1,4-xylosidase is Ca ²⁺-dependent and reversibly binds to metal ions to catalyze the hydrolysis of β-1,4 glycosidic bonds, thereby degrading xylan to produce xylose. exo-β-1,4-xylosidase can be used in research fields such as lignocellulose bioconversion, bioethanol production, and optimization of xylan saccharification processes .

HY-169352

*Mal-Exo-EVC*	ADC Linker	Cancer
Mal-Exo-EVC is a cleavable ADC linker used in the synthesis of antibody-drug conjugate (ADC) .

HY-169353

*Mal-Exo-EEVC*	ADC Linker	Cancer
Mal-Exo-EEVC is a cleavable ADC linker used in the synthesis of antibody-drug conjugate (ADC) .

HY-157052

exo-BCN-Fmoc-L-Lysine	PROTAC Linkers	Others
exo-BCN-Fmoc-L-Lysine is a Click Amino Acid that can be used as a linker in the synthesis of PROTAC molecules. exo-BCN-Fmoc-L-Lysine contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-156323

*BCN-exo-PEG4-NHS*	ADC Linker	Cancer
BCN-exo-PEG4-NHS is an ADC Linker containing 4 PEG units. BCN-exo-PEG4-NHS contains the lyophilic bidentate macrocyclic ligand BCN, which allows for further synthesis of macrocyclic complexes. In click chemistry, BCN reacts with molecules containing azide groups to form stable triazoles in the absence of catalysts.

HY-156324

*BCN-exo-PEG8-NHS*	ADC Linker	Cancer
BCN-exo-PEG8-NHS is an ADC Linker containing 8 PEG units. BCN-exo-PEG8-NHS contains the lyophilic bidentate macrocyclic ligand BCN, which allows for further synthesis of macrocyclic complexes. In click chemistry, BCN reacts with molecules containing azide groups to form stable triazoles in the absence of catalysts.

HY-132177D

exo-α-Fucosidase, Emticicia oligotrophica	Biochemical Assay Reagents	Others
exo-α-Fucosidase, Emticicia oligotrophica (EC 3.2.1.51) is a glycoside hydrolase that would release free fucose .

HY-132177E

exo-α-Fucosidase, Elizabethkingia meningoseptica	Biochemical Assay Reagents	Others
exo-α-Fucosidase, Elizabethkingia meningoseptica (EC 3.2.1.51) is a glycoside hydrolase that would release free fucose .

HY-156319

*BCN-exo-PEG2-NH2*	ADC Linker	Cancer
BCN-exo-PEG2-NH2 is an ADC Linker containing 2 PEG units. BCN-exo-PEG2-NH2 contains the lyophilic bidentate macrocyclic ligand BCN, which can further synthesize macrocyclic complexes. In click chemistry, BCN reacts with molecules containing azide groups to form stable triazoles in the absence of catalysts.

HY-132177I

exo-α-1,2-Fucosidase, Bifidobacterium bifidum	Biochemical Assay Reagents	Others
exo-α-1,2-Fucosidase,Bifidobacterium bifidum is a glycoside hydrolase that would release free fucose .

HY-149620

*Cy5-PEG2-exo-BCN*	Fluorescent Dye	Others
Cy5-PEG2-exo-BCN is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) containing 2 PEG units. Cy5-PEG2-exo-BCN contains the lyophilic bidentate macrocyclic ligand BCN, which can further synthesize macrocyclic complexes. In click chemistry, BCN reacts with molecules containing azide groups to form stable triazoles in the absence of catalysts.

HY-169324

APL-1092 Mal-exo-EEVC-Exatecan	Drug-Linker Conjugates for ADC	Cancer
APL-1092 (Mal-Exo-EEVC-Exatecan) is a drug-linker conjugate for ADC, which contains Exatecan (HY-13631) (ADC payload) and a linker .

HY-P2950H

exo-α-1,3-Mannosidase, Bacteroides thetaiotaomicron	Biochemical Assay Reagents	Others
exo-α-1,3-Mannosidase, Bacteroides thetaiotaomicron is a glycoside hydrolase that can hydrolyze mannose α-1,3 linkages in host N-glycans .

HY-179028

DHGA5 exo-16,17-Dihydro-gibberellin A5-13-acetate	Phytohormone	Others
DHGA5 (exo-16,17-Dihydro-gibberellin A5-13-acetate) is a GA3β-hydroxylase (OsGA3ox2) inhibitor. DHGA5 inhibits Arabidopsis root growth with an IC₅₀ of 97 μM. DHGA5 also suppresses the elongation of rice second leaf sheath. DHGA5 can alleviate oxidative damage to Arabidopsis seedlings under NaCl salt stress and reduce the accumulation of superoxide anion .

HY-162274

Oxazepine	Hedgehog Antibiotic	Infection Cancer
Oxazepine (compound 4a) has antimicrobial viability via binding OMPA/ exo-1,3-beta-glucanase proteins. Oxazepine is a hedgehog signaling inhibitor with antitumor viability .

HY-E70597

endo-α-1,5-Arabinanase, Bacteroides thetaiotaomicron	Biochemical Assay Reagents	Others
endo-α-1,5-Arabinanase, Bacteroides thetaiotaomicron (EC.3.2.1.99) is a glycoside hydrolase involved in arabinan decomposition. exo-α-1,5-Arabinanase is capable of cleaving arabinan main chains .

HY-E70598

endo-α-1,5-Arabinanase, Bacillus subtilis 168	Biochemical Assay Reagents	Others
endo-α-1,5-Arabinanase, Bacillus subtilis 168 (EC.3.2.1.99) is a glycoside hydrolase involved in arabinan decomposition. exo-α-1,5-Arabinanase is capable of cleaving arabinan main chains .

HY-170695

exo-THCP exo-Tetrahydrocannabiphorol	Cannabinoid Receptor	Neurological Disease
exo-THCP (exo-Tetrahydrocannabiphorol) is structurally similar to known phytocannabinoids.

HY-168368

exo-Tetrahydrocannabivarin	Cannabinoid Receptor	Others
exo-Tetrahydrocannabivarin (Compound 12) is a Δ ^9,11-THC analogue. exo-Tetrahydrocannabivarin weakly binds to cannabinoid receptors (CB) (IC₅₀: 1.4 μM). exo-Tetrahydrocannabivarin is active on both motor and analgesic aspects in mice .

HY-157076S

exo-Hydroxytandospirone-d8	Isotope-Labeled Compounds	Others
exo-Hydroxytandospirone-d₈ is deuterium-labeled exo-Hydroxytandospirone .

HY-RS04586

EXO5 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
EXO5 Human Pre-designed siRNA Set A contains three designed siRNAs for EXO5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

EXO5 Human Pre-designed siRNA Set A EXO5 Human Pre-designed siRNA Set A

HY-RS27243

Exo1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Exo1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Exo1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Exo1 Rat Pre-designed siRNA Set A Exo1 Rat Pre-designed siRNA Set A

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N5132

(-)-Fenchone	Structural Classification Other Monoterpenes Classification of Application Fields Terpenoids Other Diseases Umbelliferae Plants Vernonia Schreb. Disease Research Fields Source Classification	Cytochrome P450
(-)-Fenchone is a bicyclic monoterpene and serves as a substrate for human liver microsomal cytochrome P450 enzymes CYP2A6 and CYP2B6. (-)-Fenchone is not metabolized by human CYP1A1, CYP1A2, CYP1B1, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, or CYP3A4 enzymes. (-)-Fenchone undergoes hydroxylation to produce 6-exo-hydroxyfenchone, 6-endo-hydroxyfenchone, and 10-hydroxyfenchone. During the metabolism of (-)-Fenchone, CYP2A6 may play a more important role than CYP2B6 .

HY-108826

Iduronate sulfatase Iduronate sulfate sulfatase	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Iduronate sulfatase (Iduronate sulfate sulfatase) is an exo-sulfatase that hydrolyzes the C2-sulfate ester bond from nonreducing terminal α-L-iduronic acid residues in HS .

HY-155411

HPSE1-IN-2	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
HPSE1-IN-2 (compound 2) is a Heparanase-1 (HPSE1) inhibitor that also inhibits exo-β-d-glucuronidase (GUSβ) and glucocerebrosidase (GBA) activity .

HY-155410

HPSE1-IN-1	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
HPSE1-IN-1 (compound 16) is a selective inhibitor of Heparanase-1 (HPSE1) with moderate inhibitory activity against exo-β-d-glucuronidase (GUSβ) and glucocerebrosidase (GBA) .

HY-N5132R

(-)-Fenchone (Standard)	Structural Classification Other Monoterpenes Terpenoids Umbelliferae Plants Vernonia Schreb. Source Classification	Reference Standards Others
(-)-Fenchone (Standard) is the analytical standard of (-)-Fenchone. This product is intended for research and analytical applications. (-)-Fenchone, a bicyclic monoterpene, is widely distributed in plants and found in essential oils from Foeniculum vulgare. (-)-Fenchone is oxidized to 6-endo-hydroxyfenchone, 6-exo-hydroxyfenchone and 10-hydroxyfenchone derivatives by CYP2A6 and CYP2B6 in human liver microsomes with CYP2A6 playing a more important role than CYP2B6 .

HY-N17250

*5-exo-Hydroxyborneol*	Structural Classification Natural Products Microorganisms Source Classification	Drug Derivative
5-exo-Hydroxyborneol is a hydroxylated monoterpenoid that is a product of microbial transformation of (+)-bornyl acetate by Helminthosporium sativum .

Cat. No.	Product Name	Chemical Structure