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Antitumor agent-212

Antitumor agent-212 is a α-exo-methylene-selenolactone derivative with prominent selective antitumor activity. Antitumor agent-212 exhibits an MIC value of 128 μg/mL against Gram-positive bacteria. Antitumor agent-212 exhibits significant antitumor effects in the U87 human glioma xenograft model. Antitumor agent-212 can be used for the study of glioma, breast cancer and non-small cell lung cancer, and antibacterial study.

For research use only. We do not sell to patients.

CAS No.: 3108305-08-1
Formula: C₂₀H₂₂ClNO₂Se
Molecular Weight:422.81

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Antitumor agent-212 Chemical Structure

CAS No.: 3108305-08-1

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

In Vitro

Antitumor agent-212 (compound 2d) (72 h) exhibits potent antiproliferative activity against U87 cells (IC₅₀ = 0.87 μM), C6 cells (IC₅₀ = 0.85 μM), 4T1 cells (IC₅₀ = 0.95 μM) and A549 cells (IC₅₀ = 1.32 μM), and shows high selectivity for cancer cells over normal HEK293T cells (IC₅₀ = 77.15 μM)^[1].
Antitumor agent-212 exhibits an MIC value of 128 μg/mL (302.6 μM) against Gram-positive Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA), and no activity against Gram-negative Pseudomonas aeruginosa (MIC > 256 μg/mL)^[1].PARP1/NAMPT-IN-1 (0.3-1 μM; 48 h) enhances TBK1 and IRF3 phosphorylation in MDA-MB-231 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Antitumor agent-212 (compound 2d) (30 mg/kg; i.p. and S.C.; once a day; for 15 days) exerts significant tumor growth inhibition with no obvious toxicity in U87 human glioma xenograft models of male BALB/C nude mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male BALB/C nude mice were implanted with U87 human glioma cells to establish orthotopic xenograft models^[1].
Dosage:

30 mg/kg
Administration:

Intraperitoneal (IP) and subcutaneous (S.C.) injection; once daily; for 15 days
Result:

Significantly inhibited tumor growth from day 12 and reduced tumor volume markedly on day 15 compared to the control group.
No obvious toxicity was observed in mice, with no body weight loss during the experimental period.

Chemical Information

CAS No. 3108305-08-1
Molecular Weight 422.81
Formula C₂₀H₂₂ClNO₂Se
SMILES

CN(C)CC(CC(C[Se]C1=CC=CC=C1)(C2=CC=C(Cl)C=C2)O3)C3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li D, et al. Synthesis and antitumor activities of quaternary carbon-containing selenolactones. Bioorg Med Chem Lett. 2026 Feb 1;131:130439. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

100 mg

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