2. Anti-infection
  3. Bacterial
  4. Antitumor agent-212

Antitumor agent-212 is a α-exo-methylene-selenolactone derivative with prominent selective antitumor activity. Antitumor agent-212 exhibits an MIC value of 128 μg/mL against Gram-positive bacteria. Antitumor agent-212 exhibits significant antitumor effects in the U87 human glioma xenograft model. Antitumor agent-212 can be used for the study of glioma, breast cancer and non-small cell lung cancer, and antibacterial study.

For research use only. We do not sell to patients.

Antitumor agent-212

Antitumor agent-212 Chemical Structure

CAS No. : 3108305-08-1

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Antitumor agent-212 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Antitumor agent-212 is a α-exo-methylene-selenolactone derivative with prominent selective antitumor activity. Antitumor agent-212 exhibits an MIC value of 128 μg/mL against Gram-positive bacteria. Antitumor agent-212 exhibits significant antitumor effects in the U87 human glioma xenograft model. Antitumor agent-212 can be used for the study of glioma, breast cancer and non-small cell lung cancer, and antibacterial study[1].

In Vitro

Antitumor agent-212 (compound 2d) (72 h) exhibits potent antiproliferative activity against U87 cells (IC50 = 0.87 μM), C6 cells (IC50 = 0.85 μM), 4T1 cells (IC50 = 0.95 μM) and A549 cells (IC50 = 1.32 μM), and shows high selectivity for cancer cells over normal HEK293T cells (IC50 = 77.15 μM)[1].
Antitumor agent-212 exhibits an MIC value of 128 μg/mL (302.6 μM) against Gram-positive Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA), and no activity against Gram-negative Pseudomonas aeruginosa (MIC > 256 μg/mL)[1].PARP1/NAMPT-IN-1 (0.3-1 μM; 48 h) enhances TBK1 and IRF3 phosphorylation in MDA-MB-231 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-212 Related Antibodies
In Vivo

Antitumor agent-212 (compound 2d) (30 mg/kg; i.p. and S.C.; once a day; for 15 days) exerts significant tumor growth inhibition with no obvious toxicity in U87 human glioma xenograft models of male BALB/C nude mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/C nude mice were implanted with U87 human glioma cells to establish orthotopic xenograft models[1].
Dosage: 30 mg/kg
Administration: Intraperitoneal (IP) and subcutaneous (S.C.) injection; once daily; for 15 days
Result: Significantly inhibited tumor growth from day 12 and reduced tumor volume markedly on day 15 compared to the control group.
No obvious toxicity was observed in mice, with no body weight loss during the experimental period.
Molecular Weight

422.81

Formula

C20H22ClNO2Se
CAS No.
SMILES

CN(C)CC(CC(C[Se]C1=CC=CC=C1)(C2=CC=C(Cl)C=C2)O3)C3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Antitumor agent-212 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-2123108305-08-1Antitumor agent212Antitumor agent 212BacterialAntitumor agentU87 cellsC6 cells4T1 cellsA549 cellsHEK293T cellsmale BALB/C nude miceU87 human glioma xenograft modelorthotopic xenograft modelgliomabreast cancernon-small cell lung cancerantibacterial activityInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Antitumor agent-212
Cat. No.:
HY-181517
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.